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1
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0026587743
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CD19: Lowering the threshold for antigen receptor stimulation of B lymphocytes
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Carter RH, Fearon DT. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science. 256:1992;105-107.
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Science
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Carter, R.H.1
Fearon, D.T.2
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2
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0027169534
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CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase
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Tuveson DA, Carter RH, Soltoff SP, Fearon DT. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science. 260:1993;986-989.
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Science
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Tuveson, D.A.1
Carter, R.H.2
Soltoff, S.P.3
Fearon, D.T.4
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4
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0028832247
-
Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology domains
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Chalupny NJ, Aruffo A, Esselstyn JM, Chan P-Y, Bajorath J, Blake J, Gilliland LK, Ledbetter JA, Tepper MA. Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology domains. Eur J Immunol. 25:1995;2978-2984.
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Eur J Immunol
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Chalupny, N.J.1
Aruffo, A.2
Esselstyn, J.M.3
Chan, P.-Y.4
Bajorath, J.5
Blake, J.6
Gilliland, L.K.7
Ledbetter, J.A.8
Tepper, M.A.9
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5
-
-
0028597993
-
Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors
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Weng WK, Jarvis L, LeBien TW. Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors. J Biol Chem. 269:1994;32514-32521.
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J Biol Chem
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Weng, W.K.1
Jarvis, L.2
Lebien, T.W.3
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6
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-
0030466893
-
Faciogentital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPase
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Olson MF, Pasretis NG, Gorski JL, Hall A. Faciogentital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPase. Curr Biol. 6:1996;1628-1633.
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Curr Biol
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Olson, M.F.1
Pasretis, N.G.2
Gorski, J.L.3
Hall, A.4
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7
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0031033292
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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
-
of outstanding interest. Tyrosine phosphorylation of Vav induces nucleotide exchange on Rac-1 and stimulates c-Jun kinase. This is the first demonstration of a molecular modification of Vav found to regulate its function.
-
Crespo P, Schuebel KE, Ostrom AA, Gutkind JS, Bustelo XR. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. of outstanding interest Nature. 385:1997;169-172 Tyrosine phosphorylation of Vav induces nucleotide exchange on Rac-1 and stimulates c-Jun kinase. This is the first demonstration of a molecular modification of Vav found to regulate its function.
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Nature
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, pp. 169-172
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Crespo, P.1
Schuebel, K.E.2
Ostrom, A.A.3
Gutkind, J.S.4
Bustelo, X.R.5
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8
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0029094609
-
Abnormal B lymphocyte development, activation and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
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of outstanding interest. This paper along with [9] demonstrates the important biological role of CD19 in vivo. CD19 is required for the B cell response to T cell dependent antigens, germinal center formation and affinity maturation of serum antibodies.
-
Engel P, Zhou L-J, Ord DC, Sato S, Koller B, Tedder TF. Abnormal B lymphocyte development, activation and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. of outstanding interest Immunity. 3:1995;39-50 This paper along with [9] demonstrates the important biological role of CD19 in vivo. CD19 is required for the B cell response to T cell dependent antigens, germinal center formation and affinity maturation of serum antibodies.
-
(1995)
Immunity
, vol.3
, pp. 39-50
-
-
Engel, P.1
Zhou, L.-J.2
Ord, D.C.3
Sato, S.4
Koller, B.5
Tedder, T.F.6
-
9
-
-
0029064680
-
Impairment of T-cell dependent B-cell responses and B-1 cell development in CD19-deficient mice
-
of outstanding interest. See annotation [8].
-
Rickert RC, Rajewsky K, Roes J. Impairment of T-cell dependent B-cell responses and B-1 cell development in CD19-deficient mice. of outstanding interest Nature. 376:1995;352-355 See annotation [8].
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(1995)
Nature
, vol.376
, pp. 352-355
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-
Rickert, R.C.1
Rajewsky, K.2
Roes, J.3
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10
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-
15844412034
-
Disruption of the Cr2 locus results in a reduction of B-1a cells and in an impaired B cell response to T-dependent antigen
-
-/- mice to that of a deficiency in CD19 supports the model that CD21 (CR2) enhances AgR signal transduction by providing a co-stimulatory signal via the CD21-CD19-TAPA-1 complex. See also [12].
