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Volumn 8, Issue , 2017, Pages

Transcriptome assembly and systematic identification of novel cytochrome P450s in taxus chinensis

Author keywords

Cytochrome P450; Gene expression; Taxol biosynthesis; Taxus chinensis; Transcriptome wide identification

Indexed keywords


EID: 85029187237     PISSN: None     EISSN: 1664462X     Source Type: Journal    
DOI: 10.3389/fpls.2017.01468     Document Type: Article
Times cited : (38)

References (46)
  • 1
    • 77957329119 scopus 로고    scopus 로고
    • Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli
    • Ajikumar, P. K., Xiao, W. H., Tyo, K. E., Wang, Y., Simeon, F., Leonard, E., et al. (2010). Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science 330, 70-74. doi: 10.1126/science.1191652
    • (2010) Science , vol.330 , pp. 70-74
    • Ajikumar, P.K.1    Xiao, W.H.2    Tyo, K.E.3    Wang, Y.4    Simeon, F.5    Leonard, E.6
  • 2
    • 84872383614 scopus 로고    scopus 로고
    • Structural organization and classification of cytochrome P450 genes in flax (Linum usitatissimum L.)
    • Babu, P. R., Rao, K. V., and Reddy, V. D. (2013). Structural organization and classification of cytochrome P450 genes in flax (Linum usitatissimum L.). Gene 513, 156-162. doi: 10.1016/j.gene.2012.10.040
    • (2013) Gene , vol.513 , pp. 156-162
    • Babu, P.R.1    Rao, K.V.2    Reddy, V.D.3
  • 3
    • 84929493482 scopus 로고    scopus 로고
    • The gymnosperm cytochrome P450 CYP750B1 catalyzes stereospecific monoterpene hydroxylation of (+)-sabinene in thujone biosynthesis in Thuja plicata
    • Bohlmann, J., Gesell, A., Blaukopf, M., Madilao, L., Macaire, M. S., Stephen, G. W., et al. (2015). The gymnosperm cytochrome P450 CYP750B1 catalyzes stereospecific monoterpene hydroxylation of (+)-sabinene in thujone biosynthesis in Thuja plicata. Plant Physiol. 168, 94-106. doi: 10.1104/pp.15.00315
    • (2015) Plant Physiol , vol.168 , pp. 94-106
    • Bohlmann, J.1    Gesell, A.2    Blaukopf, M.3    Madilao, L.4    Macaire, M.S.5    Stephen, G.W.6
  • 4
    • 0031766440 scopus 로고    scopus 로고
    • Molecular-genetic analysis of plant cytochrome P450-dependent monooxygenases. Annu
    • Chapple, C. (1998). Molecular-genetic analysis of plant cytochrome P450-dependent monooxygenases. Annu. Rev. Plant Biol. 49, 311-343. doi: 10.1146/annurev.arplant.49.1.311
    • (1998) Rev. Plant Biol , vol.49 , pp. 311-343
    • Chapple, C.1
  • 5
    • 2642547256 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a cytochrome P450 taxoid 2a-hydroxylase involved in Taxol biosynthesis
    • Chau, M., and Croteau, R. (2004). Molecular cloning and characterization of a cytochrome P450 taxoid 2a-hydroxylase involved in Taxol biosynthesis. Arch. Biochem. Biophys. 427, 48-57. doi: 10.1016/j.abb.2004.04.016
    • (2004) Arch. Biochem. Biophys , vol.427 , pp. 48-57
    • Chau, M.1    Croteau, R.2
  • 6
    • 2642550828 scopus 로고    scopus 로고
    • Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7b-hydroxylase
    • Chau, M., Jennewein, S., Walker, K., and Croteau, R. (2004). Taxol biosynthesis: molecular cloning and characterization of a cytochrome P450 taxoid 7b-hydroxylase. Chem Biol. 11, 663-672. doi: 10.1016/j.chembiol.2004.02.025
