Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review

Journal of Ethnopharmacology

Volumn 235, Issue , 2019, Pages 329-360

  Chukwuma, Chika Ifeanyi ^a   Matsabisa, Motlalepula G ^a   Ibrahim, Mohammed Auwal ^b   Erukainure, Ochuko L ^c   Chabalala, Matimbha H ^a   Islam, Md Shahidul ^c  

^a UNIVERSITY OF THE FREE STATE   (South Africa)

^b AHMADU BELLO UNIVERSITY   (Nigeria)

^c UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Anti diabetic; Anti hypertensive; Concomitant; Diabetes; Hypertension; Medicinal plants

Indexed keywords

ACTEOSIDE; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; CAFFEIC ACID; CANAVALIA ENSIFORMIS EXTRACT; CARICA PAPAYA EXTRACT; CENTELLA ASIATICA EXTRACT; CICHORIC ACID; CITRULLUS VULGARIS EXTRACT; CUCURBITA PEPO EXTRACT; ERYTHRAEA CENTAURIUM EXTRACT; FUCOXANTHIN; GINKGO BILOBA EXTRACT; GLIBENCLAMIDE; HYSSOPUS OFFICINALIS EXTRACT; ISOACTEOSIDE; LUPINUS MUTABILIS EXTRACT; MANIHOT ESCULENTA EXTRACT; MILLETTIA PINNATA EXTRACT; NICOTINAMIDE; PARKIA BIGLOBOSA EXTRACT; PLANT EXTRACT; PSOPHOCARPUS TETRAGONOLOBUS EXTRACT; RHODIOLA ROSEA EXTRACT; SOYBEAN EXTRACT; SPHENOSTYLIS STENOCARPA EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VICIA FABA EXTRACT; VIGNA ANGULARIS EXTRACT; VIGNA SUBTERRANEA EXTRACT; PLANT MEDICINAL PRODUCT;

AFRICAN YAM-BEAN; ANTIDIABETIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; CACAO; CANAVALIA ENSIFORMIS; CASSAVA; CITRUS; CITRUS MAXIMA; CLEMENTINE; CONTROLLED STUDY; CORCHORUS OLITORIUS; CUCURBITA PEPO; DIABETES MELLITUS; DIURESIS; FABACEAE; FRUIT PULP; GARLIC; GINKGO BILOBA; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; GRAPEFRUIT; HYPERTENSION; HYSSOPUS OFFICINALIS; IN VITRO STUDY; IN VIVO STUDY; LEMON; MAIZE; MEDICINAL PLANT; MEDLINE; MELISSA OFFICINALIS; MOMORDICA CHARANTIA; NONHUMAN; OREGANO; PHYLLANTHUS AMARUS; PLEUROTUS; PLEUROTUS CITRINOPILEATUS; PSOPHOCARPUS TETRAGONOLOBUS; REVIEW; RICE; RISK FACTOR; ROSEMARY; SALVIA; SALVIA ACETABULOSA; SIDERITIS; SIDERITIS PERFOLIATA; SOYBEAN; SWEET ORANGE; VERONICA PERSICA; VIGNA; VIGNA ANGULARIS; WATERMELON; WITHANIA SOMNIFERA; ANIMAL; CHEMISTRY; DRUG EFFECT; HUMAN; ISOLATION AND PURIFICATION; PHYTOTHERAPY; PROCEDURES; TRADITIONAL MEDICINE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD GLUCOSE; DIABETES MELLITUS; HUMANS; HYPERTENSION; HYPOGLYCEMIC AGENTS; MEDICINE, TRADITIONAL; PHYTOTHERAPY; PLANT PREPARATIONS; PLANTS, MEDICINAL;

EID: 85061783635     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2019.02.024     Document Type: Review

References (119)

1. Abdel-Moneim, A., Yousef, A.I., Abd El-Twab, S.M., Abdel Reheim, E.S., Ashour, M.B., Gallic acid and p-coumaric acid attenuate type 2 diabetes-induced neurodegeneration in rats. Metab. Brain Dis. 32:4 (2017), 1279–1286, 10.1007/s11011-017-0039-8.
2. Adefegha, A.O., Oboh, G., Antioxidant and inhibitory properties of Clerodendrum volubile leaf extracts on key enzymes relevant to non-insulin dependent diabetes mellitus and hypertension. J. Taibah Univ. Sci. 10 (2016), 521–533, 10.1016/j.jtusci.2015.10.008.
3. Adefegha, S.A., Oboh, G., Antioxidant and inhibitory properties of Clerodendrum volubile leaf extracts on key enzymes relevant to non-insulin dependent diabetes mellitus and hypertension. J. Taibah Univ. Sci. 10 (2016), 521–533, 10.1016/j.jtusci.2015.10.008.
4. Adefegha, S.A., Olasehinde, T.A., Oboh, G., Essential oil composition, antioxidant, antidiabetic and antihypertensive properties of two afromomum species. J. Oleo Sci. 66:1 (2017), 51–63, 10.5650/jos.ess16029.
