Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B

Journal of Neuropathology and Experimental Neurology

Volumn 60, Issue 7, 2001, Pages 711-723

  Catania, Michael G ^a   Mischel, Paul S ^a   Vinters, Harry V ^a  

^a UCLA MEDICAL CENTER   (United States)

Author keywords

cdc2; CDK1; Cell cycle; Cyclin B; Hamartin; Tuberin; Tuberous sclerosis

Indexed keywords

CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE 1; HAMARTIN; TUBERIN;

ARTICLE; CELL CYCLE; CONTROLLED STUDY; ENZYME LOCALIZATION; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TUBEROUS SCLEROSIS;

EID: 0034936816     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/60.7.711     Document Type: Article

References (39)

1. New developments in the neurobiology of the tuberous sclerosis complex
2. The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor
3. Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients
4. 9q34 loss of heterozygosity in a tuberous sclerosis astrocytoma suggests a growth suppressor-like activity also for the TSC1 gene
5. Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: An immunohistochemical, ultrastructural, and immunoelectron and microscopic study
6. Two loci for tuberous sclerosis: One on 9q34 and one on 16p13
7. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
8. The TSC1 tumor suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
9. Identification and characterization of the tuberous sclerosis gene on chromosome 16
10. Identification of tuberin, the tuberous sclerosis-2 product
11. Mutational spectrum of the TSC1 gene in a cohort of 225 tuberous sclerosis complex patients: No evidence for genotype-phenotype correlation
12. Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
13. Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
14. Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice
15. Hereditary renal adenomas, and adenocarcinomas in rats
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17. Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene
18. gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
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20. Nuclear localization of vertebrate cyclin A correlates with its ability to form complexes with cdk catalytic subunits
21. Tuberin, the product of the tuberous sclerosis-2 gene, interacts with CDK1 in NT2 cells
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26. Human cyclins A and B1 are differentially located in the cell and undergo cell-cycle-dependent nuclear transport
27. Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation
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29. Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene
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33. Characterization of the cytosolic tuberin-hamartin complex
34. Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development
35. The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas
36. Localization of tuberous sclerosis 2 mRNA and its protein product tuberin in normal brain and in cerebral lesions of patients with tuberous sclerosis
37. Tissue and cell-type specific expression of the tuberous sclerosis gene, TSC2, in human tissues