메뉴 건너뛰기




Volumn 11, Issue 7, 1997, Pages 824-834

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin- sensitive intramolecular interaction

Author keywords

Calcineurin; cyclosporin nuclear localization sequence; protein phosphorylation; tacrolimus

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; T LYMPHOCYTE RECEPTOR; TACROLIMUS; TRANSCRIPTION FACTOR;

EID: 0030899131     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.7.824     Document Type: Article
Times cited : (347)

References (46)
  • 1
    • 0030271387 scopus 로고    scopus 로고
    • NF-κB: Ten years after
    • Baeuerle, P.A. and D. Baltimore. 1996. NF-κB: Ten years after. Cell 87: 13-20.
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 4
    • 0029097801 scopus 로고
    • Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin
    • Chang, H.Y., K. Takei, A.M. Sydor, T. Born, F. Rusnak, and D.G. Jay. 1995. Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. Nature 376: 686-690.
    • (1995) Nature , vol.376 , pp. 686-690
    • Chang, H.Y.1    Takei, K.2    Sydor, A.M.3    Born, T.4    Rusnak, F.5    Jay, D.G.6
  • 6
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T cell activation
    • Clipstone, N.A. and G.R. Crabtree. 1992. Identification of calcineurin as a key signalling enzyme in T cell activation. Nature 357: 695-697.
    • (1992) Nature , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 7
    • 0028930789 scopus 로고
    • Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c
    • Cockerill, P.N., A.G. Bert, F. Jenkins, G.R. Ryan, M.F. Shannon, and M.A. Vadas. 1995. Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c. Mol. Cell. Biol. 15: 2071-2079.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2071-2079
    • Cockerill, P.N.1    Bert, A.G.2    Jenkins, F.3    Ryan, G.R.4    Shannon, M.F.5    Vadas, M.A.6
  • 8
    • 0024397415 scopus 로고
    • The structure and regulation of protein phosphatases
    • Cohen, P. 1989. The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58: 453-508.
    • (1989) Annu. Rev. Biochem. , vol.58 , pp. 453-508
    • Cohen, P.1
  • 11
    • 0024833664 scopus 로고
    • Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation
    • Emmel, E.A., C.L. Verweij, D.B. Durand, K.M. Higgins, E. Lacy, and G.R. Crabtree. 1989. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 246: 1617-1620.
    • (1989) Science , vol.246 , pp. 1617-1620
    • Emmel, E.A.1    Verweij, C.L.2    Durand, D.B.3    Higgins, K.M.4    Lacy, E.5    Crabtree, G.R.6
  • 12
    • 0028670773 scopus 로고
    • A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. a role for glycogen synthase kinase-3 in the control of gene expression
    • Fiol, C.J., J.S. Williams, C.H. Chou, Q.M. Wang, P.J. Roach, and O.M. Andrisani. 1994. A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J. Biol. Chem. 269: 32187-32197.
    • (1994) J. Biol. Chem. , vol.269 , pp. 32187-32197
    • Fiol, C.J.1    Williams, J.S.2    Chou, C.H.3    Wang, Q.M.4    Roach, P.J.5    Andrisani, O.M.6
  • 13
    • 0025871394 scopus 로고
    • Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A
    • Flanagan, W.M., B. Corthesy, R.J. Bram, and G.R. Crabtree. 1991. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 352: 803-807.
    • (1991) Nature , vol.352 , pp. 803-807
    • Flanagan, W.M.1    Corthesy, B.2    Bram, R.J.3    Crabtree, G.R.4
  • 14
    • 0029012409 scopus 로고
    • Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells
    • Fruman, D.A., S.Y. Pai, S.J. Burakoff, and B.E. Bierer. 1995. Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells. Mol. Cell. Biol. 15: 3857-3863.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3857-3863
    • Fruman, D.A.1    Pai, S.Y.2    Burakoff, S.J.3    Bierer, B.E.4
  • 15
    • 0027326457 scopus 로고
    • Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor α gene promoter
    • Goldfeld, A.E., P.G. McCaffrey, J.L. Strominger, and A. Rao. 1993. Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor α gene promoter. J. Exp. Med. 178: 1365-1379.
    • (1993) J. Exp. Med. , vol.178 , pp. 1365-1379
    • Goldfeld, A.E.1    McCaffrey, P.G.2    Strominger, J.L.3    Rao, A.4