5. Adefegha, S.A., Oyeleye, S.I., Oboh, G., Distribution of phenolic contents, antidiabetic potentials, antihypertensive properties, and antioxidative effects of soursop (Annona muricata l.) fruit parts in vitro. Biochem. Res. Int., 2015, 2015, 347673, 10.1155/2015/347673.
6. Ademiluyi, A.O., Oboh, G., Phenolic-rich extracts from selected tropical underutilized legumes inhibit α -amylase, α -glucosidase, and angiotensin I converting enzyme in vitro. J. Basic Clin. Physiol. Pharmacol. 23:1 (2012), 17–25, 10.1515/jbcpp-2011-0005.
7. Ademiluyi, A.O., Oboh, G., Soybean phenolic-rich extracts inhibit key-enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting enzyme) in vitro. Exp. Toxicol. Pathol. 65:3 (2013), 305–309, 10.1016/j.etp.2011.09.005.
8. Al Disi, S.S., Anwar, M.A., Eid, A.H., Anti-hypertensive herbs and their mechanisms of action: part I. Front. Pharmacol., 6, 2016, 323, 10.3389/fphar.2015.00323.
9. Alauddin, M., Shirakawa, H., Koseki, T., Kijima, N., Ardiansyah, Budijanto, S., Islam, J., Goto, T., Komai, M., Fermented rice bran supplementation mitigates metabolic syndrome in stroke prone spontaneously hypertensive rats. BMC Complement. Altern. Med., 16(1), 2016, 442, 10.1186/s12906-016-1427-z.
10. Alu'datt, M.H., Rababah, T., Alhamad, M.N., Al-Mahasneh, M.A., Ereifej, K., Al-Karaki, G., Al-Duais, M., Andrade, J.E., Tranchant, C.C., Kubow, S., Ghozlan, K.A., Extracted free and bound phenolics profiles from Citrus fruits and their roles in biological system: content, antioxidant, anti-diabetic and anti-hypertensive properties. Food Funct. 8:9 (2017), 3187–3197, 10.1039/c7fo00212b.
11. Amalan, V., Vijayakumar, N., Indumathi, D., Ramakrishnan, A., Antidiabetic and antihyperlipidemic activity of p-coumaric acid in diabetic rats, role of pancreatic GLUT 2: In vivo approach. Biomed. Pharmacother. 84 (2016), 230–236, 10.1016/j.biopha.2016.09.039.
12. Andallu, B., Radhika, B., Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J. Exp. Biol. 38:6 (2000), 607–609.
13. Apostolidis, E., Kwon, Y.I., Shetty, K., Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac. J. Clin. Nutr. 15:3 (2006), 433–441.
14. Ardiansyah, Shirakawa, H., Koseki, T., Hashizume, K., Komai, M., The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid. Br. J. Nutr. 97:1 (2007), 67–76, 10.1017/S000711450721013X.
15. Ardiansyah, Shirakawa, H., Koseki, T., Ohinata, K., Hashizume, K., Komai, M., Rice bran fractions improve blood pressure, lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats. J. Agric. Food Chem. 54:5 (2006), 1914–1920, 10.1021/jf052561l.
16. Ardiansyah, Shirakawa, H., Shimeno, T., Koseki, T., Shiono, Y., Murayama, T., Hatakeyama, E., Komai, M., adenosine, an identified active component from the driselase-treated fraction of rice bran, is effective at improving metabolic syndrome in stroke-prone spontaneously hypertensive rats. J. Agric. Food Chem. 57:6 (2009), 2558–2564, 10.1021/jf803347c.
17. Arenda, D.P., dos Santosa, T.C., Cazarolli, L.H., Hortc, M.A., Sonaglioa, D., dos Santosa, A.L.G., Ribeiro-do-Vallec, R.M., Silva, F.R.M.B., de Camposa, A.M., In vivo potential hypoglycemic and in vitro vasorelaxant effects of Cecropia glaziovii standardized extracts. Rev. Bras. Farmacogn. 25:2015 (2015), 473–484, 10.1016/j.bjp.2015.05.010.
18. Arumugama, G., Manjulab, P., Paari, N., A review: anti diabetic medicinal plants used for diabetes mellitus. J. Acute Dis. 2:3 (2013), 196–200, 10.1016/S2221-6189(13)60126-2.
19. Bellahcen, S., Hakkou, Z., Ziyyat, A., Legssyer, A., Mekhfi, H., Aziz, M., Bnouham, M., Antidiabetic and antihypertensive effect of Virgin Argan Oil in model of neonatal streptozotocin-induced diabetic and L-nitroarginine methylester (L-NAME) hypertensive rats. J. Complement. Integr. Med. 10:1 (2013), 29–36, 10.1515/jcim-2013-0008.
20. Bhullar, K.S., Lassalle-Claux, G., Touaibia, M., Rupasinghe, H.P.V., Antihypertensive effect of caffeic acid and its analogs through dual renin–angiotensin–aldosterone system inhibition. Eur. J. Pharmacol. 730 (2014), 125–132, 10.1016/j.ejphar.2014.02.038.