-
-/- mice to that of a deficiency in CD19 supports the model that CD21 (CR2) enhances AgR signal transduction by providing a co-stimulatory signal via the CD21-CD19-TAPA-1 complex. See also [12].
-
(1996)
Immunity
, vol.4
, pp. 251-262
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-
Ahearn, J.M.1
Fischer, M.B.2
Croix, D.3
Goerg, S.4
Ma, M.5
Xia, J.6
Zhou, X.7
Howard, R.G.8
Rothstein, T.L.9
Carroll, M.C.10
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11
-
-
0029916530
-
Antibody response to a T-dependent antigen requires B cell expression of complement receptors
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Croix D, Ahearn JM, Rosengard AM, Han S, Kelsoe G, Ma M, Carroll MC. Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J Exp Med. 183:1996;1857-1864.
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(1996)
J Exp Med
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Croix, D.1
Ahearn, J.M.2
Rosengard, A.M.3
Han, S.4
Kelsoe, G.5
Ma, M.6
Carroll, M.C.7
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12
-
-
0029926153
-
Markedly impaired humoral response in mice deficient in complement receptors 1 and 2
-
of outstanding interest. See annotation [10].
-
Molina H, Holers VM, Li B, Fang Y-F, Mariathasan S, Goellner J, Strauss-Schoenberger J, Karr RW, Chaplin DD. Markedly impaired humoral response in mice deficient in complement receptors 1 and 2. of outstanding interest Proc Natl Acad Sci USA. 93:1996;3357-3361 See annotation [10].
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3357-3361
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Molina, H.1
Holers, V.M.2
Li, B.3
Fang, Y.-F.4
Mariathasan, S.5
Goellner, J.6
Strauss-Schoenberger, J.7
Karr, R.W.8
Chaplin, D.D.9
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13
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0028958669
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The CD19/CR2/TAPA-1 complex of B lymphocytes: Linking natural to acquired immunity
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Fearon DT, Carter RH. The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity. Annu Rev Immunol. 13:1995;127-150.
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(1995)
Annu Rev Immunol
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, pp. 127-150
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Fearon, D.T.1
Carter, R.H.2
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14
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0030593030
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C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
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of outstanding interest. This paper reports that the immunization with antigen fused to C3d, a CD21 ligand which targets Ag to the CD19-CD21 complex, enhances the acquired immune response by two to three orders of magnitude.
-
Dempsey PW, Allison MED, Akkaraju S, Goodnow CC, Fearon DT. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. of outstanding interest Science. 271:1996;348-350 This paper reports that the immunization with antigen fused to C3d, a CD21 ligand which targets Ag to the CD19-CD21 complex, enhances the acquired immune response by two to three orders of magnitude.
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(1996)
Science
, vol.271
, pp. 348-350
-
-
Dempsey, P.W.1
Allison, M.E.D.2
Akkaraju, S.3
Goodnow, C.C.4
Fearon, D.T.5
-
15
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-
0029821683
-
Regulation of B cell growth and differentiation via CD21 and CD40
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Axcrona K, Gray D, Leanderson T. Regulation of B cell growth and differentiation via CD21 and CD40. Eur J Immunol. 26:1996;2203-2207.
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(1996)
Eur J Immunol
, vol.26
, pp. 2203-2207
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Axcrona, K.1
Gray, D.2
Leanderson, T.3
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16
-
-
0028905909
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Co-ligation of mouse complement receptors 1 and 2 with surface IgM rescues splenic B cells and WEHI-231 cells from anti-surface IgM-induces apoptosis
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Kozono Y, Duke RC, Schleicher MS, Holers VM. Co-ligation of mouse complement receptors 1 and 2 with surface IgM rescues splenic B cells and WEHI-231 cells from anti-surface IgM-induces apoptosis. Eur J Immunol. 25:1995;1013-1017.
