Low plasma leptin levels contribute to diabetic hyperphagia in rats

Diabetes

Volumn 48, Issue 6, 2000, Pages 1275-1280

  Sindelar, Dana K ^a,d   Havel, Peter J ^b   Seeley, Randy J ^c   Wilkinson, Charles W ^a   Woods, Stephen C ^c   Schwartz, Michael W ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APPETITE; ARTICLE; CONTROLLED STUDY; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HYPERPHAGIA; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; HYPERPHAGIA; INSULIN; LEPTIN; MALE; OBESITY; PROTEINS; RATS; RATS, LONG-EVANS;

EID: 0344848622     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.6.1275     Document Type: Article

References (46)

1. Keesey RE, Powley TL: The regulation of body weight. Ann Rev Psychol 37: 109-133, 1986
2. Leibel RL, Rosenbaum M, Hirsch J: Changes in energy expenditure resulting from altered body weight. N Engl J Med 332:621-628, 1995
3. Zhang Y, Proenca R, Maffie M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
4. Considine RV, Sinha MK, Heiman ML, Kriaucinas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Eng J Med 334:292-295, 1996
5. Havel P, Kasim-Karakas S, Mueller W, Johnson P, Gingerich R, Stern J: Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab 81:4406-4413, 1996
6. Ahren B, Mansson S, Gingerich R, Havel P: Regulation of plasma leptin in mice: influence of age, high-fat diet and fasting. Am J Physiol 273:R113-R120, 1997
7. Weigle D, Duell P, Conner W, Steiner R, Soules M, Kuijper J: Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels. J Clin Endocrinol Metab 86:561-565, 1997
8. Dubuc G, Phinney S, Stern J, Havel P: Changes of serum leptin and endocrine and metabolic parameters after 7 days energy restriction in men and women. Metabolism 47:429-434, 1998
9. Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte D Jr: Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev 13:387-414, 1992
10. Baskin DG, Wilcox BJ, Figlewicz DP, Dorsa DM: Insulin and insulin-like growth factors in the CNS. Trends Neurosci 11:107-111, 1988
11. Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurinck A, Kahn SE, Baskin DG, Woods SC, Figlewicz DP, Porte D Jr. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130: 3608-3616, 1992
12. Campfield LA, Smith FJ, Gulsez Y, Devos R, Burn P: Mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
13. Seeley RJ, van Dijk G, Campfield LA, Smith FJ, Burn P, Nelligan JA, Bell SM, Baskin DG, Woods SC, Schwartz MW: Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm Metab Res 28:664-668, 1996
14. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D Jr, Woods SC, Seeley RJ, Weigle DS: Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-535, 1996
15. Saladin R, DeVos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J: Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-529, 1995
16. Mizuno T, Bergen H, Funabashi T, Kleopoulos S, Zhong Y, Bauman W, Mobbs C: Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet induced) and genetic (yellow agouti) obesity. Proc Natl Acad Sci U S A 93:3434-3438, 1996
17. Cusin I, Sainsbury A, Doyle P, Rohner-Jeanrenaud F, Jeanrenaud B: The ob gene and insulin: a relationship leading to clues to the understanding of obesity. Diabetes 44:1467-1470, 1995
18. Hardie LJ, Rayner DV, Holmes S, Trayhurn P: Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem Biophys Res Commun 223:660-665, 1996
19. Sivitz WI, Bailey HL, Donahue P: Rat adipose ob mRNA levels in states of altered circulating glucose and insulin. Biochem Biophys Res Commun 220:520-525, 1996
20. Utrianinen R, Malmstrom R, Makimattila S, Yki-Jarvinen H: Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects. Diabetes 47:544-549, 1996
21. Saad M, Kahn A, Sharma A, Michael R, Riad-Gabriel M, Boyadjian R, Jinagouda S, Steil G, Kadmar V: Physiological insulinemia acutely modulates plasma leptin. Diabetes 47:544-549, 1998
22. Muller W, Gregoire F, Stanhope K, Mobbs C, Mizuno T, Warden C, Stern J, Havel P: Evidence that glucose metabolism regulates leptin secretion from cultured adipocytes. Endocrinology 139:551-558, 1998
