Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis

Metabolic Engineering

Volumn 37, Issue , 2016, Pages 24-34

  Jia, Meirong ^a   Potter, Kevin C ^a,b   Peters, Reuben J ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Diterpene synthases; Diterpenes; Metabolic engineering; Substrate specificity

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; METABOLIC ENGINEERING; METABOLISM;

COMBINATORIAL BIOSYNTHESIS; DITERPENE CYCLASES; DITERPENE SYNTHASES; DITERPENES; DIVERSE RANGE; HYDROXYL GROUPS; PHYSIOLOGICAL FUNCTIONS; SUBSTRATE SPECIFICITY;

OLEFINS;

ALKENE; BACTERIAL ENZYME; DITERPENE; DITERPENE SYNTHASE; HYDROXYL GROUP; SYNTHETASE; UNCLASSIFIED DRUG; VEGETABLE PROTEIN; PLANT PROTEIN; RECOMBINANT PROTEIN; TERPENE SYNTHASE; TRANSFERASE;

ARTICLE; BIOSYNTHESIS; COMBINATORIAL CHEMISTRY; CYCLIZATION; MASS FRAGMENTOGRAPHY; METABOLIC ENGINEERING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PRECURSOR; PRIORITY JOURNAL; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; GENETIC RECOMBINATION; GENETICS; METABOLIC FLUX ANALYSIS; METABOLISM; PROCEDURES;

ALKYL AND ARYL TRANSFERASES; BIOSYNTHETIC PATHWAYS; DITERPENES; ESCHERICHIA COLI; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; METABOLIC NETWORKS AND PATHWAYS; PLANT PROTEINS; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC;

EID: 84962850728     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.04.001     Document Type: Article

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