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(1995)
Eur J Immunol
, vol.25
, pp. 1013-1017
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Kozono, Y.1
Duke, R.C.2
Schleicher, M.S.3
Holers, V.M.4
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17
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0028786573
-
Engaging CD19 or target of an antiproliferative antibody 1 on human B lymphocytes induces binding of B cells to the interfollicular stroma of human tonsils via integrin α4/β1 and fibronectin
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Behr S, Schriever F. Engaging CD19 or target of an antiproliferative antibody 1 on human B lymphocytes induces binding of B cells to the interfollicular stroma of human tonsils via integrin α4/β1 and fibronectin. J Exp Med. 182:1995;1191-1199.
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(1995)
J Exp Med
, vol.182
, pp. 1191-1199
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Behr, S.1
Schriever, F.2
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18
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0029665081
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Signal transduction through the β1 integrin family surface adhesion molecules VLA-4 and VLA-5 of human B-cell precursors activates CD19 receptor-associated protein-tyrosine kinases
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Xiao J, Messinger Y, Jin J, Myers DE, Bolen JB, Uckun FM. Signal transduction through the β1 integrin family surface adhesion molecules VLA-4 and VLA-5 of human B-cell precursors activates CD19 receptor-associated protein-tyrosine kinases. J Biol Chem. 271:1996;7659-7664.
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(1996)
J Biol Chem
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Xiao, J.1
Messinger, Y.2
Jin, J.3
Myers, D.E.4
Bolen, J.B.5
Uckun, F.M.6
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19
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0028915948
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Defective signalling through the T- And B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene
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-/- blastocyst complementation. The B-1a subset was absent in the vav deficient mice. The similar phenotype of CD19- and CD21-deficient mice and the known interaction of Vav with CD19 would support the possibility that Vav mediates the co-stimulatory role of CD19 in B-1a maintenance.
-
-/- blastocyst complementation. The B-1a subset was absent in the vav deficient mice. The similar phenotype of CD19- and CD21-deficient mice and the known interaction of Vav with CD19 would support the possibility that Vav mediates the co-stimulatory role of CD19 in B-1a maintenance.
-
(1995)
Nature
, vol.374
, pp. 470-473
-
-
Zhang, R.1
Alt, F.W.2
Davidson, L.3
Orkin, S.H.4
Swat, W.5
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20
-
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0028956337
-
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav
-
of outstanding interest. See annotation [19].
-
Tarakhovsky A, Turner M, Schaal S, Mee PJ, Duddy LP, Rajewsky K, Tybulewicz VLJ. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. of outstanding interest Nature. 374:1995;467-470 See annotation [19].
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(1995)
Nature
, vol.374
, pp. 467-470
-
-
Tarakhovsky, A.1
Turner, M.2
Schaal, S.3
Mee, P.J.4
Duddy, L.P.5
Rajewsky, K.6
Tybulewicz, V.L.J.7
-
21
-
-
0029893866
-
The signaling activity of murine CD19 is regulated during B cell development
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Krop I, Shaffer AL, Fearon DT, Schlissel MS. The signaling activity of murine CD19 is regulated during B cell development. J Immunol. 157:1996;48-56.
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(1996)
J Immunol
, vol.157
, pp. 48-56
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Krop, I.1
Shaffer, A.L.2
Fearon, D.T.3
Schlissel, M.S.4
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22
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0030588569
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CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity
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Sato S, Ono N, Steeber DA, Pisetsky DS, Tedder TF. CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. J Immunol. 157:1996;4371-4378.
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(1996)
J Immunol
, vol.157
, pp. 4371-4378
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-
Sato, S.1
Ono, N.2
Steeber, D.A.3
Pisetsky, D.S.4
Tedder, T.F.5
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23
-
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0030044169
-
Self-renewal of B-1 lymphocytes is dependent on CD19
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Krop I, de Fougerolles AR, Hardy RR, Allison M, Schlissel MS, Fearon DT. Self-renewal of B-1 lymphocytes is dependent on CD19. Eur J Immunol. 26:1996;238-242.
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(1996)
Eur J Immunol
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, pp. 238-242
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-
Krop, I.1
De Fougerolles, A.R.2
Hardy, R.R.3
Allison, M.4
Schlissel, M.S.5
Fearon, D.T.6
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24
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0030474683
-
CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells
-
of outstanding interest. This paper demonstrates that AgR signaling is negatively regulated by CD5 in B-1 cells.
