Enantioselective Total Synthesis of Nigelladine A via Late-Stage C-H Oxidation Enabled by an Engineered P450 Enzyme

Journal of the American Chemical Society

Volumn 139, Issue 30, 2017, Pages 10196-10199

  Loskot, Steven A ^a   Romney, David K ^a   Arnold, Frances H ^a   Stoltz, Brian M ^a  

^a California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENANTIOSELECTIVITY; ENZYMES; OXIDATION; REACTION INTERMEDIATES; SYNTHESIS (CHEMICAL);

CHEMICAL METHOD; CYTOCHROME P450 ENZYMES; ENANTIOSELECTIVE TOTAL SYNTHESIS; LATE STAGE; P450 ENZYMES; REGIO-SELECTIVE; TO EFFECT;

REGIOSELECTIVITY;

ALKALOID; CYTOCHROME P450; NIGELLADINE A; UNCLASSIFIED DRUG; DITERPENE;

ARTICLE; CHEMICAL STRUCTURE; ENANTIOSELECTIVITY; OXIDATION; REGIOSELECTIVITY; SYNTHESIS; CHEMISTRY; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN ENGINEERING; STEREOISOMERISM;

CYTOCHROME P-450 ENZYME SYSTEM; DITERPENES; OXIDATION-REDUCTION; PROTEIN ENGINEERING; STEREOISOMERISM;

EID: 85026846169     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.7b05196     Document Type: Article

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