-
1
-
-
0035522894
-
Two genetic hits (more or less) to cancer
-
Knudson, A.G. Two genetic hits (more or less) to cancer. Nat. Rev., Cancer 2001, 1, 157-162.
-
(2001)
Nat. Rev., Cancer
, vol.1
, pp. 157-162
-
-
Knudson, A.G.1
-
2
-
-
0034511179
-
Chasing the cancer demon
-
Knudson, A.G. Chasing the cancer demon. Annu. Rev. Genet. 2000, 34, 1-19.
-
(2000)
Annu. Rev. Genet.
, vol.34
, pp. 1-19
-
-
Knudson, A.G.1
-
3
-
-
0003152306
-
Sclérose tubéreuse des circonvolutions céré brales: Idiotie et épilepsie hémiplégique
-
Bourneville, D.M. Sclérose tubéreuse des circonvolutions cérébrales: idiotie et épilepsie hémiplé gique. Arch. Neurol. (Paris) 1880, 1, 81-91.
-
(1880)
Arch. Neurol. (Paris)
, vol.1
, pp. 81-91
-
-
Bourneville, D.M.1
-
4
-
-
0000801327
-
Definition and criteria for diagnosis
-
Gomez, M.R., Sampson, J.R., Whittemore, V.H., Eds.; Oxford University Press: New York
-
Gomez, M.R. Definition and criteria for diagnosis. In Tuberous Sclerosis Complex; Gomez, M.R., Sampson, J.R., Whittemore, V.H., Eds.; Oxford University Press: New York, 1999; 10-23.
-
(1999)
Tuberous Sclerosis Complex
, pp. 10-23
-
-
Gomez, M.R.1
-
5
-
-
0025734821
-
Tuberous sclerosis complex in Olmsted County, Minnesota, 1950-1989
-
Shepherd, C.W.; Beard, C.M.; Gomez, M.R.; Kurland, L.T.; Whisnant, J.P. Tuberous sclerosis complex in Olmsted County, Minnesota, 1950-1989. Arch. Neurol. 1991, 48, 400-401.
-
(1991)
Arch. Neurol.
, vol.48
, pp. 400-401
-
-
Shepherd, C.W.1
Beard, C.M.2
Gomez, M.R.3
Kurland, L.T.4
Whisnant, J.P.5
-
6
-
-
0030064630
-
Morbidity associated with tuberous sclerosis: A population study
-
Webb, D.W.; Fryer, A.E.; Osborne, J.P. Morbidity associated with tuberous sclerosis: a population study. Dev. Med. Child Neurol. 1996, 38, 146-155.
-
(1996)
Dev. Med. Child Neurol.
, vol.38
, pp. 146-155
-
-
Webb, D.W.1
Fryer, A.E.2
Osborne, J.P.3
-
7
-
-
0030447484
-
Embryonic neuronal markers in tuberous sclerosis: Single-cell molecular pathology
-
Crino, P.B.; Trojanowski, J.Q.; Dichter, M.A.; Eberwine, J. Embryonic neuronal markers in tuberous sclerosis: single-cell molecular pathology. Proc. Natl. Acad. Sci. U. S. A. 1996, 93, 14152-14157.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 14152-14157
-
-
Crino, P.B.1
Trojanowski, J.Q.2
Dichter, M.A.3
Eberwine, J.4
-
8
-
-
0029098454
-
Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: An immunohistochemical, ultrastructural, and immunoelectron and microscopic study
-
Hirose, T.; Scheithauer, B.W.; Lopes, M.B.; Gerber, H.A.; Altermatt, H.J.; Hukee, M.J.; VandenBerg, S.R.; Charlesworth, J.C. Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: an immunohistochemical, ultrastructural, and immunoelectron and microscopic study. Acta. Neuropathol. (Berl) 1995, 90, 387-399.
-
(1995)
Acta. Neuropathol. (Berl)
, vol.90
, pp. 387-399
-
-
Hirose, T.1
Scheithauer, B.W.2
Lopes, M.B.3
Gerber, H.A.4
Altermatt, H.J.5
Hukee, M.J.6
VandenBerg, S.R.7
Charlesworth, J.C.8
-
9
-
-
0029834567
-
Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features
-
Bjornsson, J.; Short, M.P.; Kwiatkowski, D.J.; Henske, E.P. Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features. Am. J. Pathol. 1996, 149, 1201-1208.
-
(1996)
Am. J. Pathol.
, vol.149
, pp. 1201-1208
-
-
Bjornsson, J.1
Short, M.P.2
Kwiatkowski, D.J.3
Henske, E.P.4
-
10
-
-
0035888683
-
Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis
-
Yu, J.; Astrinidis, A.; Henske, E.P. Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis. Am. J. Respir. Crit. Care Med. 2001, 164, 1537-1540.
-
(2001)
Am. J. Respir. Crit. Care Med.
, vol.164
, pp. 1537-1540
-
-
Yu, J.1
Astrinidis, A.2
Henske, E.P.3
-
11
-
-
0030879277
-
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
-
van Slegtenhorst, M.; de Hoogt, R.; Hermans, C.; Nellist, M.; Janssen, B.; Verhoef, S.; Lindhout, D.; van den Ouweland, A.; Halley, D.; Young, J.; et al. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 1997, 277, 805-808.
-
(1997)
Science
, vol.277
, pp. 805-808
-
-
Van Slegtenhorst, M.1
De Hoogt, R.2
Hermans, C.3
Nellist, M.4
Janssen, B.5
Verhoef, S.6
Lindhout, D.7
Van Den Ouweland, A.8
Halley, D.9
Young, J.10
-
12
-
-
0027770784
-
Identification and characterization of the tuberous sclerosis gene on chromosome 16
-
The European Chromosome 16 Tuberous Sclerosis Consortium
-
Consortium. Identification and characterization of the tuberous sclerosis gene on chromosome 16. The European Chromosome 16 Tuberous Sclerosis Consortium. Cell 1993, 75, 1305-1315.
-
(1993)
Cell
, vol.75
, pp. 1305-1315
-
-
-
13
-
-
0028051871
-
Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease-a contiguous gene syndrome
-
Brook-Carter, P.T.; Peral, B.; Ward, C.J.; Thompson, P.; Hughes, J.; Maheshwar, M.M.; Nellist, M.; Gamble, V.; Harris, P.C.; Sampson, J.R. Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease-a contiguous gene syndrome. Nat. Genet. 1994, 8, 328-332.
-
(1994)
Nat. Genet.
