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Volumn 24, Issue 34, 2017, Pages 3698-3710

The typical metabolic modifiers conferring improvement in cancer resistance

Author keywords

2 deoxy Dglucose; 3 bromopyruvate; Cancer metabolic reprogramming; Cancer resistance; Lonidamine; Metabolic modifiers

Indexed keywords

3 BROMOPYRUVATE; ANTINEOPLASTIC AGENT; DEOXYGLUCOSE; LONIDAMINE; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG; BROMOPYRUVATE; FATTY ACID; INDAZOLE DERIVATIVE;

EID: 85038222811     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867324666170203121449     Document Type: Review
Times cited : (11)

References (121)
  • 1
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • Pelicano, H.; Martin, D.S.; Xu, R.H.; Huang, P. Glycolysis inhibition for anticancer treatment. Oncogene, 2006, 25(34), 4633-4646.
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.H.3    Huang, P.4
  • 2
    • 84862884672 scopus 로고    scopus 로고
    • Influence of resistance to 5-fluorouracil and tomudex on [18F] FDG incorporation, glucose transport and hexokinase activity
    • Law, A.A.; Collie-Duguid, E.S.; Smith, T.A. Influence of resistance to 5-fluorouracil and tomudex on [18F]FDG incorporation, glucose transport and hexokinase activity. Int. J. Oncol., 2012, 41(1), 378-382.
    • (2012) Int. J. Oncol. , vol.41 , Issue.1 , pp. 378-382
    • Law, A.A.1    Collie-Duguid, E.S.2    Smith, T.A.3
  • 4
    • 79953679983 scopus 로고    scopus 로고
    • Genome-wide gene expression analysis of chemoresistant pulmonary carcinoid cells
    • Olszewski, U.; Zeillinger, R.; Geissler, K.; Hamilton, G. Genome-wide gene expression analysis of chemoresistant pulmonary carcinoid cells. Lung Cancer, 2010, 1, 107-117.
    • (2010) Lung Cancer , vol.1 , pp. 107-117
    • Olszewski, U.1    Zeillinger, R.2    Geissler, K.3    Hamilton, G.4
  • 5
    • 84941955458 scopus 로고    scopus 로고
    • Intratumoral heterogeneity: From diversity comes resistance
    • Pribluda, A.; de la Cruz, C.C.; Jackson, E.L. Intratumoral Heterogeneity: From Diversity Comes Resistance. Clin. Cancer Res., 2015, 21(13), 2916-2923.
    • (2015) Clin. Cancer Res. , vol.21 , Issue.13 , pp. 2916-2923
    • Pribluda, A.1    De La Cruz, C.C.2    Jackson, E.L.3
  • 6
    • 84870667447 scopus 로고    scopus 로고
    • Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate
    • Wintzell, M.; Lofstedt, L.; Johansson, J.; Pedersen, A.B.; Fuxe, J.; Shoshan, M. Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate. Cancer boil. therap., 2012, 13(14), 1454-1462.
    • (2012) Cancer Boil. Therap. , vol.13 , Issue.14 , pp. 1454-1462
    • Wintzell, M.1    Lofstedt, L.2    Johansson, J.3    Pedersen, A.B.4    Fuxe, J.5    Shoshan, M.6
  • 7
    • 84887483618 scopus 로고    scopus 로고
    • Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction
    • Long, Y.; Tsai, W.B.; Wangpaichitr, M.; Tsukamoto, T.; Savaraj, N.; Feun, L.G.; Kuo, M.T. Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction. Mol. Cancer Ther., 2013, 12(11), 2581-2590.
    • (2013) Mol. Cancer Ther. , vol.12 , Issue.11 , pp. 2581-2590
    • Long, Y.1    Tsai, W.B.2    Wangpaichitr, M.3    Tsukamoto, T.4    Savaraj, N.5    Feun, L.G.6    Kuo, M.T.7
  • 8
    • 84947704464 scopus 로고    scopus 로고
    • Cancer's fuel choice: New flavors for a picky eater
    • DeNicola, G.M.; Cantley, L.C., Cancer's fuel choice: New flavors for a picky eater. Mol. Cell, 2015, 60(4), 514-523.
    • (2015) Mol. Cell , vol.60 , Issue.4 , pp. 514-523
    • Denicola, G.M.1    Cantley, L.C.2
  • 9
    • 12544256565 scopus 로고    scopus 로고
    • Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    • Xu, R.H.; Pelicano, H.; Zhou, Y.; Carew, J.S.; Feng, L.; Bhalla, K.N.; Keating, M.J.; Huang, P. Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res., 2005, 65(2), 613-621.
