Predominately glucocorticoid agonist actions of RU-486 in young specific-pathogen-free Zucker rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 271, Issue 3 40-3, 1996, Pages

  Havel, Peter J ^a   Busch, Bonnie L ^b   Curry, Donald L ^b   Johnson, Patricia R ^b   Dallman, Mary F ^b   Stern, Judith S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

adrenal; adrenocorticotropic hormone; corticosterone; glucagon; glucose; insulin; mifepristone; pancreatic polypeptide; thymus

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; GLUCAGON; INSULIN; MIFEPRISTONE; PANCREAS POLYPEPTIDE; PROGESTERONE RECEPTOR;

ADIPOSE TISSUE; ADRENAL GLAND; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; DRUG EFFECT; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN BLOOD LEVEL; MALE; NONHUMAN; OBESITY; OVARY; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; THYMUS; WEIGHT GAIN;

EID: 0029796709     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.271.3.r710     Document Type: Article

References (46)

1. Akpan, J. O., P. J. Havel, S. J. Parry, R. A. Shalwitz, and R. L. Gingerich. The characterization of radioimmunoassay for rat pancreatic polypeptide in serum. Regul. Pept. 37: 59-60, 1992.
2. Arase, K., N. S. Shargill, and G. A. Bray. Effects of corticotropin releasing factor on genetically obese fatty rats. Physiol. Behav. 45: 1131-1137, 1989.
3. Bertagna, X., H. Escourolle, J. L. Pinquier, J. Coste, M. C. Raux-Demay, P. Perles, L. Silvestre, J. P. Luton, and G. Strauch. Administration of RU 486 for 8 days in normal volunteers: antiglucocorticoid effect with no evidence of peripheral cortisol deprivation. J. Clin. Endocrinol. Metab. 78: 375-380, 1994.
4. Boss-Williams, K. A., and T. J. Bartness. Effects of RU-486 on body weight and fat, and food intake in Siberian hamsters. (Abstract). Obes. Res. 1, Suppl. 1: 105S, 1993.
5. Bradbury, M. J., S. F. Akana, C. S., Cascio, N. Levin, L. Jacobson, and M. F. Dallman. Regulation of basal ACTH secretion by corticosterone is mediated by both type I (MR) and type II (GR) receptors in rat brain. J. Steroid Biochem. Molec. Biol. 40: 133-142, 1991.
6. Bray, G. A. Hypothalamic and genetic obesity: an appraisal of the autonomic hypothesis and the endocrine hypothesis. Int. J. Obes. 8, Suppl. 1: 119-137, 1984.
7. Brown, M. R., L. A. Fisher, J. Spiess, C. Rivier, J. Rivier, and W. Vale. Corticotropin-releasing factor: actions on the sympathetic nervous system and metabolism. Endocrinology 111: 928-931, 1982.
8. Bryce, G. F., P. R. Johnson, A. C. Sullivan, and J. S. Stern. Insulin and glucagon: plasma levels and pancreatic release in the genetically obese Zucker rat Norm. Metab. Res. 9: 366-370, 1977.
9. Chen, H. L., and D. R. Romsos. Type II glucocorticoid receptors in the CNS regulate metabolism in ob/ob mice independent of protein synthesis. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E427-E432, 1994.
10. Chua, S. C., W. K. Chung, X. S. Wu-Peng, Y. Zhang, S. M. Liu, L. Tartaglia, and R. L. Leibel. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science Wash. DC 271: 994-996, 1996.
11. Dubuc, P. U., and C. M. Peterson. Ineffectiveness of parenteral fluoxetine or RU-486 to alter long-term food intake, body weight or body composition of genetically obese mice. J. Pharmacol. Exp. Ther. 255: 976-979, 1990.
12. Fletcher, J. M., and N. McKenzie. The parasympathetic nervous system and glucocorticoid-mediated hyperinsulinemia in the genetically obese (fa/fa) Zucker rat. J. Endocrinol. 118: 87-92, 1988.
