메뉴 건너뛰기




Volumn 27, Issue 1, 2015, Pages 286-301

OSC2 and CYP716A14V2 catalyze the biosynthesis of triterpenoids for the cuticle of aerial organs of Artemisia annua

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISIA ANNUA; NICOTIANA BENTHAMIANA; SACCHAROMYCES CEREVISIAE;

EID: 84923041998     PISSN: 10404651     EISSN: 1532298X     Source Type: Journal    
DOI: 10.1105/tpc.114.134486     Document Type: Article
Times cited : (98)

References (53)
  • 1
    • 35349022993 scopus 로고    scopus 로고
    • A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharo-myces cerevisiae
    • Alberti, S., Gitler, A.D., and Lindquist, S. (2007). A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharo-myces cerevisiae. Yeast 24: 913–919.
    • (2007) Yeast , vol.24 , pp. 913-919
    • Alberti, S.1    Gitler, A.D.2    Lindquist, S.3
  • 2
    • 79952900480 scopus 로고    scopus 로고
    • Molecular activities, biosynthesis and evolution of triterpenoid saponins
    • Augustin, J.M., Kuzina, V., Andersen, S.B., and Bak, S. (2011). Molecular activities, biosynthesis and evolution of triterpenoid saponins. Phytochemistry 72: 435–457.
    • (2011) Phytochemistry , vol.72 , pp. 435-457
    • Augustin, J.M.1    Kuzina, V.2    Ersen, S.B.3    Bak, S.4
  • 3
    • 33750689113 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a multifunctional triterpene synthase cDNA from a mangrove species Kandelia candel (L.) Druce
    • Basyuni, M., Oku, H., Inafuku, M., Baba, S., Iwasaki, H., Oshiro, K., Okabe, T., Shibuya, M., and Ebizuka, Y. (2006). Molecular cloning and functional expression of a multifunctional triterpene synthase cDNA from a mangrove species Kandelia candel (L.) Druce. Phy-tochemistry 67: 2517–2524.
    • (2006) Phy-Tochemistry , vol.67 , pp. 2517-2524
    • Basyuni, M.1    Oku, H.2    Inafuku, M.3    Baba, S.4    Iwasaki, H.5    Oshiro, K.6    Okabe, T.7    Shibuya, M.8    Ebizuka, Y.9
  • 4
    • 0002944810 scopus 로고    scopus 로고
    • Secondary metabolites of Artemisia annua and their biological activity
    • Bhakuni, R.S., Jain, D.C., Sharma, R.P., and Kumar, S. (2001). Secondary metabolites of Artemisia annua and their biological activity. Curr. Sci. 80: 35–48.
    • (2001) Curr. Sci , vol.80 , pp. 35-48
    • Bhakuni, R.S.1    Jain, D.C.2    Sharma, R.P.3    Kumar, S.4
  • 5
    • 78651274406 scopus 로고    scopus 로고
    • The genus Artemisia: A comprehensive review
    • Bora, K.S., and Sharma, A. (2011). The genus Artemisia: a comprehensive review. Pharm. Biol. 49: 101–109.
    • (2011) Pharm. Biol , vol.49 , pp. 101-109
    • Bora, K.S.1    Sharma, A.2
  • 6
    • 79959941055 scopus 로고    scopus 로고
    • An unusual plant triterpene synthase with predominant a-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus 3 domestica
    • Brendolise, C., Yauk, Y.K., Eberhard, E.D., Wang, M., Chagne, D., Andre, C., Greenwood, D.R., and Beuning, L.L. (2011). An unusual plant triterpene synthase with predominant a-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus 3 domestica. FEBS J. 278: 2485–2499.
    • (2011) FEBS J , vol.278 , pp. 2485-2499
    • Brendolise, C.1    Yauk, Y.K.2    Eberhard, E.D.3    Wang, M.4    Chagne, D.5    Re, C.6    Greenwood, D.R.7    Beuning, L.L.8
  • 7
    • 29344438247 scopus 로고    scopus 로고
    • Ontogenetic variation in chemical and physical characteristics of adaxial apple leaf surfaces
    • Bringe, K., Schumacher, C.F., Schmitz-Eiberger, M., Steiner, U., and Oerke, E.C. (2006). Ontogenetic variation in chemical and physical characteristics of adaxial apple leaf surfaces. Phytochemistry 67: 161–170.
