Neuropil threads are collinear with MAP2 immunostaining in neuronal dendrites of Alzheimer brain

Journal of Neuropathology and Experimental Neurology

Volumn 57, Issue 10, 1998, Pages 972-978

  Ashford, J Wesson ^a   Soultanian, Natalie S ^a   Zhang, Shu Xin ^a   Geddes, James W ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer disease; Cytoskeleton; Neurodegeneration; Paired helical filaments; Tau

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DENDRITE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MALE; MOTOR CORTEX; NERVE DEGENERATION; NEUROPIL; PAIRED HELICAL FILAMENT; PARIETAL LOBE; PRIORITY JOURNAL;

EID: 0031754290     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199810000-00009     Document Type: Article

References (42)

1. Stelzmann RA, Schnitzlein HN, Murtagh FR. An English translation of Alzheimer's 1907 paper, "Über eine eigenartige Erkankung der Hirnrinde." Clin Anat 1995;8:429-31
2. Jarvik L, Greenson H. About a peculiar disease of the cerebral cortex. By Alois Alzheimer, 1907 (Translation). Alzheimer Dis Assoc Disord 1987;1:3-8
3. Tomlinson BE, Blessed G, Roth M. Observations on the brains of demented old people. J Neurol Sci 1970;11:205-42
4. Braak H, Braak E, Grundke-Iqbal I, Iqbal K. Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett 1986;65:351-55
5. Markesbery WR, Wang HZ, Kowall NW, Kosik KS, McKee AC. Morphometric image analysis of neuropil threads in Alzheimer's disease. Neurobiol Aging 1993;14:303-7
6. Ihara Y. Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease. Brain Res 1988;459:138-44
7. Yamaguchi H, Nakazato Y, Shoji M, Ihara Y, Hirai S. Ultrastructure of the neuropil threads in the Alzheimer brain: Their dendritic origin and accumulation in the senile plaques. Acta Neuropathol (Berl) 1990;80:368-74
8. Onorato M, Mulvihill P, Copnnolly J, Galloway P, Whitehouse P, Perry G. Alteration of neuritic cytoarchitecture in Alzheimer disease. Prog Clin Biol Res 1989;317:781-89
9. Ohtsubo K, Izumiyama N, Kuzuhara S, Mori H, Shimada H. Curly fibers are tau-positive strands in the pre-and post-synaptic neurites, consisting of paired helical filaments: Observations by the freezeetch and replica method. Acta Neuropathol (Berl) 1990;81:111-15
10. Perry G, Kawai M, Tabaton M, et al. Neuropil threads of Alzheimer's disease show a marked alteration of the normal cytoskeleton. J Neurosci 1991;11:1748-55
11. Braak H, Braak E. Neuropil threads occur in dendrites of tangle-bearing nerve cells. Neuropathol Appl Neurobiol 1988;14:39-44
12. Kowall NW, Kosik KS. Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease. Ann Neurol 1987;22:639-43
13. Braak E, Braak H, Mandelkow EM. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol (Berl) 1994;87:554-67
14. Schmidt ML, Murray JM, Trojanowski JQ. Continuity of neuropil threads with tangle-bearing and tangle-free neurons in Alzheimer disease cortex. A confocal laser scanning microscopy study. Mol. Chem. Neuropath. 1993;18:299-312
15. Szendrei GI, Lee VM, Otvos L, Jr. Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location. J Neurosci Res 1993;34: 243-49
16. Gallyas F. Silver staining of Alzheimer's neurofibrillary changes by means of physical development. Acta Morphol Acad Sci Hung 1971;19:1-8
17. Lee VM, Trojanowski JQ. The disordered neuronal cytoskeleton in Alzheimer's disease. Curr Opin Neurobiol 1992;2:653-56
18. Geddes JW, Mattson MP. Tau hyperphosphoryation and free radicals in PHF formation: Early or late events? Neurobiol. Aging 1995;16:399-402