13. Freedman, M. R., B. A. Horwitz, and J. S. Stern. Effect of adrenalectomy and glucocorticoid replacement on development of obesity. Am. J. Physiol. 250 (Regulatory Integrative Comp. Physiol. 19): R595-R607, 1986.
14. Gagne, D., M. Pons, and D. Philibert. RU 38486: a potent antiglucocorticoid in vitro and in vivo. J. Steroid Biochem. 23: 247-251, 1985.
15. Gruol, D. J., and J. Altschmied. Synergistic induction of apoptosis with glucocorticoids and 3′,5′-cyclic adenosine monophosphate reveals agonist activity by RU 486. Mol. Endocrinol. 7: 104-113, 1993.
16. Guillaume-Gentil, C., F. Rohner-Jeanrenaud, F. Abramo, G. E. Bestetti, G. L. Rossi, and B. Jeanrenaud. Abnormal regulation of the hypothalamo-pituitary-adrenal axis in the genetically obese fa/fa rat. Endocrinology 126: 1873-1879, 1990.
17. Havel, P. J., J. O. Akpan, D. L. Curry, J. S. Stern, R. L. Gingerich, and B. Ahren. Autonomic control of pancreatic polypeptide and glucagon secretion during neuroglucopenia and hypoglycemia in mice. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R246-R254, 1993.
18. Havel, P. J., D. L. Curry, P. R. Johnson, and J. S. Stern. Effects of RU-486 administration on body weight and food intake in 12 week-old male obese and lean Zucker rats. Obes. Res. 1, Suppl. 1, 1993.
19. Havel, P. J., S. J. Parry, D. L. Curry, J. S. Stern, J. O. Akpan, and R. L. Gingerich. Autonomic nervous system mediation of the pancreatic polypeptide response to insulin-induced hypoglycemia in conscious rats. Endocrinology 130: 2225-2229, 1992.
20. Havel, P. J., and G. J. Taborsky, Jr. The contribution of the autonomic nervous system to changes of glucagon and insulin secretion during hypoglycemic stress. Endocr. Rev. 10: 332-350, 1989.
21. Healy, D. L., G. P. Chrousos, H. M. Schulte, R. F. Williams, P. W. Gold, E. E. Baulieu, and G. D. Hodgen. Pituitary and adrenal responses to the anti-progesterone and anti-glucocorticoid steroid RU 486 in primates. J. Clin. Endocrinol. Metab. 57: 863-865, 1983.
22. Kalimi, M. Role of antiglucocorticoid RU 486 on dexamethasone-induced hypertension in rats. Am. J. Physiol. 256 (Endocrinol. Metab. 19): E682-E685, 1989.
23. Kohn, D. F., and S. W. Barthold. Biology and diseases of rats. In: Laboratory Animal Medicine, editeaby J. G. Fox, B. J. Cohan, and F. M. Loew. San Diego, CA: Academic, 1984, p. 91-122.
24. Kramlik, S. K., M. Altemus, and T. W. Castonguay. The effects of RU-486 on dietary fat preference in fasted lean and obese men. Physiol. Behav. 54: 717-724, 1993.
25. Langley, S. C., and D. A. York. Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucker rats. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R539-R544, 1990.
26. Laue, L., G. P. Chrousos, D. L. Loriaux, K. Barnes, P. Munson, L. K. Nieman, and G. Sciason. The antiglucocorticoid and antiprogestin steroid RU-486 suppresses the ACTH response to ovine corticotropin-releasing factor in man. J. Clin. Endocrinol. Metab. 66: 290-293, 1988.
27. Laue, L., W. Gallucci, D. L. Loriaux, R. Udelsman, and G. P. Chrousos. The antiglucocorticoid and antiprogestin steroid RU486: its glucocorticoid agonist effect is inadequate to prevent adrenal insufficiency in primates. J. Clin. Endocrinol. Metab. 67: 602-606, 1988.
28. Moguilewsky, M., and D. Philibert. RU 38486: potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation. J. Steroid Biochem. 20: 271-276, 1984.
