Serum leptin and body weight in females with anorexia and bulimia nervosa

Hormone and Metabolic Research

Volumn 30, Issue 5, 1998, Pages 272-275

  Kopp W ^a,f   Blum, W F ^b,c   Ziegler, A ^d   Mathiak, K ^a   Lubbert H ^a   Herpertz, S ^e   Deter, H C ^a   Hebebrand, J ^d  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c Lilly GmbH   (Germany)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

^e UNIVERSITY OF DUISBURG ESSEN   (Germany)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Body Mass Index; Eating Disorders; Obese Gene Product

Indexed keywords

LEPTIN;

ADULT; AMENORRHEA; ANOREXIA NERVOSA; ARTICLE; BODY MASS; BODY WEIGHT; BULIMIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEEDING BEHAVIOR; FEMALE; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; WEIGHT GAIN;

EID: 0031833972     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-978882     Document Type: Article

References (19)

1. Zhang Z, Proenca R, Maffei M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-32
2. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-6
3. Considine EL, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee L, Bauer TL, Caro JF. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-5
4. Boden G, Chen X, Mozzoli M, Ryan I. Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metabol 1996; 81: 3419-23
5. Sinha MK, Opentanova I, Ohannesian JP, Kolaczynski JW, Heiman ML, Hale J, Becker GW, Bowsher RR, Stephens TW, Caro JF. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. J Clin Invest 1996; 98: 1277-82
6. Kolaczynski MR, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsky J, Caro JF. Acute and chronic effects of insulin on leptin production in humans. Studies in vivo and in vitro. Diabetes 1996; 45: 699-701
7. Kolaczynski JW, Considine RV, Ohannesian J, Marco C, Opentanova I, Nyce MR, Myint M, Caro JF. Responses of leptin to short-term fasting and refeeding in humans. A link with ketogenesis but not ketones themselves. Diabetes 1996; 45: 1511-5
8. Wing RR, Sinha MK, Considine MV, Lang W, Caro JF. Relationship between weight loss maintenance and changes in serum leptin levels. Horm Metab Res 1996; 28: 698-703
9. Scholz GH, Englaro P, Thiele I, Scholz M, Klusmann T, Kellner K, Rascher W, Blum WF. Dissociation of serum leptin concentration and body fat content during long term dietary intervention in obese individuals. Horm Metab Res 1996; 28: 718-23
10. Barash IA, Cheung CC, Weigle DS, Ren HP, Kabigting EB, Kuijper JL, Clifton DK, Steiner RA. Leptin is a metabolic signal to the reproductive system. Endocrinology 1996; 137: 3144-7
11. Anima RS, Prabakaran D, Mantzoros C, Qu DQ, Lowell B, Maratosflie E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382: 250-2
12. Hebebrand J, van der Heyden J, Devos R, Köpp W, Herpertz S, Reinschmidt H, Herzog W. Plasma concentrations of obese protein in anorexia nervosa. Lancet 1995; 346: 1624-5
13. Hebebrand J, Blum WF, Barth N, Coners H, Englaro P, Juul A, Ziegler A, Warnke A, Rascher W, Remschmidt H. Leptin synthesis in patients with anorexia nervosa is reduced in the acute stage and elevated upon short term weight restoration. Mol Psychiatry 1997; 2: 330-4
14. Grinspoon S, Gulick T, Askari H, Landt M, Lee K, Anderson E, Ma ZM, Vignati L, Bowsher R, Herzog D, Klibanksi A. Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab 1996; 81: 3861-3
15. Köpp W, Blum WF, v. Prittwitz S, Ziegler A, Lübbert H, Emons G, Herzog W, Herpertz S, Deter HC, Remschmidt H, Hebebrand J. Low leptin levels predict amenorrhea in underweight and eating disordered females. Mol Psychiatry 1997; 2: 335-40
16. Sørensen TI, Echwald SM, Holm JC. Leptin in obesity. Brit Med J 1996; 313: 953-4
17. Licinio J, Mantzoros C, Negrao AB, Cizza G, Wong ML, Bongiorno PB, Chrousos GP, Karp B, Allen C, Flier JS, Gold PW. Human leptin levels are pulsatile and inversely related to pituary-adrenal function. Nat Medicine 1997; 3: 575-9
18. Mantzoros CS, Qu D, Frederich RC, Susulic VS, Lowell BB, Maratos-Flier E, Flier JS. Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes 1996; 45: 909-14
19. v. Prittwitz S, Blum WF, Ziegler A, Scharmann S, Remschmidt H, Hebebrand J. Restrained eating is associated with a low leptin synthesis in underweight females. Mol Psychiatry 1997; 2: 420-2