, vol.8
, pp. 328-332
-
-
Brook-Carter, P.T.1
Peral, B.2
Ward, C.J.3
Thompson, P.4
Hughes, J.5
Maheshwar, M.M.6
Nellist, M.7
Gamble, V.8
Harris, P.C.9
Sampson, J.R.10
-
14
-
-
0031296846
-
The TSC2/PKD1 contiguous gene syndrome
-
Harris, P.C. The TSC2/PKD1 contiguous gene syndrome. Contrib. Nephrol. 1997, 122, 76-82.
-
(1997)
Contrib. Nephrol.
, vol.122
, pp. 76-82
-
-
Harris, P.C.1
-
15
-
-
0035167932
-
Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
-
Dabora, S.L.; Jozwiak, S.; Franz, D.N.; Roberts, P.S.; Nieto, A.; Chung, J.; Choy, Y.S.; Reeve, M.P.; Thiele, E.; Egelhoff, J.C.; et al. Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am. J. Hum. Genet. 2001, 68, 64-80.
-
(2001)
Am. J. Hum. Genet.
, vol.68
, pp. 64-80
-
-
Dabora, S.L.1
Jozwiak, S.2
Franz, D.N.3
Roberts, P.S.4
Nieto, A.5
Chung, J.6
Choy, Y.S.7
Reeve, M.P.8
Thiele, E.9
Egelhoff, J.C.10
-
16
-
-
0033365408
-
Comprehensive mutation analysis of TSC1 and TSC2 and phenotypic correlations in 150 families with tuberous sclerosis
-
Jones, A.C.; Shyamsundar, M.M.; Thomas, M.W.; Maynard, J.; Idziaszczyk, S.; Tomkins, S.; Sampson, J.R.; Cheadle, J.P. Comprehensive mutation analysis of TSC1 and TSC2 and phenotypic correlations in 150 families with tuberous sclerosis. Am. J. Hum. Genet. 1999, 64, 1305-1315.
-
(1999)
Am. J. Hum. Genet.
, vol.64
, pp. 1305-1315
-
-
Jones, A.C.1
Shyamsundar, M.M.2
Thomas, M.W.3
Maynard, J.4
Idziaszczyk, S.5
Tomkins, S.6
Sampson, J.R.7
Cheadle, J.P.8
-
17
-
-
0033361939
-
High rate of mosaicism in tuberous sclerosis complex
-
Verhoef, S.; Bakker, L.; Tempelaars, A.M.; Hesseling-Janssen, A.L.; Mazurczak, T.; Jozwiak, S.; Fois, A.; Bartalini, G.; Zonnenberg, B.A.; van Essen, A.J.; et al. High rate of mosaicism in tuberous sclerosis complex. Am. J. Hum. Genet. 1999, 64, 1632-1637.
-
(1999)
Am. J. Hum. Genet.
, vol.64
, pp. 1632-1637
-
-
Verhoef, S.1
Bakker, L.2
Tempelaars, A.M.3
Hesseling-Janssen, A.L.4
Mazurczak, T.5
Jozwiak, S.6
Fois, A.7
Bartalini, G.8
Zonnenberg, B.A.9
Van Essen, A.J.10
-
18
-
-
0030772273
-
Female germline mosaicism in tuberous sclerosis confirmed by molecular genetic analysis
-
Yates, J.R.; van Bakel, I.; Sepp, T.; Payne, S.J.; Webb, D.W.; Nevin, N.C.; Green, A.J. Female germline mosaicism in tuberous sclerosis confirmed by molecular genetic analysis. Hum. Mol. Genet. 1997, 6, 2265-2269.
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 2265-2269
-
-
Yates, J.R.1
Van Bakel, I.2
Sepp, T.3
Payne, S.J.4
Webb, D.W.5
Nevin, N.C.6
Green, A.J.7
-
19
-
-
0028029278
-
The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor
-
Green, A.J.; Johnson, P.H.; Yates, J.R. The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor. Hum. Mol. Genet. 1994, 3, 1833-1834.
-
(1994)
Hum. Mol. Genet.
, vol.3
, pp. 1833-1834
-
-
Green, A.J.1
Johnson, P.H.2
Yates, J.R.3
-
20
-
-
0030725540
-
Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors
-
Henske, E.P.; Wessner, L.L.; Golden, J.; Scheithauer, B.W.; Vortmeyer, A.O.; Zhuang, Z.; Klein-Szanto, A.J.; Kwiatkowski, D.J.; Yeung, R.S. Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. Am. J. Pathol. 1997, 151, 1639-1647.
-
(1997)
Am. J. Pathol.
, vol.151
, pp. 1639-1647
-
-
Henske, E.P.1
Wessner, L.L.2
Golden, J.3
Scheithauer, B.W.4
Vortmeyer, A.O.5
Zhuang, Z.6
Klein-Szanto, A.J.7
Kwiatkowski, D.J.8
Yeung, R.S.9
-
21
-
-
0035009866
-
Tuberous sclerosis gene products in proliferation control
-
Hengstschlager, M.; Rodman, D.M.; Miloloza, A.; Hengstschlager-Ottnad, E.; Rosner, M.; Kubista, M. Tuberous sclerosis gene products in proliferation control. Mutat. Res. 2001, 488, 233-239.
-
(2001)
Mutat. Res.
, vol.488
, pp. 233-239
-
-
Hengstschlager, M.1
Rodman, D.M.2
Miloloza, A.3
Hengstschlager-Ottnad, E.4
Rosner, M.5
Kubista, M.6
-
22
-
-
0842325813
-
Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions
-
Han, S.; Santos, T.M.; Puga, A.; Roy, J.; Thiele, E.A.; McCollin, M.; Stemmer-Rachamimov, A.; Ramesh, V. Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions. Cancer Res. 2004, 64, 812-816.
-
(2004)
Cancer Res.
, vol.64
, pp. 812-816
-
-
Han, S.1
Santos, T.M.2
Puga, A.3
Roy, J.4
Thiele, E.A.5
McCollin, M.6
Stemmer-Rachamimov, A.7
Ramesh, V.8
-
23
-
-
0032213545
-
Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
-
Plank, T.L.; Yeung, R.S.; Henske, E.P. Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res. 1998, 58, 4766-4770.
-
(1998)
Cancer Res.
, vol.58
, pp. 4766-4770
-
-
Plank, T.L.1
Yeung, R.S.2
Henske, E.P.3
-
24
-
-
7144255533
-
Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
-
van Slegtenhorst, M.; Nellist, M.; Nagelkerken, B.; Cheadle, J.; Snell, R.; van den Ouweland, A.; Reuser, A.; Sampson, J.; Halley, D.; van der Sluijs, P. Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum. Mol. Genet. 1998, 7, 1053-1057.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1053-1057
-
-
Van Slegtenhorst, M.1
Nellist, M.2
Nagelkerken, B.3
Cheadle, J.4
Snell, R.5
Van Den Ouweland, A.6
Reuser, A.7
Sampson, J.8
Halley, D.9
Van Der Sluijs, P.10
-
25
-
-
0035805162
-
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
-
Potter, C.J.; Huang, H.; Xu, T. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 2001, 105, 357-368.