    • (2006) Phytochemistry , vol.67 , pp. 161-170
    • Bringe, K.1    Schumacher, C.F.2    Schmitz-Eiberger, M.3    Steiner, U.4    Oerke, E.C.5
  • 8
    • 79251496983 scopus 로고    scopus 로고
    • Composition differences between epicuticular and intracuticular wax substructures: How do plants seal their epidermal surfaces
    • Buschhaus, C., and Jetter, R. (2011). Composition differences between epicuticular and intracuticular wax substructures: how do plants seal their epidermal surfaces? J. Exp. Bot. 62: 841–853.
    • (2011) J. Exp. Bot , vol.62 , pp. 841-853
    • Buschhaus, C.1    Jetter, R.2
  • 9
    • 84905538254 scopus 로고    scopus 로고
    • Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins
    • Carelli, M., et al. (2011). Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins. Plant Cell 23: 3070–3081.
    • (2011) Plant Cell , vol.23 , pp. 3070-3081
    • Carelli, M.1
  • 10
    • 84861889349 scopus 로고    scopus 로고
    • Transcriptional machineries in jasmonate-elicited plant secondary metabolism
    • De Geyter, N., Gholami, A., Goormachtig, S., and Goossens, A. (2012). Transcriptional machineries in jasmonate-elicited plant secondary metabolism. Trends Plant Sci. 17: 349–359.
    • (2012) Trends Plant Sci , vol.17 , pp. 349-359
    • De Geyter, N.1    Gholami, A.2    Goormachtig, S.3    Goossens, A.4
  • 11
    • 0028042851 scopus 로고
    • Localization of artemisinin and artemisitene in foliar tissues of glanded and glandless biotypes of Artemisia annua L
    • Duke, M.V., Paul, R.N., Elsohly, H.N., Sturtz, G., and Duke, S.O. (1994). Localization of artemisinin and artemisitene in foliar tissues of glanded and glandless biotypes of Artemisia annua L. Int. J. Plant Sci. 155: 365–372.
    • (1994) Int. J. Plant Sci , vol.155 , pp. 365-372
    • Duke, M.V.1    Paul, R.N.2    Elsohly, H.N.3    Sturtz, G.4    Duke, S.O.5
  • 12
    • 0037312874 scopus 로고    scopus 로고
    • Functional genomics approach to the study of triterpene biosynthesis
    • Ebizuka, Y., Katsube, Y., Tsutsumi, T., Kushiro, T., and Shibuya, M. (2003). Functional genomics approach to the study of triterpene biosynthesis. Pure Appl. Chem. 75: 369–374.
    • (2003) Pure Appl. Chem , vol.75 , pp. 369-374
    • Ebizuka, Y.1    Katsube, Y.2    Tsutsumi, T.3    Kushiro, T.4    Shibuya, M.5
  • 13
    • 0028926025 scopus 로고
    • Developmental studies of Artemisia annua: Flowering and artemisinin production under greenhouse and field conditions
    • Ferreira, J.F., Simon, J.E., and Janick, J. (1995). Developmental studies of Artemisia annua: flowering and artemisinin production under greenhouse and field conditions. Planta Med. 61: 167–170.
    • (1995) Planta Med , vol.61 , pp. 167-170
    • Ferreira, J.F.1    Simon, J.E.2    Janick, J.3
  • 15
    • 74549123642 scopus 로고    scopus 로고
    • The genetic map of Artemisia annua L. Identifies loci affecting yield of the antimalarial drug artemisinin
    • Graham, I.A., et al. (2010). The genetic map of Artemisia annua L. identifies loci affecting yield of the antimalarial drug artemisinin. Science 327: 328–331.
