Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: Reversal by insulin

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 274, Issue 5 43-5, 1998, Pages

  Havel, Peter J ^a   Uriu Hare, Janet Y ^b   Liu, Tina ^b   Stanhope, Kimber L ^b   Stern, Judith S ^b   Keen, Carl L ^b   Ahrén, Bo ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

C peptide; Epididymal fat; Food intake; Glucose

Indexed keywords

C PEPTIDE; GLUCOSE; LEPTIN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; EPIDIDYMIS; GLUCOSE TRANSPORT; HYPERGLYCEMIA; HYPOTHESIS; IMPLANT; INSULIN DEFICIENCY; INSULIN RESPONSE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

EID: 0031859473     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.274.5.r1482     Document Type: Article

References (48)

1. Ahrén, B., S. Månsson, R. L. Gingerich, and P. J. Havel. Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting. Am. J. Physiol. 273 (Regulatory Integrative Comp. Physiol. 42): R113-R120, 1997.
2. Ahrén, B., J. S. Stern, R. L. Gingerich, D. L. Curry, and P. J. Havel. Glucagon secretory responses to hypoglycemia, adrenaline, and carbachol in streptozotocin diabetic rats. Acta Physiol. Scand. 155: 215-221, 1995.
3. Ahima, S. R., D. Prabakaran, C. Mantzoros, D. Qu, B. Lowell, E. Maratos-Flier, and J. S. Flier. Role of leptin in the neuroendocrine response to fasting. Nature 382: 250-252, 1996.
4. Becker, D. J., L. N. Ongemba, V. Brichard, J.-C. Henquin, and S. M. Brichard. Diet- and diabetes-induced changes of ob gene expression in rat adipose tissue. FEBS Lett. 371: 324-328, 1995.
5. Boden, G., X. Chen, M. Mozzoli, and I. Ryan. Effect of fasting on serum leptin in normal human subjects. J. Clin. Endocrinol. Metab. 81: 3419-3423, 1996.
6. Campfield, L. A., F. J. Smith, Y. Guisez, R. Devos, and P. Burn. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549, 1995.
7. Caro, J. R., M. K. Sinha, J. W. Kolaczynski, P. L. Zhang, and R. V. Considine. Leptin: the tale of an obesity gene. Diabetes 45: 1455-1466, 1996.
8. Chua, S. C., A. W. Brown, J. Kim, K. L. Hennessey, R. L. Leibel, and J. Hirsch. Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation. Mol. Brain. Res. 11: 291-299, 1991.
9. Clark, J. T., P. S. Kalra, W. R. Crowley, and S. P. Kalra. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115: 427-429, 1984.
10. Considine, R. V., M. K. Sinha, M. L. Heiman, A. Kriauciunas, T. W. Stephens, M. R. Nyce, J. P. Ohhanesian, C. C. Marco, L. J. McKee, T. L. Bauer, and J. F. Caro. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Engl. J. Med 334: 292-295, 1996.
11. Cusin, R., A. Sainsbury, P. Doyle, F. Rohner-Jeanrenaud, and B. Jeanrenaud. The ob gene and insulin: a relationship leading to clues to the understanding of obesity. Diabetes 44: 1467-1470, 1995.
12. Dagogo-Jack, S., C. Fanelli, D. Paramore, J. Brothers, and M. Landt. Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 45: 695-698, 1996.
13. Dubuc, G. R., S. D. Phinney, J. S. Stern, and P. J. Havel. Changes of serum leptin and endocrine and metabolic parameters after 7 days energy restriction in men and women. Metabolism 47: 429-434, 1998.
14. Erickson, J. C., G. Hollopeter, and R. D. Palmiter. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide-Y. Science 274: 1704-1707, 1996.
