메뉴 건너뛰기




Volumn 34, Issue 3, 2016, Pages 242-255

Production of Useful Terpenoids by Higher-Fungus Cell Factory and Synthetic Biology Approaches

Author keywords

Biochemical engineering; Cell factory; Higher fungus; Metabolic engineering; Synthetic biology; Terpenoid production

Indexed keywords

BIOCHEMICAL ENGINEERING; CELLS; CYTOLOGY; FUNGI; HEALTH CARE; LIPIDS; METABOLIC ENGINEERING; MOLECULAR BIOLOGY;

EID: 84958729519     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2015.12.007     Document Type: Review
Times cited : (58)

References (91)
  • 1
    • 84930919262 scopus 로고    scopus 로고
    • Secondary metabolites and bioactivities from higher fungi in China
    • Zhang L. Secondary metabolites and bioactivities from higher fungi in China. Mini Rev. Med. Chem. 2015, 15:157-177.
    • (2015) Mini Rev. Med. Chem. , vol.15 , pp. 157-177
    • Zhang, L.1
  • 2
    • 84954475740 scopus 로고    scopus 로고
    • Cell factories of higher fungi for useful metabolite production
    • Qin H., et al. Cell factories of higher fungi for useful metabolite production. Adv. Biochem. Eng. Biotechnol. 2016, 155:199-235.
    • (2016) Adv. Biochem. Eng. Biotechnol. , vol.155 , pp. 199-235
    • Qin, H.1
  • 3
    • 0035206258 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic trial of irofulven
    • Thomas J.P., et al. Phase I clinical and pharmacokinetic trial of irofulven. Cancer Chemother. Pharmacol. 2001, 48:467-472.
    • (2001) Cancer Chemother. Pharmacol. , vol.48 , pp. 467-472
    • Thomas, J.P.1
  • 4
    • 33644504528 scopus 로고    scopus 로고
    • A phase II study of irofulven in women with recurrent and heavily pretreated ovarian cancer
    • Seiden M.V., et al. A phase II study of irofulven in women with recurrent and heavily pretreated ovarian cancer. Gynecol. Oncol. 2006, 101:55-61.
    • (2006) Gynecol. Oncol. , vol.101 , pp. 55-61
    • Seiden, M.V.1
  • 5
    • 33750600405 scopus 로고    scopus 로고
    • Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes
    • Yan K., et al. Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes. Antimicrob. Agents Chemother. 2006, 50:3875-3881.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 3875-3881
    • Yan, K.1
  • 6
    • 84862908524 scopus 로고    scopus 로고
    • Pleuromutilin and its derivatives - the lead compounds for novel antibiotics
    • Tang Y.Z., et al. Pleuromutilin and its derivatives - the lead compounds for novel antibiotics. Mini Rev. Med. Chem. 2012, 12:53-61.
    • (2012) Mini Rev. Med. Chem. , vol.12 , pp. 53-61
    • Tang, Y.Z.1
  • 7
    • 33845231348 scopus 로고    scopus 로고
    • Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells
    • Tang W., et al. Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci. 2006, 80:205-211.
    • (2006) Life Sci. , vol.80 , pp. 205-211
    • Tang, W.1
  • 8
    • 84868610107 scopus 로고    scopus 로고
    • Enhancement of ganoderic acid accumulation by overexpression of an N-terminally truncated 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in the basidiomycete Ganoderma lucidum
    • Xu J.W., et al. Enhancement of ganoderic acid accumulation by overexpression of an N-terminally truncated 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in the basidiomycete Ganoderma lucidum. Appl. Environ. Microbiol. 2012, 78:7968-7976.
    • (2012) Appl. Environ. Microbiol. , vol.78 , pp. 7968-7976
    • Xu, J.W.1
  • 9
    • 76649132986 scopus 로고    scopus 로고
    • Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum
    • Xu J.W., et al. Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. Appl. Microbiol. Biotechnol. 2010, 85:941-948.
    • (2010) Appl. Microbiol. Biotechnol. , vol.85 , pp. 941-948
    • Xu, J.W.1
  • 10
    • 84862831797 scopus 로고    scopus 로고
    • Constructing the electricity-carbohydrate-hydrogen cycle for a sustainability revolution
    • Zhang Y.H.P., Huang W.D. Constructing the electricity-carbohydrate-hydrogen cycle for a sustainability revolution. Trends Biotechnol. 2012, 30:301-306.
    • (2012) Trends Biotechnol. , vol.30 , pp. 301-306
    • Zhang, Y.H.P.1    Huang, W.D.2
  • 11
    • 84892973839 scopus 로고    scopus 로고
    • A high-energy-density sugar biobattery via a synthetic enzymatic pathway
    • Zhu Z., et al. A high-energy-density sugar biobattery via a synthetic enzymatic pathway. Nat. Commun. 2014, 5:3026.