    • (2010) Science , vol.327 , pp. 328-331
    • Graham, I.A.1
  • 16
    • 84866386264 scopus 로고    scopus 로고
    • Cytochrome P450 CYP716A53v2 catalyzes the formation of proto-panaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng
    • Han, J.Y., Hwang, H.S., Choi, S.W., Kim, H.J., and Choi, Y.E. (2012). Cytochrome P450 CYP716A53v2 catalyzes the formation of proto-panaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol. 53: 1535–1545.
    • (2012) Plant Cell Physiol , vol.53 , pp. 1535-1545
    • Han, J.Y.1    Hwang, H.S.2    Choi, S.W.3    Kim, H.J.4    Choi, Y.E.5
  • 17
    • 83255165496 scopus 로고    scopus 로고
    • The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng
    • Han, J.Y., Kim, H.J., Kwon, Y.S., and Choi, Y.E. (2011). The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol. 52: 2062–2073.
    • (2011) Plant Cell Physiol , vol.52 , pp. 2062-2073
    • Han, J.Y.1    Kim, H.J.2    Kwon, Y.S.3    Choi, Y.E.4
  • 18
    • 84890471488 scopus 로고    scopus 로고
    • The involvement of b-amyrin 28-oxidase (CYP716A52v2) in oleanane-type ginsenoside biosynthesis in Panax ginseng
    • Han, J.Y., Kim, M.J., Ban, Y.W., Hwang, H.S., and Choi, Y.E. (2013). The involvement of b-amyrin 28-oxidase (CYP716A52v2) in oleanane-type ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol. 54: 2034–2046.
    • (2013) Plant Cell Physiol , vol.54 , pp. 2034-2046
    • Han, J.Y.1    Kim, M.J.2    Ban, Y.W.3    Hwang, H.S.4    Choi, Y.E.5
  • 19
    • 45449087921 scopus 로고    scopus 로고
    • QBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data
    • Hellemans, J., Mortier, G., De Paepe, A., Speleman, F., and Vandesompele, J. (2007). qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biol. 8: R19.
    • (2007) Genome Biol , vol.8 , pp. R19
    • Hellemans, J.1    Mortier, G.2    De Paepe, A.3    Speleman, F.4    Vandesompele, J.5
  • 20
    • 84868091024 scopus 로고    scopus 로고
    • Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus
    • Huang, L., Li, J., Ye, H., Li, C., Wang, H., Liu, B., and Zhang, Y. (2012). Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. Planta 236: 1571–1581.
    • (2012) Planta , vol.236 , pp. 1571-1581
    • Huang, L.1    Li, J.2    Ye, H.3    Li, C.4    Wang, H.5    Liu, B.6    Zhang, Y.7
  • 21
    • 0342803564 scopus 로고    scopus 로고
    • Leaf cuticular waxes are arranged in chemically and mechanically distinct layers: Evidence from Prunus laurocerasus L
    • Jetter, R., Schäffer, S., and Riederer, M. (2000). Leaf cuticular waxes are arranged in chemically and mechanically distinct layers: evidence from Prunus laurocerasus L. Plant Cell Environ. 23: 619–628.
    • (2000) Plant Cell Environ , vol.23 , pp. 619-628
    • Jetter, R.1    Schäffer, S.2    Riederer, M.3
  • 22
    • 0036581417 scopus 로고    scopus 로고
    • GATEWAY vectors for Agrobacterium-mediated plant transformation
    • Karimi, M., Inzé, D., and Depicker, A. (2002). GATEWAY vectors for Agrobacterium-mediated plant transformation. Trends Plant Sci. 7: 193–195.
    • (2002) Trends Plant Sci , vol.7 , pp. 193-195
    • Karimi, M.1    Inzé, D.2    Depicker, A.3
  • 23
    • 0000108956 scopus 로고
    • Subcellular-localization of saponins in green and etiolated leaves and green protoplasts of oat (Avena sativa L)
    • Kesselmeier, J., and Urban, B. (1983). Subcellular-localization of saponins in green and etiolated leaves and green protoplasts of oat (Avena sativa L). Protoplasma 114: 133–140.
