Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering

Nature Biotechnology

Volumn 35, Issue 1, 2017, Pages 48-55

  Garst, Andrew D ^a,b   Bassalo, Marcelo C ^a,c   Pines, Gur ^a   Lynch, Sean A ^a   Halweg Edwards, Andrea L ^a,b   Liu, Rongming ^a   Liang, Liya ^a   Wang, Zhiwen ^a,d   Zeitoun, Ramsey ^a   Alexander, William G ^b   Gill, Ryan T ^a  

^a University of Colorado at Boulder   (United States)

^b Muse Biotechnology Inc   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d TIANJIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; GENE ENCODING; NUCLEIC ACIDS; PROTEINS;

ANTIBIOTIC RESISTANCE GENES; COMPREHENSIVE ASSESSMENT; GENOME ENGINEERING; GENOME WIDE ANALYSIS; HIGH-THROUGHPUT METHOD; MASSIVELY PARALLELS; PROTEIN ENGINEERING; SATURATION MUTAGENESIS;

GENES;

BACTERIAL PROTEIN; GUIDE RNA; NUCLEOTIDE; OLIGOMER; PROTEOME;

ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; CRISPR CAS SYSTEM; GENE EDITING; GENE LOCUS; GENE MAPPING; GENE SYNTHESIS; GENOTYPE PHENOTYPE CORRELATION; METABOLIC ENGINEERING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; ALGORITHM; BACTERIAL GENOME; CHROMOSOMAL MAPPING; DNA MUTATIONAL ANALYSIS; FUNGAL GENOME; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLOME; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SINGLE NUCLEOTIDE POLYMORPHISM; SOFTWARE;

ALGORITHMS; CHROMOSOME MAPPING; DNA MUTATIONAL ANALYSIS; GENE EDITING; GENOME, BACTERIAL; GENOME, FUNGAL; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; METABOLIC ENGINEERING; METABOLOME; NUCLEOTIDES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN ENGINEERING; PROTEOME; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOFTWARE;

EID: 85011034228     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3718     Document Type: Article

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