-
Bikah G, Carey J, Ciallella JR, Tarakhovsky A, Bondada S. CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. of outstanding interest Science. 274:1996;1906-1909 This paper demonstrates that AgR signaling is negatively regulated by CD5 in B-1 cells.
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(1996)
Science
, vol.274
, pp. 1906-1909
-
-
Bikah, G.1
Carey, J.2
Ciallella, J.R.3
Tarakhovsky, A.4
Bondada, S.5
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25
-
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0030031886
-
Augmented humoral and anaphylactic responses in FcγRII-deficient mice
-
of special interest. Analysis of FcγRII-deficient mice confirmed the negative regulatory role of the receptor in immune complex initiated signaling.
-
Takai T, Ono M, Hikida M, Ohmori H, Ravetch JV. Augmented humoral and anaphylactic responses in FcγRII-deficient mice. of special interest Nature. 379:1996;346-349 Analysis of FcγRII-deficient mice confirmed the negative regulatory role of the receptor in immune complex initiated signaling.
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(1996)
Nature
, vol.379
, pp. 346-349
-
-
Takai, T.1
Ono, M.2
Hikida, M.3
Ohmori, H.4
Ravetch, J.V.5
-
26
-
-
0028932411
-
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by FcγRIIB1
-
of outstanding interest. This paper shows that FcγRIIB recruits and activates the phosphotyrosine phosphatase SHP-1 after AgR co-ligation. See also [30].
-
D'Ambrosio D, Hippen KL, Minskoff SA, Mellman I, Pani G, Siminovitch KA, Cambier JC. Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by FcγRIIB1. of outstanding interest Science. 268:1995;293-297 This paper shows that FcγRIIB recruits and activates the phosphotyrosine phosphatase SHP-1 after AgR co-ligation. See also [30].
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(1995)
Science
, vol.268
, pp. 293-297
-
-
D'Ambrosio, D.1
Hippen, K.L.2
Minskoff, S.A.3
Mellman, I.4
Pani, G.5
Siminovitch, K.A.6
Cambier, J.C.7
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27
-
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0029786742
-
Negative signaling via FcγRII in B cells blocks phospholipase Cγ2 tyrosine phosphorylation but not Syk or Lyn activation
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Sarkar S, Schlottmann K, Cooney D, Coggeshall KM. Negative signaling via FcγRII in B cells blocks phospholipase Cγ2 tyrosine phosphorylation but not Syk or Lyn activation. J Biol Chem. 271:1996;20182-20186.
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(1996)
J Biol Chem
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Sarkar, S.1
Schlottmann, K.2
Cooney, D.3
Coggeshall, K.M.4
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28
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0022319106
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Crosslinking of surface immunoglobulin and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via antigen receptors
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Bijsterbosch MK, Klaus GGB. Crosslinking of surface immunoglobulin and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via antigen receptors. J Exp Med. 162:1985;1825-1836.
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Bijsterbosch, M.K.1
Klaus, G.G.B.2
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29
-
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0028347321
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A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling
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Muta T, Kurosaki T, Misulovin Z, Sanchez M, Nussenzweig MC, Ravetch JV. A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling. Nature. 368:1994;70-73.
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Nature
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Muta, T.1
Kurosaki, T.2
Misulovin, Z.3
Sanchez, M.4
Nussenzweig, M.C.5
Ravetch, J.V.6
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30
-
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0029835940
-
Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB
-
of outstanding interest. Co-ligating FcγRIIB to AgR results in the recruitment of the SH2-domain-containing inositol polyphosphate 5-phosphatase (SHIP) to pITIM of FcγRIIB in both mast cells and B cells, offering another mechanism for FcγRIIB inhibition of AgR signaling (see [26] for the first).
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Ono M, Bolland S, Tempst P, Ravetch JV. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB. of outstanding interest Nature. 383:1996;263-266 Co-ligating FcγRIIB to AgR results in the recruitment of the SH2-domain-containing inositol polyphosphate 5-phosphatase (SHIP) to pITIM of FcγRIIB in both mast cells and B cells, offering another mechanism for FcγRIIB inhibition of AgR signaling (see [26] for the first).