    • (2014) Nat. Commun. , vol.5 , pp. 3026
    • Zhu, Z.1
  • 13
    • 84931420611 scopus 로고    scopus 로고
    • Direct biosynthesis of adipic acid from a synthetic pathway in recombinant Escherichia coli
    • Yu J.L., et al. Direct biosynthesis of adipic acid from a synthetic pathway in recombinant Escherichia coli. Biotechnol. Bioeng. 2014, 111:2580-2586.
    • (2014) Biotechnol. Bioeng. , vol.111 , pp. 2580-2586
    • Yu, J.L.1
  • 14
    • 84876784070 scopus 로고    scopus 로고
    • High-level semi-synthetic production of the potent antimalarial artemisinin
    • Paddon C.J., et al. High-level semi-synthetic production of the potent antimalarial artemisinin. Nature 2013, 496:528-532.
    • (2013) Nature , vol.496 , pp. 528-532
    • Paddon, C.J.1
  • 15
    • 84879142653 scopus 로고    scopus 로고
    • High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin in Escherichia coli
    • Tsuruta H., et al. High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin in Escherichia coli. PLoS ONE 2009, 4:e4489.
    • (2009) PLoS ONE , vol.4 , pp. e4489
    • Tsuruta, H.1
  • 16
    • 84930199213 scopus 로고    scopus 로고
    • Biosynthesis of terpenoid natural products in fungi
    • Schmidt-Dannert C. Biosynthesis of terpenoid natural products in fungi. Adv. Biochem. Eng. Biotechnol. 2015, 148:19-61.
    • (2015) Adv. Biochem. Eng. Biotechnol. , vol.148 , pp. 19-61
    • Schmidt-Dannert, C.1
  • 17
    • 84866494995 scopus 로고    scopus 로고
    • Discovery and characterization of terpenoid biosynthetic pathways of fungi
    • Wawrzyn G.T., et al. Discovery and characterization of terpenoid biosynthetic pathways of fungi. Methods Enzymol. 2012, 515:83-105.
    • (2012) Methods Enzymol. , vol.515 , pp. 83-105
    • Wawrzyn, G.T.1
  • 18
    • 0023244069 scopus 로고
    • Preclinical evaluation of illudins as anticancer agents
    • Kelner M.J., et al. Preclinical evaluation of illudins as anticancer agents. Cancer Res. 1987, 47:3186-3189.
    • (1987) Cancer Res. , vol.47 , pp. 3186-3189
    • Kelner, M.J.1
  • 19
    • 84862732885 scopus 로고    scopus 로고
    • Draft genome of Omphalotus olearius provides a predictive framework for sesquiterpenoid natural product biosynthesis in basidiomycota
    • Wawrzyn G.T., et al. Draft genome of Omphalotus olearius provides a predictive framework for sesquiterpenoid natural product biosynthesis in basidiomycota. Chem. Biol. 2012, 19:772-783.
    • (2012) Chem. Biol. , vol.19 , pp. 772-783
    • Wawrzyn, G.T.1
  • 20
    • 84912095857 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of new pleuromutilin derivatives as antibacterial agents
    • Shang R.F., et al. Synthesis and biological evaluation of new pleuromutilin derivatives as antibacterial agents. Molecules 2014, 19:19050-19065.
    • (2014) Molecules , vol.19 , pp. 19050-19065
    • Shang, R.F.1
  • 21
    • 84986535294 scopus 로고
    • Triterpenoid natural-products in the fungus Ganoderma lucidum
    • Shiao M.S. Triterpenoid natural-products in the fungus Ganoderma lucidum. J. Chin. Chem. Soc. 1992, 39:669-674.
    • (1992) J. Chin. Chem. Soc. , vol.39 , pp. 669-674
    • Shiao, M.S.1
  • 22
    • 84863299258 scopus 로고    scopus 로고
    • Genome sequence of the model medicinal mushroom Ganoderma lucidum
    • Chen S., et al. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nat. Commun. 2012, 3:913.
    • (2012) Nat. Commun. , vol.3 , pp. 913
    • Chen, S.1
  • 23
    • 33644829325 scopus 로고    scopus 로고
    • A highly efficient polyethylene glycol-mediated transformation method for mushrooms
    • Li G., et al. A highly efficient polyethylene glycol-mediated transformation method for mushrooms. FEMS Microbiol. Lett. 2006, 256:203-208.
