Discovery and Engineering of Cytochrome P450s for Terpenoid Biosynthesis

Trends in Biotechnology

Volumn 37, Issue 6, 2019, Pages 618-631

  Xiao, Han ^a   Zhang, Yue ^a,b,c   Wang, Meng ^b,c  

^a Shanghai Jiao Tong University   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c Chinese Academy of Sciences   (China)

Author keywords

cytochrome P450s (CYPs); discovery; engineering; synthetic biology; terpenoid

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; DRUG PRODUCTS; ENGINEERING;

BIOSYNTHETIC PATHWAY; DISCOVERY; DRUG CANDIDATES; HETEROLOGOUS PRODUCTION; NATURAL PRODUCTS; SYNTHETIC BIOLOGY; TERPENOIDS;

LIPIDS;

CYTOCHROME P450; CYTOCHROME P450 101A1; CYTOCHROME P450 260A1; CYTOCHROME P450 264B1; CYTOCHROME P450 5150L8; CYTOCHROME P450 51H10; CYTOCHROME P450 716A12; CYTOCHROME P450 716A75; CYTOCHROME P450 725A4; CYTOCHROME P450 750B1; CYTOCHROME P450 76AH1; CYTOCHROME P450 87D16; CYTOCHROME P450 93E2; CYTOCHROME P450 BM3; UNCLASSIFIED DRUG; TERPENE;

BIOSYNTHESIS; DIRECTED EVOLUTION; ENZYMATIC ASSAY; EVOLUTION; GENE DELETION; GENE SILENCING; HETEROLOGOUS EXPRESSION; IN VITRO STUDY; METABOLIC ENGINEERING; MULTIOMICS; NONHUMAN; OMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ENGINEERING; PROTEIN MODIFICATION; RATIONAL PROTEIN DESIGN; REVIEW; SYNTHETIC BIOLOGY; TERPENOID BIOSYNTHESI; BACTERIUM; FUNGUS; GENETICS; METABOLISM;

BACTERIA; BIOSYNTHETIC PATHWAYS; CYTOCHROME P-450 ENZYME SYSTEM; FUNGI; METABOLIC ENGINEERING; SYNTHETIC BIOLOGY; TERPENES;

EID: 85057719613     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2018.11.008     Document Type: Review

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