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(1996)
Nature
, vol.383
, pp. 263-266
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Ono, M.1
Bolland, S.2
Tempst, P.3
Ravetch, J.V.4
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31
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0029665083
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Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity
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Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev. 10:1996;1085-1095.
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(1996)
Genes Dev
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Lioubin, M.N.1
Algate, P.A.2
Tsai, S.3
Carlberg, K.4
Aebersold, R.5
Rohrschneider, L.R.6
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32
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0029978202
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The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
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Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Proc Natl Acad Sci USA. 93:1996;1689-1693.
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Proc Natl Acad Sci USA
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Damen, J.E.1
Liu, L.2
Rosten, P.3
Humphries, R.K.4
Jefferson, A.B.5
Majerus, P.W.6
Krystal, G.7
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34
-
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0027418367
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Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes
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Choquet D, Partiseti M, Amigorena S, Bonnerot C, Fridman WH, Korn H. Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes. J Cell Biol. 121:1993;355-363.
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J Cell Biol
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Choquet, D.1
Partiseti, M.2
Amigorena, S.3
Bonnerot, C.4
Fridman, W.H.5
Korn, H.6
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35
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0028179403
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Crosslinking of Fcγ receptor to surface immunoglobulin on B cells provides an inhibitory signal that closes the plasma membrane calcium channel
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Diegel ML, Rankin BM, Bolen JB, Dubois PM, Kiener PA. Crosslinking of Fcγ receptor to surface immunoglobulin on B cells provides an inhibitory signal that closes the plasma membrane calcium channel. J Biol Chem. 269:1994;11409-11416.
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J Biol Chem
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Diegel, M.L.1
Rankin, B.M.2
Bolen, J.B.3
Dubois, P.M.4
Kiener, P.A.5
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36
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0031039024
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Direct regulation of the AKTi proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
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Franke TF, Kaplan DR, Cantley LC, Toker A. Direct regulation of the AKTi proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science. 275:1997;665-668.
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Science
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Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
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37
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0029152796
-
Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3-kinase
-
Jackson SP, Schoenwaelder SM, Matzaris M, Brown S, Mitchell CA. Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3-kinase. EMBO J. 14:1994;4490-4500.
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EMBO J
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Jackson, S.P.1
Schoenwaelder, S.M.2
Matzaris, M.3
Brown, S.4
Mitchell, C.A.5
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38
-
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0030587116
-
Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP
-
of special interest. Co-ligating the AgR to FcγRIIB induces SHIP tyrosine phosphorylation and SHIP association with the adapter, Shc.
-
Chacko GW, Tridandapani S, Damen JE, Liu L, Krystal G, Coggeshall KM. Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. of special interest J Immunol. 157:1996;2234-2238 Co-ligating the AgR to FcγRIIB induces SHIP tyrosine phosphorylation and SHIP association with the adapter, Shc.
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(1996)
J Immunol
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Chacko, G.W.1
Tridandapani, S.2
Damen, J.E.3
Liu, L.4
Krystal, G.5
Coggeshall, K.M.6
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39
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0028540931
-
Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily
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Kelm S, Pelz A, Schauer R, Filbin MT, Tang S, De Bellard M-E, Schnaar RL, Mahoney JA, Hartnell A, Bradfield P, Crocker PR. Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily. Curr Biol. 4:1994;965-972.
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Curr Biol
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Kelm, S.1
Pelz, A.2
Schauer, R.3
Filbin, M.T.4
Tang, S.5
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0029918134
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Localization of the putative sialic acid-binding site on the immunoglobulin superfamily cell-surface molecule CD22
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47
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Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid dependent ligand
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50
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CD22 associates with the human surface IgM-B cell antigen receptor complex
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51
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0029012969
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A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP
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of outstanding interest. This paper describes, along with [52], the association of SHP-1 with CD22 and also demonstrates the enhanced mlg signaling seen upon sequestration of CD22.