    • (2004) Chem Biol , vol.11 , pp. 663-672
    • Chau, M.1    Jennewein, S.2    Walker, K.3    Croteau, R.4
  • 7
    • 84916627604 scopus 로고    scopus 로고
    • Computational identification and systematic classification of novel cytochrome P450 genes in Salvia miltiorrhiza
    • Chen, H., Wu, B., Nelson, D. R., Wu, K., and Liu, C. (2014). Computational identification and systematic classification of novel cytochrome P450 genes in Salvia miltiorrhiza. PLoS ONE 9:e115149. doi: 10.1371/journal.pone.0115149
    • (2014) Plos ONE , pp. 9
    • Chen, H.1    Wu, B.2    Nelson, D.R.3    Wu, K.4    Liu, C.5
  • 8
    • 0027430002 scopus 로고
    • The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents
    • Cragg, G. M., Schepartz, S. A., Suffness, M., and Grever, M. R. (1993). The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents. J. Nat. Prod. 56, 1657-1668. doi: 10.1021/np50100a001
    • (1993) J. Nat. Prod , vol.56 , pp. 1657-1668
    • Cragg, G.M.1    Schepartz, S.A.2    Suffness, M.3    Grever, M.R.4
  • 10
    • 0036890399 scopus 로고    scopus 로고
    • The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans
    • Danielson, P. B. (2002). The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr. Drug Metab. 3, 561-597. doi: 10.2174/1389200023337054
    • (2002) Curr. Drug Metab , vol.3 , pp. 561-597
    • Danielson, P.B.1
  • 11
  • 12
    • 0029621245 scopus 로고
    • Diversity and evolution of plant P450 and P450-reductases. Drug Metabol
    • Durst, F., and Nelson, D. R. (1995). Diversity and evolution of plant P450 and P450-reductases. Drug Metabol. Drug Interact. 12, 189-206. doi: 10.1515/DMDI.1995.12.3-4.189
    • (1995) Drug Interact , vol.12 , pp. 189-206
    • Durst, F.1    Nelson, D.R.2
  • 13
    • 84880380223 scopus 로고    scopus 로고
    • CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts
    • Guo, J., Zhou, Y. J., Hillwig, M. L., Shen, Y., Yang, L., Wang, Y., et al. (2013). CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. Proc. Natl. Acad. Sci. U.S.A. 110, 12108-12113. doi: 10.1073/pnas.1218061110
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 12108-12113
    • Guo, J.1    Zhou, Y.J.2    Hillwig, M.L.3    Shen, Y.4    Yang, L.5    Wang, Y.6
  • 14
    • 78049520843 scopus 로고    scopus 로고
    • Whole genome co-expression analysis of soybean cytochrome P450 genes identifies nodulation-specific P450 monooxygenases
    • Guttikonda, S. K., Trupti, J., Bisht, N. C., Chen, H., An, Y. Q. C., Pandey, S., et al. (2010). Whole genome co-expression analysis of soybean cytochrome P450 genes identifies nodulation-specific P450 monooxygenases. BMC Plant Biol. 10:243. doi: 10.1186/1471-2229-10-243
    • (2010) BMC Plant Biol , vol.10 , pp. 243
    • Guttikonda, S.K.1    Trupti, J.2    Bisht, N.C.3    Chen, H.4    An, Y.Q.C.5    Pandey, S.6
  • 15
    • 34248631420 scopus 로고    scopus 로고
    • Cytochrome P450 mono-oxygenases in conifer genomes: Discovery of members of the terpenoid oxygenase superfamily in spruce and pine. Biochem. Soc
    • Hamberger, B., and Bohlmann, J. (2006). Cytochrome P450 mono-oxygenases in conifer genomes: discovery of members of the terpenoid oxygenase superfamily in spruce and pine. Biochem. Soc. Trans. 34, 1209-1214. doi: 10.1042/BST0341209