  • 16
    • 0024520745 scopus 로고
    • Site-directed mutagensis by overlap extension using the polymerase chain reaction
    • Ho, S.N., H.D. Hunt, R.M. Horton, J.K. Pullen, and L.R. Pease. 1989. Site-directed mutagensis by overlap extension using the polymerase chain reaction. Gene 77: 51-59.
    • (1989) Gene , vol.77 , pp. 51-59
    • Ho, S.N.1    Hunt, H.D.2    Horton, R.M.3    Pullen, J.K.4    Pease, L.R.5
  • 17
    • 0029125831 scopus 로고
    • NFATc3, a lymphoid-specinc NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity
    • Ho, S.N., D.J. Thomas, L.A. Timmerman, X. Li, U. Francke, and G.R. Crabtree. 1995. NFATc3, a lymphoid-specinc NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J. Biol Chem. 270: 19898-19900.
    • (1995) J. Biol Chem. , vol.270 , pp. 19898-19900
    • Ho, S.N.1    Thomas, D.J.2    Timmerman, L.A.3    Li, X.4    Francke, U.5    Crabtree, G.R.6
  • 19
    • 0029053852 scopus 로고
    • Isolation of two new members of thr NF-AT gene family and functional characterization of the NF-AT proteins
    • Hoey, T., Y.-L. Sun, K. Williamson, and X. Xu. 1995. Isolation of two new members of thr NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2: 461-472.
    • (1995) Immunity , vol.2 , pp. 461-472
    • Hoey, T.1    Sun, Y.-L.2    Williamson, K.3    Xu, X.4
  • 21
    • 0027491776 scopus 로고
    • The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun
    • Jain, J., P.G. McCaffrey, Z. Miner, T.K. Kerppola, J.N. Lambert, G.L. Verdine, T. Curran, and A. Rao. 1993. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365: 352-355.
    • (1993) Nature , vol.365 , pp. 352-355
    • Jain, J.1    McCaffrey, P.G.2    Miner, Z.3    Kerppola, T.K.4    Lambert, J.N.5    Verdine, G.L.6    Curran, T.7    Rao, A.8
  • 22
    • 0021716406 scopus 로고
    • A short amino acid sequence able to specify nuclear location
    • Kalderon, D., B.L. Roberts, W.D. Richardson, and A.E. Smith. 1984. A short amino acid sequence able to specify nuclear location. Cell 39: 499-509.
    • (1984) Cell , vol.39 , pp. 499-509
    • Kalderon, D.1    Roberts, B.L.2    Richardson, W.D.3    Smith, A.E.4
  • 23
    • 0001018554 scopus 로고
    • Calcineurin: A calcium- and calmodulin-binding protein of the nervous system
    • Klee, C.B., T.H. Crouch, and M.H. Krinks. 1979. Calcineurin: A calcium- and calmodulin-binding protein of the nervous system. Proc. Natl. Acad. Sci. 76: 6270-6273.
    • (1979) Proc. Natl. Acad. Sci. , vol.76 , pp. 6270-6273
    • Klee, C.B.1    Crouch, T.H.2    Krinks, M.H.3
  • 24
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • Liu, J., J.D. Farmer, Jr., W.S. Lane, J. Friedman, I. Weissman, and S.L. Schreiber. 1991. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66: 807-815.
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer Jr., J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 25
    • 15844416253 scopus 로고    scopus 로고
    • Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity
    • Loh, C., K.T. Shaw, J. Carew, J.P. Viola, C. Luo, B.A. Perrino, and A. Rao. 1996. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J. Biol Chem. 271: 10884-10891.
    • (1996) J. Biol Chem. , vol.271 , pp. 10884-10891
    • Loh, C.1    Shaw, K.T.2    Carew, J.3    Viola, J.P.4    Luo, C.5    Perrino, B.A.6    Rao, A.7
  • 28
    • 0028930843 scopus 로고
    • NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus
    • Masuda, E.S., Y. Naito, H. Tokumitsu, D. Campbell, F. Saito, C. Hannum, K. Arai, and N. Arai. 1995. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. Mol. Cell. Biol. 15: 2697-2706.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2697-2706
    • Masuda, E.S.1    Naito, Y.2    Tokumitsu, H.3    Campbell, D.4    Saito, F.5    Hannum, C.6    Arai, K.7    Arai, N.8
  • 29
    • 0029070887 scopus 로고
    • Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • Minden, A., A. Lin, F.X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81: 1147-1157.
    • (1995) Cell , vol.81 , pp. 1147-1157
    • Minden, A.1    Lin, A.2    Claret, F.X.3    Abo, A.4    Karin, M.5
  • 31
    • 0026632557 scopus 로고
    • FK506 and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