    • (2006) FEMS Microbiol. Lett. , vol.256 , pp. 203-208
    • Li, G.1
  • 24
    • 0442280804 scopus 로고    scopus 로고
    • Efficient transformation of the medicinal mushroom Ganoderma lucidum
    • Li S., et al. Efficient transformation of the medicinal mushroom Ganoderma lucidum. Plant Mol. Biol. Rep. 2001, 19:383.
    • (2001) Plant Mol. Biol. Rep. , vol.19 , pp. 383
    • Li, S.1
  • 25
    • 84889448071 scopus 로고    scopus 로고
    • PEG-mediated transformation of Lentinus edodes
    • Sun L., et al. PEG-mediated transformation of Lentinus edodes. Acta Bot. Sin. 2001, 43:1089-1092.
    • (2001) Acta Bot. Sin. , vol.43 , pp. 1089-1092
    • Sun, L.1
  • 26
    • 38049049926 scopus 로고    scopus 로고
    • A reliable transformation method and heterologous expression of beta-glucuronidase in Lentinula edodes
    • Kuo C.Y., Huang C.T. A reliable transformation method and heterologous expression of beta-glucuronidase in Lentinula edodes. J. Microbiol. Methods 2008, 72:111-115.
    • (2008) J. Microbiol. Methods , vol.72 , pp. 111-115
    • Kuo, C.Y.1    Huang, C.T.2
  • 27
    • 84876546736 scopus 로고    scopus 로고
    • Beta-glucan synthase gene overexpression and beta-glucans overproduction in Pleurotus ostreatus using promoter swapping
    • Chai R., et al. Beta-glucan synthase gene overexpression and beta-glucans overproduction in Pleurotus ostreatus using promoter swapping. PLoS ONE 2013, 8:e61693.
    • (2013) PLoS ONE , vol.8 , pp. e61693
    • Chai, R.1
  • 28
    • 84875037949 scopus 로고    scopus 로고
    • Enhancement of heterologous gene expression in Flammulina velutipes using polycistronic vectors containing a viral 2A cleavage sequence
    • Lin Y.J., et al. Enhancement of heterologous gene expression in Flammulina velutipes using polycistronic vectors containing a viral 2A cleavage sequence. PLoS ONE 2013, 8:e59099.
    • (2013) PLoS ONE , vol.8 , pp. e59099
    • Lin, Y.J.1
  • 29
    • 3242887232 scopus 로고    scopus 로고
    • The SC15 protein of Schizophyllum commune mediates formation of aerial hyphae and attachment in the absence of the SC3 hydrophobin
    • Lugones L.G., et al. The SC15 protein of Schizophyllum commune mediates formation of aerial hyphae and attachment in the absence of the SC3 hydrophobin. Mol. Microbiol. 2004, 53:707-716.
    • (2004) Mol. Microbiol. , vol.53 , pp. 707-716
    • Lugones, L.G.1
  • 30
    • 77956870902 scopus 로고    scopus 로고
    • An efficient gene deletion procedure for the mushroom-forming basidiomycete Schizophyllum commune
    • Ohm R.A., et al. An efficient gene deletion procedure for the mushroom-forming basidiomycete Schizophyllum commune. World J. Microbiol. Biotechnol. 2010, 26:1919-1923.
    • (2010) World J. Microbiol. Biotechnol. , vol.26 , pp. 1919-1923
    • Ohm, R.A.1
  • 31
    • 77955241103 scopus 로고    scopus 로고
    • Inactivation of ku80 in the mushroom-forming fungus Schizophyllum commune increases the relative incidence of homologous recombination
    • De Jong J.F., et al. Inactivation of ku80 in the mushroom-forming fungus Schizophyllum commune increases the relative incidence of homologous recombination. FEMS Microbiol. Lett. 2010, 310:91-95.
    • (2010) FEMS Microbiol. Lett. , vol.310 , pp. 91-95
    • De Jong, J.F.1
  • 32
    • 80052261097 scopus 로고    scopus 로고
    • Efficient gene targeting in delta Cc.ku70 or delta Cc.lig4 mutants of the Agaricomycetes Coprinopsis cinerea
    • Nakazawa T., et al. Efficient gene targeting in delta Cc.ku70 or delta Cc.lig4 mutants of the Agaricomycetes Coprinopsis cinerea. Fungal Genet. Biol. 2011, 48:939-946.
    • (2011) Fungal Genet. Biol. , vol.48 , pp. 939-946
    • Nakazawa, T.1
  • 33
    • 37149022966 scopus 로고    scopus 로고
    • A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium
    • Godio R.P., et al. A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium. Chem. Biol. 2007, 14:1334-1346.