19. McKee AC, Kowall NW, Kosik KS. Microtubular reorganization and dendritic growth response in Alzheimer's disease. Ann Neurol 1989;26:652-59
20. Schmidt ML, Lee VM, Trojanowski JQ. Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads. Lab Invest 1991;64:352-57
21. Greenberg SG, Davies P, Schein JD, Binder LI. Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. J Biol Chem 1992;267:564-69
22. Tucker RP, Binder LI, Viereck C, Hemmings B, A., Matus A. The sequential appearance of low-and high-molecular weight forms of MAP 2 in the developing cerebellum. J. Neurosci. 1988;8:4503-12
23. Geddes JW, Tekirian TL, Soultanian NS, Ashford JW, Davis DG, Markesbery WR. Comparison of neuropathologic criteria for the diagnosis of Alzheimer's disease. Neurobiol Aging 1997;18:S99-105
24. Schwab C, Bondada V, Sparks DL, Cahan LD, Geddes JW. Post-mortem changes in the levels and localization of microtubule-associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus. Hippocampus 1994;4:210-25
25. Otvos L, Jr., Feiner L, Lang E, Szendrei GI, Goedert M, Lee VM. Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404. J Neurosci Res 1994;39:669-73
26. Pettigrew LC, Holtz ML, Craddock SD, Minger SL, Hall N, Geddes JW. Microtubular proteolysis in focal cerebral ischemia. J Cereb Blood Flow Metab 1996;16:1189-1202
27. Geddes JW, Schwab C, Craddock S, Wilson JL, Pettigrew LC. Alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia. J Cereb Blood Flow Metab 1994;14: 554-64
28. Geddes JW, Bondada V, Keller JN. Effects of intrahippocampal colchicine administration on the levels and localization of microtubule-associated proteins, tau and MAP2. Brain Res 1994;633:1-8
29. Pang Z, Umberger GH, Geddes JW. Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: Lack of protection by MK-801. J Neurochem 1996;66:474-84
30. Davis DR, Anderton BH, Brion JP, Reynolds CH, Hanger DP. Oxidative stress induces dephosphorylation of tau in rat brain primary neuronal cultures. J Neurochem 1997;68:1590-97
31. Iwatsubo T, Hasegawa M, Esaki Y, Ihara Y. Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads. Am J Pathol 1992;140:277-82
32. Goedert M, Jakes R, Vanmechelen E. Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205. Neurosci Lett 1995;189:167-69
33. Kimura T, Ono T, Takamatsu J, et al. Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments. Dementia 1996;7:177-81
34. Braak H, Braak E, Strothjohann M. Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat. Neurosci Lett 1994;171:1-4
35. Nelson PT, Saper CB. Ultrastructure of neurofibrillary tangles in the cerebral cortex of sheep. Neurobiol Aging 1995;16:315-23
36. Peters A, Palay SL, Webster HD. The fine structure of the nervous system. 3rd ed. New York: Oxford University Press, 1991
37. Ahmad FJ, Baas PW. Microtubules released from the neuronal centrosome are transported into the axon. J Cell Sci 1995;108:2761-69
38. Baas PW, Yu W. A composite model for establishing the microtubule arrays of the neuron. Mol Neurobiol 1996;12:145-61
39. Park JS, Bateman MC, Goldberg MP. Rapid alterations in dendrite morphology during sublethal hypoxia or glutamate receptor activation. Neurobiol Dis 1996;3:215-27
40. Matesic DF, Lin RC. Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forebrain. J Neurochem 1994;63:1012-20
41. Geddes JW, Bondada V, Tekirian TL, Pang Z, Siman RG. Perikaryal accumulation and proteolysis of neurofilament proteins in the post-mortem rat brain. Neurobiol Aging 1995;16:651-60
42. Bancher C, Braak H, Fischer P. Jellinger KA. Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients. Neurosci Lett 1993;162:179-82