    • (1983) Protoplasma , vol.114 , pp. 133-140
    • Kesselmeier, J.1    Urban, B.2
  • 25
    • 41549107616 scopus 로고    scopus 로고
    • Engineering triterpene production in Saccharomyces cerevisiae-b-amyrin synthase from Artemisia annua
    • Kirby, J., Romanini, D.W., Paradise, E.M., and Keasling, J.D. (2008). Engineering triterpene production in Saccharomyces cerevisiae-b-amyrin synthase from Artemisia annua. FEBS J. 275: 1852–1859.
    • (2008) FEBS J , vol.275 , pp. 1852-1859
    • Kirby, J.1    Romanini, D.W.2    Paradise, E.M.3    Keasling, J.D.4
  • 26
    • 34548757971 scopus 로고    scopus 로고
    • An oxidosqualene cyclase makes numerous products by diverse mechanisms: A challenge to prevailing concepts of triterpene biosynthesis
    • Lodeiro, S., Xiong, Q., Wilson, W.K., Kolesnikova, M.D., Onak, C.S., and Matsuda, S.P. (2007). An oxidosqualene cyclase makes numerous products by diverse mechanisms: a challenge to prevailing concepts of triterpene biosynthesis. J. Am. Chem. Soc. 129: 11213–11222.
    • (2007) J. Am. Chem. Soc , vol.129 , pp. 11213-11222
    • Lodeiro, S.1    Xiong, Q.2    Wilson, W.K.3    Kolesnikova, M.D.4    Onak, C.S.5    Matsuda, S.P.6
  • 28
    • 0001031993 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase
    • Morita, M., Shibuya, M., Kushiro, T., Masuda, K., and Ebizuka, Y. (2000). Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase. Eur. J. Biochem. 267: 3453-3460.
    • (2000) Eur. J. Biochem , vol.267 , pp. 3453-3460
    • Morita, M.1    Shibuya, M.2    Kushiro, T.3    Masuda, K.4    Ebizuka, Y.5
  • 31
    • 84883054025 scopus 로고    scopus 로고
    • Bioengineering of plant (tri)terpenoids: From metabolic engineering of plants to synthetic biology in vivo and in vitro
    • Moses, T., Pollier, J., Thevelein, J.M., and Goossens, A. (2013). Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro. New Phytol. 200: 27-43.
    • (2013) New Phytol , vol.200 , pp. 27-43
    • Moses, T.1    Pollier, J.2    Thevelein, J.M.3    Goossens, A.4
  • 32
    • 48249155450 scopus 로고    scopus 로고
    • The leaf epidermome of Catharanthus roseus reveals its biochemical specialization
    • Murata, J., Roepke, J., Gordon, H., and De Luca, V. (2008). The leaf epidermome of Catharanthus roseus reveals its biochemical specialization. Plant Cell 20: 524-542.
    • (2008) Plant Cell , vol.20 , pp. 524-542
    • Murata, J.1    Roepke, J.2    Gordon, H.3    De Luca, V.4
  • 34
    • 77952869007 scopus 로고    scopus 로고
    • Comparison of cytochrome P450 genes from six plant genomes
    • Nelson, D.R., Ming, R., Alam, M., and Schuler, M.A. (2008). Comparison of cytochrome P450 genes from six plant genomes. Trop. Plant Biol. 1: 216-235.
    • (2008) Trop. Plant Biol , vol.1 , pp. 216-235
    • Nelson, D.R.1    Ming, R.2    Alam, M.3    Schuler, M.A.4
  • 36
    • 69249228525 scopus 로고    scopus 로고
    • Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L
    • Olsson, M.E., Olofsson, L.M., Lindahl, A.L., Lundgren, A., Brodelius, M., and Brodelius, P.E. (2009). Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L. Phytochemistry 70: 1123-1128.
    • (2009) Phytochemistry , vol.70 , pp. 1123-1128
    • Olsson, M.E.1    Olofsson, L.M.2    Lindahl, A.L.3    Lundgren, A.4    Brodelius, M.5    Brodelius, P.E.6
  • 38
    • 68849097943 scopus 로고    scopus 로고
    • PEAQ: Versatile expression vectors for easy and quick transient expression of heterologous proteins in plants
    • Sainsbury, F., Thuenemann, E.C., and Lomonossoff, G.P. (2009). pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants. Plant Biotechnol. J. 7: 682-693.