21. Bnouham, M., Benalla, W., Bellahcen, S., Hakkou, Z., Ziyyat, A., Mekhfi, H., Aziz, M., Legssyer, A., Antidiabetic and antihypertensive effect of a polyphenolrich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin-diabetic and NG-nitro-L-arginine methyl ester-hypertensive rats. J. Diabet. 4 (2012), 307–313, 10.1111/j.1753-0407.2012.00202.x.
22. Bönner, G., Hyperinsulinemia, insulin resistance, and hypertension. J. Cardiovasc. Pharmacol. 24:2 (1994), S39–S49.
23. Bouzabata, A., Traditional treatment of high blood pressure and diabetes in Souk Ahras District. J. Pharmacogn. Phytother. 5:1 (2013), 12–20, 10.5897/JPP11.065.
24. Ceylan-Isik, A.F., Fliethman, R.M., Wold, L.E., Ren, J., Herbal and traditional Chinese medicine for the treatment of cardiovascular complications in diabetes mellitus. Curr. Diabetes Rev. 4:4 (2008), 320–328, 10.2174/157339908786241142.
25. Chen, C.K., Pace-Asciak, C.R., Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen. Pharmacol. 27:2 (1996), 363–366, 10.1016/0306-3623(95)02001-2.
26. Chen, P.H., Weng, Y.M., Lin, S.M., Yu, Z.R., Wang, B.J., Molecular weight affected antioxidant, hypoglycemic and hypotensive activities of cold water extract from Pleurotus citrinopileatus. J. Food Sci. 82:10 (2017), 2456–2461, 10.1111/1750-3841.13851.
27. Chen, P.H., Weng, Y.M., Yu, Z.R., Koo, M., Wang, B.J., Extraction temperature affects the activities of antioxidation, carbohydrate-digestion enzymes, and angiotensin-converting enzyme of Pleurotus citrinopileatus extract. J. Food Drug Anal. 24:3 (2016), 548–555, 10.1016/j.jfda.2016.02.005.
28. Cheplick, S., Kwon, Y.I., Bhowmik, P., Shetty, K., Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension. Bioresour. Technol. 101:1 (2010), 404–413, 10.1016/j.biortech.2009.07.068.
29. Cheung, B.M., Li, C., Diabetes and hypertension: is there a common metabolic pathway?. Curr. Atheroscler. Rep. 14:2 (2012), 160–166, 10.1007/s11883-012-0227-2.
30. Chiou, S.Y., Sung, J.M., Huang, P.W., Lin, S.D., Antioxidant, antidiabetic, and antihypertensive properties of Echinacea purpurea flower extract and caffeic acid derivatives using in vitro models. J. Med. Food 20:2 (2017), 171–179, 10.1089/jmf.2016.3790.
31. Chukwuma, C.I., Islam, M.S., Effects of xylitol on carbohydrate digesting enzymes activity, intestinal glucose absorption and muscle glucose uptake: a multi-mode study. Food Funct. 6:3 (2015), 955–962, 10.1039/c4fo00994k.
32. Chukwuma, C.I., Mopuri, R., Nagiah, S., Chuturgoon, A.A., Islam, M.S., Erythritol reduces small intestinal glucose absorption, increases muscle glucose uptake, improves glucose metabolic enzymes activities and increases expression of Glut-4 and IRS-1in type 2 diabetic rats. Eur. J. Nutr. 57:7 (2018), 2431–2444, 10.1007/s00394-017-1516-x.
33. Clouatre, D.L., Rao, S.N., Preuss, H.G., Bitter melon extracts in diabetic and normal rats favorably influence blood glucose and blood pressure regulation. J. Med. Food 14:12 (2011), 1496–1504, 10.1089/jmf.2010.0276.
34. Deo, P., Hewawasam, E., Karakoulakis, A., Claudie, D.J., Nelson, R., Simpson, B.S., Smith, N.M., Semple, S.J., In vitro inhibitory activities of selected Australian medicinal plant extracts against protein glycation, angiotensin converting enzyme (ACE) and digestive enzymes linked to type II diabetes. BMC Complement. Altern. Med., 16(1), 2016, 435, 10.1186/s12906-016-1421-5.
35. Drobiova, H., Thomson, M., Al-Qattan, K., Peltonen-Shalaby, R., Al-Amin, Z., Ali, M., Garlic increases antioxidant levels in diabetic and hypertensive rats determined by a modified peroxidase method. Evid. Based Complement. Altern. Med., 2011, 2011, 703049, 10.1093/ecam/nep011.
36. Eddouks, M., Maghrani, M., Lemhadri, A., Ouahidi, M.L., Jouad, H., Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). J. Ethnopharmacol. 82:2–3 (2002), 97–103, 10.1016/S0378-8741(02)00164-2.
37. Epstein, M., Sowers, J.R., Diabetes mellitus and hypertension. Hypertension 19 (1992), 403–418, 10.1161/01.HYP.19.5.403.
38. Erukainure, O.L., Chukwuma, C.I., Sanni, O., Matsabisa, M.G., Islam, M.S., Histochemistry, phenolic content, antioxidant, and anti-diabetic activities of Vernonia amygdalina leaf extract. J. Food Biochem., 2018, e12737, 10.1111/jfbc.12737.
