Antioxidant, Antidiabetic, and Antihypertensive Properties of Echinacea purpurea Flower Extract and Caffeic Acid Derivatives Using in Vitro Models

Journal of Medicinal Food

Volumn 20, Issue 2, 2017, Pages 171-179

  Chiou, Shiow Ying ^a   Sung, Jih Min ^a   Huang, Po Wei ^a   Lin, Sheng Dun ^a  

^a HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

angiotensin converting enzyme; antioxidant activity; caffeic acid derivatives; Echinacea purpurea; Amylase; glucosidase

Indexed keywords

ALPHA GLUCOSIDASE; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTIOXIDANT; BETA AMYLASE; CAFFEIC ACID; CAFFEIC ACID DERIVATIVE; CHLOROGENIC ACID; CICHORIC ACID; DIPEPTIDYL CARBOXYPEPTIDASE; ECHINACEA PURPUREA EXTRACT; PHENOL DERIVATIVE; AMYLASE; ENZYME INHIBITOR; PLANT EXTRACT;

ANTIDIABETIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; DRUG ISOLATION; ECHINACEA PURPUREA; ENZYME ACTIVITY; HYPERGLYCEMIA; HYPERTENSION; IN VITRO STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ECHINACEA; FLOWER; HUMAN; KINETICS;

ALPHA-AMYLASES; ALPHA-GLUCOSIDASES; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; CAFFEIC ACIDS; ECHINACEA; ENZYME INHIBITORS; FLOWERS; HUMANS; HYPOGLYCEMIC AGENTS; KINETICS; PEPTIDYL-DIPEPTIDASE A; PHENOLS; PLANT EXTRACTS;

EID: 85011421257     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2016.3790     Document Type: Article

References (37)