-
(2001)
Cell
, vol.105
, pp. 357-368
-
-
Potter, C.J.1
Huang, H.2
Xu, T.3
-
26
-
-
0035667191
-
Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin
-
Hodges, A.K.; Li, S.; Maynard, J.; Parry, L.; Braverman, R.; Cheadle, J.P.; DeClue, J.E.; Sampson, J.R. Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin. Hum. Mol. Genet. 2001, 10, 2899-2905.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 2899-2905
-
-
Hodges, A.K.1
Li, S.2
Maynard, J.3
Parry, L.4
Braverman, R.5
Cheadle, J.P.6
DeClue, J.E.7
Sampson, J.R.8
-
27
-
-
0033544919
-
Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin
-
Nellist, M.; van Slegtenhorst, M.A.; Goedbloed, M.; van den Ouweland, A.M.; Halley, D.J.; van der Sluijs, P. Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin. J. Biol. Chem. 1999, 274, 35647-35652.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 35647-35652
-
-
Nellist, M.1
Van Slegtenhorst, M.A.2
Goedbloed, M.3
Van Den Ouweland, A.M.4
Halley, D.J.5
Van Der Sluijs, P.6
-
28
-
-
0037102523
-
Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin
-
Yamamoto, Y.; Jones, K.A.; Mak, B.C.; Muehlenbachs, A.; Yeung, R.S. Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin. Arch. Biochem. Biophys. 2002, 404, 210-217.
-
(2002)
Arch. Biochem. Biophys.
, vol.404
, pp. 210-217
-
-
Yamamoto, Y.1
Jones, K.A.2
Mak, B.C.3
Muehlenbachs, A.4
Yeung, R.S.5
-
29
-
-
0035877758
-
Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis
-
Aicher, L.D.; Campbell, J.S.; Yeung, R.S. Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis. J. Biol. Chem. 2001, 276, 21017-21021.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21017-21021
-
-
Aicher, L.D.1
Campbell, J.S.2
Yeung, R.S.3
-
30
-
-
0035660247
-
TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex
-
Nellist, M.; Verhaaf, B.; Goedbloed, M.A.; Reuser, A.J.; van den Ouwel, A.M.; Halley, D.J. TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex. Hum. Mol. Genet. 2001, 10, 2889-2898.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 2889-2898
-
-
Nellist, M.1
Verhaaf, B.2
Goedbloed, M.A.3
Reuser, A.J.4
Van Den Ouwel, A.M.5
Halley, D.J.6
-
31
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki, K.; Li, Y.; Zhu, T.; Wu, J.; Guan, K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 2002, 4, 648-657.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
32
-
-
0030090948
-
Expression and differential splicing of the mouse TSC2 homolog
-
Olsson, P.G.; Schofield, J.N.; Edwards, Y.H.; Frischauf, A.M. Expression and differential splicing of the mouse TSC2 homolog. Mamm. Genome 1996, 7, 212-215.
-
(1996)
Mamm. Genome
, vol.7
, pp. 212-215
-
-
Olsson, P.G.1
Schofield, J.N.2
Edwards, Y.H.3
Frischauf, A.M.4
-
33
-
-
0034034954
-
Similarities and differences in the subcellular localization of hamartin and tuberin in the kidney
-
Murthy, V.; Haddad, L.A.; Smith, N.; Pinney, D.; Tyszkowski, R.; Brown, D.; Ramesh, V. Similarities and differences in the subcellular localization of hamartin and tuberin in the kidney. Am. J. Physiol., Renal Physiol. 2000, 278, F737-F746.
-
(2000)
Am. J. Physiol., Renal Physiol.
, vol.278
-
-
Murthy, V.1
Haddad, L.A.2
Smith, N.3
Pinney, D.4
Tyszkowski, R.5
Brown, D.6
Ramesh, V.7
-
34
-
-
0031033220
-
Expression of the TSC2 product tuberin and its target Rap1 in normal human tissues
-
Wienecke, R.; Maize, J.C., Jr.; Reed, J.A.; de Gunzburg, J.; Yeung, R.S.; DeClue, J.E. Expression of the TSC2 product tuberin and its target Rap1 in normal human tissues. Am. J. Pathol. 1997, 150, 43-50.
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 43-50
-
-
Wienecke, R.1
Maize Jr., J.C.2
Reed, J.A.3
De Gunzburg, J.4
Yeung, R.S.5
DeClue, J.E.6
-
35
-
-
1842861671
-
Tuberin is a component of lipid rafts and mediates caveolin-1 localization: Role of TSC2 in post-Golgi transport
-
Jones, K.A.; Jiang, X.; Yamamoto, Y.; Yeung, R.S. Tuberin is a component of lipid rafts and mediates caveolin-1 localization: role of TSC2 in post-Golgi transport. Exp. Cell Res. 2004, 295, 512-524.
-
(2004)
Exp. Cell Res.
, vol.295
, pp. 512-524
-
-
Jones, K.A.1
Jiang, X.2
Yamamoto, Y.3
Yeung, R.S.4
-
36
-
-
0035193108
-
The tuberous sclerosis 2 gene product can localize to nuclei in a phosphorylation-dependent manner
-
Lou, D.; Griffith, N.; Noonan, D.J. The tuberous sclerosis 2 gene product can localize to nuclei in a phosphorylation-dependent manner. Mol. Cell. Biol. Res. Commun. 2001, 4, 374-380.
-
(2001)
Mol. Cell. Biol. Res. Commun.
, vol.4
, pp. 374-380
-
-
Lou, D.1
Griffith, N.2
Noonan, D.J.3
-
37
-
-
0034936816
-
Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B
-
Catania, M.G.; Mischel, P.S.; Vinters, H.V. Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B. J. Neuropathol. Exp. Neurol. 2001, 60, 711-723.
-
(2001)
J. Neuropathol. Exp. Neurol.
, vol.60
, pp. 711-723
-
-
Catania, M.G.1
Mischel, P.S.2
Vinters, H.V.3
-
38
-
-
0034982971
-
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
-
Gao, X.; Pan, D. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev. 2001, 15, 1383-1392.
-
(2001)
Genes Dev.