    • (2006) Trans , vol.34 , pp. 1209-1214
    • Hamberger, B.1    Bohlmann, J.2
  • 16
    • 82855167372 scopus 로고    scopus 로고
    • Evolution of diterpene metabolism: Sitka spruce CYP720B4 catalyzes multiple oxidations in resin acid biosynthesis of conifer defense against insects
    • Hamberger, B., Ohnishi, T., Hamberger, B., Séguin, A., and Bohlmann, J. (2011). Evolution of diterpene metabolism: sitka spruce CYP720B4 catalyzes multiple oxidations in resin acid biosynthesis of conifer defense against insects. Plant Physiol. 157, 1677-1695. doi: 10.1104/pp.111.185843
    • (2011) Plant Physiol , vol.157 , pp. 1677-1695
    • Hamberger, B.1    Ohnishi, T.2    Hamberger, B.3    Séguin, A.4    Bohlmann, J.5
  • 17
    • 0029643786 scopus 로고
    • Structure and function of cytochromes P450: A comparative analysis of three crystal structures
    • Hasemann, C. A., Kurumbail, R. G., Boddupalli, S. S., Peterson, J. A., and Deisenhofer, J. (1995). Structure and function of cytochromes P450: a comparative analysis of three crystal structures. Structure 3, 41-62. doi: 10.1016/S0969-2126(01)00134-4
    • (1995) Structure , vol.3 , pp. 41-62
    • Hasemann, C.A.1    Kurumbail, R.G.2    Boddupalli, S.S.3    Peterson, J.A.4    Deisenhofer, J.5
  • 18
    • 0034789998 scopus 로고    scopus 로고
    • Taxol: Biosynthesis, molecular genetics, and biotechnological applications
    • Jennewein, S., and Croteau, R. (2001). Taxol: biosynthesis, molecular genetics, and biotechnological applications. Appl. Microbiol. Biotechnol. 57, 13-19. doi: 10.1007/s002530100757
    • (2001) Appl. Microbiol. Biotechnol , vol.57 , pp. 13-19
    • Jennewein, S.1    Croteau, R.2
  • 19
    • 2642518854 scopus 로고    scopus 로고
    • Cytochrome P450 taxadiene 5a-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis
    • Jennewein, S., Long, R. M., Williams, R. M., and Croteau, R. (2004). Cytochrome P450 taxadiene 5a-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis. Chem. Biol. 11, 379-387. doi: 10.1016/j.chembiol.2004.02.022
    • (2004) Chem. Biol , vol.11 , pp. 379-387
    • Jennewein, S.1    Long, R.M.2    Williams, R.M.3    Croteau, R.4
  • 20
    • 0242669969 scopus 로고    scopus 로고
    • Taxoid metabolism: Taxoid 14b-hydroxylase is a cytochrome P450-dependent monooxygenase
    • Jennewein, S., Rithner, C. D., Williams, R. M., and Croteau, R. (2003). Taxoid metabolism: taxoid 14b-hydroxylase is a cytochrome P450-dependent monooxygenase. Arch. Biochem. Biophys. 413, 262-270. doi: 10.1016/S0003-9861(03)00090-0
    • (2003) Arch. Biochem. Biophys , vol.413 , pp. 262-270
    • Jennewein, S.1    Rithner, C.D.2    Williams, R.M.3    Croteau, R.4
  • 21
    • 0035923612 scopus 로고    scopus 로고
    • Taxol biosynthesis: Taxane 13a-hydroxylase is a cytochrome P450-dependent monooxygenase
    • Jennewein, S., Rithner, C. D., Williams, R. M., and Croteau, R. B. (2001). Taxol biosynthesis: taxane 13a-hydroxylase is a cytochrome P450-dependent monooxygenase. Proc. Natl. Acad. Sci. U.S.A. 98, 13595-13600. doi: 10.1073/pnas.251539398
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 13595-13600
    • Jennewein, S.1    Rithner, C.D.2    Williams, R.M.3    Croteau, R.B.4
  • 22
