Leptin does not fully account for the satiety activity of adipose tissue-conditioned medium

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 275, Issue 4 44-4, 1998, Pages

  Weigle, David S ^a,c   Hutson, Amy M ^a   Kramer, Janet M ^b   Fallon, Margaret G M ^b   Lehner, Joyce M ^b   Lok, Si ^b   Kuijper, Joseph L ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b ZYMOGENETICS INC   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Appetite; Body composition; Energy balance; Lipostatic factor; Obesity

Indexed keywords

LEPTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APPETITE; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; ENERGY BALANCE; FOOD INTAKE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SATIETY;

EID: 0031793560     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.275.4.r976     Document Type: Article

References (37)

1. Aggarwal, B. B., W. J. Kohr, P. E. Hass, B. Moffat, S. A. Spencer, W. J. Henzel, T. S. Bringman, G. E. Nedwin, D. V. Goeddel, and R. N. Harkins. Human tumor necrosis factor. Production, purification, and characterization. J. Biol. Chem. 260: 2345-2354, 1985.
2. Ahima, R. S., D. Prabakaran, C. Mantzoros, D. Qu, B. Lowell, E. Maratos-Flier, and J. S. Flier. Role of leptin in the neuroendocrine response to fasting. Nature 382: 250-252, 1996.
3. Campfield, L. A., F. J. Smith, Y. Guisez, R. Devos, and P. Burn. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549, 1995.
4. Caro, J. F., M. K. Sinha, J. W. Kolaczynski, P. L. Zhang, and R. V. Considine. Leptin: the tale of an obesity gene. Diabetes 45: 1455-1462, 1996.
5. Clemmons, D. R. Insulin-like growth factor binding proteins and their role in controlling IGF actions. Cytokine Growth Factor Rev. 8: 45-62, 1997.
6. Coleman, D. L. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9: 294-298, 1973.
7. Coleman, D. L., and K. P. Hummel. Effects of parabiosis of normal with genetically diabetic mice. Am. J. Physiol. 217: 1298-1304, 1969.
8. Faggioni, R., J. Fuller, A. Moser, K. R. Feingold, and C. Grunfeld. LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice. Am. J. Physiol. 273 (Regulatory Integrative Comp. Physiol. 42): R181-R186, 1997.
9. Goodner, G. C., and C. J. Goodner. Demonstration that acid-ethanol extracts of rat adipose tissue contain an inhibitor of food intake in the mouse. J. Lab. Clin. Med. 128: 246-250, 1996.
10. Grunfeld, C., C. Zhao, J. Fuller, A. Pollock, A. Moser, J. Friedman, and K. R. Feingold. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J. Clin. Invest. 97: 2152-2157, 1996.
11. Halaas, J. L., C. Boozer, J. Blair-West, N. Fidahusein, D. A. Denton, and J. M. Friedman. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. USA 94: 8878-8883, 1997.
12. Halaas, J. L., K. S. Gajiwala, M. Maffei, S. L. Cohen, B. T. Chait, D. Rabinowitz, R. L. Lallone, S. K. Burley, and J. M. Friedman. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546, 1995.
13. Harris, R. B. S., E. Hervey, G. R. Hervey, and G. Tobin. Body composition of lean and obese Zucker rats in parabiosis. Int. J. Obes. 11: 275-283, 1987.
14. Harris, R. B. S., J. Zhou, S. M. Redmann, Jr., G. N. Smagin, S. R. Smith, E. Rodgers, and J. J. Zachwieja. A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology 139: 8-19, 1998.
15. Hotamisligil, G. S., N. S. Shargill, and B. M. Spiegelman. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91, 1993.
16. Houseknecht, K. L., C. S. Mantzoros, R. Kuliawat, E. Hadro, J. S. Flier, and B. B. Kahn. Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity. Diabetes 45: 1638-1643, 1996.
17. Hulsey, M. G., and R. J. Martin. An anorectic agent from adipose tissue of overfed rats: effects on feeding behavior. Physiol. Behav. 52: 1141-1149, 1992.
18. Hutson, A. M., G. E. Meyer, and D. S. Weigle. Bioassay for a satiety factor produced by adipose tissue from overfed obese rats (Abstract). Clin. Res. 40: 60A, 1992.