, vol.15
, pp. 1383-1392
-
-
Gao, X.1
Pan, D.2
-
40
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter, C.J.; Pedraza, L.G.; Xu, T. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 2002, 4, 658-665.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
41
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
-
Gao, X.; Zhang, Y.; Arrazola, P.; Hino, O.; Kobayashi, T.; Yeung, R.S.; Ru, B.; Pan, D. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat. Cell Biol. 2002, 4, 699-704.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
Ru, B.7
Pan, D.8
-
42
-
-
0037163033
-
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleio-myomatosis (LAM)
-
Goncharova, E.A.; Goncharov, D.A.; Eszterhas, A.; Hunter, D.S.; Glassberg, M.K.; Yeung, R.S.; Walker, C.L.; Noonan, D.; Kwiatkowski, D.J.; Chou, M.M.; et al. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleio-myomatosis (LAM). J. Biol. Chem. 2002, 277, 30958-30967.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30958-30967
-
-
Goncharova, E.A.1
Goncharov, D.A.2
Eszterhas, A.3
Hunter, D.S.4
Glassberg, M.K.5
Yeung, R.S.6
Walker, C.L.7
Noonan, D.8
Kwiatkowski, D.J.9
Chou, M.M.10
-
43
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
Manning, B.D.; Tee, A.R.; Logsdon, M.N.; Blenis, J.; Cantley, L.C. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell 2002, 10, 151-162.
-
(2002)
Mol. Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
Blenis, J.4
Cantley, L.C.5
-
44
-
-
18544375193
-
Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
-
Dan, H.C.; Sun, M.; Yang, L.; Feldman, R.I.; Sui, X.M.; Ou, C.C.; Nellist, M.; Yeung, R.S.; Halley, D.J.; Nicosia, S.V.; et al. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J. Biol. Chem. 2002, 277, 35364-35370.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35364-35370
-
-
Dan, H.C.1
Sun, M.2
Yang, L.3
Feldman, R.I.4
Sui, X.M.5
Ou, C.C.6
Nellist, M.7
Yeung, R.S.8
Halley, D.J.9
Nicosia, S.V.10
-
45
-
-
0037191045
-
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
-
Jaeschke, A.; Hartkamp, J.; Saitoh, M.; Roworth, W.; Nobukuni, T.; Hodges, A.; Sampson, J.; Thomas, G.; Lamb, R. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. J. Cell. Biol. 2002, 159, 217-224.
-
(2002)
J. Cell. Biol.
, vol.159
, pp. 217-224
-
-
Jaeschke, A.1
Hartkamp, J.2
Saitoh, M.3
Roworth, W.4
Nobukuni, T.5
Hodges, A.6
Sampson, J.7
Thomas, G.8
Lamb, R.9
-
46
-
-
0037123438
-
Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load
-
Reynolds, T.H.T.; Bodine, S.C.; Lawrence, J.C., Jr. Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. J. Biol. Chem. 2002, 277, 17657-17662.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 17657-17662
-
-
Reynolds, T.H.T.1
Bodine, S.C.2
Lawrence Jr., J.C.3
-
47
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
Kwiatkowski, D.J.; Zhang, H.; Bandura, J.L.; Heiberger, K.M.; Glogauer, M.; el-Hashemite, N.; Onda, H. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum. Mol. Genet. 2002, 11, 525-534.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
El-Hashemite, N.6
Onda, H.7
-
48
-
-
0029021621
-
Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity
-
Wienecke, R.; Konig, A.; DeClue, J.E. Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity. J. Biol. Chem. 1995, 270, 16409-16414.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 16409-16414
-
-
Wienecke, R.1
Konig, A.2
DeClue, J.E.3
-
49
-
-
0030972969
-
The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis
-
Xiao, G.H.; Shoarinejad, F.; Jin, F.; Golemis, E.A.; Yeung, R.S. The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis. J. Biol. Chem. 1997, 272, 6097-6100.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6097-6100
-
-
Xiao, G.H.1
Shoarinejad, F.2
Jin, F.3
Golemis, E.A.4
Yeung, R.S.5
-
50
-
-
0038643484
-
Rheb promotes cell growth as a component of the insulin/TOR signalling network
-
Saucedo, L.J.; Gao, X.; Chiarelli, D.A.; Li, L.; Pan, D.; Edgar, B.A. Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell Biol. 2003, 5, 566-571.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 566-571
-
-
Saucedo, L.J.1
Gao, X.2
Chiarelli, D.A.3
Li, L.4
Pan, D.5
Edgar, B.A.6
-
51
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker, H.; Radimerski, T.; Schindelholz, B.; Wittwer, F.; Belawat, P.; Daram, P.; Breuer, S.; Thomas, G.; Hafen, E. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 2003, 5, 559-565.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 559-565
-
-
Stocker, H.1
Radimerski, T.2
Schindelholz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
52
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
-
Zhang, Y.; Gao, X.; Saucedo, L.J.; Ru, B.; Edgar, B.A.; Pan, D. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 2003, 5, 578-581.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 578-581
-
-
Zhang, Y.1
Gao, X.2
Saucedo, L.J.3
Ru, B.4
Edgar, B.A.5
Pan, D.6
-
53
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki, K.; Li, Y.; Xu, T.; Guan, K.L. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003, 77, 1829-1834.
-
(2003)
Genes Dev.
, vol.77
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
54
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee, A.R.; Manning, B.D.; Roux, P.P.; Cantley, L.C.; Blenis, J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 2003, 13, 1259-1268.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
55
-
-
0041356888
-
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
-
Castro, A.F.; Rebhun, J.F.; Clark, G.J.; Quilliam, L.A. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J. Biol. Chem. 2003, 278, 32493-32496.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32493-32496
-
-
Castro, A.F.1
Rebhun, J.F.2
Clark, G.J.3
Quilliam, L.A.4
-
56
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami, A.; Zwartkruis, F.J.; Nobukuni, T.; Joaquin, M.; Roccio, M.; Stocker, H.; Kozma, S.C.; Hafen, E.; Bos, J.L.; Thomas, G. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 2003, 11, 1457-1466.
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
57
-
-
0035971180
-
The TOR kinases link nutrient sensing to cell growth
-
Rohde, J.; Heitman, J.; Cardenas, M.E. The TOR kinases link nutrient sensing to cell growth. J. Biol. Chem. 2001, 276, 9583-9586.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9583-9586
-
-
Rohde, J.1
Heitman, J.2
Cardenas, M.E.3
-
58
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara, K.; Maruki, Y.; Long, X.; Yoshino, K.; Oshiro, N.; Hidayat, S.; Tokunaga, C.; Avruch, J.; Yonezawa, K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002, 110, 177-189.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
59
-
-
0037623417
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
Kim, D.H.; Sarbassov dos, D.; Ali, S.M.; Latek, R.R.; Guntur, K.V.; Erdjument-Bromage, H.; Tempst, P.; Sabatini, D.M. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell 2003, 11, 895-904.
