The neurotoxicity of amyloid beta protein in aged primates

Amyloid

Volumn 5, Issue 1, 1998, Pages 1-9

  McKee, A C ^a,b   Kowall, N W ^a,b,c   Schumacher, J S ^c   Beal, M Flint ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; Amyloid beta peptide; Neurotoxicity; Primate

Indexed keywords

ALZHEIMER'S DISEASE ANTIGEN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; ANTIGEN; PEPTIDE FRAGMENT; THIAZOLE DERIVATIVE; THIOFLAVINE; UBIQUITIN;

AGE; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BRAIN; FEMALE; FLUORESCENCE MICROSCOPY; HAPLORHINI; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; MALE; METABOLISM; MICROINJECTION; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS; BRAIN; FEMALE; HAPLORHINI; IMMUNOHISTOCHEMISTRY; MALE; MICROINJECTIONS; MICROSCOPY, FLUORESCENCE; NEURONS; PEPTIDE FRAGMENTS; THIAZOLES; UBIQUITINS;

EID: 0032014664     PISSN: 13506129     EISSN: None     Source Type: Journal    
DOI: 10.3109/13506129809007283     Document Type: Article

References (59)

1. Goate A, Chartier-Harlin M-C, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N and James L (1991). Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706
2. Mullan M, Crawford F and Axelman K (1992). A pathogenetic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid. Nature Genetics 1, 345-347
3. Murrell J, Farlow M, Ghetti B and Benson MD (1991). A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254, 97-99
4. Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L Jr, Eckman C, Golde TE and Younkin SG (1994). An increased percentage of long amyloid β protein secreted by familial amyloid β-protein precursor (ββPP 717) mutants. Science 264, 1336-1340
5. Cai X-D, Golde TE and Younkin SG (1993). Release of excess amyloid β protein from mutant amyloid β protein precursor. Science 259, 514-516
6. Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I and Selkoe DJ (1992). Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature 360:672-674
7. Yankner B, Duffy L and Kirschner D (1990). Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 250, 279-282
8. Pike CJ, Walencewicz AJ, Glabe CG and Cotman CW (1991). In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res 563, 311-314
9. Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I and Rydel RE (1992). β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12, 376-389
10. Pike CJ, Burdick DW, Walencewicz AJ, Glabe CG and Cotman CW (1993). Neurodegeneration induced by β-amyloid peptides in vitro: the role of the peptide assembly state. J Neurosci 13, 1676-1687
11. Ueda K, Fukui Y and Kageyama H (1994). Amyloid β-protein induced neuronal cell death: neurotoxic properties of aggregated amyloid β protein. Br Research 639, 240-244.
12. Copani A, Koh J-Y and Cotman CW (1991). β-amyloid increases neuronal susceptibility to injury by glucose deprivation. Brain Research 639, 240-244
13. Kowall NW, Beal MF, Busciglio J, Duffy LK and Yankner BA (1991). An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. Proc Natl Acad Sci USA 88, 7247-7251
14. Kowall NW, McKee AC, Yankner BA and Beal MF (1992). In vivo neurotoxicity of beta amyloid [β(1-40)] and the β(25-35) fragment. Neurobiol Aging 13, 537-42
15. Frautschy SA, Baird A and Cole GM (1991). Effects of injected Alzheimer beta-amyloid cores in rat brain. Proc Natl Acad Sci USA 88, 8362-6
16. Neve RL, Kammersheidt A and Hohmann CF (1992). Brain transplants of cells expressing the carboxy-terminal fragment of the Alzheimer amyloid precursor protein cause specific neuropathology in vivo. Proc Natl Acad Sci USA 89, 3448-3452
17. Nelson PT and Saper CB (1994). Alz-50 and PHF immunoreactivity near β-AP injections in the cerebral cortex of sheep. Soc. Neurosci. Abs. 20, 1036
18. Higgins LS, Holtzman DM, Rabin J, Mobley WC and Cordell B (1994). Transgenic mouse brain histopathology resembles early Alzheimer's disease. Ann Neurol 35, 3448-3452
19. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T and Gillespie F (1995). Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Science 37, 523-527
20. Busciglio J, Yeh J and Yankner BA (1992). Methodological variables in the assessment of β amyloid neurotoxicity. Neurobiol Aging 13, 609-612
21. Lee VM-Y, Balin BJ, Otvos LJ and, Trojanowski JQ (1991). A68: A major subunit of paired helical filaments and derivatized forms of normal tau. Science 251, 675-678
22. Wolozin B and Davies P (1987). Alzheimer-related neuronal protein A68: specificity and distribution. Ann Neurol 22, 521-6
23. Selkoe DJ (1994). Alzheimer's disese: a central role for amyloid. J Neuropathol Exp Neurol 53, 438-447
24. Lorenzo A and Yankner BA (1995). Beta amyloid neurotoxicity requires fibril formation and is inhibited by Congo Red. Proc Natl Acad Sci USA 91, 12243-12248
25. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ and Cotman CW (1993). Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci USA 90, 7951-7955
26. Forloni G, Chiesa R, Smiroldo S, Verga L, Salmona M, Tagliavini F and Angeretti N (1993). Apoptosis mediated neurotoxicity induced by chronic application of the β-amyloid fragment 25-35. NeuroReport 4, 523-526
27. Behl C, Davis JB, Klier FG and Schubert D (1994). Amyloid beta peptide induces necrosis rather than apoptosis. Brain Res 645, 253-64