    • (2007) Chem. Biol. , vol.14 , pp. 1334-1346
    • Godio, R.P.1
  • 34
    • 33745184416 scopus 로고    scopus 로고
    • Increasing pleuromutilin activity of Clitopilus passeckerianus by chemical mutagenesis and improvement of production medium
    • Papa I.A., et al. Increasing pleuromutilin activity of Clitopilus passeckerianus by chemical mutagenesis and improvement of production medium. Philipp. Agric. Sci. 2006, 89:20-33.
    • (2006) Philipp. Agric. Sci. , vol.89 , pp. 20-33
    • Papa, I.A.1
  • 35
    • 34347206335 scopus 로고    scopus 로고
    • Batch kinetics and modelling of pleuromutilin production by Pleurotus mutilis
    • Benkortbi O., et al. Batch kinetics and modelling of pleuromutilin production by Pleurotus mutilis. Biochem. Eng. J. 2007, 36:14-18.
    • (2007) Biochem. Eng. J. , vol.36 , pp. 14-18
    • Benkortbi, O.1
  • 36
    • 84863023200 scopus 로고    scopus 로고
    • Fed-batch fermentation for pleuromutilin production by Pleurotus mutilis
    • Zou X., et al. Fed-batch fermentation for pleuromutilin production by Pleurotus mutilis. Res. J. Biotechnol. 2012, 7:67-72.
    • (2012) Res. J. Biotechnol. , vol.7 , pp. 67-72
    • Zou, X.1
  • 37
    • 84958729873 scopus 로고    scopus 로고
    • Glaxo Group Limited & the University of Bristol, United Kingdom, US 20130017608 A1
    • Bailey A.M., et al. Methods of increasing yields of pleuromutilins 2013, Glaxo Group Limited & the University of Bristol, United Kingdom, US 20130017608 A1.
    • (2013) Methods of increasing yields of pleuromutilins
    • Bailey, A.M.1
  • 38
    • 84880235677 scopus 로고    scopus 로고
    • Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum - a review
    • Wu G.S., et al. Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum - a review. Exp. Opin. Investig. Drugs 2013, 22:981-992.
    • (2013) Exp. Opin. Investig. Drugs , vol.22 , pp. 981-992
    • Wu, G.S.1
  • 39
    • 0036007988 scopus 로고    scopus 로고
    • Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum
    • Fang Q.H., Zhong J.J. Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum. Biotechnol. Prog. 2002, 18:51-54.
    • (2002) Biotechnol. Prog. , vol.18 , pp. 51-54
    • Fang, Q.H.1    Zhong, J.J.2
  • 40
    • 57049144759 scopus 로고    scopus 로고
    • Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum
    • Tang Y.J., et al. Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum. Bioresour. Technol. 2009, 100:1852-1859.
    • (2009) Bioresour. Technol. , vol.100 , pp. 1852-1859
    • Tang, Y.J.1
  • 41
    • 77952891347 scopus 로고    scopus 로고
    • Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction
    • Liang C.X., et al. Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction. Appl. Microbiol. Biotechnol. 2010, 86:1367-1374.
    • (2010) Appl. Microbiol. Biotechnol. , vol.86 , pp. 1367-1374
    • Liang, C.X.1
  • 42
    • 84878397719 scopus 로고    scopus 로고
    • + on ganoderic acid biosynthesis in static liquid culture of Ganoderma lucidum via calcineurin signal transduction
    • + on ganoderic acid biosynthesis in static liquid culture of Ganoderma lucidum via calcineurin signal transduction. Biotechnol. Bioeng. 2013, 110:1913-1923.
    • (2013) Biotechnol. Bioeng. , vol.110 , pp. 1913-1923
    • Xu, Y.N.1
  • 43
    • 84925270796 scopus 로고    scopus 로고
    • 2+ in static liquid cultivation of Ganoderma lucidum
    • 2+ in static liquid cultivation of Ganoderma lucidum. Biotechnol. Bioeng. 2014, 111:2358-2365.
    • (2014) Biotechnol. Bioeng. , vol.111 , pp. 2358-2365
    • Xu, Y.N.1
  • 44
    • 84867736102 scopus 로고    scopus 로고
    • Impacts of calcium signal transduction on the fermentation production of antitumor ganoderic acids by medicinal mushroom Ganoderma lucidum
    • Xu Y.N., Zhong J.J. Impacts of calcium signal transduction on the fermentation production of antitumor ganoderic acids by medicinal mushroom Ganoderma lucidum. Biotechnol. Adv. 2012, 30:1301-1308.
