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Volumn 276, Issue 5311, 1997, Pages 418-420

The product of the proto-oncogene c-cbl: A negative regulator of the Syk tyrosine kinase

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; HISTAMINE; ONCOPROTEIN; PROTEIN TYROSINE KINASE; SEROTONIN;

EID: 0030889218     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.276.5311.418     Document Type: Article
Times cited : (228)

References (29)
  • 1
    • 0028027169 scopus 로고
    • J. A. Donovan, R. L. Wange, W. Y. Langdon, L. E. Samelson, J. Biol. Chem. 269, 22921 (1994); H. Meisner, B. R. Conway, D. Hartley, M. P. Czech, Mol. Cell. Biol. 15, 3571 (1995); T. Fukazawa et al., J. Biol. Chem. 270, 19141 (1995); G. O. Cory et al., J. Exp. Med. 182, 611 (1995); G. Panchamoorthy et al., J. Biol. Chem. 271, 3187 (1996); J. A. Donovan, Y. Ota, W. Y. Langdon, L. E. Samelson, ibid., p. 26369.
    • (1994) J. Biol. Chem. , vol.269 , pp. 22921
    • Donovan, J.A.1    Wange, R.L.2    Langdon, W.Y.3    Samelson, L.E.4
  • 2
    • 0029034440 scopus 로고
    • J. A. Donovan, R. L. Wange, W. Y. Langdon, L. E. Samelson, J. Biol. Chem. 269, 22921 (1994); H. Meisner, B. R. Conway, D. Hartley, M. P. Czech, Mol. Cell. Biol. 15, 3571 (1995); T. Fukazawa et al., J. Biol. Chem. 270, 19141 (1995); G. O. Cory et al., J. Exp. Med. 182, 611 (1995); G. Panchamoorthy et al., J. Biol. Chem. 271, 3187 (1996); J. A. Donovan, Y. Ota, W. Y. Langdon, L. E. Samelson, ibid., p. 26369.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3571
    • Meisner, H.1    Conway, B.R.2    Hartley, D.3    Czech, M.P.4
  • 3
    • 0029051695 scopus 로고
    • J. A. Donovan, R. L. Wange, W. Y. Langdon, L. E. Samelson, J. Biol. Chem. 269, 22921 (1994); H. Meisner, B. R. Conway, D. Hartley, M. P. Czech, Mol. Cell. Biol. 15, 3571 (1995); T. Fukazawa et al., J. Biol. Chem. 270, 19141 (1995); G. O. Cory et al., J. Exp. Med. 182, 611 (1995); G. Panchamoorthy et al., J. Biol. Chem. 271, 3187 (1996); J. A. Donovan, Y. Ota, W. Y. Langdon, L. E. Samelson, ibid., p. 26369.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19141
    • Fukazawa, T.1
  • 4
    • 0029098389 scopus 로고
    • J. A. Donovan, R. L. Wange, W. Y. Langdon, L. E. Samelson, J. Biol. Chem. 269, 22921 (1994); H. Meisner, B. R. Conway, D. Hartley, M. P. Czech, Mol. Cell. Biol. 15, 3571 (1995); T. Fukazawa et al., J. Biol. Chem. 270, 19141 (1995); G. O. Cory et al., J. Exp. Med. 182, 611 (1995); G. Panchamoorthy et al., J. Biol. Chem. 271, 3187 (1996); J. A. Donovan, Y. Ota, W. Y. Langdon, L. E. Samelson, ibid., p. 26369.
    • (1995) J. Exp. Med. , vol.182 , pp. 611
    • Cory, G.O.1
  • 5
    • 0029671073 scopus 로고    scopus 로고
    • J. A. Donovan, R. L. Wange, W. Y. Langdon, L. E. Samelson, J. Biol. Chem. 269, 22921 (1994); H. Meisner, B. R. Conway, D. Hartley, M. P. Czech, Mol. Cell. Biol. 15, 3571 (1995); T. Fukazawa et al., J. Biol. Chem. 270, 19141 (1995); G. O. Cory et al., J. Exp. Med. 182, 611 (1995); G. Panchamoorthy et al., J. Biol. Chem. 271, 3187 (1996); J. A. Donovan, Y. Ota, W. Y. Langdon, L. E. Samelson, ibid., p. 26369.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3187