    • (2005) Cancer Res. , vol.65 , Issue.2 , pp. 613-621
    • Xu, R.H.1    Pelicano, H.2    Zhou, Y.3    Carew, J.S.4    Feng, L.5    Bhalla, K.N.6    Keating, M.J.7    Huang, P.8
  • 12
    • 84905095742 scopus 로고    scopus 로고
    • Association of overexpression of hexokinase II with chemoresistance in epithelial ovarian cancer
    • Suh, D.H.; Kim, M.A.; Kim, H.; Kim, M.K.; Kim, H.S.; Chung, H.H.; Kim, Y.B.; Song, Y.S. Association of overexpression of hexokinase II with chemoresistance in epithelial ovarian cancer. J. Clin. Exp. Med., 2014, 14(3), 345-353.
    • (2014) J. Clin. Exp. Med. , vol.14 , Issue.3 , pp. 345-353
    • Suh, D.H.1    Kim, M.A.2    Kim, H.3    Kim, M.K.4    Kim, H.S.5    Chung, H.H.6    Kim, Y.B.7    Song, Y.S.8
  • 13
    • 0242610852 scopus 로고    scopus 로고
    • Glucose depletion enhances P-glycoprotein expression in hepatoma cells: Role of endoplasmic reticulum stress response
    • Ledoux, S.; Yang, R.; Friedlander, G.; Laouari, D. Glucose depletion enhances P-glycoprotein expression in hepatoma cells: role of endoplasmic reticulum stress response. Cancer Res., 2003, 63(21), 7284-7290.
    • (2003) Cancer Res. , vol.63 , Issue.21 , pp. 7284-7290
    • Ledoux, S.1    Yang, R.2    Friedlander, G.3    Laouari, D.4
  • 14
    • 84896981887 scopus 로고    scopus 로고
    • HIF-1alpha and GLUT1 gene expression is associated with chemoresistance of acute myeloid leukemia
    • Song, K.; Li, M.; Xu, X.J.; Xuan, L.; Huang, G.N.; Song, X.L.; Liu, Q.F. HIF-1alpha and GLUT1 gene expression is associated with chemoresistance of acute myeloid leukemia. Asian Pac. J. Cancer Prev., 2014, 15(4), 1823-1829.
    • (2014) Asian Pac. J. Cancer Prev. , vol.15 , Issue.4 , pp. 1823-1829
    • Song, K.1    Li, M.2    Xu, X.J.3    Xuan, L.4    Huang, G.N.5    Song, X.L.6    Liu, Q.F.7
  • 16
    • 84908305843 scopus 로고    scopus 로고
    • Metabolic orchestration between cancer cells and tumor microenvironment as a co-evolutionary source of chemoresistance in ovarian cancer: A therapeutic implication
    • Suh, D.H.; Kim, H.S.; Kim, B.; Song, Y.S. Metabolic orchestration between cancer cells and tumor microenvironment as a co-evolutionary source of chemoresistance in ovarian cancer: a therapeutic implication. Biochem. Pharmacol., 2014, 92(1), 43-54.
    • (2014) Biochem. Pharmacol. , vol.92 , Issue.1 , pp. 43-54
    • Suh, D.H.1    Kim, H.S.2    Kim, B.3    Song, Y.S.4
  • 17
    • 84859941115 scopus 로고    scopus 로고
    • Retinoblastoma treatment: Utilization of the glycolytic inhibitor, 2-deoxy-2-fluoro-D-glucose (2-FG), to target the chemoresistant hypoxic regions in LH(BETA)T(AG) retinal tumors
    • Pina, Y.; Decatur, C.; Murray, T.G.; Houston, S.K.; Lopez- Cavalcante, M.; Hernandez, E.; Celdran, M.; Shah, N.; Feuer, W.; Lampidis, T. Retinoblastoma treatment: utilization of the glycolytic inhibitor, 2-deoxy-2-fluoro-D-glucose (2-FG), to target the chemoresistant hypoxic regions in LH(BETA)T(AG) retinal tumors. Invest. Ophthalmol. Vis. Sci., 2012, 53(2), 996-1002.
