Leptin selectively decreases visceral adiposity and enhances insulin action

Journal of Clinical Investigation

Volumn 100, Issue 12, 1997, Pages 3105-3110

  Barzilai, Nir ^a   Wang, Jiali ^a   Massilon, Duna ^a   Vuguin, Patricia ^a   Hawkins, Meredith ^a   Rossetti, Luciano ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Gluconeogenesis; Glucose uptake; Hepatic glucose production; Obesity; PEPCK

Indexed keywords

INSULIN; LEPTIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CALORIC RESTRICTION; CONTROLLED STUDY; ENERGY BALANCE; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TRANSPORT; GLYCOGENOLYSIS; INSULIN RESISTANCE; MALE; NONHUMAN; OBESITY; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT;

EID: 0031439778     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119865     Document Type: Article

References (29)

1. Kissebah, A.H. 1991. Insulin resistance in visceral obesity. Int. J. Obes. 15: (Suppl. 2):109-115.
2. Bjorntorp, P. 1991. Metabolic implications of body fat distribution. Diabetes Care. 14:1132-1143.
3. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
4. Halaas, J.L., K.S. Gajiwala, M. Maffei, S.L. Cohen, B.T. Chait, D. Rabinowitz, R.L. Lallone, S.K. Burley, and J.M. Friedman. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:543-546.
5. Pelleymounter, M.A., M.J. Cullen, M.B. Baker, R. Hecht, D. Winters, T. Boone, and F. Collins. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:540-543.
6. Rentsch, J., N. Levens, and M. Chiesi. 1995. Recombinant ob-gene product reduces food intake in fasted mice. Biochem. Biophys. Res. Commun. 214: 131-136.
7. Weigle, D.S., T.R. Bukowski, D.C. Foster, S. Holderman, J.M. Kramer, G. Lasser, C.E. Lofton-Day, D.E. Prunkard, C. Raymond, and J.L. Kuijper. 1995. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J. Clin. Invest. 96:2065-2070.
8. Campfield, L., F.J. Smith, Y. Guisez, R. Devos, and P. Burn. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:546-549.
9. Frederich, R.C., A. Hamann, S. Anderson, B. Lollmann, B.B. Lowell, and J.S. Flier. 1995. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1:1311-1314.
10. Schwartz, M.W., R.J. Seeley, L.A. Campfield, P. Burn, and D.G. Baskin. 1996. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98:1101-1106.
11. Considine, R.V., M.K. Sinha, M.L. Heiman, A. Kriauciunas, T.W. Stephens, M.R. Nyce, J.P. Ohannesian, C.C. Marco, L.J. McKee, T. Bauer, et al. 1996. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334:324-325.
12. Tartaglia, L., M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G. Richards, L. Campfield, F. Clark, J. Deeds, et al. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1263-1271.
13. Cohen, B., D. Novick, and M. Rubinstein. 1996. Modulation of insulin activities by leptin. Science. 274:1185-1188.
14. Barzilai, N., D. Massillon, and L. Rossetti. 1995. Effects of fasting on hepatic and peripheral glucose metabolism in conscious rats with near-total fat depletion. Biochem. J. 310:819-826.
15. Rossetti, L., D. Smith, G.I. Shulman, D. Papachristou, and R.A. DeFronzo. 1987. Corrrection of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J. Clin. Invest. 79:1510-1515.
16. Rossetti, L., and A. Giaccari. 1990. Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats. J. Clin. Invest. 85:1785-1792.
17. Rossetti, L., A. Giaccari, N. Barzilai, K. Howard, G. Sebel, and M. Hu. 1993. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. J. Clin. Invest. 92:1126-1134.
18. Barzilai, N., and L. Rossetti. 1993. Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin. J. Biol. Chem. 268:25019-25025.
19. Massillon, D., N. Barzilai, W. Chen, M. Hu, and L. Rossetti. 1996. Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats. J. Biol. Chem. 271:9871-9874.
20. Mantzoros, C.S., D. Qu, R.C. Frederich. V.S. Susulic, B.B. Lowell, E. Maratos-Flier, and J.S. Flier. 1996. Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leplin-independent inhibition of food intake in mice. Diabetes. 45:909-914.
21. Himms-Hagen, J., J. Cui, E.J. Danforth, D.J. Taatjes, S.S. Lang, B.L. Waters, and T. Claus. 1994. Effect of CL-316,243, a thermogenic beta 3-agonist. on energy balance and brown and white adipose tissues in rats. Am. J. Physiol. 266:R1371-R1382.
22. Schwartz, M.W., D.G. Baskin, T.R. Bukowski, J.L. Kuijper, D. Foster, G. Lasser, D.E. Prunkard, D.J. Porte, S.C. Woods, R. Seeley, and D. Weigle. 1996. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 45:531-535.
23. McGarry, J.D., G.P. Mannaerts. and D.W. Foster. 1977. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J. Clin. Invest. 60:265-270.
24. Moir, A.M., and V.A. Zammit. 1993. Rapid switch of hepatic fatty acid metabolism from oxidation to esterification during diurnal feeding of meal-fed rats correlates with changes in the properties of acctyl-CoA carboxylase, but not of carnitine palmitoyltransferase I. Biochem. J. 291:241-246.
25. Prentki, M., and B.E. Corkey. 1996. Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM Diabetes. 45:273-283.
26. Sidossis, L.S., C.A. Stuart, G.I. Shulman, G.D. Lopaschuk, and R. Wolfe. 1996. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J. Clin. Invest. 98:2244-2250.
27. Shimabukuro, M., K. Koyama, G. Chen, M.-Y. Wang, F. Trieu, Y. Lee, C.B. Newgard, and R.H. Unger. 1997. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc. Natl. Acad. Sci. USA. 94:4637-4641.
28. Sivitz, W.I., S.A. Walsh, D.A. Morgan, M.J. Thomas, and W.G. Haynes. 1997. Effects of leptin on insulin sensititvity in normal rats. Endocrinology. 138: 3395-3401.
29. Rossetti, L., D. Massillon, N. Barzilai, P. Vuguin, J. Wu, R. Liu, and J. Wang. 1997. Short-term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J. Biol. Chem. 272:27758-27763.