    • 33845402189 scopus 로고    scopus 로고
    • Cytochrome P450 oxygenases of Taxol biosynthesis
    • Kaspera, R., and Croteau, R. (2006). Cytochrome P450 oxygenases of Taxol biosynthesis. Phytochem. Rev. 5, 433-444. doi: 10.1007/s11101-006-9006-4
    • (2006) Phytochem. Rev , vol.5 , pp. 433-444
    • Kaspera, R.1    Croteau, R.2
  • 23
    • 84875945076 scopus 로고    scopus 로고
    • Transcriptome analysis reveals ginsenosides biosynthetic genes, microRNAs and simple sequence repeats in Panax ginseng CA Meyer
    • Li, C., Zhu, Y., Guo, X., Sun, C., Luo, H., Song, J., et al. (2013). Transcriptome analysis reveals ginsenosides biosynthetic genes, microRNAs and simple sequence repeats in Panax ginseng CA Meyer. BMC Genomics 14:245. doi: 10.1186/1471-2164-14-245
    • (2013) BMC Genomics , vol.14 , pp. 245
    • Li, C.1    Zhu, Y.2    Guo, X.3    Sun, C.4    Luo, H.5    Song, J.6
  • 24
    • 84863091483 scopus 로고    scopus 로고
    • Transcriptional profile of Taxus chinensis cells in response to methyl jasmonate
    • Li, S. T., Zhang, P., Zhang, M., Fu, C. H., Zhao, C. F., Dong, Y. S., et al. (2012). Transcriptional profile of Taxus chinensis cells in response to methyl jasmonate. BMC Genomics 13:295. doi: 10.1186/1471-2164-13-295
    • (2012) BMC Genomics , vol.13 , pp. 295
    • Li, S.T.1    Zhang, P.2    Zhang, M.3    Fu, C.H.4    Zhao, C.F.5    Dong, Y.S.6
  • 25
    • 84870433755 scopus 로고    scopus 로고
    • Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis
    • Li, S., Zhang, P., Zhang, M., Fu, C., and Yu, L. (2013). Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis. Plant Biol. 15, 19-26. doi: 10.1111/j.1438-8677.2012.00611.x
    • (2013) Plant Biol , vol.15 , pp. 19-26
    • Li, S.1    Zhang, P.2    Zhang, M.3    Fu, C.4    Yu, L.5
  • 26
    • 84986551368 scopus 로고    scopus 로고
    • Comparative transcriptome analysis identifies putative genes involved in the biosynthesis of Xanthanolides in Xanthium strumarium L
    • Li, Y., Gou, J., Chen, F., Li, C., and Zhang, Y. (2016). Comparative transcriptome analysis identifies putative genes involved in the biosynthesis of Xanthanolides in Xanthium strumarium L. Front Plant. Sci. 7:1317. doi: 10.3389/fpls.2016.01317
    • (2016) Front Plant. Sci , vol.7 , pp. 1317
    • Li, Y.1    Gou, J.2    Chen, F.3    Li, C.4    Zhang, Y.5
  • 27
    • 0027412646 scopus 로고
    • Phase II study of taxol in patients with untreated advanced non-small-cell lung cancer
    • Murphy, W. K., Fossella, F. V., Winn, R. J., Shin, D. M., Hynes, H. E., Gross, H. M., et al. (1993). Phase II study of taxol in patients with untreated advanced non-small-cell lung cancer. J. Natl. Cancer Inst. 85, 384-388. doi: 10.1093/jnci/85.5.384
    • (1993) J. Natl. Cancer Inst , vol.85 , pp. 384-388
    • Murphy, W.K.1    Fossella, F.V.2    Winn, R.J.3    Shin, D.M.4    Hynes, H.E.5    Gross, H.M.6
  • 28
    • 73249132581 scopus 로고    scopus 로고
    • The cytochrome p450 homepage
    • Nelson, D. R. (2009). The cytochrome p450 homepage. Hum. Genomics. 4, 59-65. doi: 10.1186/1479-7364-4-1-59
    • (2009) Hum. Genomics , vol.4 , pp. 59-65
    • Nelson, D.R.1
  • 29
    • 84878420758 scopus 로고    scopus 로고
    • The Norway spruce genome sequence and conifer genome evolution