15. Halaas, J. L., K. S. Gajiwala, M. Maffei, S. L. Cohen, B. T. Chait, D. Rabinowitz, R. L. Lallone, S. K. Burley, and J. M. Friedman. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546, 1995.
16. Hardie, L. J., D. V. Rayner, S. Holmes, and P. Trayhurn. Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem. Biophys. Res. Commun. 223: 660-665, 1996.
17. Havel, P. J. Glucose, but not fructose, infusion increases circulating leptin in proportion to adipose stores in rhesus monkeys. J. Endocrinol. Diabetes. 105, Suppl. 3: 37-38, 1997.
18. Havel, P. J. Leptin production and action: relevance to energy balance in humans. Am. J. Clin. Nutr. 67: 355-356, 1998.
19. Havel, P. J., T. T. Aoki, E. O. Grecu, J. S. Stern, and S. Kasim-Karakas. Leptin/adiposity relationships in intensively-treated IDDM and NIDDM and increased plasma leptin after 6 hours of high dose insulin infusion (Abstract). Obesity Res. 4: 15S, 1996.
20. Havel, P. J., M. H. Connors, C. L. Acerini, E. C. Crowne, and D. B. Dunger. Plasma leptin is increased proportionally to adiposity by physiologic insulinemia in insulin-dependent diabetes (Abstract). Diabetologia 40, Suppl. 1: A268, 1997.
21. Havel, P. J., S. Kasim-Karakas, W. M. Mueller, P. R. Johnson, R. L. Gingerich, and J. S. Stern. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J. Clin. Endocrinol. Metab. 81: 4406-4413, 1996.
22. Kolaczynski, J. W., B. J. Goldstein, and R. V. Considine. Dexamethasone, OB gene, and leptin in humans: effect of exogenous hyperinsulinemia. J. Clin. Endocrinol. Metab. 82: 3895-3897, 1997.
23. Kolaczynski, J. W., M. R. Nyce, R. V. Considine, G. Boden, J. J. Nolan, R. Henry, S. R. Mudaliar, J. Olefsky, and J. F. Caro. Acute and chronic effect of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes 45: 699-701, 1996.
24. Lambert, P. D., J. P. H. Wilding, M. D. Turton, M. A. Ghatei, and S. R. Bloom. Effect of food deprivation and streptozotocin diabetes on hypothalamic neuropeptide Y release as measured by a radioimmunoassay-linked microdialysis procedure. Brain Res. 656: 135-140, 1994.
25. Landt, M., R. L. Gingerich, P. J. Havel, W. M. Mueller, B. Schoner, J. E. Hale, and M. L. Heiman. Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans. Clin. Chem. 44: 565-570, 1998.
26. Larrson, H., S. Elmstahl, and B. Ahrén. Plasma leptin levels correlate to islet function independently of body fat in postmenopausal women. Diabetes 45: 1580-1584, 1996.
27. Laughlin, G. A., and S. S. C. Yen. Hypoleptinemia in women athletes: absence of diurnal rhythm with amenorrhea. J. Clin. Endocrinol. Metab. 82: 318-321, 1997.
28. MacDougald, O. A., C. S. Hwang, H. Fan, and M. D. Lane. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc. Natl. Acad. Sci. USA 92: 9034-9037, 1995.
29. Maffei, M., J. Halaas, E. Ravussin, R. E. Pratley, G. H. Lee, Y. Zhang, H. Fei, R. Lallone, S. Ranganathan, P. A. Kern, and J. M. Friedman. Leptin levels in human and rodents measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med. 1: 1155-1161, 1995.
30. Mizuno, T. M., H. Bergen, T. Funabashi, S. P. Kleopoulos, Y. G. Zhong, W. A. Bauman, and C. V. Mobbs. Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proc. Natl. Acad. Sci. USA 93: 3434-3438, 1996.
31. Mueller, W. M., F. Gregoire, K. L. Stanhope, C. V. Mobbs, T. M. Mizuno, C. H. Warden, J. S. Stern, and P. J. Havel. Evidence that glucose metabolism regulates leptin secretion from cultured adipocytes. Endocrinology 139: 551-558, 1998.