    • (2012) Invest. Ophthalmol. Vis. Sci. , vol.53 , Issue.2 , pp. 996-1002
    • Pina, Y.1    Decatur, C.2    Murray, T.G.3    Houston, S.K.4    Lopez-Cavalcante, M.5    Hernandez, E.6    Celdran, M.7    Shah, N.8    Feuer, W.9    Lampidis, T.10
  • 18
    • 84856692165 scopus 로고    scopus 로고
    • Clotrimazole preferentially inhibits human breast cancer cell proliferation, viability and glycolysis
    • Furtado, C.M.; Marcondes, M.C.; Sola-Penna, M.; de Souza, M.L.; Zancan, P. Clotrimazole preferentially inhibits human breast cancer cell proliferation, viability and glycolysis. PLoS One, 2012, 7(2), e30462.
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e30462
    • Furtado, C.M.1    Marcondes, M.C.2    Sola-Penna, M.3    De Souza, M.L.4    Zancan, P.5
  • 20
    • 77952553756 scopus 로고    scopus 로고
    • Clotrimazole potentiates the inhibitory effects of ATP on the key glycolytic enzyme 6-phosphofructo-1-kinase
    • Marcondes, M.C.; Sola-Penna, M.; Zancan, P. Clotrimazole potentiates the inhibitory effects of ATP on the key glycolytic enzyme 6-phosphofructo-1-kinase. Arch .Biochem Biophys., 2010, 497(1-2), 62-67.
    • (2010) Arch .Biochem Biophys. , vol.497 , Issue.1-2 , pp. 62-67
    • Marcondes, M.C.1    Sola-Penna, M.2    Zancan, P.3
  • 23
    • 84939888469 scopus 로고    scopus 로고
    • Metabolic consequences of LDHA inhibition by epigallocatechin gallate and oxamate in MIA PaCa-2 pancreatic cancer Cells
    • Lu, Q.Y.; Zhang, L.; Yee, J.K.; Go, V.W.; Lee, W.N. Metabolic consequences of LDHA inhibition by epigallocatechin gallate and oxamate in MIA PaCa-2 pancreatic cancer Cells. Metabolomics, 2015, 11(1), 71-80.
    • (2015) Metabolomics , vol.11 , Issue.1 , pp. 71-80
    • Lu, Q.Y.1    Zhang, L.2    Yee, J.K.3    Go, V.W.4    Lee, W.N.5
  • 25
    • 84923856475 scopus 로고    scopus 로고
    • Investigating and targeting chronic lymphocytic leukemia metabolism with the human immunodeficiency virus protease inhibitor ritonavir and metformin
    • Adekola, K.U.; Dalva Aydemir, S.; Ma, S.; Zhou, Z.; Rosen, S.T.; Shanmugam, M. Investigating and targeting chronic lymphocytic leukemia metabolism with the human immunodeficiency virus protease inhibitor ritonavir and metformin. Leuk. Lymphoma, 2015, 56(2), 450-459.
    • (2015) Leuk. Lymphoma , vol.56 , Issue.2 , pp. 450-459
    • Adekola, K.U.1    Dalva Aydemir, S.2    Ma, S.3    Zhou, Z.4    Rosen, S.T.5    Shanmugam, M.6
  • 26
    • 85027930334 scopus 로고    scopus 로고
    • Glycative stress from advanced glycation end products (AGEs) and dicarbonyls: An emerging biological factor in cancer onset and progression
    • Lin, J.A.; Wu, C.H.; Lu, C.C.; Hsia, S.M.; Yen, G.C. Glycative stress from advanced glycation end products (AGEs) and dicarbonyls: An emerging biological factor in cancer onset and progression. Mol. Nutr. Food Res., 2016, 60(8), 1850-1864
    • (2016) Mol. Nutr. Food Res. , vol.60 , Issue.8 , pp. 1850-1864
    • Lin, J.A.1    Wu, C.H.2    Lu, C.C.3    Hsia, S.M.4    Yen, G.C.5
  • 27
    • 84961775804 scopus 로고    scopus 로고
    • Oxidative stress and glyoxalase i activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen resistant derivative
    • Nass, N.; Sel, S.; Ignatov, A.; Roessner, A.; Kalinski, T. Oxidative stress and glyoxalase I activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen resistant derivative. Biochim. Biophys. Acta., 2016, 1860(6), 1272-1280.