23. Havel PJ, Uriu-Hare JY, Liu T, Stanhope KL, Stern JS, Keen CL, Ahren B: Marked and rapid decrease of circulating leptin in streptozotocin diabetic rats: reversal by insulin. Am J Phys 274:R1482-R1491, 1998
24. Ahren B, Stern JS, Gingerich RL, Curry DL, Havel PJ: Glucagon secretory responses to hypoglycemia, adrenaline, and carbachol in streptozotocin diabetic rats. Acta Physiol Scand 155:215-221, 1995
25. Green PK, Wilkinson CW, Woods SC: Intraventricular corticosterone increases the rate of body weight gain in underweight adrenalectomized rats. Endocrinology 130:269-275, 1992
26. Schwartz MW, Marks J, Sipols AJ, Baskin DG, Woods SC, Kahn SE, Porte D Jr: Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rate. Endocrinology 128:2645-2647, 1991
27. Landt M, Gingerich R, Havel P, Mueller W, Schoner B, Hale J, Heiman M: Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans. Clin Chem 44:565-570, 1998
28. Sipols AJ, Baskin DG, Schwartz MW: Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44:147-151, 1995
29. Kumaresan P, Turner CW: Effect of alloxan on feed consumption and on replacement therapy with graded levels of insulin in rats. Proc Soc Exp Biol Med 122:526-527, 1966
30. Leedom LJ, Meehan WP: The psychoneuroendocrinology of diabetes mellitus in rodents. Psychoneuroendocrinology 14:275-294, 1989
31. Baskin D, Seeley R, Kuijper J, Lok S, Weigle D, Erickson J, Palmiter R, Schwartz M: Increased expression of mRNA for the long form of the receptor in the hypothalamus is associated with leptin hypersensitivity and fasting. Diabetes 47:538-543, 1998
32. Bennett PA, Lindell K, Karlsson C, Robinson IC, Carlsson LM, Carlsson B: Differential expression and regulation of leptin receptor isoforms in the rat brain: effects of fasting and oestrogen. Neuroendocrinology 67:29-36, 1998
33. Harris R, Zhou J, Redmann S, Smagin G, Smith S, Rodgers E, Zachwieja J: A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology 138:8-19, 1998
34. Barzilai N, Wang J, Massilon D, Vuguin P, Hawkins M, Rossetti L: Leptin selectively decreases visceral adiposity and enhances insulin action. J Clin Invest 100:3105-3110, 1997
35. Schwartz MW, Seely RJ: Neuroendocrine responses to starvation and weight loss. N Engl J Med 336:1802-1811, 1997
36. Rossi M, Choi S, O'Shea D, Miyoshi T, Ghatel M, Bloom S: Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 138:351-355, 1997
37. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek J, Kanarek R, Maratos-Flier E: A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380:243-247, 1996
38. Shutter J, Graham M, Kinsey A, Scully S, Luthy R, Stark K: Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev 11:593-602 1997
39. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemeili RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JRS, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu W, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M: Orexins and orexin receptors: a family of hypothalmic neuropeptides and G protein-coupled receptors that regualte feeding behaviour. Cell 92:573-585, 1998
40. Kristensen P, Judge M, Thim L, Ribel U, Christjansen K, Wulff B, Clausen J, Jensen P, Madsen O, Vrang N, Larsen P, Hastrup S: Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393:72-76, 1998
41. Legradi G, Emerson CH, Ahima RS, Flier JS, Lechan RM: Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 138:2569-2576, 1997
42. Schwartz MW, Sipols AJ, Kahn SE, Lattemann DP, Taborsky GJ Jr, Bergman RN, Woods SC, Porte D Jr: Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid. Am J Physiol 259:E378-383, 1990
43. Schwartz MW, Bergman RN, Kahn SE, Taborsky GJ Jr, Fisher LD, Sipols AJ, Woods SC, Steil GM, Porte D Jr: Evidence for uptake of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. J Clin Invest 88:1272-1281, 1991
44. Cusin I, Rohner-Jeanrenaud F, Stricker-Krongrad A, Jeanrenaud B: The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obest fa/fa rats. Diabetes 45:1446-1450, 1996
45. Jacob RJ, Dziura J, Medwick MB, Leone P, Caprio S, During M, Shulman GI, Sherwin RS: The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus, Diabetes 46:150-152, 1997
46. Flier JS: What's in a name? In search of leptin's physiological role. J Clin Endocrinol Metab 83:1407-1413, 1998