Tuberous sclerosis gene products in proliferation control

Mutation Research - Reviews in Mutation Research

Volumn 488, Issue 3, 2001, Pages 233-239

  Hengstschläger, Markus ^a   Rodman, David M ^b   Miloloza, Angelina ^a   Hengstschläger Ottnad, Elke ^a   Rosner, Margit ^a   Kubista, Marion ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Cell cycle; Proliferation; TSC1; TSC2; Tuberous sclerosis

Indexed keywords

HAMARTIN; TUBERIN;

CANCER INHIBITION; CELL; CELL CYCLE; CELL FUNCTION; CELL PROLIFERATION; DEREGULATION; DISEASE COURSE; DROSOPHILA; GENE; GENE EXPRESSION; GENE MUTATION; HAMARTOMA; HETEROZYGOSITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEQUENCE HOMOLOGY; TRANSGENE; TUBEROUS SCLEROSIS; TUMOR GROWTH;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CARCINOMA, RENAL CELL; CELL COMPARTMENTATION; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL SIZE; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, HUMAN, PAIR 9; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENES, DOMINANT; GENES, TUMOR SUPPRESSOR; HAMARTOMA; HUMANS; INSECT PROTEINS; KIDNEY NEOPLASMS; LOSS OF HETEROZYGOSITY; MACROMOLECULAR SUBSTANCES; PROTEINS; RATS; RATS, MUTANT STRAINS; REPRESSOR PROTEINS; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS;

RODENTIA;

EID: 0035009866     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5742(01)00058-8     Document Type: Review

References (40)

1. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
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5. Suppression of the neoplastic phenotype by replacement of the TSC2 gene in Eker rat renal carcinoma cells
6. Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (TSC2) gene and its C-terminal region
7. Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene
8. A germline insertion in the tuberous sclerosis (TSC2) gene gives rise to the Eker rat model of dominantly inherited cancer
9. Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer
10. Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepthelial growth and development
11. TSC2+/- mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background
12. Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line TSC2 mutation in mice
13. Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2
14. A role of the tuberous sclerosis gene-2 product during neuronal differentiation
15. Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene
16. The TSC1 gene product, hamartin, negatively regulates cell proliferation
17. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
18. Role of tuberous sclerosis gene-2 product in cell cycle control
19. Mutation and cancer: Statistical study of retinoblastoma
20. Sustained cardiomyocyte DNA synthesis in whole embryo cultures lacking the TSC2 gene product
21. Rodent model of reproductive tract leiomyomata: Establishment and characterization of tumor-derived cell lines
22. gigas, A Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
23. Identification of tuberin, the tuberous sclerosis-2 product - Tuberin possesses specific rap1GAP activity
24. Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes
25. The tuberous sclerosis 2 gene product, tuberin, functions as a rab5 GTPase activating protein (GAP) in modulating endocytosis
26. Presence of potent transcriptional activation domains in the predisposing tuberous sclerosis (TSC2) gene product of the Eker rat model
27. Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members
28. The TSC1 tumous suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
29. The retinoblastoma protein and cell cycle control
30. Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation
31. Distribution of TSC1 protein detected by immunohistochemistry in various normal rat tissues and ther enal carcinomas of Eker rat: Detection of limited colocalization with TSC1 and TSC2 gene products in vivo
32. New insights into the tumor suppression function of p27kip1
33. Co-localization of the TSC2 product tuberin with its target rap1 in the Golgi apparatus
34. Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localised to cytoplasmic vesicles
35. Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
36. Characterization of the cytosolic tuberin-hamartin complex: Tuberin is a cytosolic chaperone for hamartin
37. Similarities and differences in the subcellular localization of hamartin and tuberin in the kidney
38. Expression of the tuberous sclerosis complex gene products, hamartin and tuberin, in central nervous system tissues
39. The hallmarks of cancer