39. Erukainure, O.L., Hafizur, R.M., Kabir, N., Choudhary, M.I., Atolani, O., Banerjee, P., Preissner, R., Chukwuma, C.I., Muhammad, A., Amonsou, E.O., Islam, M.S., Suppressive effects of Clerodendrum volubile P Beauv. [Labiatae] Methanolic extract and its fractions on type 2 diabetes and its complications. Front. Pharmacol., 9, 2018, 8, 10.3389/fphar.2018.00008.
40. Fallahi, F., Roghani, M., Moghadami, S., Citrus flavonoid naringenin improves aortic reactivity in streptozotocin-diabetic rats. Indian J. Pharmacol. 44:3 (2012), 382–386, 10.4103/0253-7613.96350.
41. Farzaei, F., Morovati, M.R., Farjadmand, F., Farzaei, M.H., A mechanistic review on medicinal plants used for diabetes mellitus in traditional persian medicine. J. Evid. Based Complement. Altern. Med. 22:4 (2017), 944–955, 10.1177/2156587216686461.
42. Ghoul, J.El, Ben-Attia, M., Vasorelaxant effects of aqueous extract of Zygophyllum album and antihyperglycemic activities in streptozotocin-induced diabetic mice. J. Diabetes Metab., 5, 2014, 426, 10.4172/2155-6156.1000426.
43. Gibbons, G.H., Angiotensin-converting enzyme inhibition and vascular structure in hypertension. J. Cardiovasc. Pharmacol. 18:7 (1991), S19–S24.
44. Gómez-Olivé, F.X., Ali, S.A., Made, F., Kyobutungi, C., Nonterah, E., Micklesfield, L., Alberts, M., Boua, R., Hazelhurst, S., Debpuur, C., Mashinya, F., Dikotope, S., Sorgho, H., Cook, I., Muthuri, S., Soo, C., Mukomana, F., Agongo, G., Wandabwa, C., Afolabi, S., Oduro, A., Tinto, H., Wagner, R.G., Haregu, T., Wade, A., Kahn, K., Norris, S.A., Crowther, N.J., Tollman, S., Sankoh, O., Ramsay, M., AWIGen and the H3Africa Consortium, Regional and sex differences in the prevalence and awareness of hypertension: an H3Africa AWI-Gen study across 6 sites in Sub- Saharan Africa. Glob. Heart 12:2 (2017), 81–90, 10.1016/j.gheart.2017.01.007.
45. Gondwe, M., Kamadyaapa, D.R., Tufts, M., Chuturgoon, A.A., Musabayane, C.T., Sclerocarya birrea [(A. Rich.) Hochst.] [Anacardiaceae] stem-bark ethanolic extract (SBE) modulates blood glucose, glomerular filtration rate (GFR) and mean arterial blood pressure (MAP) of STZ-induced diabetic rats. Phytomedicine 15:9 (2008), 699–709, 10.1016/j.phymed.2008.02.004.
46. Graz, B., Kitalong, C., Yano, V., Traditional local medicines in the republic of Palau and non-communicable diseases (NCD), signs of effectiveness. J. Ethnopharmacol. 161 (2015), 233–237, 10.1016/j.jep.2014.11.047.
47. Guerrero, L., Castillo, J., Quiñones, M., Garcia-Vallvé, S., Arola, L., Pujadas, G., Muguerza, B., Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies. PLoS One, 7(11), 2012, e49493, 10.1371/journal.pone.0049493.
48. Hamden, K., Keskes, H., Belhaj, S., Mnafgui, K., Feki, A., Allouche, N., Inhibitory potential of omega-3 fatty and fenugreek essential oil on key enzymes of carbohydrate-digestion and hypertension in diabetes rats. Lipids Health Dis., 10, 2011, 226, 10.1186/1476-511X-10-226.
49. Hu, Y., Wang, Z., Wang, Y., Wang, L., Han, W., Tang, Y., Xue, F., Hou, L., Liang, S., Zhang, B., Wang, W., Asaiti, K., Pang, H., Zhang, M., Jiang, J., Prevalence, awareness, treatment, and control of hypertension among Kazakhs with high salt intake in Xinjiang, China: a Community-based Cross-sectional Study. Sci. Rep., 7, 2017, 45547, 10.1038/srep45547.
50. Hung, W.C., Ling, X.H., Chang, C.C., Hsu, H.F., Wang, S.W., Lee, Y.C., Luo, C., Lee, Y.T., Houng, J.Y., Inhibitory effects of Siegesbeckia orientalis extracts on advanced glycation end product formation and key enzymes related to metabolic syndrome. Molecules, 22(10), 2017, E1785, 10.3390/molecules22101785.
51. International Diabetes Federation, IDF Diabetes Atlas. 8th edition, 2017, International Diabetes Federation (Accessed 13 April 2018) http://diabetesatlas.org/resources/2017-atlas.html.