    • (2012) Biotechnol. Adv. , vol.30 , pp. 1301-1308
    • Xu, Y.N.1    Zhong, J.J.2
  • 45
    • 62249213406 scopus 로고    scopus 로고
    • A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom Ganoderma lucidum for the efficient production of ganoderic acid and ganoderma polysaccharides
    • Zhang W., Tang Y.J. A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom Ganoderma lucidum for the efficient production of ganoderic acid and ganoderma polysaccharides. Biotechnol. Prog. 2008, 24:1249-1261.
    • (2008) Biotechnol. Prog. , vol.24 , pp. 1249-1261
    • Zhang, W.1    Tang, Y.J.2
  • 46
    • 84903202014 scopus 로고    scopus 로고
    • Enhanced accumulation of individual ganoderic acids in a submerged culture of Ganoderma lucidum by the overexpression of squalene synthase gene
    • Zhou J.S., et al. Enhanced accumulation of individual ganoderic acids in a submerged culture of Ganoderma lucidum by the overexpression of squalene synthase gene. Biochem. Eng. J. 2014, 90:178-183.
    • (2014) Biochem. Eng. J. , vol.90 , pp. 178-183
    • Zhou, J.S.1
  • 47
    • 84955315667 scopus 로고    scopus 로고
    • The seco-iridoid pathway from Catharanthus roseus
    • Miettinen K., et al. The seco-iridoid pathway from Catharanthus roseus. Nat. Commun. 2014, 5:3606.
    • (2014) Nat. Commun. , vol.5 , pp. 3606
    • Miettinen, K.1
  • 48
    • 84924029106 scopus 로고    scopus 로고
    • De novo production of the monoterpenoid geranic acid by metabolically engineered Pseudomonas putida
    • Mi J., et al. De novo production of the monoterpenoid geranic acid by metabolically engineered Pseudomonas putida. Microb. Cell Fact. 2014, 13:170.
    • (2014) Microb. Cell Fact. , vol.13 , pp. 170
    • Mi, J.1
  • 49
    • 84921278263 scopus 로고    scopus 로고
    • Principal component analysis of proteomics (PCAP) as a tool to direct metabolic engineering
    • Alonso-Gutierrez J., et al. Principal component analysis of proteomics (PCAP) as a tool to direct metabolic engineering. Metab. Eng. 2015, 28:123-133.
    • (2015) Metab. Eng. , vol.28 , pp. 123-133
    • Alonso-Gutierrez, J.1
  • 50
    • 84899051891 scopus 로고    scopus 로고
    • Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
    • Paddon C.J., Keasling J.D. Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development. Nat. Rev. Microbiol. 2014, 12:355-367.
    • (2014) Nat. Rev. Microbiol. , vol.12 , pp. 355-367
    • Paddon, C.J.1    Keasling, J.D.2
  • 51
    • 1642300400 scopus 로고    scopus 로고
    • Class II 3-hydroxy-3-methylglutaryl coenzyme A reductases
    • Hedl M., et al. Class II 3-hydroxy-3-methylglutaryl coenzyme A reductases. J. Bacteriol. 2004, 186:1927-1932.
    • (2004) J. Bacteriol. , vol.186 , pp. 1927-1932
    • Hedl, M.1
  • 52
    • 0035814339 scopus 로고    scopus 로고
    • The in vivo synthesis of plant sesquiterpenes by Escherichia coli
    • Martin V.J.J., et al. The in vivo synthesis of plant sesquiterpenes by Escherichia coli. Biotechnol. Bioeng. 2001, 75:497-503.
    • (2001) Biotechnol. Bioeng. , vol.75 , pp. 497-503
    • Martin, V.J.J.1
  • 53
    • 84856389651 scopus 로고    scopus 로고
    • Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
    • Westfall P.J., et al. Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:E111-E118.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. E111-E118
    • Westfall, P.J.1
  • 54
    • 27844511101 scopus 로고    scopus 로고
    • Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
    • Zhou L.M., et al. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J. Clin. Pharmacol. 2005, 45:1345-1359.
    • (2005) J. Clin. Pharmacol. , vol.45 , pp. 1345-1359
    • Zhou, L.M.1
  • 55
    • 84863116515 scopus 로고    scopus 로고
    • Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production
    • Zhou Y.J., et al. Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production. J. Am. Chem. Soc. 2012, 134:3234-3241.
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 3234-3241
    • Zhou, Y.J.1
  • 56
    • 84866744325 scopus 로고    scopus 로고
    • Production of miltiradiene by metabolically engineered Saccharomyces cerevisiae
    • Dai Z., et al. Production of miltiradiene by metabolically engineered Saccharomyces cerevisiae. Biotechnol. Bioeng. 2012, 109:2845-2853.