    • Panchamoorthy, G.1
  • 6
    • 0029662222 scopus 로고    scopus 로고
    • J. A. Donovan, R. L. Wange, W. Y. Langdon, L. E. Samelson, J. Biol. Chem. 269, 22921 (1994); H. Meisner, B. R. Conway, D. Hartley, M. P. Czech, Mol. Cell. Biol. 15, 3571 (1995); T. Fukazawa et al., J. Biol. Chem. 270, 19141 (1995); G. O. Cory et al., J. Exp. Med. 182, 611 (1995); G. Panchamoorthy et al., J. Biol. Chem. 271, 3187 (1996); J. A. Donovan, Y. Ota, W. Y. Langdon, L. E. Samelson, ibid., p. 26369.
    • J. Biol. Chem. , pp. 26369
    • Donovan, J.A.1    Ota, Y.2    Langdon, W.Y.3    Samelson, L.E.4
  • 7
    • 0028932614 scopus 로고
    • H. Odai et al., J. Biol. Chem. 270, 10800 (1995); M. L. Galisteo, I. Dikic, A. G. Batzer, W. Y. Langdon, J. Schlessinger, ibid., p. 20242; D. D. Bowtell and W. Y. Langdon, Oncogene 11, 1561 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 10800
    • Odai, H.1
  • 9
    • 0028865896 scopus 로고
    • H. Odai et al., J. Biol. Chem. 270, 10800 (1995); M. L. Galisteo, I. Dikic, A. G. Batzer, W. Y. Langdon, J. Schlessinger, ibid., p. 20242; D. D. Bowtell and W. Y. Langdon, Oncogene 11, 1561 (1995).
    • (1995) Oncogene , vol.11 , pp. 1561
    • Bowtell, D.D.1    Langdon, W.Y.2
  • 11
    • 0027215275 scopus 로고
    • W. A. Langdon, J. W. Hartley, S. P. Klinken, S. K. Ruscetti, H. C. Morse III, Proc. Natl. Acad. Sci. U.S.A. 86, 1168 (1989); T. J. Blake, K. G. Heath, W. Y. Langdon, EMBO J. 12, 2017 (1993); C. E. Andoniou, C. B. Thien, W. Y. Langdon, ibid. 13, 4515 (1994).
    • (1993) EMBO J. , vol.12 , pp. 2017
    • Blake, T.J.1    Heath, K.G.2    Langdon, W.Y.3
  • 12
    • 12044256844 scopus 로고
    • W. A. Langdon, J. W. Hartley, S. P. Klinken, S. K. Ruscetti, H. C. Morse III, Proc. Natl. Acad. Sci. U.S.A. 86, 1168 (1989); T. J. Blake, K. G. Heath, W. Y. Langdon, EMBO J. 12, 2017 (1993); C. E. Andoniou, C. B. Thien, W. Y. Langdon, ibid. 13, 4515 (1994).
    • (1994) EMBO J. , vol.13 , pp. 4515
    • Andoniou, C.E.1    Thien, C.B.2    Langdon, W.Y.3
  • 14
    • 0029852837 scopus 로고    scopus 로고
    • Y. Ota et al., J. Exp. Med. 184, 1713 (1996).
    • (1996) J. Exp. Med. , vol.184 , pp. 1713
    • Ota, Y.1
  • 16
    • 1842265805 scopus 로고    scopus 로고
    • note
    • Because there was no significant change in the level of Syk and Cbl interaction following activation and the interaction of Syk with Cbl did not require the highly tyrosine phosphorylated COOH-terminal region of Cbl, we concluded that the binding was independent of phosphotyrosine (5).
  • 18
    • 1842381431 scopus 로고    scopus 로고
    • note