52. James, P.A., Oparil, S., Carter, B.L., Cushman, W.C., Dennison-Himmelfarb, C., Handler, J., Lackland, D.T., LeFevre, M.L., MacKenzie, T.D., Ogedegbe, O., Smith, S.C. Jr., Svetkey, L.P., Taler, S.J., Townsend, R.R., Wright, J.T. Jr., Narva, A.S., Ortiz, E., Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311:5 (2014), 507–520, 10.1001/jama.2013.284427.
53. Jung, U.J., Lee, M.K., Park, Y.B., Jeon, S.M., Choi, M.S., Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. J. Pharmacol. Exp. Ther. 318:2 (2006), 476–483, 10.1124/jpet.106.105163.
54. Justo, M.L., Rodriguez-Rodriguez, R., Claro, C.M., Alvarez de Sotomayor, M., Parrado, J., Herrera, M.D., Water-soluble rice bran enzymatic extract attenuates dyslipidemia, hypertension and insulin resistance in obese Zucker rats. Eur. J. Nutr. 52:2 (2013), 789–797, 10.1007/s00394-012-0385-6.
55. Karou, S.D., Tchacondo, T., Djikpo Tchibozo, M.A., Abdoul-Rahaman, S., Anani, K., Koudouvo, K., Batawila, K., Agbonon, A., Simpore, J., de Souza, C., Ethnobotanical study of medicinal plants used in the management of diabetes mellitus and hypertension in the Central Region of Togo. Pharm. Biol. 49:12 (2011), 1286–1297, 10.3109/13880209.2011.621959.
56. Kasilo, O.M., Trapsida, J.-M., Mwikisa, C., An overview of the traditional medicine situation in the African Region. WHO Afr. Health Monit. 14 (2010), 7–15.
57. Kaur, S., Muthuraman, A., Therapeutic evaluation of rutin in two-kidney one-clip model of renovascular hypertension in rat. Life Sci. 150 (2016), 89–94, 10.1016/j.lfs.2016.02.080.
58. Kim, M.J., Lim, N.K., Choi, S.J., Park, H.Y., Hypertension is an independent risk factor for type 2 diabetes: the Korean genome and epidemiology study. Hypertens. Res. 38:11 (2015), 783–789, 10.1038/h.2015.72.
59. Konaté, K., Yomalan, K., Sytar, O., Zerbo, P., Brestic, M., Patrick, V.D., Gagniuc, P., Barro, N., Free radicals scavenging capacity, antidiabetic and antihypertensive activities of flavonoid-rich fractions from leaves of Trichilia emetica and Opilia amentacea in an animal model of type 2 diabetes mellitus. Evid. Based Complement. Altern. Med., 2014, 2014, 867075, 10.1155/2014/867075.
60. Kwon, Y.I., Apostolidis, E., Kim, Y.C., Shetty, K., Health benefits of traditional corn, beans, and pumpkin: in vitro studies for hyperglycemia and hypertension management. J. Med. Food 10:2 (2007), 266–275, 10.1089/jmf.2006.234.
61. Kwon, Y.I., Apostolidis, E., Shetty, K., In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. Bioresour. Technol. 99:8 (2008), 2981–2988, 10.1016/j.biortech.2007.06.035.
62. Kwon, Y.I., Jang, H.D., Shetty, K., Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac. J. Clin. Nutr. 15:3 (2006), 425–432.
63. Kwon, Y.I., Vattem, D.A., Shetty, K., Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension. Asia Pac. J. Clin. Nutr. 15:1 (2006), 107–118.
64. Lekshmi, P.C., Arimboor, R., Nisha, V.M., Menon, A.N., Raghu, K.G., In vitro antidiabetic and inhibitory potential of turmeric (Curcuma longa L) rhizome against cellular and LDL oxidation and angiotensin converting enzyme. J. Food Sci. Technol. 51:12 (2014), 3910–3917, 10.1007/s13197-013-0953-7.
65. Li, Y.Q., Zhou, F.C., Gao, F., Bian, J.S., Shan, F., Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase. J. Agric. Food Chem. 57:24 (2009), 11463–11468, 10.1021/jf903083h.
66. Liang, X.C., Meng, W., Zhong, Y.L., Huang, L., He, W.Y., Wang, Z., Effects of chlorogenic acid on mouse insulin resistance development induced by high fat emulsion. Chin. Pharmacol. Bull. 29:5 (2013), 654–658, 10.3969/j.issn.1001-1978.2013.05.014.
67. Liu, Q., Hu, H.J., Li, P.F., Yang, Y.B., Wub, L.H., Chou, G.X., Wanga, Z.T., Diterpenoids and phenylethanoid glycosides from the roots of Clerodendrum bungei and their inhibitory effects against angiotensin converting enzyme and a-glucosidase. Phytochemistry 103 (2014), 196–202, 10.1016/j.phytochem.2014.02.015.
68. Loh, S.P., Hadira, O., In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension. Malays. J. Nutr. 17:1 (2011), 77–86.