    • (2012) Biotechnol. Bioeng. , vol.109 , pp. 2845-2853
    • Dai, Z.1
  • 57
    • 84880380223 scopus 로고    scopus 로고
    • CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts
    • Guo J., et al. CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:12108-12113.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 12108-12113
    • Guo, J.1
  • 58
    • 84892747580 scopus 로고    scopus 로고
    • Producing aglycons of ginsenosides in bakers' yeast
    • Dai Z.B., et al. Producing aglycons of ginsenosides in bakers' yeast. Sci. Rep. 2014, 4:3698.
    • (2014) Sci. Rep. , vol.4 , pp. 3698
    • Dai, Z.B.1
  • 59
    • 84886486790 scopus 로고    scopus 로고
    • Metabolic engineering of Saccharomyces cerevisiae for production of ginsenosides
    • Dai Z., et al. Metabolic engineering of Saccharomyces cerevisiae for production of ginsenosides. Metab. Eng. 2013, 20:146-156.
    • (2013) Metab. Eng. , vol.20 , pp. 146-156
    • Dai, Z.1
  • 60
    • 84901857149 scopus 로고    scopus 로고
    • Production of bioactive ginsenoside compound K in metabolically engineered yeast
    • Yan X., et al. Production of bioactive ginsenoside compound K in metabolically engineered yeast. Cell Res. 2014, 24:770-773.
    • (2014) Cell Res. , vol.24 , pp. 770-773
    • Yan, X.1
  • 61
    • 84925363742 scopus 로고    scopus 로고
    • Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts
    • Wang P., et al. Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts. Metab. Eng. 2015, 29:97-105.
    • (2015) Metab. Eng. , vol.29 , pp. 97-105
    • Wang, P.1
  • 62
    • 52949093520 scopus 로고    scopus 로고
    • Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin
    • Seki H., et al. Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:14204-14209.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 14204-14209
    • Seki, H.1
  • 63
    • 84893351504 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16 alpha hydroxylase from Bupleurum falcatum
    • Moses T., et al. Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16 alpha hydroxylase from Bupleurum falcatum. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:1634-1639.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 1634-1639
    • Moses, T.1
  • 64
    • 84939942575 scopus 로고    scopus 로고
    • Integrating an algal beta-carotene hydroxylase gene into a designed carotenoid-biosynthesis pathway increases carotenoid production in yeast
    • Chang J.J., et al. Integrating an algal beta-carotene hydroxylase gene into a designed carotenoid-biosynthesis pathway increases carotenoid production in yeast. Bioresour. Technol. 2015, 184:2-8.
    • (2015) Bioresour. Technol. , vol.184 , pp. 2-8
    • Chang, J.J.1
  • 65
    • 84888060999 scopus 로고    scopus 로고
    • Construction of a controllable beta-carotene biosynthetic pathway by decentralized assembly strategy in Saccharomyces cerevisiae
    • Xie W.P., et al. Construction of a controllable beta-carotene biosynthetic pathway by decentralized assembly strategy in Saccharomyces cerevisiae. Biotechnol. Bioeng. 2014, 111:125-133.
    • (2014) Biotechnol. Bioeng. , vol.111 , pp. 125-133
    • Xie, W.P.1
  • 66
    • 84917707014 scopus 로고    scopus 로고
    • Sequential control of biosynthetic pathways for balanced utilization of metabolic intermediates in Saccharomyces cerevisiae
    • Xie W.P., et al. Sequential control of biosynthetic pathways for balanced utilization of metabolic intermediates in Saccharomyces cerevisiae. Metab. Eng. 2015, 28:8-18.
    • (2015) Metab. Eng. , vol.28 , pp. 8-18
    • Xie, W.P.1
  • 67
    • 84875089093 scopus 로고    scopus 로고
    • Sequencing and comparative analysis of the straw mushroom (Volvariella volvacea) genome
    • Bao D., et al. Sequencing and comparative analysis of the straw mushroom (Volvariella volvacea) genome. PLoS ONE 2013, 8:e58294.
    • (2013) PLoS ONE , vol.8 , pp. e58294
    • Bao, D.1
  • 68
    • 84867919345 scopus 로고    scopus 로고
    • Genome sequence of the button mushroom Agaricus bisporus reveals mechanisms governing adaptation to a humic-rich ecological niche
    • Morin E., et al. Genome sequence of the button mushroom Agaricus bisporus reveals mechanisms governing adaptation to a humic-rich ecological niche. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:17501-17506.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 17501-17506
    • Morin, E.1
  • 69
    • 77956685978 scopus 로고    scopus 로고
    • Genome sequence of the model mushroom Schizophyllum commune
    • Ohm R.A., et al. Genome sequence of the model mushroom Schizophyllum commune. Nat. Biotechnol. 2010, 28:957-963.