    • (2016) Biochim. Biophys. Acta. , vol.1860 , Issue.6 , pp. 1272-1280
    • Nass, N.1    Sel, S.2    Ignatov, A.3    Roessner, A.4    Kalinski, T.5
  • 28
    • 79955945922 scopus 로고    scopus 로고
    • Glyoxalase in tumourigenesis and multidrug resistance
    • Thornalley, P.J.; Rabbani, N. Glyoxalase in tumourigenesis and multidrug resistance. Semin. Cell Dev. Biol., 2011, 22(3), 318-325.
    • (2011) Semin. Cell Dev. Biol. , vol.22 , Issue.3 , pp. 318-325
    • Thornalley, P.J.1    Rabbani, N.2
  • 29
    • 84876937174 scopus 로고    scopus 로고
    • Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: C-Src and hexokinase II
    • Wei, L.; Dai, Q.; Zhou, Y.; Zou, M.; Li, Z.; Lu, N.; Guo, Q. Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II. Biochim. Biophys. Acta, 2013, 1830(6), 3835-3845.
    • (2013) Biochim. Biophys. Acta , vol.1830 , Issue.6 , pp. 3835-3845
    • Wei, L.1    Dai, Q.2    Zhou, Y.3    Zou, M.4    Li, Z.5    Lu, N.6    Guo, Q.7
  • 31
  • 32
    • 0022994217 scopus 로고
    • Phase II study of lonidamine in patients with metastatic breast cancer: A National Cancer Institute of Canada Clinical Trials Group Study
    • Band, P.R.; Maroun, J.; Pritchard, K.; Stewart, D.; Coppin, C.M.; Wilson, K.; Eisenhauer, E.A. Phase II study of lonidamine in patients with metastatic breast cancer: A National Cancer Institute of Canada Clinical Trials Group Study. Cancer Treat Rep., 1986, 70(11), 1305-1310.
    • (1986) Cancer Treat Rep. , vol.70 , Issue.11 , pp. 1305-1310
    • Band, P.R.1    Maroun, J.2    Pritchard, K.3    Stewart, D.4    Coppin, C.M.5    Wilson, K.6    Eisenhauer, E.A.7
  • 33
    • 0029073748 scopus 로고
    • Mechanism of action of the antineoplastic drug lonidamine: 31P and 13C nuclear magnetic resonance studies
    • Ben-Horin, H.; Tassini, M.; Vivi, A.; Navon, G.; Kaplan, O. Mechanism of action of the antineoplastic drug lonidamine: 31P and 13C nuclear magnetic resonance studies. Cancer Res., 1995, 55(13), 2814-2821.
    • (1995) Cancer Res. , vol.55 , Issue.13 , pp. 2814-2821
    • Ben-Horin, H.1    Tassini, M.2    Vivi, A.3    Navon, G.4    Kaplan, O.5
  • 34
    • 0031048152 scopus 로고    scopus 로고
    • Comparison of action of the anti-neoplastic drug lonidamine on drug-sensitive and drug-resistant human breast cancer cells: 31P and 13C nuclear magnetic resonance studies
    • Vivi, A.; Tassini, M.; Ben-Horin, H.; Navon, G.; Kaplan, O. Comparison of action of the anti-neoplastic drug lonidamine on drug-sensitive and drug-resistant human breast cancer cells: 31P and 13C nuclear magnetic resonance studies. Breast Cancer Res. Treat, 1997, 43(1), 15-25.
    • (1997) Breast Cancer Res. Treat , vol.43 , Issue.1 , pp. 15-25
    • Vivi, A.1    Tassini, M.2    Ben-Horin, H.3    Navon, G.4    Kaplan, O.5
  • 36
    • 0033516635 scopus 로고    scopus 로고
    • Bcl-2 inhibits mitochondrial metabolism and lonidamine-induced apoptosis in adriamycin-resistant MCF7 cells
    • Biroccio, A.; Del Bufalo, D.; Fanciulli, M.; Bruno, T.; Zupi, G.; Floridi, A. bcl-2 inhibits mitochondrial metabolism and lonidamine-induced apoptosis in adriamycin-resistant MCF7 cells. Int. J. Cancer, 1999, 82(1), 125-130.