-
(2003)
Mol. Cell
, vol.11
, pp. 895-904
-
-
Kim, D.H.1
Sarbassov Dos, D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.V.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
60
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith, R.; Jacinto, E.; Wullschleger, S.; Lorberg, A.; Crespo, J.L.; Bonenfant, D.; Oppliger, W.; Jenoe, P.; Hall, M.N. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 2002, 10, 457-468.
-
(2002)
Mol. Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
61
-
-
0030906569
-
The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
-
Schmidt, A.; Bickle, M.; Beck, T.; Hall, M.N. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 1997, 88, 531-542.
-
(1997)
Cell
, vol.88
, pp. 531-542
-
-
Schmidt, A.1
Bickle, M.2
Beck, T.3
Hall, M.N.4
-
62
-
-
0034644122
-
TOR signaling regulates microtubule structure and function
-
Choi, J.H.; Adames, N.R.; Chan, T.F.; Zeng, C.; Cooper, J.A.; Zheng, X.F. TOR signaling regulates microtubule structure and function. Curr. Biol. 2000, 10, 861-864.
-
(2000)
Curr. Biol.
, vol.10
, pp. 861-864
-
-
Choi, J.H.1
Adames, N.R.2
Chan, T.F.3
Zeng, C.4
Cooper, J.A.5
Zheng, X.F.6
-
63
-
-
0036774805
-
The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase
-
Choi, J.H.; Bertram, P.G.; Drenan, R.; Carvalho, J.; Zhou, H.H.; Zheng, X.F. The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. EMBO Rep. 2002, 3, 988-994.
-
(2002)
EMBO Rep.
, vol.3
, pp. 988-994
-
-
Choi, J.H.1
Bertram, P.G.2
Drenan, R.3
Carvalho, J.4
Zhou, H.H.5
Zheng, X.F.6
-
64
-
-
0035798097
-
Mammalian TOR: A homeostatic ATP sensor
-
Dennis, P.B.; Jaeschke, A.; Saitoh, M.; Fowler, B.; Kozma, S.C.; Thomas, G. Mammalian TOR: a homeostatic ATP sensor. Science 2001, 294, 1102-1105.
-
(2001)
Science
, vol.294
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeschke, A.2
Saitoh, M.3
Fowler, B.4
Kozma, S.C.5
Thomas, G.6
-
65
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki, K.; Zhu, T.; Guan, K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115, 577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
66
-
-
0033597129
-
Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6
-
Kimball, S.R.; Shantz, L.M.; Horetsky, R.L.; Jefferson, L.S. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. J. Biol. Chem. 1999, 274, 11647-11652.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 11647-11652
-
-
Kimball, S.R.1
Shantz, L.M.2
Horetsky, R.L.3
Jefferson, L.S.4
-
67
-
-
0037108682
-
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
-
Kenerson, H.L.; Aicher, L.D.; True, L.D.; Yeung, R.S. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res. 2002, 62, 5645-5650.
-
(2002)
Cancer Res.
, vol.62
, pp. 5645-5650
-
-
Kenerson, H.L.1
Aicher, L.D.2
True, L.D.3
Yeung, R.S.4
-
68
-
-
0345732640
-
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
-
Fingar, D.C.; Richardson, C.J.; Tee, A.R.; Cheatham, L.; Tsou, C.; Blenis, J. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol. Cell. Biol. 2004, 24, 200-216.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 200-216
-
-
Fingar, D.C.1
Richardson, C.J.2
Tee, A.R.3
Cheatham, L.4
Tsou, C.5
Blenis, J.6
-
69
-
-
0034832919
-
Loss of tuberin, the tuberous-sclerosis-complex-2 gene product is associated with angiogenesis
-
Nguyen-Vu, P.A.; Fackler, I.; Rust, A.; DeClue, J.E.; Sander, C.A.; Volkenandt, M.; Flaig, M.; Yeung, R.S.; Wienecke, R. Loss of tuberin, the tuberous-sclerosis-complex-2 gene product is associated with angiogenesis. J. Cutan. Pathol. 2001, 28, 470-475.
-
(2001)
J. Cutan. Pathol.
, vol.28
, pp. 470-475
-
-
Nguyen-Vu, P.A.1
Fackler, I.2
Rust, A.3
DeClue, J.E.4
Sander, C.A.5
Volkenandt, M.6
Flaig, M.7
Yeung, R.S.8
Wienecke, R.9
-
70
-
-
0041920901
-
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
-
Brugarolas, J.B.; Vazquez, F.; Reddy, A.; Sellers, W.R.; Kaelin, W.G., Jr. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell. 2003, 4, 147-158.
-
(2003)
Cancer Cell
, vol.4
, pp. 147-158
-
-
Brugarolas, J.B.1
Vazquez, F.2
Reddy, A.3
Sellers, W.R.4
Kaelin Jr., W.G.5
-
71
-
-
0141705466
-
Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin
-
El-Hashemite, N.; Walker, V.; Zhang, H.; Kwiatkowski, D.J. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res. 2003, 63, 5173-5177.
-
(2003)
Cancer Res.
, vol.63
, pp. 5173-5177
-
-
El-Hashemite, N.1
Walker, V.2
Zhang, H.3
Kwiatkowski, D.J.4
-
72
-
-
0037842275
-
Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene
-
Liu, M.Y.; Poellinger, L.; Walker, C.L. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res. 2003, 63, 2675-2680.
-
(2003)
Cancer Res.
, vol.63
, pp. 2675-2680
-
-
Liu, M.Y.1
Poellinger, L.2
Walker, C.L.3
-
73
-
-
0037205007
-
The promise and perils of Wnt signaling through beta-catenin
-
Moon, R.T.; Bowerman, B.; Boutros, M.; Perrimon, N. The promise and perils of Wnt signaling through beta-catenin. Science 2002, 296, 1644-1646.
-
(2002)
Science
, vol.296
, pp. 1644-1646
-
-
Moon, R.T.1
Bowerman, B.2
Boutros, M.3
Perrimon, N.4
-
74
-
-
0035499603
-
Beta-catenin: Molecular plasticity and drug design
-
Daniels, D.L.; Ekolf Spink, K.; Weis, W.I. Beta-catenin: molecular plasticity and drug design. Trends Biochem. Sci. 2001, 26, 672-678.
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 672-678
-
-
Daniels, D.L.1
Ekolf Spink, K.2
Weis, W.I.3
-
75
-
-
0033590172
-
Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways
-
Miller, J.R.; Hocking, A.M.; Brown, J.D.; Moon, R.T. Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways. Oncogene 1999, 18, 7860-7872.