    • (2010) Nat. Biotechnol. , vol.28 , pp. 957-963
    • Ohm, R.A.1
  • 70
    • 84904783654 scopus 로고    scopus 로고
    • The genome of the tiger milk mushroom Lignosus rhinocerotis, provides insights into the genetic basis of its medicinal properties
    • Yap H.Y.Y., et al. The genome of the tiger milk mushroom Lignosus rhinocerotis, provides insights into the genetic basis of its medicinal properties. BMC Genomics 2014, 15:635.
    • (2014) BMC Genomics , vol.15 , pp. 635
    • Yap, H.Y.Y.1
  • 71
    • 84930960141 scopus 로고    scopus 로고
    • Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense
    • Zhu Y.J., et al. Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense. Sci. Rep. 2015, 5:11087.
    • (2015) Sci. Rep. , vol.5 , pp. 11087
    • Zhu, Y.J.1
  • 72
    • 84929572600 scopus 로고    scopus 로고
    • Homology-integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae
    • Bao Z.H., et al. Homology-integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae. ACS Synth. Biol. 2015, 4:585-594.
    • (2015) ACS Synth. Biol. , vol.4 , pp. 585-594
    • Bao, Z.H.1
  • 73
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • Cong L., et al. Multiplex genome engineering using CRISPR/Cas systems. Science 2013, 339:819-823.
    • (2013) Science , vol.339 , pp. 819-823
    • Cong, L.1
  • 74
    • 84975678715 scopus 로고    scopus 로고
    • Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system
    • Zetsche B., et al. Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system. Cell 2015, 163:759-771.
    • (2015) Cell , vol.163 , pp. 759-771
    • Zetsche, B.1
  • 75
    • 84892424438 scopus 로고    scopus 로고
    • Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting RNA-seq, and non-coding RNA analysis
    • Enyeart P.J., et al. Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting RNA-seq, and non-coding RNA analysis. Mob. DNA 2014, 5:2.
    • (2014) Mob. DNA , vol.5 , pp. 2
    • Enyeart, P.J.1
  • 76
    • 0037027835 scopus 로고    scopus 로고
    • Anti-tumour compounds Illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways
    • Jaspers N.G., et al. Anti-tumour compounds Illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst.) 2002, 1:1027-1038.
    • (2002) DNA Repair (Amst.) , vol.1 , pp. 1027-1038
    • Jaspers, N.G.1
  • 77
    • 84905369627 scopus 로고    scopus 로고
    • Four new sesquiterpenoids from fruiting bodies of the fungus Inonotus rickii
    • Chen H.P., et al. Four new sesquiterpenoids from fruiting bodies of the fungus Inonotus rickii. J. Asian Nat. Prod. Res. 2014, 16:581-586.
    • (2014) J. Asian Nat. Prod. Res. , vol.16 , pp. 581-586
    • Chen, H.P.1
  • 78
    • 84884573338 scopus 로고    scopus 로고
    • New benzoate derivatives and hirsutane type sesquiterpenoids with antimicrobial activity and cytotoxicity from the solid-state fermented rice by the medicinal mushroom Stereum hirsutum
    • Ma K., et al. New benzoate derivatives and hirsutane type sesquiterpenoids with antimicrobial activity and cytotoxicity from the solid-state fermented rice by the medicinal mushroom Stereum hirsutum. Food Chem. 2014, 143:239-245.
    • (2014) Food Chem. , vol.143 , pp. 239-245
    • Ma, K.1
  • 79
    • 0034904323 scopus 로고    scopus 로고
    • Antimicrobial cuparene-type sesquiterpenes, enokipodins C and D, from a mycelial culture of Flammulina velutipes
    • Ishikawa N.K., et al. Antimicrobial cuparene-type sesquiterpenes, enokipodins C and D, from a mycelial culture of Flammulina velutipes. J. Nat. Prod. 2001, 64:932-934.
    • (2001) J. Nat. Prod. , vol.64 , pp. 932-934
    • Ishikawa, N.K.1
  • 80
    • 84856217212 scopus 로고    scopus 로고
    • Bioactive sesquiterpenoids from the solid culture of the edible mushroom Flammulina velutipes growing on cooked rice
    • Wang Y.Q., et al. Bioactive sesquiterpenoids from the solid culture of the edible mushroom Flammulina velutipes growing on cooked rice. Food Chem. 2012, 132:1346-1353.
    • (2012) Food Chem. , vol.132 , pp. 1346-1353
    • Wang, Y.Q.1
  • 81
    • 84865064882 scopus 로고    scopus 로고
    • Cytotoxic sesquiterpenes from luminescent mushroom Neonothopanus nambi
    • Kanokmedhakul S., et al. Cytotoxic sesquiterpenes from luminescent mushroom Neonothopanus nambi. Tetrahedron 2012, 68:8261-8266.