    • (2009) Plant Biotechnol. J , vol.7 , pp. 682-693
    • Sainsbury, F.1    Thuenemann, E.C.2    Lomonossoff, G.P.3
  • 39
    • 79953254244 scopus 로고    scopus 로고
    • Molecular characterization of an oxi-dosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus
    • Sawai, S., Uchiyama, H., Mizuno, S., Aoki, T., Akashi, T., Ayabe, S., and Takahashi, T. (2011). Molecular characterization of an oxi-dosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus. FEBS Lett. 585: 1031-1036.
    • (2011) FEBS Lett , vol.585 , pp. 1031-1036
    • Sawai, S.1    Uchiyama, H.2    Mizuno, S.3    Aoki, T.4    Akashi, T.5    Ayabe, S.6    Takahashi, T.7
  • 41
    • 79953242026 scopus 로고    scopus 로고
    • New synthetic triterpenoids: Potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress
    • Sporn, M.B., Liby, K.T., Yore, M.M., Fu, L., Lopchuk, J.M., and Gribble, G.W. (2011). New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. J. Nat. Prod. 74: 537-545.
    • (2011) J. Nat. Prod , vol.74 , pp. 537-545
    • Sporn, M.B.1    Liby, K.T.2    Yore, M.M.3    Fu, L.4    Lopchuk, J.M.5    Gribble, G.W.6
  • 42
    • 84883652788 scopus 로고    scopus 로고
    • Triterpenoid profile of flower and leaf cuticular waxes of heather Calluna vulgaris
    • Szakiel, A., Niżynski, B., and Pączkowski, C. (2013). Triterpenoid profile of flower and leaf cuticular waxes of heather Calluna vulgaris. Nat. Prod. Res. 27: 1404-1407.
    • (2013) Nat. Prod. Res , vol.27 , pp. 1404-1407
    • Szakiel, A.1    Niżynski, B.2    Pączkowski, C.3
  • 43
    • 84876413596 scopus 로고    scopus 로고
    • Fruit cuticular waxes as a source of biologically active triterpenoids
    • Szakiel, A., Pączkowski, C., Pensec, F., and Bertsch, C. (2012). Fruit cuticular waxes as a source of biologically active triterpenoids. Phytochem. Rev. 11: 263-284.
    • (2012) Phytochem. Rev , vol.11 , pp. 263-284
    • Szakiel, A.1    Pączkowski, C.2    Pensec, F.3    Bertsch, C.4
  • 44
    • 79957613599 scopus 로고    scopus 로고
    • MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods
    • Tamura, K., Peterson, D., Peterson, N., Stecher, G., Nei, M., and Kumar, S. (2011). MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 28: 2731–2739.
    • (2011) Mol. Biol. Evol , vol.28 , pp. 2731-2739
    • Tamura, K.1    Peterson, D.2    Peterson, N.3    Stecher, G.4    Nei, M.5    Kumar, S.6
  • 45
    • 33748809553 scopus 로고    scopus 로고
    • Dammarenediol-II synthase, the first dedicated enzyme for ginse-noside biosynthesis
    • Tansakul, P., Shibuya, M., Kushiro, T., and Ebizuka, Y. (2006). Dammarenediol-II synthase, the first dedicated enzyme for ginse-noside biosynthesis, in Panax ginseng. FEBS Lett. 580: 5143–5149.
    • (2006) Panax Ginseng. FEBS Lett , vol.580 , pp. 5143-5149
    • Tansakul, P.1    Shibuya, M.2    Kushiro, T.3    Ebizuka, Y.4
  • 47
    • 33646940163 scopus 로고    scopus 로고
    • Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. By high performance liquid chromatography-electrospray quadrupole time-of-flight tandem mass spectrometry
    • Van Nieuwerburgh, F.C., Vande Casteele, S.R., Maes, L., Goossens, A., Inzé, D., Van Bocxlaer, J., and Deforce, D.L. (2006). Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography-electrospray quadrupole time-of-flight tandem mass spectrometry. J. Chromatogr. A 1118: 180–187.