69. Loizzo, M.R., Saab, A.M., Tundis, R., Menichini, F., Bonesi, M., Piccolo, V., Statti, G.A., de Cindio, B., Houghton, P.J., Menichini, F., In vitro inhibitory activities of plants used in Lebanon traditional medicine against angiotensin converting enzyme (ACE) and digestive enzymes related to diabetes. J. Ethnopharmacol. 119:1 (2008), 109–116, 10.1016/j.jep.2008.06.003.
70. McCue, P., Kwon, Y.I., Shetty, K., Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean. Asia Pac. J. Clin. Nutr. 14:2 (2005), 145–152.
71. Mnafgui, K., Kchaou, M., Ben Salah, H., Hajji, R., Khabbabi, G., Elfeki, A., Allouche, N., Gharsallah, N., Essential oil of Zygophyllum album inhibits key-digestive enzymes related to diabetes and hypertension and attenuates symptoms of diarrhea in alloxan-induced diabetic rats. Pharm. Biol. 54:8 (2016), 1326–1333, 10.3109/13880209.2015.1075049.
72. Montó, F., Arce, C., Noguera, M.A., Ivorra, M.D., Flanagan, J., Roller, M., Issaly, N., D'Ocon, P., Action of an extract from the seeds of Fraxinus excelsior L. on metabolic disorders in hypertensive and obese animal models. Food Funct. 5:4 (2014), 786–796, 10.1039/c3fo60539f.
73. Nagappan, H., Pee, P.P., Kee, S.H.Y., Ow, J.T., Yan, S.W., Chew, L.Y., Kong, K.W., Malaysian brown seaweeds Sargassum siliquosum and Sargassum polycystum: low density lipoprotein (LDL) oxidation, angiotensin converting enzyme (ACE), α-amylase, and α-glucosidase inhibition activities. Food Res. Int. 99:Pt 2 (2017), 950–958, 10.1016/j.foodres.2017.01.023.
74. Nair, S.S., Kavrekar, V., Mishra, A., Evaluation of in vitro anti diabetic activity of selected plant extracts. Int. J. Pharm. Sci. Invent. 2:4 (2013), 12–19.
75. Nazar, C.M.J., Mechanism of hypertension in diabetic nephropathy. J. Nephropharmacology 3:2 (2014), 49–55.
76. Nole, T., Lionel, T.D.W., Cedrix, T.F.S., Gabriel, A.A., Ethnomedical and ethnopharmacological study of plants used for potential treatments of diabetes and arterial hypertension by indigenous people in three phytogeographic regions of Cameroon. Diabetes Case Rep., 1, 2016, 110, 10.4172/2572-5629.1000110.
77. Nwanna, E.E., Ibukun, E.O., Oboh, G., Ademosun, A.O., Boligon, A.A., Athayde, M., HPLC-DAD analysis and in vitro property of polyphenols extracts from (Solanum aethiopium) fruits on α-amylase, α-glucosidase and angiotensin -1- converting enzyme activities. Int. J. Biomed. Sci. 10:4 (2014), 272–281.
78. Oboh, G., Ademiluyia, A.O., Akinyemia, A.J., Henleb, T., Saliua, J.A., Schwarzenbolzb, U., Inhibitory effect of polyphenol-rich extracts of jute leaf (Corchorus olitorius) on key enzyme linked to type 2 diabetes (a-amylase and a-glucosidase) and hypertension (angiotensin I converting) in vitro. J. Funct. Foods 4 (2012), 450–458, 10.1016/j.jff.2012.02.003.
79. Oboh, G., Ademosun, A.O., Shaddock peels (Citrus maxima) phenolic extracts inhibit a-amylase, a-glucosidase and angiotensin I-converting enzyme activities: a nutraceutical approach to diabetes management. Diabetes Metab. Syndr. Clin. Res. Rev. 5 (2011), 148–152, 10.1016/j.dsx.2012.02.008.
80. Oboh, G., Ademosun, A.O., Ademiluyi, A.O., Omojokun, O.S., Nwanna, E.E., Longe, K.O., in vitro studies on the antioxidant property and inhibition of amylase, glucosidase, and angiotensin i-converting enzyme by polyphenol-rich extracts from cocoa (Theobroma cacao) bean. Pathol. Res. Int., 2014, 2014, 549287, 10.1155/2014/549287.
81. Oboh, G., Ademosun, A.O., Odubanjo, O.V., Akinbola, I.A., Antioxidative properties and inhibition of key enzymes relevant to type-2 diabetes and hypertension by essential oils from black pepper. Adv. Pharmacol. Sci., 2013, 2013, 926047, 10.1155/2013/926047.
82. Oboh, G., Agunloye, O.M., Adefegha, S.A., Akinyemi, A.J., Ademiluyi, A.O., Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): a comparative study. J. Basic Clin. Physiol. Pharmacol. 26:2 (2015), 165–170, 10.1515/jbcpp-2013-0141.
83. Oboh, G., Ogunsuyi, O.B., Ogunbadejo, M.D., Adefegha, S.A., Influence of gallic acid on a-amylase and glucosidase inhibitory properties of acarbose. J. Food Drug Anal. 24 (2016), 627–634, 10.1016/j.jfda.2016.03.003.
84. Ojewole, J.A., Hypoglycemic and hypotensive effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract. Methods Find. Exp. Clin. Pharmacol. 27:10 (2005), 689–695.
