Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity

Diabetes

Volumn 46, Issue 11, 1997, Pages 1782-1785

  Widdowson, P S ^a,c   Upton, R ^a   Buckingham, R ^b   Arch, J ^b   Williams, G ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; FEEDING BEHAVIOR; LIPID STORAGE; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SATIETY; SIGNAL TRANSDUCTION;

EID: 0030669288     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.11.1782     Document Type: Article

References (26)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Freidman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
2. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
3. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
4. Leroy P, Dessolin S, Villageois P, Moon BC, Freidman JM, Ailhaud G, Dani C: Expression of ob gene in adipose cells. J. Biol. Chem. 271:2365-2368, 1996
5. Frederick RC, Lollmann B, Hammann A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS: Expression of the ob mRNA and its encoded protein in rodents, J Clin. Invest. 986:1658-1663, 1995
6. Frederich RC, Hamann A, Anderson S, Löllmann B, Lowell BB, Flier JS: Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Med. 1:1311-1314, 1995
7. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J: Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-529, 1995
8. Slieker LJ, Sloop KW, Suface PL, Kriauciunas A, LaQuier F, Manetta J, Bue-Valleskey, J, Stephens TW: Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J. Biol. Chem. 271:5301-5304, 1996
9. Sinha MK, Ohannesian JP, Heiman ML, Kriauciunas A, Stephens TW, Magosin S, Marco C, Caro JF: Nocturnal rise of leptin in lean, obese and non-insulin-dependent diabetes mellitus subjects. J. Clin Invest 97:1344-1347, 1996
10. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper JC, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI: Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271, 1995
11. Lynn RB, Cao G-Y, Considine RV, Hyde TM, Caro JF: Autoradiographic localisation of leptin binding in the choroid plexus of ob/ob and db/db mice. Biochem Biophys Res Commun 219:884-889, 1996
12. Malik KF, Young WS III: Localisation of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob) and diabetic (db/db) C57BL/6 mice. Endocrinology 137:1497-1500, 1996
13. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhum P: Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Letts. 387:113-116, 1996
14. Banks WA, Kastin AJ, Huang W, Jaspin JP, Maness LM: Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311, 1996
15. Levin N, Nelson C, Gurney A, Vandlen R, DeSauvage F: Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci USA 93:1726-1730, 1996
16. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP: Evidence that the diabetes gene encodes the Leptin receptor identification of a mutation in the Leptin receptor gene in db/db mice. Cell 84:491-495, 1996
17. Lee G-H, Proenca R, Montez JM, Carroll KM, Darvish-zadeh JG, Lee JI, Freidman JM: Abnormal splicing of the leptin receptor in diabetic mice. Nature 279:632-635, 1996
18. Chua SC Jr, Chung WK, Wu-Peng S, Zhang Y, Liu S-M, Tartaglia L, Leibel RL: Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor Science 271:994-996, 1996
19. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CT, Hess JF: Leptin receptor missense mutation in the fatty Zucker rat. Nature Genetics 13:18-19, 1996
20. Iiada M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima, K: Substitution at codon 269 (glutamine to proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat Biochem Biophys Res Commun 224:597-604, 1996
21. Considine RV, Considine EL, Williams CJ, Hyde TM, Caro JF: The hypothalamic leptin receptor in humans: Identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 45:992-994, 1996
22. Schwartz, MW, Peskind E, Raskind M, Boyko EJ, Porte D: 1996 Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat. Med. 2:589-593, 1996
23. Considine TV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Engl. J. Med. 334:292-295, 1996
24. Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, Davis, HR Jr: Diet-induced obese mice develop peripheral, but not central, resistance to leptin J. Clin Invest. 99:385-390, 1997
25. Wilding JPH, Gilbey SG, Mannan M, Asian N, Ghatei MA, Bloom SR: Increased neuropeptide Y content in individual hypothalamic nuclei, but not neuropeptide Y mRNA, in diet-induced obesity in rats. J. Neuroendocrinol. 132:299-304, 1992
26. Paxinos G, Watson C., The Rat Brain in Stereotaxic Coordinates, Academic, San Diego, 1982