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Doody GM, Justement LB, Delibrias CC, Matthews RJ, Lin J, Thomas ML, Fearon DT. A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. of outstanding interest Science. 269:1995;242-244 This paper describes, along with [52], the association of SHP-1 with CD22 and also demonstrates the enhanced mlg signaling seen upon sequestration of CD22.
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Science
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Doody, G.M.1
Justement, L.B.2
Delibrias, C.C.3
Matthews, R.J.4
Lin, J.5
Thomas, M.L.6
Fearon, D.T.7
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52
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0029048060
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Phosphotyrosine-dependent association between CD22 and the protein tyrosine phosphatase 1C
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of outstanding interest. of special interest. See annotation [51].
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of outstanding interest Campbell MA, Klinman NR. Phosphotyrosine-dependent association between CD22 and the protein tyrosine phosphatase 1C. of special interest Eur J Immunol. 25:1995;1573-1579 See annotation [51].
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Campbell, M.A.1
Klinman, N.R.2
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53
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0029944192
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Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation
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Tuscano J, Engel P, Tedder TF, Kehrl JH. Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation. Blood. 87:1996;4723-4730.
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Tuscano, J.1
Engel, P.2
Tedder, T.F.3
Kehrl, J.H.4
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54
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0030053270
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Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via human B lymphocyte antigen CD22
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of special interest. References [54,55] describe the association of CD22 with a number of signaling molecules which may represent a positive signaling capacity for CD22
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Tuscano JM, Engel P, Tedder TF, Agarwal A, Kehrl JH. Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via human B lymphocyte antigen CD22. of special interest Eur J Immunol. 26:1996;1246-1252 References [54,55] describe the association of CD22 with a number of signaling molecules which may represent a positive signaling capacity for CD22.
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Eur J Immunol
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Tuscano, J.M.1
Engel, P.2
Tedder, T.F.3
Agarwal, A.4
Kehrl, J.H.5
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55
-
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0030047811
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CD22 associates with protein tyrosine phosphatase 1C, syk and phospholipase C-γ1 upon B cell activation
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of special interest. See annotation [54].
-
Law C-L, Sidorenko SP, Chandran KA, Zhao Z, Shen S-H, Fischer EH, Clark EA. CD22 associates with protein tyrosine phosphatase 1C, syk and phospholipase C-γ1 upon B cell activation. of special interest J Exp Med. 183:1996;547-560 See annotation [54].
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J Exp Med
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Law, C.-L.1
Sidorenko, S.P.2
Chandran, K.A.3
Zhao, Z.4
Shen, S.-H.5
Fischer, E.H.6
Clark, E.A.7
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56
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0028961264
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Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection
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of outstanding interest. This paper conclusively demonstrates a role for SHP-1 in regulating mlg signaling thresholds, but does not determine whether this is mediated through CD22, FcγRIIB or some other membrane protein.
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Cyster JG, Goodnow CC. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. of outstanding interest Immunity. 2:1995;13-24 This paper conclusively demonstrates a role for SHP-1 in regulating mlg signaling thresholds, but does not determine whether this is mediated through CD22, FcγRIIB or some other membrane protein.
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(1995)
Immunity
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Cyster, J.G.1
Goodnow, C.C.2
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57
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0028989144
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Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling
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Pani G, Kozlowski M, Cambier JC, Mills GB, Siminovitch KA. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med. 181:1995;2077-2084.
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Pani, G.1
Kozlowski, M.2
Cambier, J.C.3
Mills, G.B.4
Siminovitch, K.A.5
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58
-
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0029904138
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Direct regulation if ZAP-70 by SHP-1 in T cell antigen receptor signaling
-
of outstanding interest. This paper demonstrates that SHP-1 regulates T-cell receptor signaling by acting directly on ZAP-70. This suggests that the ZAP-70 homologue Syk, expressed in B cells, which associates with CD22 [54,55], may be a target for SHP-1 in regulating mlg signaling.
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Plas DR, Johnson R, Pingel JT, Matthews RJ, Dalton M, Roy G, Chan AC, Thomas ML. Direct regulation if ZAP-70 by SHP-1 in T cell antigen receptor signaling. of outstanding interest Science. 272:1996;1173-1176 This paper demonstrates that SHP-1 regulates T-cell receptor signaling by acting directly on ZAP-70. This suggests that the ZAP-70 homologue Syk, expressed in B cells, which associates with CD22 [54,55], may be a target for SHP-1 in regulating mlg signaling.