28. Walker LC, Kitt CA, Scwam E, Buckwald B, Garcia F, Sepinwall J and Price DL (1987). Senile plaques in aged squirrel monkeys. Neurobiology of Aging 8, 291-296
29. Wisniewski HM and Terry RD (1973). Reexamination of the Pathogenesis of the Senile Plaque, pp 1-26. Grune amd Stratton, New York
30. Hall ET, Andrus PK and Yonkers PA (1993). Brain hydroxyl radical in acute experimental head injury. J Neurochem 60, 588-594
31. Podlisny MB, Stephenson DT, Frosch MP, Lieberburg I, Clemens JA and Selkoe DJ (1993). Microinjection of synthetic amyloid β-protein in monkey cerebral cortex fails to produce acute neurotoxicity. Amer J Pathol 142, 17-24
32. Forno LS, Langston JW, DeLanney LE, Irwin I and Ricaurte GA (1986). Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann Neurol 20, 449-455
33. Gupta M, Gupta BK, Thomas R, Bruemmer V, Sladek JRJ and Felten DL (1986). Aged mice are more sensitive to MPTP treatment than young adults. Neurosci. Lett. 70, 326-331
34. Higgins LS, Rodems JM, Catalano R, Quon D and Cordell B (1995). Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for β-βPP751. Proc Natl Acad Sci USA 92, 4402-4406
35. Moran PM, Higgins LS, Cordell B and Moser PC (1995). Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human β-amyloid precursor protein. Proc Natl Acad Sci USA 92, 5341-5345
36. Hensley K, Carney JM, Mattson MP, Aksenova M, Harris M, Wu JF, Floyd RA and Butterfield DA (1994). A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer's disease. Proc Natl Acad Sci USA 91, 3270-3274
37. Behl C, Davis J, Lesley R and Schubert D (1994). Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77, 817-827
38. Behl C, Davis J, Cole GM and Schubert D(1992). Vitamin E protects nerve cells from amyloid β protein toxicity. Biochem Biophys Res Comm 1, 944-950
39. Mecocci P, MacGarvey U, Kaufman AE, Koontz D, Shoffner JM, Wallace DC and Beal MF (1993). Oxidative damage to mitochondrial DNA shows marked age-dependent increases in the human brain. Ann Neurol 34, 609-616
40. Mecocci P, MacGarvey U and Beal M(1994). Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 36, 747-51
41. Dubey A, Forster MJ, Lal H and Sohal RS (1996). Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Archives of Biochemistry & Biophysics 333, 189-197
42. Sohal RS and Weindruch R (1996). Oxidative stress, caloric restriction, and aging. Science 273, 59-63
43. Joseph JA, Villalobos-Molina R, Denisova N, Erat S, Jimenez N and Strain J (1996). Increased sensitivity to oxidative stress and the loss of muscarinic receptor responsiveness in senescence. Ann New York Acad Sci 786, 112-119
44. Lyras L, Cairns NJ, Jenner A, Jenner P and Halliwell B (1997) An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. Journal of Neurochemistry 68, 2061-2069
45. Smith MA, Richey Harris PL, Sayre LM, Beckman JS and Perry G (1997) Widespread peroxynitrite-mediated damage in Alzheimer's disease. Journal of Neuroscience 17, 2653-2657
46. Good PF, Werner P, Hsu A, Olanow CW and Perl DP (1996) Evidence of neuronal oxidative damage in Alzheimer's disease. Amer J Pathology 149, 21-28
47. Smith MA, Perry G, Richey PL, Sayre LM, Anderson VE, Beal MF and Kowall N (1996) Oxidative damage in Alzheimer's disease. Nature 382, 120-121
48. Price JL, Davis PB, Morris JC and White DL (1991). The distribtuion of tangles, plaques and related immunohistochemcial markers in healthy aging and Alzheimer's disease. Neurobiol Aging 12, 295-312
49. Arriagada PV, Marzloff K and Hyman BT (1992). Distribtion of Alzheimer-type pathologic changes in non-demented elderly individuals matches the pattern of Alzheimer's disease. Neurology 42, 1681-1688
50. McKee AC, Kosik KS and Kowall NW (1991). Neuritic pathology and dementia in Alzheimer's disease. Ann. Neurol 30, 156-165
51. Roses AD (1994). Apolipoprotein E affects the rate of Alzheimer disease expression: β-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. J Neuropathol Exp Neurol 53, 429-437
52. Crystal H, Dickson D, Fuld P, Masur D, Scott R, Mehler M, Masdeu J, Kawas C, Aronson M and Wolfson L (1988). Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology 1988 38, 1682-1687
53. Katzman R, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, Renbing X and Peck A (1988). Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 23, 138-144
54. Davies L, Wolska B, Hilbich C, Multhaup G, Martins R, Simms G, Beyreuther K and Masters CL (1988). A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: Prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathological techniques. Neurology 38, 1688-1693
55. Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA and Katzman R (1991). Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30, 572-580
56. DeKosky ST and Scheff SW (1990). Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann. Neurol 27, 457-464
57. Bellomo G and Mirabelli F (1992). Oxidative stress and cytoskeletal alterations. Ann New York Acad Sci 663, 97-109
58. Dyrks T, Dyrks E, Masters CL and Beyreuther K (1993). Amyloidogenicity of rodent and human βA4 sequences. FEBS Letters 342, 231-236
59. Troncosco JC, Costello A, Watson JAL and Johnson GVW (1993). In vitro polymerization of oxidized tau into filaments. Brain Research 613, 313-316