-
(1999)
Oncogene
, vol.18
, pp. 7860-7872
-
-
Miller, J.R.1
Hocking, A.M.2
Brown, J.D.3
Moon, R.T.4
-
76
-
-
0037458733
-
The tuberin-hamartin complex negatively regulates beta -catenin signaling activity
-
Mak, B.C.; Takemaru, K.; Kenerson, H.L.; Moon, R.T.; Yeung, R.S. The tuberin-hamartin complex negatively regulates beta -catenin signaling activity. J. Biol. Chem. 2003, 278, 5947-5951.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 5947-5951
-
-
Mak, B.C.1
Takemaru, K.2
Kenerson, H.L.3
Moon, R.T.4
Yeung, R.S.5
-
77
-
-
0035907390
-
Akt participation in the Wnt signaling pathway through Dishevelled
-
Fukumoto, S.; Hsieh, C.M.; Maemura, K.; Layne, M.D.; Yet, S.F.; Lee, K.H.; Matsui, T.; Rosenzweig, A.; Taylor, W.G.; Rubin, J.S.; et al. Akt participation in the Wnt signaling pathway through Dishevelled. J. Biol. Chem. 2001, 276, 17479-17483.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 17479-17483
-
-
Fukumoto, S.1
Hsieh, C.M.2
Maemura, K.3
Layne, M.D.4
Yet, S.F.5
Lee, K.H.6
Matsui, T.7
Rosenzweig, A.8
Taylor, W.G.9
Rubin, J.S.10
-
78
-
-
0035966322
-
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daaml
-
Habas, R.; Kato, Y.; He, X. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daaml. Cell 2001, 107, 843-854.
-
(2001)
Cell
, vol.107
, pp. 843-854
-
-
Habas, R.1
Kato, Y.2
He, X.3
-
79
-
-
0037018841
-
Zebrafish Rho kinase 2 acts down-stream of Wnt11 to mediate cell polarity and effective convergence and extension movements
-
Marlow, F.; Topczewski, J.; Sepich, D.; Solnica-Krezel, L. Zebrafish Rho kinase 2 acts down-stream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr. Biol. 2002, 12, 876-884.
-
(2002)
Curr. Biol.
, vol.12
, pp. 876-884
-
-
Marlow, F.1
Topczewski, J.2
Sepich, D.3
Solnica-Krezel, L.4
-
80
-
-
0033775869
-
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
-
Lamb, R.F.; Roy, C.; Diefenbach, T.J.; Vinters, H.V.; Johnson, M.W.; Jay, D.G.; Hall, A. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho [see comments]. Nat. Cell. Biol. 2000, 2, 281-287.
-
(2000)
Nat. Cell. Biol.
, vol.2
, pp. 281-287
-
-
Lamb, R.F.1
Roy, C.2
Diefenbach, T.J.3
Vinters, H.V.4
Johnson, M.W.5
Jay, D.G.6
Hall, A.7
-
81
-
-
0037028305
-
Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration
-
Astrinidis, A.; Cash, T.P.; Hunter, D.S.; Walker, C.L.; Chernoff, J.; Henske, E.P. Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene 2002, 21, 8470-8476.
-
(2002)
Oncogene
, vol.21
, pp. 8470-8476
-
-
Astrinidis, A.1
Cash, T.P.2
Hunter, D.S.3
Walker, C.L.4
Chernoff, J.5
Henske, E.P.6
-
82
-
-
0043245151
-
Regulation of PDGF production and ERK activation by estrogen is associated with TSC2 gene expression
-
Finlay, G.A.; Hunter, D.S.; Walker, C.L.; Paulson, K.E.; Fanburg, B.L. Regulation of PDGF production and ERK activation by estrogen is associated with TSC2 gene expression. Am. J. Physiol., Cell Physiol. 2003, 285, C409-C418.
-
(2003)
Am. J. Physiol., Cell Physiol.
, vol.285
-
-
Finlay, G.A.1
Hunter, D.S.2
Walker, C.L.3
Paulson, K.E.4
Fanburg, B.L.5
-
83
-
-
0347988005
-
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
-
Zhang, H.; Cicchetti, G.; Onda, H.; Koon, H.B.; Asrican, K.; Bajraszewski, N.; Vazquez, F.; Carpenter, C.L.; Kwiatkowski, D.J. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J. Clin. Invest. 2003, 112, 1223-1233.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1223-1233
-
-
Zhang, H.1
Cicchetti, G.2
Onda, H.3
Koon, H.B.4
Asrican, K.5
Bajraszewski, N.6
Vazquez, F.7
Carpenter, C.L.8
Kwiatkowski, D.J.9
-
84
-
-
0032493629
-
Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members
-
Henry, K.W.; Yuan, X.; Koszewski, N.J.; Onda, H.; Kwiatkowski, D.J.; Noonan, D.J. Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members. J. Biol. Chem. 1998, 273, 20535-20539.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 20535-20539
-
-
Henry, K.W.1
Yuan, X.2
Koszewski, N.J.3
Onda, H.4
Kwiatkowski, D.J.5
Noonan, D.J.6
-
85
-
-
2942560247
-
Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins: A molecular link of two tumor suppressor pathways
-
Birchenall-Roberts, M.C.; Fu, T.; Bang, O.S.; Dambach, M.; Resau, J.H.; Sadowski, C.L.; Bertolette, D.C.; Lee, HJ.; Kim, S.J.; Ruscetti, F.W. Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins: a molecular link of two tumor suppressor pathways. J. Biol. Chem. 2004, 25605-25613.
-
(2004)
J. Biol. Chem.
, pp. 25605-25613
-
-
Birchenall-Roberts, M.C.1
Fu, T.2
Bang, O.S.3
Dambach, M.4
Resau, J.H.5
Sadowski, C.L.6
Bertolette, D.C.7
Lee, H.J.8
Kim, S.J.9
Ruscetti, F.W.10
-
86
-
-
2342471301
-
Akt interacts directly with Smad3 to regulate the sensitivity to TGF-b-induced apoptosis
-
Conery, A.C.Y.; Thompson, E.A.; Townsend, C.M.; Ko, T.C.; Luo, K. Akt interacts directly with Smad3 to regulate the sensitivity to TGF-b-induced apoptosis. Nat. Cell. Biol. 2004, 6, 366-372.
-
(2004)
Nat. Cell. Biol.
