The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog

Diabetes

Volumn 46, Issue 2, 1997, Pages 187-196

  Sindelar, Dana K ^a   Chu, Chang A ^a   Rohlie, Michelle ^a   Neal, Doss W ^a   Swift, Larry L ^b   Cherrington, Alan D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; FATTY ACID; GLUCAGON; GLUCOSE; GLYCEROL; HEPARIN; INSULIN; INTRALIPID; LACTIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; GLUCONEOGENESIS; GLUCOSE UTILIZATION; GLYCOGENOLYSIS; INSULIN INFUSION; LIPOLYSIS; LIVER; NONHUMAN; PRIORITY JOURNAL;

EID: 0030969441     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.2.187     Document Type: Article

References (26)

1. Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD: A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the concious dog. Diabetes 45:1594-1604, 1996
2. Prager R, Wallace P, Olefsky JM: Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes 36:607-611, 1987
3. Ader M, Bergman RN: Peripheral effects of insulin dominate suppression of fasting hyperglycemia. Am J Physiol 258:E1029-E1032, 1990
4. Giacca A, Fisher S, Shi ZQ, Gupta R, Lavina H, Lickley A, Vranic M: Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest 90:1769-1777, 1992
5. Fisher S, Shi ZQ, Lekas M, Vranic M, Giacca A: Inhibition of glucagon secretion represents a dominant mechanism of insulin's indirect suppression of hepatic glucose production (Abstract). Diabetes 42 (Suppl. 1):118, 1993
6. Rebrin K, Steil GM, Getty L, Bergman RN: Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 44:1038-1045, 1995
7. Bonadonna R, Groop L, Zych K, Shank M, DeFronzo R: Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans. Am J Physiol 259:E736, 1990
8. Campbell P, Carlson M, Hill J, Nurjhan N: Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am J Physiol 263:E1063, 1992
9. Foley J: Rationale and application of fatty acid oxidation inhibitors in treatment of diabetes mellitus. Diabetes Care 15:773-784, 1992
10. Boden G, Chen X, Ruiz J, White J, Rossetti L: Mechanism of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93:2438-2446, 1994
11. Bevilacqua S, Bonadonna R, Buzzigoli G, Boni C, Ciociaro D, Maccari F, Giorico M, Ferrannini E: Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects. Metabolism 36:502-506, 1987
12. Saloranta C, Taskinen M, Widen E, Harkonen M, Melander A, Groop L: Metabolic consequences of sustained suppression of free fatty acids by acipimox in patients with NIDDM. Diabetes 42:1559-1566, 1993
13. Adkins BA, Myers SR, Hendrick GK, Stevenson RW, Williams PE, Cherrington AD: Importance of the route of intravenous glucose delivery on hepatic glucose balance in the conscious dog. J Clin Invest 79:557-565, 1987
14. Dobbins R, Davis S, Neal D, Cobelli C, Jaspan J, Cherrington A: Compartmental modeling of glucagon kinetics in the conscious dog. Metabolism 44:452-459, 1995
15. Myers SR, McGuiness OP, Neal DW, Cherrington AD: Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J Clin Invest 87:930-939, 1991
16. Goresky CA, Bach CG, Nadeau BE: Red cell carriage of label: its limiting effect on the exchange of materials in the liver. Circ Res 36:328-351, 1975
17. Lloyd B, Burrin J, Smythe P, Alberti KGMM: Enzymatic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin Chem 24:1724-1729, 1978
18. Wasserman DH, Geer RJ, Williams PE, Lacy DB, Abumard NN: Interaction of gut and liver in nitrogen metabolism during exercise. Metabolism 40:307-314, 1991
19. Morgan CR, Lazarow AL: Immunoassay of insulin: two antibody system. Plasma insulin of normal, subdiabetic, and diabetic rats. Am J Med Sci 257:415-419, 1963
20. Venkatakrishnan A, Abel MJ, Campbell RA, Donahue EP, Uselton TC, Flakoll PJ: Whole blood analysis of gluconeogenic amino acids of de novo gluconeogenesis using pre-column O-phthalaldehyde derivatization and high performance liquid chromatography. J Chromatogr B Biomed Appl 676:1-6, 1996
21. Leevy CM, Mendenhall CL, Lesko W, Howard MM: Estimation of hepatic blood flow with indocyanine green. J Clin Invest 41:1169-1179, 1962
22. Price CP, Lloyd B, Alberti KG: A kinetic spectrophotometric assay for rapid determination of acetoacetate in blood. Clin Chem 23:1893-1897, 1977
23. Mari A: Estimation of the rate of appearance in the non-steady state with a two-compartment model. Am J Phys 263 (E&M 26):E400-E415, 1992
24. Dobbins R, Davis S, Neal DW, Cobelli C, Cherrington AD: Pulsatility does not alter the response to a physiological increment in glucagon in the conscious dog. Am J Physiol 266 (29):E467-E478, 1994
25. Moore MC, Cherrington AD, Cline G, Jones EM, Neal DW, Badet C, Shulman GI: Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin Invest 88:578-587, 1991
26. Lee KU, Lee HK, Koh CS, Min HK: Artificial induction of intravascular lipolysis by lipid-heparin infusion leads to insulin resistance in man. Diabetalogia 31:285-290, 1988