1. Oboh G, Bello FO, Ademosun AO, Akinyemi, AJ, Adewuni TM: Antioxidant, hypolipidemic, and anti-angiotensin-1-converting enzyme properties of lemon (Citrus limon) and lime (Citrus aurantifolia) juices. Comp Clin Path 2015;24:1395-1406
2. Adefegha, SA, Oyeleye SI, Oboh G: Distribution of phenolic contents, antidiabetic potentials, antihypertensive properties, and antioxidative effects of soursop (Annona muricata L.) fruit parts in vitro. Biochem Res Int 2015;2015:347673
3. Chiang YC, Chen CL, Jeng TL, Sung JM: In vitro inhibitory effects of cranberry bean (Phaseolus vulgaris L.) extracts on aldose reductase, a-glucosidase and a-amylase. Int J Food Sci Tech 2014;49:1470-1479
4. Pinto MS, de Carvalho JE, Lajolo FM, Genovese MI, Shetty K: Evaluation of antiproliferative, anti-type 2 diabetes, and antihypertension potentials of ellagitannins from strawberries (Fragaria ananassa Duch.) using in vitro models. J Med Food 2010;13:1027-1035
5. Hanhineva K, Törrönen R, Bondia-Pons I, et al.: Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci 2010;11:1365-1402
6. Ademiluyi AO, Oboh G, Ogunsuyi OB, Oloruntoba FM: A comparative study on antihypertensive and antioxidant properties of phenolic extracts from fruit and leaf of some guava (Psidium guajava L.) varieties. Comp Clin Path 2016;25:363-374
7. Sharifi N, Souri E, Ziai SA, Amin G, Amanlou M: Discovery of new angiotensin converting enzyme (ACE) inhibitors from medicinal plants to treat hypertension using an in vitro assay. DARU J 2013;21:74
8. Taler SJ, Agarwal R, Bakris GL, et al.: KDOQI US commentary on the 2012 KDIGO clinical practice guideline for management of blood pressure in CKD. Am J Kidney Dis 2013;62:201-213
9. Zhang ZL, Lia QL, Lia BG, et al.: Three angiotensin-converting enzyme inhibitors from Rabdosia coetsa. Phytomedicine 2008;15: 386-388
10. Penas E, Limón RI, Martnez-Villaluenga C, et al.: Impact of elicitation on antioxidant and potential antihypertensive properties of lentil sprouts. Plant Food Hum Nutr 2015;70:401-407
11. Schiffrin EL: Antioxidants in hypertension and cardiovascular diseases. Mol Interv 2010;10:354-362
12. Actis-Goretta L, Ottaviani JI, Fraga CG: Inhibition of angiotensin converting enzyme activity by flavanol-rich foods. J Agric Food Chem 2006;54:229-234
13. Thygesen L, Thulinn J, Mortensen A, Skibsted LH, Molgaard P: Antioxidant activity of cichoric acid and alkamides from Echinacea purpurea, alone and in combination. Food Chem 2007; 101:74-81
14. Barnes J, Anderson LA, Gibbons S, Phillipson JD: Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): A review of their chemistry, pharmacology and clinical properties. J Pharm Pharmacol 2005;57:929-954
15. Bauer R, Wagner H: Echinacea species as potential immunostimulating drugs. In: Economic and Medicinal Plant Research, Vol. 5. (Wagner H, Farnsworth NR, ed.), Academic Press, New York, 1991, pp. 253-321
16. Pellati F, Benvenuti S, Magro L, Melegari M, Soragni F: Analysis of phenolic compounds and radical scavenging activity of Echinacea spp. J Pharm Biomed Anal 2004;35:289-301
17. Tsai YL, Chiu CC, Chen JYF, Chan KC, Lin SD: Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis. J Ethnopharmacol 2012;143:914-919
18. Lin SD, Sung JM, Chen CL: Effect of drying and storage conditions on caffeic acid derivatives and total phenolics of Echinacea purpurea grown in Taiwan. Food Chem 2011;125: 226-231
19. Chen YL, Sung JM, Lin SD: Effect of extraction methods on the active compounds and antioxidant properties of ethanolic extracts of Echinacea purpurea flower. Am J Plant Sci 2015;6: 201-212
20. Tsai YL, Chiou SY, Chan KC, Sung JM, Lin SD: Caffeic acid derivatives, total phenols, antioxidant and antimutagenic activities of Echinacea purpurea flower extracts. LWT-Food Sci Technol 2012;46:169-176
21. Yilmazer-Musa M, Griffith, AM, Michels AJ, Schneider E, Frei, B: Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of a-amylase and a-glucosidase activity. J Agric Food Chem 2012;60:8924-8929
22. Lin TC: The analysis of caffeic acid derivatives and antioxidant capacity in Echinacea spp. MS thesis, National Chung Hsing University, Taichung, Taiwan, 2003
23. Halliwell B: Antioxidants in human health and disease. Annu Rev Nutr 1996;16:33-50
24. Prior RL: Fruits and vegetables in the prevention of cellular oxidative damage. Am J Clin Nutr 2003;78:570S-578S
25. Ebrahimzadeh MA, Pourmorad F, Bekhradnia AR: Iron chelating activity, phenol and flavonoid content of some medicinal plants from Iran. Afr J Biotechnol 2008;7:3188-3192
26. Yamauchi R, Tatsumi Y, Asano M, Kato K, Ueno Y: Effect of metal salts fructose on the autoxidation of methyl linoleate in emulsions. Agric Biol Chem 1988;52:849-850
27. Shahidi F, Janitha PK, Wanasundara PD: Phenolic antioxidants. Crit Rev Food Sci Nutr 1992;32:67-103
28. Kwon YI, Vattem DV, Shetty K: Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:107-118
29. Pinto MS, Kwon YI, Apostolidis E, et al.: Functionality of bioactive compounds of Brazilian strawberry (Fragaria ananassa Duch.) cultivars: Evaluation of hyperglycemia and hypertension potential. J Agric Food Chem 2008;56:4386-4392
30. Ranilla LG, Kwon YI, Genovese MI, Lajolo FM, Shetty K: Effect of thermal treatment on phenolic compounds and functionality linked to type 2 diabetes and hypertension management of Peruvian and Brazilian bean cultivars (Phaseolus vulgaris L.) using in vitro methods. J Food Biochem 2010;34: 329-355
31. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS: Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 2003;26:1277-1294
32. Piparo EL, Scheib H, Frei N, et al.: Flavonoids for controlling starch digestion: Structure requirements for inhibiting human aamylase. J Med Chem 2008;51:3555-3561
33. Rosak C, Mertes G: Critical evaluation of the role of acarbose in the treatment of diabetes: Patient considerations. Diabetes Metab Syndr Obes 2012;5:357-367
34. Qian M, Nahoum V, Bonicel J, et al.: Enzyme-catalyzed condensation reaction in a mammalian a-amylase high-resolution structure analysis of an enzyme-inhibitor complex. Biochemistry 2001;40:7700-7709
35. Naim HY, Niermann T, Kleinhans U, Hollenberg CP, Strasser AWM: Striking structural and functional similarities suggest that intestinal sucrase-isomaltase, human lysosomal a-glucosidase and Schwanniomyces occidentalis glucoamylase are derived from a common ancestral gene. FEBS Lett 1991;294:109-112
36. Oboh G, Ademiluyi AO, Akinyemi AJ, et al.: Inhibitory effect of polyphenolrich extracts of jute leaf (Corchorus olitorius) on key enzyme linked to type 2 diabetes (a-amylase and a-glucosidase) and hypertension (angiotensin I converting) in vitro. J Funct Foods 2012;4:450-458
37. Umamaheswari M, Ajith MP, Asokkumar K, et al.: In vitro angiotensin converting enzyme inhibitory and antioxidant activities of methanolic seed extract of Apium graveolens Linn. J Pharmaceut Allied Sci 2011;8:1400-1410.