, vol.6
, pp. 366-372
-
-
Conery, A.C.Y.1
Thompson, E.A.2
Townsend, C.M.3
Ko, T.C.4
Luo, K.5
-
87
-
-
2442700142
-
Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex
-
Shah, O.J.; Hunter, T. Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex. J. Biol. Chem. 2004, 20816-20823.
-
(2004)
J. Biol. Chem.
, pp. 20816-20823
-
-
Shah, O.J.1
Hunter, T.2
-
88
-
-
0344796378
-
Identification and characterization of the interaction between tuberin and 14-3-3zeta
-
Nellist, M.; Goedbloed, M.A.; De Winter, C.; Verhaaf, B.; Jankie, A.; Reuser, A.J.; Van Den Ouweland, A.M.; Van Der Sluijs, P.; Halley, D.J. Identification and characterization of the interaction between tuberin and 14-3-3zeta. J. Biol. Chem. 2002, 9, 9.
-
(2002)
J. Biol. Chem.
, vol.9
, pp. 9
-
-
Nellist, M.1
Goedbloed, M.A.2
De Winter, C.3
Verhaaf, B.4
Jankie, A.5
Reuser, A.J.6
Van Den Ouweland, A.M.7
Van Der Sluijs, P.8
Halley, D.J.9
-
89
-
-
0037160104
-
Regulation of TSC2 by 14-3-3 binding
-
Li, Y.; Inoki, K.; Yeung, R.; Guan, K.L. Regulation of TSC2 by 14-3-3 binding. J. Biol. Chem. 2002, 277, 44593-44596.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 44593-44596
-
-
Li, Y.1
Inoki, K.2
Yeung, R.3
Guan, K.L.4
-
90
-
-
0038190932
-
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
-
Li, Y.; Inoki, K.; Vacratsis, P.; Guan, K.L. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J. Biol. Chem. 2003, 278, 13663-13671.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13663-13671
-
-
Li, Y.1
Inoki, K.2
Vacratsis, P.3
Guan, K.L.4
-
91
-
-
0037462662
-
14-3-3Beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin
-
Shumway, S.D.; Li, Y.; Xiong, Y. 14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin. J. Biol. Chem. 2003, 278, 2089-2092.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2089-2092
-
-
Shumway, S.D.1
Li, Y.2
Xiong, Y.3
-
92
-
-
0032430241
-
Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2
-
Soucek, T.; Yeung, R.S.; Hengstschlager, M. Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Proc. Natl. Acad. Sci. U. S. A. 1998, 95, 15653-15658.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 15653-15658
-
-
Soucek, T.1
Yeung, R.S.2
Hengstschlager, M.3
-
93
-
-
0037047268
-
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization
-
Fujita, N.; Sato, S.; Katayama, K.; Tsuruo, T. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J. Biol. Chem. 2002, 277, 28706-28713.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 28706-28713
-
-
Fujita, N.1
Sato, S.2
Katayama, K.3
Tsuruo, T.4
-
94
-
-
0037113967
-
The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton
-
Haddad, L.A.; Smith, N.; Bowser, M.; Niida, Y.; Murthy, V.; Gonzalez-Agosti, C.; Ramesh, V. The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton. J. Biol. Chem. 2002, 277, 44180-44186.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 44180-44186
-
-
Haddad, L.A.1
Smith, N.2
Bowser, M.3
Niida, Y.4
Murthy, V.5
Gonzalez-Agosti, C.6
Ramesh, V.7
-
95
-
-
0347065349
-
Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B
-
Astrinidis, A.; Senapedis, W.; Coleman, T.R.; Henske, E.P. Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B. J. Biol. Chem. 2003, 278, 51372-51379.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 51372-51379
-
-
Astrinidis, A.1
Senapedis, W.2
Coleman, T.R.3
Henske, E.P.4
-
96
-
-
0030809956
-
Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8
-
Roberg, K.J.; Bickel, S.; Rowley, N.; Kaiser, C.A. Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8. Genetics 1997, 147, 1569-1584.
-
(1997)
Genetics
, vol.147
, pp. 1569-1584
-
-
Roberg, K.J.1
Bickel, S.2
Rowley, N.3
Kaiser, C.A.4
-
97
-
-
0037069414
-
Amino acids regulate the intracellular trafficking of the general amino acid permease of Saccharomycescerevisiae
-
Chen, E.J.; Kaiser, C.A. Amino acids regulate the intracellular trafficking of the general amino acid permease of Saccharomycescerevisiae. Proc. Natl. Acad. Sci. U. S. A. 2002, 99, 14837-14842.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 14837-14842
-
-
Chen, E.J.1
Kaiser, C.A.2
-
98
-
-
0037732600
-
LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway
-
Chen, E.J.; Kaiser, C.A. LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J. Cell. Biol. 2003, 161, 333-347.
-
(2003)
J. Cell. Biol.
, vol.161
, pp. 333-347
-
-
Chen, E.J.1
Kaiser, C.A.2
-
99
-
-
0036021402
-
Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast schizosaccharomyces pombe
-
Matsumoto, S.; Bandyopadhyay, A.; Kwiatkowski, D.J.; Maitra, U.; Matsumoto, T. Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast schizosaccharomyces pombe. Genetics 2002, 161, 1053-1063.
-
(2002)
Genetics
, vol.161
, pp. 1053-1063
-
-
Matsumoto, S.1
Bandyopadhyay, A.2
Kwiatkowski, D.J.3
Maitra, U.4
Matsumoto, T.5
-
100
-
-
1842424927
-
Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe
-
van Slegtenhorst, M.; Carr, E.; Stoyanova, R.; Kruger, W.D.; Henske, E.P. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. J. Biol. Chem. 2004, 279, 12706-12713.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 12706-12713
-
-
Van Slegtenhorst, M.1
Carr, E.2
Stoyanova, R.3
Kruger, W.D.4
Henske, E.P.5
-
101
-
-
0035019467
-
Tuberin-dependent membrane localization of polycystin-1: A functional link between polycystic kidney disease and the TSC2 tumor suppressor gene
-
Kleymenova, E.; Ibraghimov-Beskrovnaya, O.; Kugoh, H.; Everitt, J.; Xu, H.; Kiguchi, K.; Landes, G.; Harris, P.; Walker, C. Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. Mol. Cell 2001, 7, 823-832.
-
(2001)
Mol. Cell
, vol.7
, pp. 823-832
-
-
Kleymenova, E.1
Ibraghimov-Beskrovnaya, O.2
Kugoh, H.3
Everitt, J.4
Xu, H.5
Kiguchi, K.6
Landes, G.7
Harris, P.8
Walker, C.9
-
102
-
-
0034700483
-
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
-
Hanaoka, K.; Qian, F.; Boletta, A.; Bhunia, A.K.; Piontek, K.; Tsiokas, L.; Sukhatme, V.P.; Guggino, W.B.; Germino, G.G. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 2000, 408, 990-994.