    • (2012) Tetrahedron , vol.68 , pp. 8261-8266
    • Kanokmedhakul, S.1
  • 82
    • 67650730279 scopus 로고    scopus 로고
    • Investigating pleuromutilin-producing Clitopilus species and related basidiomycetes
    • Hartley A.J., et al. Investigating pleuromutilin-producing Clitopilus species and related basidiomycetes. FEMS Microbiol. Lett. 2009, 297:24-30.
    • (2009) FEMS Microbiol. Lett. , vol.297 , pp. 24-30
    • Hartley, A.J.1
  • 83
    • 84860479580 scopus 로고    scopus 로고
    • Secoscabronine M, a novel diterpenoid from the Chinese bitter mushroom Sarcodon scabrosus
    • Shi X.W., et al. Secoscabronine M, a novel diterpenoid from the Chinese bitter mushroom Sarcodon scabrosus. Chirality 2012, 24:386-390.
    • (2012) Chirality , vol.24 , pp. 386-390
    • Shi, X.W.1
  • 84
    • 84928662259 scopus 로고    scopus 로고
    • Striatoids A-F, cyathane diterpenoids with neurotrophic activity from cultures of the fungus Cyathus striatus
    • Bai R., et al. Striatoids A-F, cyathane diterpenoids with neurotrophic activity from cultures of the fungus Cyathus striatus. J. Nat. Prod. 2015, 78:783-788.
    • (2015) J. Nat. Prod. , vol.78 , pp. 783-788
    • Bai, R.1
  • 85
    • 84873337715 scopus 로고    scopus 로고
    • Anti-inflammatory and cytotoxic cyathane diterpenoids from the medicinal fungus Cyathus africanus
    • Han J., et al. Anti-inflammatory and cytotoxic cyathane diterpenoids from the medicinal fungus Cyathus africanus. Fitoterapia 2013, 84:22-31.
    • (2013) Fitoterapia , vol.84 , pp. 22-31
    • Han, J.1
  • 86
    • 0036372245 scopus 로고    scopus 로고
    • Anti-inflammatory compounds from the bitter mushroom Sarcodon scabrosus
    • Hirota M., et al. Anti-inflammatory compounds from the bitter mushroom Sarcodon scabrosus. Biosci. Biotechnol. Biochem. 2002, 66:179-184.
    • (2002) Biosci. Biotechnol. Biochem. , vol.66 , pp. 179-184
    • Hirota, M.1
  • 87
    • 77953082317 scopus 로고    scopus 로고
    • Biotechnological production and application of ganoderic acids
    • Xu J.W., et al. Biotechnological production and application of ganoderic acids. Appl. Microbiol. Biotechnol. 2010, 87:457-466.
    • (2010) Appl. Microbiol. Biotechnol. , vol.87 , pp. 457-466
    • Xu, J.W.1
  • 88
    • 38049016812 scopus 로고    scopus 로고
    • The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain
    • Weng C.J., et al. The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain. Mol. Nutr. Food Res. 2007, 51:1472-1477.
    • (2007) Mol. Nutr. Food Res. , vol.51 , pp. 1472-1477
    • Weng, C.J.1
  • 89
    • 84878263659 scopus 로고    scopus 로고
    • Lanostane triterpenoids from the mushroom Naematoloma fasciculare
    • Kim K.H., et al. Lanostane triterpenoids from the mushroom Naematoloma fasciculare. J. Nat. Prod. 2013, 76:845-851.
    • (2013) J. Nat. Prod. , vol.76 , pp. 845-851
    • Kim, K.H.1
  • 90
    • 84906719469 scopus 로고    scopus 로고
    • Ganoboninketals A-C, antiplasmodial 3,4-seco-27-norlanostane triterpenes from Ganoderma boninense Pat
    • Ma K., et al. Ganoboninketals A-C, antiplasmodial 3,4-seco-27-norlanostane triterpenes from Ganoderma boninense Pat. J. Nat. Prod. 2014, 77:1847-1852.
    • (2014) J. Nat. Prod. , vol.77 , pp. 1847-1852
    • Ma, K.1
  • 91
    • 84884614808 scopus 로고    scopus 로고
    • Cattienoids A-C, three novel steroids from the mushroom Tomophagus cattienensis
    • Hien B.T., et al. Cattienoids A-C, three novel steroids from the mushroom Tomophagus cattienensis. Fitoterapia 2013, 91:125-127.
    • (2013) Fitoterapia , vol.91 , pp. 125-127
    • Hien, B.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.