85. Ojewole, J.A., Hypoglycaemic and hypotensive effects of Harpephyllum caffrum Bernh ex CF Krauss (Anacardiaceae) stem-bark aqueous extract in rats. Cardiovasc. J. S. Afr. 17:2 (2006), 67–72.
86. Ojewole, J.A., Adewole, S.O., Hypoglycaemic and hypotensive effects of Globimetula cupulata (DC) Van Tieghem (Loranthaceae) aqueous leaf extract in rats. Cardiovasc. J. S. Afr. 18:1 (2007), 9–15.
87. Ojewole, J.A., Adewole, S.O., Olayiwola, G., Hypoglycaemic and hypotensive effects of Momordica charantia Linn (Cucurbitaceae) whole-plant aqueous extract in rats. Cardiovasc. J. S. Afr. 17:5 (2006), 227–232.
88. Olaleye, M.T., Crown, O.O., Akinmoladun, A.C., Akindahunsi, A.A., Rutin and quercetin show greater efficacy than nifedipin in ameliorating hemodynamic, redox, and metabolite imbalances in sodium chloride-induced hypertensive rats. Hum. Exp. Toxicol. 33:6 (2014), 602–608, 10.1177/0960327113504790.
89. Ozougwu, J.C., Nigerian medicinal plants with anti-diabetic and anti-hypertensive properties. Eur. J. Med. Plants 21:3 (2017), 1–9, 10.9734/EJMP/2017/37468.
90. Patel, D.K., Kumar, R., Laloo, D., Hemalatha, S., Natural medicines from plant source used for therapy of diabetes mellitus: an overview of its pharmacological aspects. Asian Pac. J. Trop. Dis. 2012 (2012), 239–350, 10.1016/S2222-1808(12)60054-1.
91. Peng, N., Prasain, J.K., Dai, Y., Moore, R., Arabshahi, A., Barnes, S., Carlson, S., Wyss, J.M., Chronic dietary Kudzu isoflavones improve components of metabolic syndrome in stroke-prone spontaneously hypertensive rats. J. Agric. Food Chem. 57:16 (2009), 7268–7273, 10.1021/jf901169y.
92. Perez-Vizcaino, F., Duarte, J., Jimenez, R., Santos-Buelga, C., Osuna, A., Antihypertensive effects of the flavonoid quercetin. Pharmacol. Rep. 61 (2009), 67–75, 10.1016/S1734-1140(09)70008-8.
93. Pinto Mda, S., de Carvalho, J.E., Lajolo, F.M., Genovese, M.I., Shetty, K., evaluation of antiproliferative, anti-type 2 diabetes, and antihypertensive potential of ellagitannins from strawberries (Fragaria ananassa Duch.) using in vitro models. J. Med. Food 13:5 (2010), 1027–1035, 10.1089/jmf.2009.0257.
94. Pinto Mda, S., Kwon, Y.I., Apostolidis, E., Lajolo, F.M., Genovese, M.I., Shetty, K., Potential of Ginkgo biloba L. leaves in the management of hyperglycemia and hypertension using in vitro models. Bioresour. Technol. 100:24 (2009), 6599–6609, 10.1016/j.biortech.2009.07.021.
95. Pinto Mda, S., Ranilla, L.G., Apostolidis, E., Lajolo, F.M., Genovese, M.I., Shetty, K., Evaluation of antihyperglycemia and antihypertension potential of native Peruvian fruits using in vitro models. J. Med. Food 12:2 (2009), 278–291, 10.1089/jmf.2008.0113.
96. Preuss, H.G., Clouatre, D., Mohamadi, A., Jarrell, S.T., Wild garlic has a greater effect than regular garlic on blood pressure and blood chemistries of rats. Int. Urol. Nephrol. 32:4 (2001), 525–530.
97. Prince, P.S.M., Kamalakkannan, N., Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes. J. Biochem. Mol. Toxicol. 20:2 (2006), 96–102, 10.1002/jbt.20117.
98. Priscilla, D.H., Jayakumar, M., Thirumurugan, K., Flavanone naringenin: an effective antihyperglycemic and antihyperlipidemic nutraceutical agent on high fat diet fed streptozotocin induced type 2 diabetic rats. J. Funct. Foods 14 (2015), 363–373, 10.1016/j.jff.2015.02.005.
99. Priscilla, D.H., Roy, D., Suresh, A., Kumar, V., Thirumurugan, K., Naringenin inhibits a-glucosidase activity: a promising strategy for the regulation of postprandial hyperglycemia in high fat diet fed streptozotocin induced diabetic rats. Chem. Biol. Interact. 210 (2014), 77–85, 10.1016/j.cbi.2013.12.014.
100. Ranilla, L.G., Apostolidis, E., Genovese, M.I., Lajolo, F.M., Shetty, K., Evaluation of indigenous grains from the Peruvian Andean region for antidiabetes and antihypertension potential using in vitro methods. J. Med. Food 12:4 (2009), 704–713, 10.1089/jmf.2008.0122.