32. Nishimura, H., H. Kuzuya, M. Okamato, K. Yamada, A. Kosaki, G. Inoue, S. Kono, and H. Imura. Postreceptor defect in insulin action in streptozotocin-induced diabetic rats. Am. J. Physiol. 256 (Endocrinol. Metab. 19): E624-E630, 1989.
33. Pelleymounter, M. A., M. J. Cullen, M. B. Baker, R. Hecht, D. Winters, T. Boone, and F. Collins. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995.
34. Pratley, R. E., M. Nicolson, C. Bogardus, and E. Ravussin. Effects of acute hyperinsulinemia on plasma leptin concentration in insulin-sensitive and insulin-resistant Pima Indians. J. Clin. Endocrinol. Metab. 81: 4418-4421, 1996.
35. Saladin, R., P. De Vos, M. Guerre-Millo, A. Leturque, J. Girard, B. Staels, and J. Auwerx. Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527-529, 1995.
36. Schwartz, M. W., D. G. Baskin, T. R. Bukowski, J. L. Kuijper, D. Foster, G. Lasser, D. E. Prunkard, D. Porte, S. C. Woods, R. J. Seeley, and D. S. Weigle. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45: 531-535, 1996.
37. Schwartz, M. W., D. P. Figlewicz, D. G. Baskin, S. C. Woods, and D. Porte. Insulin and the central regulation of energy balance: update 1994. In: The Endocrine Pancreas, Insulin Action, and Diabetes, edited by A. Negro Vilar and L. E. Underwood. Bethesda, MD: Endocrine Soc., 1994, p. 81-113. (Endocrine Rev. Monogr. 2)
38. Schwartz, M. W., J. L. Marks, A. J. Sipols, D. G. Baskin, S. C. Woods, S. E. Kahn, and D. Porte. Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats. Endocrinology 128: 2645-2647, 1991.
39. Schwartz, M. W., R. J. Seeley, L. A. Campfield, P. Burn, and D. G. Baskin. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98: 1101-1106, 1996.
40. Sinha, M. K., J. P. Ohannesian, M. L. Heiman, A. Kriauciunas, T. W. Stephens, S. Magosin, C. Marco, and J. F. Caro. Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J. Clin. Invest. 97: 1344-1347, 1996.
41. Sipols, A. J., D. G. Baskin, and M. W. Schwartz. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44: 147-151, 1994.
42. Sivitz, W. I., H. L. Bailey, and P. Donohue. Rat adipose ob mRNA levels in states of altered circulating glucose and insulin. Biochim. Biophys. Res. Commun. 220: 520-525, 1996.
43. Sonnenberg, G. E., G. R. Krakower, R. G. Hoffmann, D. L. Maas, M. M. I. Hennes, and A. H. Kissebah. Plasma leptin concentrations: effects of extended fasting and stepwise increases in glucose infusions (Abstract). Obesity Res. 4: 13S, 1996.
44. Stephens, T. W., M. Basinski, P. K. Bristow, J. M. Bui-Valleskey, S. G. Burgett, L. Craft, J. Hale, J. Hoffmann, H. M. Hsiung, A. Kriauciunas, W. MacKellar, P. R. Rosteck, B. Schoner, D. Smith, F. C. Tinsley, X. Y. Zhang, and M. Heiman. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377: 530-532, 1995.
45. Utriainen, R., R. Malmstrom, S. Makimattila, and H. Yki-Jarvinen. Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects. Diabetes 45: 1364-1366, 1996.
46. Weigle, D. S., P. B. Duell, W. E. Connor, R. A. Steiner, M. R. Soules, and J. L. Kuijper. Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels. J. Clin. Endocrinol. Metab. 82: 561-565, 1997.
47. White, J. D., D. Olchovsky, M. Kershaw, and M. Berelowitz. Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozotocin diabetic rats. Endocrinology 126: 765-772, 1990.
48. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.