19. Kennedy, G. C. The role of depot fat in the hypothalamic control of food intake in the rat. Proc. R. Soc. Lond. B Biol. Sci. 140: 578-592, 1953.
20. Lee, G.-H., R. Proenca, J. M. Montez, K. M. Carroll, J. G. Darvishzadeh, J. I. Lee, and J. M. Friedman. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635, 1996.
21. Lok, S., K. Kaushansky, R. D. Holly, J. L. Kuijper, C. E. Lofton-Day, P. J. Oort, F. J. Grant, M. D. Heipel, S. K. Burkhead, J. M. Kramer, L. A. Bell, C. A. Sprecher, H. Blumberg, R. Johnson, D. Prunkard, A. F. T. Ching, S. L. Mathewes, M. C. Bailey, J. W. Forstrom, M. M. Buddle, S. G. Osborn, S. J. Evans, P. O. Sheppard, S. R. Presnell, P. J. O'Hara, F. S. Hagen, G. J. Roth, and D. C. Foster. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369; 565-568, 1994.
22. Maffei, M., J. Halaas, E. Ravussin, R. E. Pratley, G. H. Lee, Y. Zhang, H. Fei, S. Kim, R. Lallone, S. Ranganathan, P. A. Kern, and J. M. Friedman. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1: 1155-1161, 1995.
23. Nachman, M., and J. H. Ashe. Learned taste aversions in rats as a function of dosage, concentration, and route of administration of LiCl. Physiol. Behav. 10: 73-78, 1973.
24. Pelleymounter, M. A., M. J. Cullen, M. B. Baker, R. Hecht, D. Winters, T. Boone, and F. Collins. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995.
25. Porte, D., Jr., and S. C. Woods. Regulation of food intake and body weight by insulin. Diabetologia 20: 274-279, 1981.
26. Sarraf, P., R. C. Frederich, E. M. Turner, G. Ma, N. T. Jaskowiak, D. J. Rivet III, J. S. Flier, B. B. Lowell, D. L. Fraker, and H. R. Alexander. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J. Exp. Med. 185: 171-175, 1997.
27. Schwartz, M. W., E. Peskind, M. Raskind, E. J. Boyko, and D. Porte, Jr. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat. Med. 2: 589-593, 1996.
28. Sinha, M. K., I. Opentanova, J. P. Ohannesian, J. W. Kolaczynski, M. L. Heiman, J. Hale, G. W. Becker, R. R. Bowsher, T. W. Stephens, and J. F. Caro. Evidence for free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. J. Clin. Invest. 98: 1277-1282, 1996.
29. Skoda, R. C., D. C. Seldin, M. K. Chiang, C. L. Peichel, T. F. Vogt, and P. Leder. Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J. 12: 2645-2653, 1993.
30. Spear, N. E., D. Kucharski, and H. Hoffman. Contextual influences on conditioned taste aversions in the developing rat. Ann. NY Acad. Sci. 443: 42-53, 1985.
31. Tartaglia, L. A., M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G. J. Richards, L. A. Campfield, F. T. Clark, J. Deeds, C. Muir, S. Sanker, A. Moriarty, K. J. Moore, J. S. Smutko, G. G. Mays, E. A. Woolf, C. A. Monroe, and R. I. Tepper. Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271, 1995.
32. Thim, L., L. T. Hansen, K. Norris, I. Hoegh, E. Boel, J. Forstrom, G. Ammerer, and N. P. Fiil. Secretion and processing of insulin precursors in yeast. Proc. Natl. Acad. Sci. USA 83: 6766-6770, 1986.
33. Truett, G. E., N. Bahary, J. M. Friedman, and R. L. Leibel. Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db). Proc. Natl. Acad. Sci. USA 88: 7806-7809, 1991.
34. Weigle, D. S., T. R. Bukowski, D. C. Foster, S. Holderman, J. M. Kramer, G. Lasser, C. E. Lofton-Day, D. E. Prunkard, C. Raymond, and J. L. Kuijper. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J. Clin. Invest. 96: 2065-2070, 1995.
35. Weigle, D. S., S. L. Ganter, J. L. Kuijper, D. L. Leonetti, E. J. Boyko, and W. Y. Fujimoto. Effect of regional fat distribution and Prader-Willi syndrome on plasma leptin levels. J. Clin. Endocrinol. Metab. 82: 566-570, 1997.
36. Wilson, B. E., G. E. Meyer, J. C. Cleveland, Jr., and D. S. Weigle. Identification of candidate genes for a factor regulating body weight in primates. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R1148-R1155, 1990.
37. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.