The evaluation of insulin as a metabolic signal influencing behavior via the brain

Neuroscience and Biobehavioral Reviews

Volumn 20, Issue 1, 1996, Pages 139-144

  Woods, Stephen C ^a   Chavez, Mark ^a   Park, Collin R ^a   Riedy, Christine ^a   Kaiyala, Karl ^a,b   Richardson, Ralph D ^a   Figlewicz, Dianne P ^a,b   Schwartz, Michael W ^a,b   Daniel Jr , Porte ^a,b   Seeley, Randy J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cholecystokinin; Insulin; Neuropeptide Y; Oxytocin brain insulin

Indexed keywords

CHOLECYSTOKININ; INSULIN; INSULIN RECEPTOR; NEUROPEPTIDE Y; OXYTOCIN;

BODY WEIGHT; CONFERENCE PAPER; FEEDING BEHAVIOR; FOOD INTAKE; HORMONE RELEASE; METABOLIC REGULATION; OBESITY; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANIMAL; BODY WEIGHT; BRAIN; EATING; INSULIN; OXYTOCIN; RATS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029655982     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/0149-7634(95)00044-F     Document Type: Article

References (42)

1. Bagdade, J. D.; Bierman, E. L.; Porte, D., Jr. The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J. Clin. Invest. 46:1549-1557; 1967.
2. Baskin, D. G.; Figlewicz, D. P.; Woods, S. C.; Porte, D. Jr.; Dorsa, D. M. Insulin in the brain. Ann. Rev. Physiol. 49:335-347; 1987.
3. Bernstein, I. L.; Goehler, L. E. Vagotomy produces learned food aversions in the rat. Behav. Neurosci. 97:585-594; 1983.
4. Bernstein, I. L.; Lotter, E. C.; Kulkosky, P. J.; Porte, D., Jr; Woods, S. C. Effect of force-feeding upon basal insulin levels of rats. Proc. Soc. Exp. Biol. Med. 150:546-548; 1975.
5. Brief, D. J.; Sipols, A. J.; Woods, S. C. Intraventricular neuropeptide Y injections stimulate food intake in lean but not obese Zucker rats. Physiol. Behav. 51:1105-1110; 1992.
6. Chavez, M.; Kaiyala, K.; Madden, L. J.; Schwartz, M. W.; Woods, S. C. Intraventricular insulin and the level of maintained body weight in rats. Behav. Neurosci. 109:528-531; 1995.
7. Chavez, M.; Seeley, R. J.; Woods, S. C. A comparison between effects of intraventricular insulin and intraperitoneal lithium chloride on three measures sensitive to emetic agents. Behav. Neurosci. 109:547-550; 1995.
8. Coleman, D. L.; Hummel, K. P. Effects of parabiosis of normal with genetically diabetic mice. Am. J. Physiol. 217:1298-1304; 1969.
9. Cook, D. L.; Taborsky, J. G., Jr. B-cell function and insulin secretion. In: Rifkin, H.; Porte, D., Jr. eds. Diabetes mellitus: theory and practice. New York: Elsevier Science; 1990:89-103.
10. Corp, E. S.; Woods, S. C.; Porte, D., Jr; Dorsa, D. M.; Figlewicz, D. P.; Baskin, D. G. Localization of 125-I-insulin binding sites in the rat hypothalamus by quantitative autoradiography. Neurosci. Lett. 70:17-22; 1986.
11. Figlewicz, D. P.; Szot, P.; Chavez, M.; Woods, S. C.; Veith, R. C. Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra. Brain Res. 644:331-334; 1994.
12. Hervey, G. R. The effects of lesions in the hypothalamus in parabiotic rats. J. Physiol. Lond. 145:336-352; 1952.
13. Hewson, G.; Leighton, G. E.; Hill, R. G.; Hughes, J. Cholecystokinin receptor antagonist L-364,718 increases food intake in the rat by attenuation of the action of endogenous Cholecystokinin. Br. J. Pharm. 93:79-84; 1988.
14. Kalra, S. P,; Clark, J. T.; Sahu, A.; Dube, M. G.; Kalra, P. S. Control of feeding and sexual behaviors by neuropeptide Y: physiological implications. Synapse 2:254-257; 1988.
15. Kalra, S. P.; Dube, M. G.; Sahu, A.; Phelps, C. P.; Kalra, P. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. USA 88:10931-10935; 1991.
16. Lotter, E. C.; Woods, S. C. Injections of insulin and changes of body weight. Physiol. Behav. 18:293-297; 1977.
17. MacKay, E. M.; Callaway, J. W.; Barnes, R. F. Hyperalimentation in normal animals produced by protamine insulin. J. Nutr. 20:59-66; 1940.
18. McGowan, M. K.; Andrews, K. M.; Kelly, J.; Grossman, S. P. Effects of chronic intrahypothalamic infusion of insulin on food intake and diurnal meal patterning in the rat. Behav. Neurosci. 104:373-385; 1990.
19. Moran, T. H.; Ameglio, P. J.; Schwartz, G. J.; McHugh, P. R. Blockade of type-A, not type-B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK. Am. J. Physiol. 262:R46-R50; 1992.