29. Nordeen, S. K., B. J. Bona, C. A. Beck, D. P. Edwards, K. C. Borror, and D. B. DeFranco. The two faces of a steroid antagonist: when an antagonist isn't. Steroids 60: 97-104, 1995.
30. Nordeen, S. K., B. J. Bona, and M. L. Moyer. Latent agonist activity of the steroid antagonist, RU486 is unmasked in cells treated with activators of protein kinase A. Mol. Endocrinol. 7: 731-742, 1993.
31. Okada, S., D.A. York, and G. A. Bray. Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity. Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 31): R1106-R1110, 1992.
32. Pakes, S. P., Y.-S. Lu, and P. C. Meunier. Factors that complicate laboratory animal research. In: Laboratory Animal Medicine, edited by J. G. Fox, B. J. Cohan, and F. M. Loew. San Diego, CA: Academic, 1984, p. 649-665.
33. Pesonen, U., M. Koulu, O. Heikinheimo, and R. Huupponen. The glucocorticoid antagonist mifepristone reveals abnormal regulation of the adrenocortical system in obese Zucker rats. J. Endocrinol. 132: 425-431, 1992.
34. Plotsky, P. M., K. V. Thrivikraman, A. G. Watts, and R. L. Hauger. Hypothalamic-pituitary-adrenal axis function in the Zucker obese rat. Endocrinology 130: 1931-1941, 1992.
35. Rees, L. H., D. M. Cook, J. W. Kendall, C. F. Allen, R. M. Kramer, J. G. Ratcliff, and R. A. Knight. Aradioimmunoassay for rat plasma ACTH. Endocrinology 89: 254-261, 1971.
36. Rohner-Jeanrenaud, F., A.-C. Hochstrasser, and B. Jeanrenaud. Hyperinsulinemia of preobese and obese fa/fa rats is partly vagus nerve mediated. Am. J. Physiol. 244 (Endocrinol. Metab. 7): E317-E322, 1983.
37. Rohner-Jeanrenaud, F., and B. Jeanrenaud. Abnormal regulation of pancreatic glucagon secretion in obese fa/fa rats. Diabetologia 31: 235-240, 1988.
38. Rohner-Jeanrenaud, F., and B. Jeanrenaud. Obesity, leptin, and the brain. N. Engl. J. Med. 334: 324-325, 1996.
39. Rohner-Jeanrenaud, F., C.-D. Walker, R. Greco-Peratto, and B. Jeanrenaud. Central corticotropin-releasing factor administration prevents the excessive body weight gain of genetically obese (fa/fa) rats. Endocrinology 124: 733-739, 1989.
40. Rothwell, N. J. Central effects of CRF on metabolism and energy balance. Neurosci. Biobehav. Rev. 14: 263-271, 1990.
41. Rouleau, A. M., P. R. Kovacs, H. W. Kunz, and D. T. Armstrong. Decontamination of rat embryos and transfer to specific pathogen-free recipients for the production of a breeding colony. Lab. Anim. Sci. 43: 611-615, 1993.
42. Schaison, G. Antagonist and agonist effects of the anitprogesterone RU 486. Ann. Endocrinol. 50: 200-207, 1989.
43. Tokunaga, K., M. Fukushima, J. R. Lupien, G. A. Bray, J. W. Kemnitz, and R. Schemmel. Effects of food restriction and adrenalectomy in rats with VMH or PVH lesions. Physiol. Behav. 45: 1131-1137, 1989.
44. Trocki, D., J. Baer, and T. W. Castonguay. Comparison of adrenalectomy and RU-486 in rats given a choice of maintenance diet and fat supplement. Am. J. Physiol. 269 (Regulatory Integrative Comp. Physiol. 38): R708-R719, 1995.
45. Walker, H. C., and D. R. Romsos. Glucocorticoids in the CNS regulate BAT metabolism and plasma insulin in ob/ob mice. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E110-E117, 1992.
46. Wilkinson, C., J. Shinsako, and M. F. Dallman. Return of pituitary-adrenal function after adrenal enucleation or transplantation: diurnal rhythms and responses to ether. Endocrinology 109: 162-169, 1981.