Plasma leptin in diabetic and insulin-treated diabetic and normal rats

Metabolism: Clinical and Experimental

Volumn 47, Issue 5, 1998, Pages 584-591

  Sivitz, William I ^a   Walsh, Susan ^b   Morgan, Donald ^b   Donohoue, Patricia ^b   Haynes, William ^b   Leibel, Rudy L ^b  

^a UNIVERSITY OF IOWA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; LEPTIN;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; EPIDIDYMIS FAT; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INFUSION; HYPOGLYCEMIA; INSULIN DEFICIENCY; INSULIN TREATMENT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031946765     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(98)90244-X     Document Type: Article

References (33)

1. Pellymounter MA, Cullen MJ, Baker MB, et al: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995
2. Halaas JL, Gajiwala KS, Maffei M, et al: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
3. Campfield LA, Smith FJ, Guisez Y, et al: Recombinant mouse ob protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
4. Sivitz WI, Bailey HL, Donohoue P: Rat adipose ob mRNA levels in states of altered circulating glucose and insulin. Biochem Biophys Res Commun 220:520-525, 1996
5. Becker DJ, Ongemba LN, Brichard V, et al: Diet- and diabetesinduced changes of ob gene expression in rat adipose tissue. FEBS Lett 371:324-328, 1995
6. MacDougald OA, Hwang CS, Fan H, et al: Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA 92:9034-9037, 1995
7. Frederich RC, Lollman B, Hamann A, et al: Expression of ob mRNA and its encoded protein in rodents: Impact of nutrition and obesity. J Clin Invest 96:1658-1663, 1995
8. Saladin R, DeVos P, Guerre-Millo M, et al: Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-529, 1995
9. Cusin I, Sainsbury A, Doyle P, et al: The ob gene and insulin: A relationship leading to clues to the understanding of obesity. Diabetes 44:1467-1470, 1995
10. Mizuno TM, Bergen H, Funabashi T, et al: Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proc Natl Acad Sci USA 93:3434-3438, 1996
11. Zheng D, Jones JP, Usala SJ, et al: Differential expression of ob mRNA in rat adipose tissue in response to insulin. Biochem Biophys Res Commun 218:434-437, 1996
12. Trayhurn P, Thomas MEA, Duncan JS, et al: Effects of fasting and refeeding on ob expression in white adipose tissue of lean and obese (ob/ob) mice. FEBS Lett 368:488-490, 1995
13. Morgan DA, Balon TW, Ginsberg BH, et al: Nonuniform regional sympathetic nerve responses to hyperinsulinemia in rats. Am J Physiol 264:R423-R427, 1993
14. Sivitz WI, DeSautel SL, Kayano T, et al: Regulation of glucose transporter messenger RNA levels in rat adipose tissue by insulin. Mol Endocrinol 4:583-588, 1990
15. Birnbaum MJ: Identification of a novel gene encoding an insulin-responsive glucose transporter protein. Cell 57:305-315, 1989
16. Clapham JC, Smith SA, Moore GBT, et al: Plasma leptin concentrations and OB gene expression in subcutaneous adipose tissue are not regulated acutely by physiological hyperinsulinaemia in lean and obese humans. Int J Obes Rel Metab Disord 21:179-183, 1997
17. Sinha MK, Ohannesian JP, Heiman ML, et al: Nocturnal rise in leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest 97:1344-1347, 1995
18. Frederich RC, Hamann A, Anderson S, et al: Leptin levels reflect body lipid content in mice: Evidence for diet induced resistance to leptin action. Nature 1:1311-1314, 1995
19. McGregor GP, Desaga JF, Ehlenz K, et al: Radioimmunological measurement of leptin in plasma of obese and diabetic subjects. Endocrinology 137:1501-1504, 1996
20. Tuominen JA, Ebeling P, Stenman UH, et al: Leptin synthesis is resistant to acute effects of insulin in insulin-dependent diabetes mellitus patients. J Clin Endocrinol Metab 82:381-382, 1997
21. Dagogo-Jack S, Fanelli C, Paramore D, et al: Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 45:695-698, 1996
22. Kolaczynski JW, Nyce MR, Considine RV, et al: Acute and chronic effect of insulin on leptin production in humans: Studies in vivo and in vitro. Diabetes 45:699-701, 1996
23. Muscelli E, Camastra S, Masoni A, et al: Acute insulin administration does not affect plasma leptin in lean or obese subjects. Eur J Clin Invest 26:940-943, 1996
24. Utrianen T, Malmstrom R, Makimattila S, et al: Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects. Diabetes 45:1364-1366, 1966
25. Malmstrom R, Taskinen MR, Karonen SL, et al: Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 39:993-996, 1996
26. Hardie LJ, Rayner DV, Holmes S, et al: Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem Biophys Res Commun 223:660-665, 1996
27. Kraegen EW, James DE, Bennett SP, et al: In vivo insulin sensitivity in the rat determined by euglycemic clamp. Am J Physiol 245:E1-E7, 1983
28. DeVos P, Saladin R, Auwerx J, et al: Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 270:15958-15961, 1995
29. Remesar X, Rafecas I, Fernandezlopez JA, et al: Is leptin an insulin counter-regulatory hormone? FEBS Lett 402:9-11, 1997
30. Cohen B, Novick D, Rubenstein M: Modulation of insulin activities by leptin. Science 274:1185-1188, 1996
31. Emilsson V, Liu YL, Cawthorne MA, et al: Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46:313-316, 1997
32. Chen GX, Koyama K, Yuan X, et al: Disappearance of body fat in normal rats by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci USA 93:14795-14799, 1996
33. Sivitz WI, Walsh SA, Morgan DA, et al: Effects of leptin on insulin sensitivity in normal rats. Endocrinology 138:3395-3401, 1997