    • O'Keefe, S.J., J. Tamura, R.L. Kincaid, M.J. Tocci, and E.A. O'Neill. 1992. FK506 and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357: 692-695.
    • (1992) Nature , vol.357 , pp. 692-695
    • O'Keefe, S.J.1    Tamura, J.2    Kincaid, R.L.3    Tocci, M.J.4    O'Neill, E.A.5
  • 32
    • 0026742527 scopus 로고
    • The precursor of NF-κ B p50 has I kappa B-like functions
    • Rice, N.R., M.L. MacKichan, and A. Israel. 1992. The precursor of NF-κ B p50 has I kappa B-like functions. Cell 71: 243-253.
    • (1992) Cell , vol.71 , pp. 243-253
    • Rice, N.R.1    MacKichan, M.L.2    Israel, A.3
  • 33
    • 0022546215 scopus 로고
    • Nuclear location signals in polyoma virus large-T
    • Richardson, W.D., B.L. Roberts, and A.E. Smith. 1986. Nuclear location signals in polyoma virus large-T. Cell 44: 77-85.
    • (1986) Cell , vol.44 , pp. 77-85
    • Richardson, W.D.1    Roberts, B.L.2    Smith, A.E.3
  • 34
    • 0023669094 scopus 로고
    • The effect of protein context on nuclear location signal function
    • Roberts, B.L., W.D. Richardson, and A.E. Smith. 1987. The effect of protein context on nuclear location signal function. Cell 50: 465-475.
    • (1987) Cell , vol.50 , pp. 465-475
    • Roberts, B.L.1    Richardson, W.D.2    Smith, A.E.3
  • 35
    • 0029030775 scopus 로고
    • Coordinate and cooperative roles for NF-AT and AP-I in the regulation of the murine IL-4 gene
    • Rooney, J.W., T. Hoey, and L.H. Glimcher. 1995. Coordinate and cooperative roles for NF-AT and AP-I in the regulation of the murine IL-4 gene. Immunity 2: 473-483.
    • (1995) Immunity , vol.2 , pp. 473-483
    • Rooney, J.W.1    Hoey, T.2    Glimcher, L.H.3
  • 36
    • 0028990801 scopus 로고
    • Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody
    • Ruff, V.A. and K.L. Leach. 1995. Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody. J. Biol. Chem. 270: 22602-22607.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22602-22607
    • Ruff, V.A.1    Leach, K.L.2
  • 37
  • 38
    • 0028885878 scopus 로고
    • Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells
    • Shaw, K.T.-Y., A.M. Ho, A. Raghavan, J. Kim, J. Jain, J. Park, S. Sharma, A. Rao, and P.G. Hogan. 1995. Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc. Natl. Acad. Sci. 92: 11205-11209.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 11205-11209
    • Shaw, K.T.-Y.1    Ho, A.M.2    Raghavan, A.3    Kim, J.4    Jain, J.5    Park, J.6    Sharma, S.7    Rao, A.8    Hogan, P.G.9
  • 39
    • 0029761681 scopus 로고    scopus 로고
    • Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
    • Shibasaki, F., E.R. Price, D. Milan, and F. McKeon. 1996. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 382: 370-373.
    • (1996) Nature , vol.382 , pp. 370-373
    • Shibasaki, F.1    Price, E.R.2    Milan, D.3    McKeon, F.4
  • 40
    • 0023806075 scopus 로고
    • Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase
    • Smith, D.B. and K.S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase. Gene 67: 31-40.
    • (1988) Gene , vol.67 , pp. 31-40
    • Smith, D.B.1    Johnson, K.S.2
  • 41
    • 0029008280 scopus 로고
    • Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42
    • Stowers, L., D. Yelon, L.J. Berg, and J. Chant. 1995. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc. Natl. Acad. Sci. 92: 5027-5031.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 5027-5031
    • Stowers, L.1    Yelon, D.2    Berg, L.J.3    Chant, J.4
  • 43
    • 0028803402 scopus 로고
    • Journey to the surface of the cell: Fos regulation and the SRE
    • Treisman, R. 1995. Journey to the surface of the cell: Fos regulation and the SRE. EMBO J. 14: 4905-4913.
    • (1995) EMBO J. , vol.14 , pp. 4905-4913
    • Treisman, R.1
  • 45
    • 0027331410 scopus 로고
    • p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells
    • Woodrow, M., N.A. Clipstone, and D. Cantrell. 1993. p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 178: 1517-1522.
    • (1993) J. Exp. Med. , vol.178 , pp. 1517-1522
    • Woodrow, M.1    Clipstone, N.A.2    Cantrell, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.