-
(2000)
Nature
, vol.408
, pp. 990-994
-
-
Hanaoka, K.1
Qian, F.2
Boletta, A.3
Bhunia, A.K.4
Piontek, K.5
Tsiokas, L.6
Sukhatme, V.P.7
Guggino, W.B.8
Germino, G.G.9
-
103
-
-
0029560256
-
Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps
-
Conrad, P.A.; Smart, E.J.; Ying, Y.S.; Anderson, R.G.; Bloom, O.S. Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps. J. Cell. Biol. 1995, 131, 1421-1433.
-
(1995)
J. Cell. Biol.
, vol.131
, pp. 1421-1433
-
-
Conrad, P.A.1
Smart, E.J.2
Ying, Y.S.3
Anderson, R.G.4
Bloom, O.S.5
-
104
-
-
0042316755
-
PTEN: One gene, many syndromes
-
Eng, C. PTEN: one gene, many syndromes. Hum. Mutat. 2003, 22, 183-198.
-
(2003)
Hum. Mutat.
, vol.22
, pp. 183-198
-
-
Eng, C.1
-
105
-
-
0034463918
-
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
-
Haruta, T.; Uno, T.; Kawahara, J.; Takano, A.; Egawa, K.; Sharma, P.M.; Olefsky, J.M.; Kobayashi, M. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol. Endocrinol. 2000, 14, 783-794.
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 783-794
-
-
Haruta, T.1
Uno, T.2
Kawahara, J.3
Takano, A.4
Egawa, K.5
Sharma, P.M.6
Olefsky, J.M.7
Kobayashi, M.8
-
106
-
-
1542616960
-
Mammalian target of rapamycin regulates IRS-I serine 307 phosphorylation
-
Carlson, C.J.; White, M.F.; Rondinone, C.M. Mammalian target of rapamycin regulates IRS-I serine 307 phosphorylation. Biochem. Biophys. Res. Commun. 2004, 316, 533-539.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.316
, pp. 533-539
-
-
Carlson, C.J.1
White, M.F.2
Rondinone, C.M.3
-
107
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw, R.J.; Kosmatka, M.; Bardeesy, N.; Hurley, R.L.; Witters, L.A.; DePinho, R.A.; Cantley, L.C. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 3329-3335.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
108
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
Lizcano, J.M.; Goransson, O.; Toth, R.; Deak, M.; Morrice, N.A.; Boudeau, J.; Hawley, S.A.; Udd, L.; Makela, T.P.; Hardie, D.G.; et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 2004, 23, 833-843.
-
(2004)
EMBO J.
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Makela, T.P.9
Hardie, D.G.10
-
109
-
-
0032495530
-
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
-
Hemminki, A.; Markie, D.; Tomlinson, I.; Avizienyte, E.; Roth, S.; Loukola, A.; Bignell, G.; Warren, W.; Aminoff, M.; Hoglund, P.; et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998, 391, 184-187.
-
(1998)
Nature
, vol.391
, pp. 184-187
-
-
Hemminki, A.1
Markie, D.2
Tomlinson, I.3
Avizienyte, E.4
Roth, S.5
Loukola, A.6
Bignell, G.7
Warren, W.8
Aminoff, M.9
Hoglund, P.10
-
111
-
-
1942487890
-
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
-
Oshiro, N.; Yoshino, K.; Hidayat, S.; Tokunaga, C.; Hara, K.; Eguchi, S.; Avruch, J.; Yonezawa, K. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells 2004, 9, 359-366.
-
(2004)
Genes Cells
, vol.9
, pp. 359-366
-
-
Oshiro, N.1
Yoshino, K.2
Hidayat, S.3
Tokunaga, C.4
Hara, K.5
Eguchi, S.6
Avruch, J.7
Yonezawa, K.8
-
112
-
-
17944368972
-
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
-
Podsypanina, K.; Lee, R.T.; Politis, C.; Hennessy, I.; Crane, A.; Puc, J.; Neshat, M.; Wang, H.; Yang, L.; Gibbons, J.; et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 10320-10325.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 10320-10325
-
-
Podsypanina, K.1
Lee, R.T.2
Politis, C.3
Hennessy, I.4
Crane, A.5
Puc, J.6
Neshat, M.7
Wang, H.8
Yang, L.9
Gibbons, J.10
-
113
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/ mTOR
-
Neshat, M.S.; Mellinghoff, I.K.; Tran, C.; Stiles, B.; Thomas, G.; Petersen, R.; Frost, P.; Gibbons, J.J.; Wu, H.; Sawyers, C.L. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/ mTOR. Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 10314-10319.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
Stiles, B.4
Thomas, G.5
Petersen, R.6
Frost, P.7
Gibbons, J.J.8
Wu, H.9
Sawyers, C.L.10
-
114
-
-
0030888163
-
The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation
-
Clark, G.J.; Kinch, M.S.; Rogers-Graham, K.; Sebti, S.M.; Hamilton, A.D.; Der, C.J. The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. J. Biol. Chem. 1997, 272, 10608-10615.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10608-10615
-
-
Clark, G.J.1
Kinch, M.S.2
Rogers-Graham, K.3
Sebti, S.M.4
Hamilton, A.D.5
Der, C.J.6
-
115
-
-
1642512639
-
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex
-
Lepourcelet, M.; Chen, Y.N.; France, D.S.; Wang, H.; Crews, P.; Petersen, F.; Bruseo, C.; Wood, A.W.; Shivdasani, R.A. Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell 2004, 5, 91-102.
-
(2004)
Cancer Cell
, vol.5
, pp. 91-102
-
-
Lepourcelet, M.1
Chen, Y.N.2
France, D.S.3
Wang, H.4
Crews, P.5
Petersen, F.6
Bruseo, C.7
Wood, A.W.8
Shivdasani, R.A.9
-
116
-
-
19044379044
-
Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients
-
Dabora, S.L.; Roberts, P.; Nieto, A.; Perez, R.; Jozwiak, S.; Franz, D.; Bissler, J.; Thiele, E.A.; Sims, K.; Kwiatkowski, D.J. Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients. Am. J. Hum. Genet. 2002, 71, 750-758.
-
(2002)
Am. J. Hum. Genet.
, vol.71
, pp. 750-758
-
-
Dabora, S.L.1
Roberts, P.2
Nieto, A.3
Perez, R.4
Jozwiak, S.5
Franz, D.6
Bissler, J.7
Thiele, E.A.8
Sims, K.9
Kwiatkowski, D.J.10
|