    • Nystedt, B., Street, N. R., Wetterbom, A., Zuccolo, A., Lin, Y. C., Scofield, D. G., et al. (2013). The Norway spruce genome sequence and conifer genome evolution. Nature 497, 579-584. doi: 10.1038/nature12211
    • (2013) Nature , vol.497 , pp. 579-584
    • Nystedt, B.1    Street, N.R.2    Wetterbom, A.3    Zuccolo, A.4    Lin, Y.C.5    Scofield, D.G.6
  • 30
    • 0033866508 scopus 로고    scopus 로고
    • Intron-exon organization and phylogeny in a large superfamily, the paralogous cytochrome P450 genes of Arabidopsis thaliana
    • Paquette, S. M., Bak, S., and Feyereisen, R. (2000). Intron-exon organization and phylogeny in a large superfamily, the paralogous cytochrome P450 genes of Arabidopsis thaliana. DNA Cell Biol. 19, 307-317. doi: 10.1089/10445490050021221
    • (2000) DNA Cell Biol , vol.19 , pp. 307-317
    • Paquette, S.M.1    Bak, S.2    Feyereisen, R.3
  • 31
    • 84941369863 scopus 로고    scopus 로고
    • Plant cytochrome P450s: Nomenclature and involvement in natural product biosynthesis
    • Rasool, S., and Mohamed, R. (2016). Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis. Protoplasma 253, 1197-1209. doi: 10.1007/s00709-015-0884-4
    • (2016) Protoplasma , vol.253 , pp. 1197-1209
    • Rasool, S.1    Mohamed, R.2
  • 32
    • 33645870422 scopus 로고    scopus 로고
    • Production of the antimalarial drug precursor artemisinic acid in engineered yeast
    • Ro, D. K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., et al. (2006). Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440, 940-943. doi: 10.1038/nature 04640
    • (2006) Nature , vol.440 , pp. 940-943
    • Ro, D.K.1    Paradise, E.M.2    Ouellet, M.3    Fisher, K.J.4    Newman, K.L.5    Ndungu, J.M.6
  • 33
    • 0035852639 scopus 로고    scopus 로고
    • Molecular cloning of a cytochrome P450 taxane 10b-hydroxylase cDNA from Taxus and functional expression in yeast
    • Schoendorf, A., Rithner, C. D., Williams, R. M., and Croteau, R. B. (2001). Molecular cloning of a cytochrome P450 taxane 10b-hydroxylase cDNA from Taxus and functional expression in yeast. Proc. Natl. Acad. Sci. U.S.A. 98, 1501-1506. doi: 10.1073/pnas.98.4.1501
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 1501-1506
    • Schoendorf, A.1    Rithner, C.D.2    Williams, R.M.3    Croteau, R.B.4
  • 34
    • 84898549594 scopus 로고    scopus 로고
    • Correlation analysis of the taxane core functional group modification, enzyme expression, and metabolite accumulation profiles under methyl jasmonate treatment
    • Song, G. H., Zhao, C. F., Zhang, M., Fu, C. H., Zhang, H., and Yu, L. J. (2014). Correlation analysis of the taxane core functional group modification, enzyme expression, and metabolite accumulation profiles under methyl jasmonate treatment. Biotechnol Prog. 30, 269-280. doi: 10.1002/btpr.1864
    • (2014) Biotechnol Prog , vol.30 , pp. 269-280
    • Song, G.H.1    Zhao, C.F.2    Zhang, M.3    Fu, C.H.4    Zhang, H.5    Yu, L.J.6
  • 35
    • 84896133970 scopus 로고    scopus 로고
    • Deep sequencing reveals transcriptome re-programming of Taxus × media cells to the elicitation with methyl jasmonate
