Role of adipose tissue in body-weight regulation: Mechanisms regulating leptin production and energy balance

Proceedings of the Nutrition Society

Volumn 59, Issue 3, 2000, Pages 359-371

  Havel, P J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adipose tissue; Energy expenditure; Food intake; Glucose metabolism; Leptin; Obesity

Indexed keywords

GLUCOSE; INSULIN; INTERLEUKIN 6; LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; BODY WEIGHT; CARBOHYDRATE INTAKE; CONFERENCE PAPER; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; FAT INTAKE; FEEDING BEHAVIOR; FOOD INTAKE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HORMONAL REGULATION; HUMAN; HYPOTHALAMUS; INSULIN INFUSION; NONHUMAN; OBESITY; WEIGHT GAIN;

EID: 0033811444     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0029665100000410     Document Type: Conference Paper

References (134)

1. Role of leptin in the neuroendocrine response to fasting
2. Plasma leptin and insulin in C57BI/6J mice on a high-fat diet: Relation to subsequent changes in body weight
3. Leptin increases circulating glucose, insulin and glucagon via sympathetic neural activation in fasted mice
4. Leptin inhibits insulin secretion induced by cellular cAMP in INS-1 cells
5. Regulation of plasma leptin in mice: Influence of age, high-fat diet and fasting
6. Leptin is a metabolic signal to the reproductive system
7. Leptin selectively decreases visceral adiposity and enhances insulin action
8. Injections of leptin into the anterior piriform cortex inhibit food intake in rats
9. Effect of fasting on serum leptin in normal human subjects
10. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: Leptin inhibits cortisol release directly
11. Leptin, the product of Ob gene, promotes angiogenesis
12. Dietary fat intake does affect obesity!
13. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
14. Leptin receptors in the adrenal medulla of the rat
15. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
16. Leptin: The tale of an obesity gene
17. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
18. Early onset of reproductive function in normal female mice treated with leptin
19. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
20. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy
21. Increased plasma leptin levels are associated with fat accumulation in Japanese Americans
22. Leptin is a metabolic gate for the onset of puberty in the female rat
23. Acylation stimulating protein (ASP), an adipocyte autocrine: New directions
24. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
25. Effects of parabiosis of obese with diabetes and normal mice
26. Effects of parabiosis of normal with genetically diabetic mice
27. The hypothalamic leptin receptor in humans: Identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations
28. Serum immunoreactive-leptin concentrations in normal-weight and obese humans
29. Leptin's actions on the reproductive axis: Perspectives and mechanisms
30. The ob gene and insulin: A relationship leading to clues to the understanding of obesity
31. Plasma leptin and insulin relationships in obese and nonobese humans
32. Leptin selectively increases energy expenditure of food-restricted lean mice
33. Changes of serum leptin and endocrine and metabolic parameters after 7 days of energy restriction in men and women
34. Amino acid variants in the human leptin receptor: Lack of association to juvenile onset obesity
35. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
36. Central leptin modulates behavioral and neural responsivity to CCK
37. Effects of recombinant leptin therapy in a child with congenital leptin deficiency
38. CSF leptin levels after exogenous administration of recombinant methionyl human leptin
39. Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity
40. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
41. Effects of fasting and glucose infusion on basal and overnight leptin concentrations in normal-weight women
42. Leptin concentrations do not predict weight gain: The Mexico City Diabetes Study
43. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
44. Weight-reducing effects of the plasma protein encoded by the obese gene
45. Regulation of leptin production in cultured mature white adipocytes
46. Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA
47. Specific depletion of body fat in parabiotic partners of tube-fed obese rats
48. Glucose infusion increases circulating leptin in proportion to adipose stores in rhesus monkeys
49. Leptin production and action: Relevance to energy balance in humans
50. Mechanisms regulating leptin production: Implications for the control of energy balance
51. Predominately glucocorticoid agonist actions of RU-486 in young specific-pathogen-free Zucker rats
52. Gender differences in plasma leptin concentrations
53. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: Effects of dietary fat content and sustained weight loss
54. Control of food intake
55. Acute adrenergically-mediated increases of circulating glucose and lactate after leptin administration in rhesus monkeys
56. High fat meals reduce 24 h circulating leptin concentrations in women
57. Rapid and marked decreases of circulating leptin in streptozotocin diabetic rats: Reversal by insulin
58. Receptor-mediated regional sympathetic nerve activation by leptin
59. Recombinant leptin for weight loss in lean and obese adults: A randomized, controlled, dose-escalation trial
60. Development of dietary obesity in rats: Influence of amount and composition of dietary fat
61. Fat and carbohydrate overfeeding: Different effects on energy storage