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(1996)
Science
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, pp. 1173-1176
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Plas, D.R.1
Johnson, R.2
Pingel, J.T.3
Matthews, R.J.4
Dalton, M.5
Roy, G.6
Chan, A.C.7
Thomas, M.L.8
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59
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0023907422
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Role of the CD22 human B cell antigen in B cell triggering by anti-immunoglobulin
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Pezzutto A, Rabinovitch PS, Dorken B, Moldenhauer G, Clark EA. Role of the CD22 human B cell antigen in B cell triggering by anti-immunoglobulin. J Immunol. 140:1988;1791-1795.
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Pezzutto, A.1
Rabinovitch, P.S.2
Dorken, B.3
Moldenhauer, G.4
Clark, E.A.5
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60
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0029909049
-
Hyperresponsive B cells in CD22-deficient mice
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of outstanding interest. This paper, along with [61,62], demonstrates an important biological role for CD22 as a negative regulator of mlg signaling. CD22-deficient B cells develop an anergic surface phenotype with diminished surface IgM, suggestive of low level chronic in vivo mlg stimulation, but remain hyper-responsive to mlg stimulation in vitro.
-
O'Keefe TL, Williams GT, Davies SL, Neuberger MS. Hyperresponsive B cells in CD22-deficient mice. of outstanding interest Science. 274:1996;798-801 This paper, along with [61,62], demonstrates an important biological role for CD22 as a negative regulator of mlg signaling. CD22-deficient B cells develop an anergic surface phenotype with diminished surface IgM, suggestive of low level chronic in vivo mlg stimulation, but remain hyper-responsive to mlg stimulation in vitro.
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(1996)
Science
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O'Keefe, T.L.1
Williams, G.T.2
Davies, S.L.3
Neuberger, M.S.4
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61
-
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0030467610
-
CD22 regulates thymus-independent responses and lifespan of B cells
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of outstanding interest. See annotation [60].
-
Otipoby KL, Andersson KB, Draves KE, Klaus SJ, Farr AG, Kerner JD, Perlmutter RM, Law C-L, Clark EA. CD22 regulates thymus-independent responses and lifespan of B cells. of outstanding interest Nature. 384:1996;634-637 See annotation [60].
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(1996)
Nature
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-
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Otipoby, K.L.1
Andersson, K.B.2
Draves, K.E.3
Klaus, S.J.4
Farr, A.G.5
Kerner, J.D.6
Perlmutter, R.M.7
Law, C.-L.8
Clark, E.A.9
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62
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0030499431
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CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice
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of outstanding interest. See annotation [60].
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Sato S, Miller AS, Inaoki M, Bock CB, Jansen PJ, Tang MLK, Tedder TF. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. of outstanding interest Immunity. 5:1996;551-562 See annotation [60].
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Immunity
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Sato, S.1
Miller, A.S.2
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Bock, C.B.4
Jansen, P.J.5
Tang, M.L.K.6
Tedder, T.F.7
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63
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0028127965
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Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells
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Cooke MP, Heath AW, Shokat KM, Zeng Y, Finkelman FD, Linsley PS, Howard M, Goodnow CC. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med. 179:1994;425-438.
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Cooke, M.P.1
Heath, A.W.2
Shokat, K.M.3
Zeng, Y.4
Finkelman, F.D.5
Linsley, P.S.6
Howard, M.7
Goodnow, C.C.8
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64
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0023729241
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Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
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Goodnow, C.C.1
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Adelstein, S.3
Lavoie, T.B.4
Smith-Gill, S.J.5
Brink, R.A.6
Pritchard-Briscoe, H.7
Wotherspoon, J.S.8
Loblay, R.H.9
Raphael, K.10
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65
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0026559329
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Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells
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Liu Y, Janeway CA. Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells. Proc Natl Acad Sci USA. 89:1992;3845-3949.
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Liu, Y.1
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