    • (2006) J. Chromatogr. A , vol.1118 , pp. 180-187
    • Van Nieuwerburgh, F.C.1    Vande Casteele, S.R.2    Maes, L.3    Goossens, A.4    Inzé, D.5    Van Bocxlaer, J.6    Deforce, D.L.7
  • 48
    • 84871460414 scopus 로고    scopus 로고
    • Trichome-specific expression of the amorpha-4,11-diene 12-hydroxylase (cyp71av1) gene, encoding a key enzyme of artemisinin biosynthesis in Artemisia annua, as reported by a promoter-GUS fusion
    • Wang, H., Han, J., Kanagarajan, S., Lundgren, A., and Brodelius, P.E. (2013). Trichome-specific expression of the amorpha-4,11-diene 12-hydroxylase (cyp71av1) gene, encoding a key enzyme of artemisinin biosynthesis in Artemisia annua, as reported by a promoter-GUS fusion. Plant Mol. Biol. 81: 119–138.
    • (2013) Plant Mol. Biol , vol.81 , pp. 119-138
    • Wang, H.1    Han, J.2    Kanagarajan, S.3    Lundgren, A.4    Brodelius, P.E.5
  • 49
    • 70449516453 scopus 로고    scopus 로고
    • Global characterization of Artemisia annua glandular trichome tran-scriptome using 454 pyrosequencing
    • Wang, W., Wang, Y., Zhang, Q., Qi, Y., and Guo, D. (2009). Global characterization of Artemisia annua glandular trichome tran-scriptome using 454 pyrosequencing. BMC Genomics 10: 465.
    • (2009) BMC Genomics , vol.10 , pp. 465
    • Wang, W.1    Wang, Y.2    Zhang, Q.3    Qi, Y.4    Guo, D.5
  • 50
    • 78650984754 scopus 로고    scopus 로고
    • Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids
    • Wang, Z., Guhling, O., Yao, R., Li, F., Yeats, T.H., Rose, J.K., and Jetter, R. (2011). Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids. Plant Physiol. 155: 540–552.
    • (2011) Plant Physiol , vol.155 , pp. 540-552
    • Wang, Z.1    Guhling, O.2    Yao, R.3    Li, F.4    Yeats, T.H.5    Rose, J.K.6    Jetter, R.7
  • 51
    • 77956918452 scopus 로고    scopus 로고
    • Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: Enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids
    • Wang, Z., Yeats, T., Han, H., and Jetter, R. (2010). Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids. J. Biol. Chem. 285: 29703–29712.
    • (2010) J. Biol. Chem , vol.285 , pp. 29703-29712
    • Wang, Z.1    Yeats, T.2    Han, H.3    Jetter, R.4
  • 52
    • 84877986528 scopus 로고    scopus 로고
    • Functional characterization of amyrin synthase involved in ursolic acid biosynthesis in Catharanthus roseus leaf epidermis
    • Yu, F., Thamm, A.M., Reed, D., Villa-Ruano, N., Quesada, A.L., Gloria, E.L., Covello, P., and De Luca, V. (2013). Functional characterization of amyrin synthase involved in ursolic acid biosynthesis in Catharanthus roseus leaf epidermis. Phytochemistry 91: 122–127.
    • (2013) Phytochemistry , vol.91 , pp. 122-127
    • Yu, F.1    Thamm, A.M.2    Reed, D.3    Villa-Ruano, N.4    Quesada, A.L.5    Gloria, E.L.6    Covello, P.7    De Luca, V.8
  • 53
    • 67349227971 scopus 로고    scopus 로고
    • Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing
    • Zhang, L., Jing, F., Li, F., Li, M., Wang, Y., Wang, G., Sun, X., and Tang, K. (2009). Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing. Biotechnol. Appl. Biochem. 52: 199–207.
    • (2009) Biotechnol. Appl. Biochem , vol.52 , pp. 199-207
    • Zhang, L.1    Jing, F.2    Li, F.3    Li, M.4    Wang, Y.5    Wang, G.6    Sun, X.7    Tang, K.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.