Generation of complexity in fungal terpene biosynthesis: Discovery of a multifunctional cytochrome P450 in the fumagillin pathway

Journal of the American Chemical Society

Volumn 136, Issue 11, 2014, Pages 4426-4436

  Lin, Hsiao Ching ^a   Tsunematsu, Yuta ^c   Dhingra, Sourabh ^d   Xu, Wei ^a   Fukutomi, Manami ^c   Chooi, Yit Heng ^e   Cane, David E ^f   Calvo, Ana M ^d   Watanabe, Kenji ^c   Tang, Yi ^a,b  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SHIZUOKA   (Japan)

^d NORTHERN ILLINOIS UNIVERSITY   (United States)

^e AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^f BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ASPERGILLUS; BIOCHEMISTRY; HYDROXYLATION; KETONES;

ANTI-ANGIOGENIC ACTIVITY; ASPERGILLUS FUMIGATUS; BIOCHEMICAL MECHANISMS; BIOSYNTHETIC GENE CLUSTER; BIOSYNTHETIC PATHWAY; METHIONINE AMINOPEPTIDASE; POLYKETIDE SYNTHASES; TERPENE BIOSYNTHESIS;

BIOSYNTHESIS;

ABM FAMILY MONOOXYGENASE; CYTOCHROME P450; DIOXYGENASE; FUMAGILLIN; METHIONYL AMINOPEPTIDASE 2; NONHEME IRON DEPENDENT DIOXYGENASE; POLYKETIDE SYNTHASE; SESQUITERPENOID; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; ASPERGILLUS FUMIGATUS; BIOSYNTHESIS; BIOTRANSFORMATION; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; EPOXIDATION; FUNGAL STRAIN; GENE INACTIVATION; HYDROXYLATION; NONHUMAN; RING OPENING;

ASPERGILLUS FUMIGATUS; CYCLOHEXANES; CYTOCHROME P-450 ENZYME SYSTEM; FATTY ACIDS, UNSATURATED; MOLECULAR STRUCTURE; SESQUITERPENES; TERPENES;

EID: 84896537089     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja500881e     Document Type: Article

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