Plasma leptin and insulin relationships in obese and nonobese humans

Diabetes

Volumn 45, Issue 5, 1996, Pages 695-698

  Dagogo Jack, Samuel ^a   Fanelli, Carmine ^a   Paramore, Deanna ^a   Brothers, Joy ^a   Landt, Michael ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; MESSENGER RNA; PROTEIN;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INTRAVENOUS DRUG ADMINISTRATION; MALE; OBESITY; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN SECRETION; RADIOIMMUNOASSAY;

EID: 0030012248     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.5.695     Document Type: Article

References (17)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
2. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone R, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
3. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269.540-543, 1995
4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
5. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Loften-Day CE, Prunkard DE, Raymond C, Kujiper JL: Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96 2065-2070, 1995
6. Cusin I, Sainsbury A, Doyle P, Rohner-Jeanrenaud F, Jeanrenaud B: The ob gene and insulin: a relationship leading to clues to the understanding of obesity. Diabetes 44:1467-1470, 1995
7. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Stales B, Auwerx J: Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-529, 1995
8. National Institutes of Health Technology Assessment Conference Panel: Methods for voluntary weight loss and control. Ann Intern Med 116:942-949, 1992
9. Schwartz NS, Clutter WE, Shah SD, Cryer PE: The glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms. J Clin Invest 79:777-781, 1987
10. Kuzuya H, Blix P, Horwitz D, Steiner D, Rubenstein A: Determination of free and total insulin and C-peptide in insulin-treated diabetics. Diabetes 26:22-29, 1977
11. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM: Leptin levels in human and rodent: measurement of plasma leptin and ob mRNA in obese and weight-reduced subjects. Nature Med 1:1155-1161, 1995
12. Frederich RC, Hamann A, Anderson S, Lollman B, Lowell BB, Flier JS: Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Med 1:1311-1314, 1995
13. Maffei M, Fei H, Lee G-H, Dani C, Leroy P, Zhang Y, Proenca R, Negrel R, Ailhaud G, Friedman JM: Increased expression in adipocytes of ob mRNA in mice with lesions of the hypothalamus and with mutations at the bd locus. Proc Natl Acad Sci USA 92:6957-6960, 1995
14. Mizuno T, Funabashi T, Kleopoulos S, Mobb CV: Elevated expression of (obese ob/ob) gene product in adipose tissue, and impaired induction by insulin of jun-B mRNA in liver in genetically obese yellow mice (Abstract). Endocr Soc Abstr 174, 1995
15. Bray GA, York DA: Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev 59:719-809, 1979
16. The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986, 1993
17. Carlson MG, Campbell PJ: Intensive insulin therapy and weight gain. Diabetes 42:1700-1707, 1993