    • Sun, G., Yang, Y., Xie, F., Wen, J. F., Wu, J., Wilson, I. W., et al. (2013). Deep sequencing reveals transcriptome re-programming of Taxus × media cells to the elicitation with methyl jasmonate. PLoS ONE 8:e62865. doi: 10.1371/journal.pone.0062865
    • (2013) Plos ONE , pp. 8
    • Sun, G.1    Yang, Y.2    Xie, F.3    Wen, J.F.4    Wu, J.5    Wilson, I.W.6
  • 36
    • 84968861007 scopus 로고    scopus 로고
    • Optimization of a broth conductivity controlling strategy directed by an online viable biomass sensor for enhancing Taxus cell growth rate and Taxol productivity
    • Wang, Z. J., Zhang, W., Zhang, J. W., Guo, M. J., and Zhuang, Y. P. (2016). Optimization of a broth conductivity controlling strategy directed by an online viable biomass sensor for enhancing Taxus cell growth rate and Taxol productivity. RSC Adv. 6, 40631-40640. doi: 10.1039/C5RA2 6540A
    • (2016) RSC Adv , vol.6 , pp. 40631-40640
    • Wang, Z.J.1    Zhang, W.2    Zhang, J.W.3    Guo, M.J.4    Zhuang, Y.P.5
  • 37
    • 84936845853 scopus 로고    scopus 로고
    • Improved white spruce (Picea glauca) genome assemblies and annotation of large gene families of conifer terpenoid and phenolic defense metabolism
    • Warren, R. L., Keeling, C. I., Yuen, M. M. S., Raymond, A., Taylor, G. A., Vandervalk, B. P., et al. (2015). Improved white spruce (Picea glauca) genome assemblies and annotation of large gene families of conifer terpenoid and phenolic defense metabolism. Plant J. 83, 189-212. doi: 10.1111/tpj.12886
    • (2015) Plant J , vol.83 , pp. 189-212
    • Warren, R.L.1    Keeling, C.I.2    Yuen, M.M.S.3    Raymond, A.4    Taylor, G.A.5    Vandervalk, B.P.6
  • 38
    • 27244462261 scopus 로고    scopus 로고
    • Taxol biosynthesis: Differential transformation of taxadien-5a-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells
    • Wheeler, A. L, Long, R. M., Ketchum, R. E. B., Rithner, C. D., Williams, R. M., and Croteau, R. (2001). Taxol biosynthesis: differential transformation of taxadien-5a-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells. Arch. Biochem. Biophys. 390, 265-278. doi: 10.1006/abbi.2001.2377
    • (2001) Arch. Biochem. Biophys , vol.390 , pp. 265-278
    • Wheeler, A.L.1    Long, R.M.2    Ketchum, R.E.B.3    Rithner, C.D.4    Williams, R.M.5    Croteau, R.6
  • 39
    • 0033970047 scopus 로고    scopus 로고
    • Mammalian microsomal cytochrome P450 monooxygenase: Structural adaptations for membrane binding and functional diversity
    • Williams, P. A., Cosme, J., Sridhar, V., Johnson, E. F., and McRee, D. E. (2000). Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity. Mol. Cell. 5, 121-131. doi: 10.1016/S1097-2765(00)80408-6
    • (2000) Mol. Cell , vol.5 , pp. 121-131
    • Williams, P.A.1    Cosme, J.2    Sridhar, V.3    Johnson, E.F.4    McRee, D.E.5
  • 40
    • 79952486339 scopus 로고    scopus 로고
    • Transcriptome analysis of Taxus cuspidata needles based on 454 pyrosequencing
    • Wu, Q., Sun, C., Luo, H., Li, Y., Niu, Y., Sun, Y., et al. (2011). Transcriptome analysis of Taxus cuspidata needles based on 454 pyrosequencing. Planta Med. 77, 394-400. doi: 10.1055/s-0030-1250331
    • (2011) Planta Med , vol.77 , pp. 394-400
    • Wu, Q.1    Sun, C.2    Luo, H.3    Li, Y.4    Niu, Y.5    Sun, Y.6
  • 41
    • 85017307468 scopus 로고    scopus 로고