101. Ranilla, L.G., Kwon, Y.I., Apostolidis, E., Shetty, K., Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America. Bioresour. Technol. 101:12 (2010), 4676–4689, 10.1016/j.biortech.2010.01.093.
102. Saganuwan, A.S., Tropical Plants with Antihypertensive, Antiasthmatic, and Antidiabetic Value. J. Herbs Spices Med. Plants 15:1 (2009), 24–44, 10.1080/10496470902787477.
103. Sánchez-Salgado, J.C., Ortiz-Andrade, R.R., Aguirre-Crespo, F., Vergara-Galicia, J., Le´on-Rivera, I., Montes, S., Villalobos-Molina, R., Estrada-Soto, S., Hypoglycemic, vasorelaxant and hepatoprotective effects of Cochlospermum vitifolium (Willd.) Sprengel: a potential agent for the treatment of metabolic syndrome. J. Ethnopharmacol. 109 (2007), 400–405.
104. Sharifi-Rad, M., Tayeboon, G.S., Sharifi-Rad, J., Iriti, M., Varoni, E.M., Razazi, S., Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of Veronica persica phenolic-rich extracts. Cell Mol. Biol. (Noisy-Le-Grand) 62:6 (2016), 80–85, 10.14715/cmb/2016.62.6.15.
105. Shodehinde, S.A., Ademiluyi, A.O., Oboh, G., Akindahunsi, A.A., Contribution of Musa paradisiaca in the inhibition of α-amylase, α-glucosidase and Angiotensin-I converting enzyme in streptozotocin induced rats. Life Sci. 133 (2015), 8–14, 10.1016/j.lfs.2015.03.026.
106. Siah, S.D., Konczak, I., Agboola, S., Wood, J.A., Blanchard, C.L., In vitro investigations of the potential health benefits of Australian-grown faba beans (Vicia faba L.): chemopreventative capacity and inhibitory effects on the angiotensin-converting enzyme, a-glucosidase and lipase. Br. J. Nutr. 108 (2012), S123–S134, 10.1017/S0007114512000803.
107. Srividya, N., Periwal, S., Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus. Indian J. Exp. Biol. 33:11 (1995), 861–864.
108. Suzuki, A., Yamamoto, N., Jokura, H., Yamamoto, M., Fujii, A., Tokimitsu, I., Saito, I., Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. J. Hypertens. 24:6 (2006), 1065–1073, 10.1097/01.hjh.0000226196.67052.c0.
109. Tahraoui, A., El-Hilaly, J., Israili, Z.H., Lyoussi, B., Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). J. Ethnopharmacol. 110:1 (2007), 105–117, 10.1016/j.jep.2006.09.011.
110. Touyz, R.M., Schiffrin, E.L., Hypertension Methods and Protocols, Methods in Molecular Biology. 2017, Springer, New York (ISBN 978-1-4939-6625-7).
111. Tsabang, N., Yedjou, C.G., Tsambang, L., Tchinda, A.T., Donfagsiteli, N., Agbor, G.A., Tchounwou, P., Nkongmeneck, B.A., Treatment of Diabetes and/or Hypertension Using Medicinal Plants in Cameroon. Med. Aromat. Plants (Los Angel)., 2015, 10.4172/2167-0412.S2-003.
112. Vessal, M., Hemmati, M., Vasei, M., Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 135C:3 (2003), 357–364, 10.1016/S1532-0456(03)00140-6.
113. Villiger, A., Sala, F., Suter, A., Butterweck, V., In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome. Phytomedicine 22:1 (2015), 138–144, 10.1016/j.phymed.2014.11.015.
114. Whalen, K.L., Stewart, R.D., Pharmacologic management of hypertension in patients with diabetes. Am. Fam. Physician 78:11 (2008), 1277–1282.
115. Wong, K.H., Li, G.Q., Li, K.M., Razmovski-Naumovski, V., Chan, K., Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. J. Ethnopharmacol. 134:3 (2011), 584–607, 10.1016/j.jep.2011.02.001.
116. Wu, T., Zhou, X., Deng, Y., Jing, Q., Li, M., Yuan, L., In vitro studies of Gynura divaricata (L.) DC extracts as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. J. Ethnopharmacol. 136:2 (2011), 305–308, 10.1016/j.jep.2011.04.059.
117. Xiao, Y.L., Lu, F.E., Xu, L.J., Leng, S.H., Wang, K.F., Protective effects of Huanglian Jiedu decoction on vascular endothelial function in type 2 diabetic rats. Zhongguo Zhong Yao Za Zhi. 30:22 (2005), 1767–1770.
118. Zar, C.T., Das, S., Potential effect of herbs on diabetic hypertension: alternative medicine treatment modalities. Clin. Ter. 164:6 (2013), 529–535, 10.7417/CT.2013.1633.
119. Ziyyat, A., Legssyer, A., Mekhfi, H., Dassouli, A., Serhrouchni, M., Benjelloun, W., Phytotherapy of hypertension and diabetes in oriental Morocco. J. Ethnopharmacol. 58:1 (1997), 45–54, 10.1016/S0378-8741(97)00077-9.