20. Polonsky, K. S.; Given, B. D.; Hirsch, L.; Shapiro, E. T.; Tillil, H; Beebe, C.; Galloway, J. A.; Frank, B. H.; Karrison, T.; Van Cauter, E. Quantitative study of insulin secretion in normal and obese subjects. J. Clin. Invest. 81:435-441; 1988.
21. Powley, T. L.; Keesey, R. E. Relationship of body weight to the lateral hypothalamic syndrome. J. Comp. Physiol. Psychol. 70:25-36; 1970.
22. Reidelberger, R. D.; O'Rourke, M. F. Potent cholecystokinin antagonist L-364,718 stimulates food intake in rats. Am. J. Physiol. 257:R1512-R1518; 1989.
23. Riedy, C. A.; Chavez, M.; Figlewicz, D. P.; Woods, S. C. Central insulin enhances sensitivity to cholecystokinin. Physiol. Behav., in press.
24. Schwartz, M. W.; Bergman, R. N.; Kahn, S. E.; Taborsky, G. J., Jr.; Fisher, L. D.; Sipols, A. J.; Woods, S. C.; Steil, G. M.; Porte, D. Jr. Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. J. Clin. Invest. 88:1271-1281; 1991.
25. Schwartz, M. W.; Figlewicz, D. P.; Baskin, D. G.; Woods, S. C.; Porte, D., Jr. Insulin in the brain: a hormonal regulator of energy balance. Endocrine Rev. 13:387-414; 1992.
26. Schwartz, M. W.; Figlewicz, D. P.; Baskin, D. G.; Woods, S. C.; Porte, D., Jr. Update 1994: insulin and the central regulation of energy balance. Endocrine Rev. Monogr. 2:109-113; 1994.
27. Schwartz, M. W.; Marks, J. L.; Sipols, A. J.; Baskin, D. G.; Woods, S. C.; Kahn, S. E.; Porte, D., Jr. Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats. Endocrinology 128:1081-1083; 1991.
28. Schwartz, M. W.; Sipols, A. J.; Kahn, S. E.; Lattemann, D. F.; Taborsky, G. J., Jr; Bergman, R. N.; Woods, S. C.; Porte, D., Jr. Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid. Am. J. Physiol. 259:E378-E383; 1990.
29. Schwartz, M. W.; Sipols, A. J.; Marks, J. L.; Sanacora, G.; White, J. D.; Scheurink, A. J. W.; Kahn, S. E.; Baskin, D. G.; Woods, S. C.; Figlewicz, D. P.; Porte, D., Jr. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130:3608-3616; 1992.
30. Smith, G. P.; Gibbs, J. The development and proof of the CCK hypothesis of satiety. In: Dourish, C. T.; Cooper, S. J.; Iversen, S. D.; Iversen, L. L., eds. Multiple cholecystokinin receptors in the CNS. Oxford: Oxford University Press; 1992:166-182.
31. Stanley, B. G.; Magdalin, W.; Leibowitz, S. F. Evidence that neuropeptide Y elicits eating by acting in the caudolateral paraventricular/perifornical hypothalamus. Ann. NY Acad. Sci. 611:489-492; 1990.
32. Stricker, E. M.; Verbalis, J. G. Central inhibitory control of sodium appetite in rats: correlation with pituitary oxytocin secretion. Behav. Neurosci. 101:560-567; 1987.
33. Strubbe, J. H.; Mein, C. G. Increased feeding in response to bilateral injection of insulin antibodies in the VMH. Physiol. Behav. 19:309-313; 1977.
34. Verbalis, J. G.; McHale, C. M.; Gardiner, T. W.; Stricker, E. M. Oxytocin and vasopressin secretion in response to stimuli producing learned taste aversions in rats. Behav. Neurosci. 100:466-475; 1986.
35. White, J. D.; Kershaw, M. Increased hypothalamic neuropeptide Y expression following food deprivation. Molec. Cell Neurosci. 1:41-48; 1989.
36. Woods, S. C.; Decke, E.; Vasselli, J. R. Metabolic hormones and regulation of body weight. Psychol. Rev. 81:26-43; 1974.
37. Woods, S. C; Figlewicz Lattemann, D. P.; Schwartz, M. W.; Porte, D., Jr. A re-assessment of the regulation of adiposity and appetite by the brain insulin system. Int. J. Obesity 14(Suppl. 3):69-76; 1990.
38. Woods, S. C.; Gibbs, J. The regulation of food intake by peptides. Ann. NY Acad. Sci. 575:236-243; 1989.
39. Woods, S. C.; Lotter, E. C.; McKay, L. D.; Porte, D., Jr. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282:503-505; 1979.
40. Woods, S. C.; Porte, D., Jr. Insulin and the set-point regulation of body weight. In: Novin, D.; Bray, G. A.; Wyrwichka, W., Eds. Hunger: basic mechanisms and clinical implications. New York: Raven Press; 1976: 273-280.
41. Woods, S. C.; Porte, D., Jr; Bobbioni, E.; Ionescu, E.; Sauter, J. F.; Rohner-Jeanrenaud, F.; Jeanrenaud, B. Insulin: its relationship to the central nervous system and to the control of food intake and body weight. Am. J. Clin. Nutr. 42:1063-1071; 1985.
42. Woods, S. C.; Taborsky, G. J., Jr; Porte, D., Jr. CNS control of nutrient homeostasis. In: Bloom, F. ed. Handbook of physiology. Section 1: the nervous system, vol. 4. Intrinsic regulatory systems of the brain. Bethesda, MD: American Physiology Society; 1986:365-411.