    • Methods used for vaccinia infection, cell culture, and FcεRl stimulation were reported (5). Briefly, RBL-2H3 cells were infected with five plaque forming units (PFU) per cell of recombinant porcine Syk vaccinia and the indicated dose of recombinant wild-type Cbl, 70Z Cbl, 1-480 Cbl, 1-655 Cbl, or vaccinia vector in Eagle's minimum essential medium (EMEM) with 5% fetal bovine serum for 2 hours, washed once with EMEM, and incubated for an additional 6 to 8 hours in EMEM with 5% fetal bovine serum and monoclonal anti-lgE to DNP (1 ng/ml). Infected cells were harvested with phosphate-buffered saline containing 1 mM EDTA, washed with EMEM and resuspended in EMEM. Cells were stimulated with DNP-HSA (200 ng/ml) for 2 min or the indicated time.
  • 19
    • 1842284378 scopus 로고    scopus 로고
    • note
    • 32P]ATP and 1 μg of cfb3 as an exogenous substrate. The reaction was terminated by addition of 4x reducing sample buffer. The samples were separated by SDS-polyacrylamide gel electrophoresis (PAGE), and the gel was subjected to autoradiography.
  • 20
    • 0026611481 scopus 로고
    • J. E. Hutchcroft, R. L. Geahlen, G. G. Deanin, J. M. Oliver, Proc. Natl. Acad. Sci. U.S.A. 89, 9107 (1992); M. L. Harrison, C. C. Isaacson, D. L. Burg, R. L. Geahlen, P. S. Low, J. Biol. Chem. 269, 955 (1994); R. B. Rowley, A. L. Burkhardt, H.-G. Chao, G. R. Matsueda, J. B. Bolen, ibid. 270, 11590 (1995).
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 9107
    • Hutchcroft, J.E.1    Geahlen, R.L.2    Deanin, G.G.3    Oliver, J.M.4
  • 21
    • 0028047337 scopus 로고
    • J. E. Hutchcroft, R. L. Geahlen, G. G. Deanin, J. M. Oliver, Proc. Natl. Acad. Sci. U.S.A. 89, 9107 (1992); M. L. Harrison, C. C. Isaacson, D. L. Burg, R. L. Geahlen, P. S. Low, J. Biol. Chem. 269, 955 (1994); R. B. Rowley, A. L. Burkhardt, H.-G. Chao, G. R. Matsueda, J. B. Bolen, ibid. 270, 11590 (1995).
    • (1994) J. Biol. Chem. , vol.269 , pp. 955
    • Harrison, M.L.1    Isaacson, C.C.2    Burg, D.L.3    Geahlen, R.L.4    Low, P.S.5
  • 22
    • 0029068171 scopus 로고
    • J. E. Hutchcroft, R. L. Geahlen, G. G. Deanin, J. M. Oliver, Proc. Natl. Acad. Sci. U.S.A. 89, 9107 (1992); M. L. Harrison, C. C. Isaacson, D. L. Burg, R. L. Geahlen, P. S. Low, J. Biol. Chem. 269, 955 (1994); R. B. Rowley, A. L. Burkhardt, H.-G. Chao, G. R. Matsueda, J. B. Bolen, ibid. 270, 11590 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 11590
    • Rowley, R.B.1    Burkhardt, A.L.2    Chao, H.-G.3    Matsueda, G.R.4    Bolen, J.B.5
  • 26
    • 1842315783 scopus 로고    scopus 로고
    • note
    • 3H]serotonin activity was measured in the supernatant by liquid scintillation. Determinations were done in triplicate and results were expressed as the percentage of specific release divided by total serotonin release.
  • 29
    • 1842393116 scopus 로고    scopus 로고
    • note
    • We thank J.-P. Kinet, A. M. Scharenberg, and L. O. Beitz for reagents and review of the manuscript; W. Leonard, J. Pierce, and R. L. Wange for review of the manuscript; and W. Y. Langdon for reagents.


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