62. The role of TNFalpha and TNF receptors in obesity and insulin resistance
63. The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus
64. Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women
65. The role of the fat depot in the hypothalamic control of food intake in the rat
66. Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells
67. Responses of leptin to short-term fasting and refeeding in humans: A link with ketogenesis but not ketones themselves
68. Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro
69. Response of leptin to short-term and prolonged overfeeding in humans
70. Serum leptin and body weight in females with anorexia and bulimia nervosa
71. Radioimmunoassay of rat leptin: Sexual dimorphism reversed from humans
72. Hypoleptinemia in women athletes: Absence of diurnal rhythm with amenorrhea
73. Expression of ob gene in adipose cells: Regulation by insulin
74. Decreased food intake does not completely account for adiposity reduction after ob protein infusion
75. Leptin regulates proinflammatory immune responses
76. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
77. Leptin levels in human and rodents: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
78. Insulin increases plasma leptin concentrations in normal subjects and in patients with NIDDM
79. Gain in body fat is inversely related to the nocturnal rise in serum leptin level in young females
80. Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake
81. Human leptin receptor gene in obese Japanese subjects: Evidence against either obesity-causing mutations or association of sequence variants with obesity
82. Effects of tumour necrosis factor alpha (TNFα) on leptin secretion and gene expression: Relationship to changes of glucose metabolism in isolated rat adipocytes
83. Adipose tissue as an endocrine and paracrine organ
84. Congenital leptin deficiency is associated with severe early-onset obesity in humans
85. Evidence that glucose metabolism regulates leptin secretion from cultured adipocytes
86. Leptin prevents respiratory depression in obesity
87. Effects of the obese gene product on body weight regulation in ob/ob mice
88. Relatively low plasma leptin concentrations precede weight gain in Pima Indians
89. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
90. Regulation of ob gene mRNA levels in cultured adipocytes
91. Effects of gender, body composition, and menopause on plasma concentrations of leptin
92. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action
93. Physiological insulinemia acutely modulates plasma leptin
94. Diurnal and ultradian rhythmicity of plasma leptin: Effects of gender and adiposity
95. Transient increase in obese gene expression after food intake or insulin administration
96. The arcuate nucleus as a primary site of satiety effect of leptin in rats
97. Leptin induction of UCP1 gene expression is dependent on sympathetic innervation
98. Leptin increases uncoupling protein expression and energy expenditure
99. Entrainment of the diurnal rhythm of plasma leptin to meal timing
100. Model for the regulation of energy balance and adiposity by the central nervous system
101. Insulin and the central regulation of energy balance
102. Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
103. Identification of targets of leptin action in rat hypothalamus
104. Biological action of leptin as an angiogenic factor
105. The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog
106. Low plasma leptin levels contribute to diabetic hyperphagia in rats
107. Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects
108. Plasma leptin in diabetic and insulin-treated diabetic and normal rats
109. Plasma leptin concentrations: Effects of extended fasting and stepwise increases in glucose infusions
110. A leptin missense mutation associated with hypogonadism and morbid obesity
111. Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice
112. Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques
113. The arcuate nucleus is pivotal in mediating the anorectic effects of centrally administered leptin
114. The leptin receptor
115. Identification and expression cloning of a leptin receptor, OB-R
116. Effect of fat intake on energy balance
117. Regulation of leptin production: A dominant role for the sympathetic nervous system?
118. Impact of dietary fat content and fat oxidation on energy intake in humans
119. Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects
120. Diet-induced obese mice develop peripheral, but not central, resistance to leptin
121. Insulin and cortisol promote leptin production in cultured human fat cells
122. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
123. Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels
124. Leptin does not fully account for the satiety activity of adipose tissue-conditioned medium
125. Elevated free fatty acids induce uncoupling protein 3 expression in muscle: A potential explanation for the effect of fasting
126. Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats
127. Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity
128. Identification of candidate genes for a factor regulating body weight in primates
129. The fibrinolytic enzyme system and its role in the etiology of thromboembolic disease
130. Effects of prolonged moderate and severe energy restriction and refeeding on plasma leptin concentrations in obese women
131. The evaluation of insulin as a metabolic signal influencing behavior via the brain
132. Signals that regulate food intake and energy homeostasis
133. Positional cloning of the mouse obese gene and its human homologue