    • Genome-wide identification, evolution, and expression analysis of the ATP-binding cassette transporter gene family in Brassica rapa
    • Yan, C., Duan, W., Lyu, S., Li, Y., and Hou, X. (2017). Genome-wide identification, evolution, and expression analysis of the ATP-binding cassette transporter gene family in Brassica rapa. Front Plant. Sci. 8:349. doi: 10.3389/fpls.2017. 00349
    • (2017) Front Plant. Sci. , vol.8 , pp. 349
    • Yan, C.1    Duan, W.2    Lyu, S.3    Li, Y.4    Hou, X.5
  • 42
    • 84878460164 scopus 로고    scopus 로고
    • Gene discovery of modular diterpene metabolism in nonmodel systems
    • Zerbe, P., Hamberger, B., Yuen, M. M., Chiang, A., Sandhu, H. K., Madilao, L. L., et al. (2013). Gene discovery of modular diterpene metabolism in nonmodel systems. Plant Physiol. 162, 1073-1091. doi: 10.1104/pp.113.218347
    • (2013) Plant Physiol , vol.162 , pp. 1073-1091
    • Zerbe, P.1    Hamberger, B.2    Yuen, M.M.3    Chiang, A.4    Sandhu, H.K.5    Madilao, L.L.6
  • 43
    • 84938827823 scopus 로고    scopus 로고
    • High-throughput sequencing reveals miRNA effects on the primary and secondary production properties in long-term subcultured Taxus cells
    • Zhang, M., Dong, Y., Nie, L., Lu, M., Fu, C., and Yu, L. (2015). High-throughput sequencing reveals miRNA effects on the primary and secondary production properties in long-term subcultured Taxus cells. Front Plant. Sci. 6:604. doi: 10.3389/fpls.2015.00604
    • (2015) Front Plant. Sci , vol.6 , pp. 604
    • Zhang, M.1    Dong, Y.2    Nie, L.3    Lu, M.4    Fu, C.5    Yu, L.6
  • 44
    • 84893662632 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a cytochrome P450 taxoid 9ahydroxylase in Ginkgo biloba cells
    • Zhang, N., Han, Z., Sun, G., Hoffman, A., Wilson, I. W., Yang, Y., et al. (2014). Molecular cloning and characterization of a cytochrome P450 taxoid 9ahydroxylase in Ginkgo biloba cells. Biochem Biophys. Res. Commun. 443, 938-943. doi: 10.1016/j.bbrc.2013.12.104
    • (2014) Biochem Biophys. Res. Commun , vol.443 , pp. 938-943
    • Zhang, N.1    Han, Z.2    Sun, G.3    Hoffman, A.4    Wilson, I.W.5    Yang, Y.6
  • 45
    • 84907821217 scopus 로고    scopus 로고
    • Research progress relating to the role of cytochrome P450 in the biosynthesis of terpenoids in medicinal plants
    • Zhao, Y. J., Cheng, Q. Q., Su, P., Chen, X., Wang, X. J., Gao, W., et al. (2014). Research progress relating to the role of cytochrome P450 in the biosynthesis of terpenoids in medicinal plants. Appl. Microbiol. Biotechnol. 98, 2371-2383. doi: 10.1007/s00253-013-5496-3
    • (2014) Appl. Microbiol. Biotechnol , vol.98 , pp. 2371-2383
    • Zhao, Y.J.1    Cheng, Q.Q.2    Su, P.3    Chen, X.4    Wang, X.J.5    Gao, W.6
  • 46
    • 84926646130 scopus 로고    scopus 로고
    • Distributing a metabolic pathway among a microbial consortium enhances production of natural products
    • Zhou, K., Qiao, K., Edgar, S., and Stephanopoulos, G. (2015). Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nat. Biotechnol. 33, 377-383. doi: 10.1038/nbt.3095
    • (2015) Nat. Biotechnol , vol.33 , pp. 377-383
    • Zhou, K.1    Qiao, K.2    Edgar, S.3    Stephanopoulos, G.4


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