    • (1999) Int. J. Cancer , vol.82 , Issue.1 , pp. 125-130
    • Biroccio, A.1    Del Bufalo, D.2    Fanciulli, M.3    Bruno, T.4    Zupi, G.5    Floridi, A.6
  • 37
    • 0027985539 scopus 로고
    • In vitro effect of lonidamine on the cytotoxicity of mitomycin C and BCNU in human colon adenocarcinoma cells
    • Villa, R.; Zaffaroni, N.; Orlandi, L.; Bearzatto, A.; Costa, A.; Silvestrini, R. In vitro effect of lonidamine on the cytotoxicity of mitomycin C and BCNU in human colon adenocarcinoma cells. Eur. J. cancer, 1994, 30A(10), 1534-1540.
    • (1994) Eur. J. Cancer , vol.30 A , Issue.10 , pp. 1534-1540
    • Villa, R.1    Zaffaroni, N.2    Orlandi, L.3    Bearzatto, A.4    Costa, A.5    Silvestrini, R.6
  • 38
    • 0031015908 scopus 로고    scopus 로고
    • Modulation by lonidamine on the combined activity of cisplatin and epidoxorubicin in human breast cancer cells
    • Silvestrini, R.; Gornati, D.; Zaffaroni, N.; Bearzatto, A.; De Marco, C. Modulation by lonidamine on the combined activity of cisplatin and epidoxorubicin in human breast cancer cells. Breast cancer res., 1997, 42(2), 103-112.
    • (1997) Breast Cancer Res. , vol.42 , Issue.2 , pp. 103-112
    • Silvestrini, R.1    Gornati, D.2    Zaffaroni, N.3    Bearzatto, A.4    De Marco, C.5
  • 39
    • 84975108548 scopus 로고    scopus 로고
    • Re-programming tumour cell metabolism to treat cancer: No lone target for lonidamine
    • Bhutia, Y.D.; Babu, E.; Ganapathy, V. Re-programming tumour cell metabolism to treat cancer: No lone target for lonidamine. Biochem J., 2016, 473(11), 1503-1506.
    • (2016) Biochem J. , vol.473 , Issue.11 , pp. 1503-1506
    • Bhutia, Y.D.1    Babu, E.2    Ganapathy, V.3
  • 40
    • 84924064231 scopus 로고    scopus 로고
    • Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin
    • Nath, K.; Nelson, D.S.; Heitjan, D.F.; Leeper, D.B.; Zhou, R.; Glickson, J.D. Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin. NMR Biomed., 2015, 28(3), 281-290.
    • (2015) NMR Biomed. , vol.28 , Issue.3 , pp. 281-290
    • Nath, K.1    Nelson, D.S.2    Heitjan, D.F.3    Leeper, D.B.4    Zhou, R.5    Glickson, J.D.6
  • 41
    • 84943544632 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment
    • Assanhou, A.G.; Li, W.; Zhang, L.; Xue, L.; Kong, L.; Sun, H.; Mo, R.; Zhang, C. Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment. Biomaterials, 2015, 73, 284-295.
    • (2015) Biomaterials , vol.73 , pp. 284-295
    • Assanhou, A.G.1    Li, W.2    Zhang, L.3    Xue, L.4    Kong, L.5    Sun, H.6    Mo, R.7    Zhang, C.8
  • 42
    • 80052552395 scopus 로고    scopus 로고
    • Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer
    • Milane, L.; Duan, Z.; Amiji, M. Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer. PLoS One, 2011, 6(9), e24075.
    • (2011) PLoS One , vol.6 , Issue.9 , pp. e24075
    • Milane, L.1    Duan, Z.2    Amiji, M.3
  • 43
    • 84874270687 scopus 로고    scopus 로고
    • Development of targeting lonidamine liposomes that circumvent drugresistant cancer by acting on mitochondrial signaling pathways
    • Li, N.; Zhang, C.X.; Wang, X.X.; Zhang, L.; Ma, X.; Zhou, J.; Ju, R.J.; Li, X.Y.; Zhao, W.Y.; Lu, W.L. Development of targeting lonidamine liposomes that circumvent drugresistant cancer by acting on mitochondrial signaling pathways. Biomaterials, 2013, 34(13), 3366-3380.
    • (2013) Biomaterials , vol.34 , Issue.13 , pp. 3366-3380
    • Li, N.1    Zhang, C.X.2    Wang, X.X.3    Zhang, L.4    Ma, X.5    Zhou, J.6    Ju, R.J.7    Li, X.Y.8    Zhao, W.Y.9    Lu, W.L.10
  • 44
    • 84942292107 scopus 로고    scopus 로고
    • Reviving lonidamine and 6-Diazo-5-oxo-L-norleucine to be used in combination for metabolic cancer Therapy
    • Cervantes-Madrid, D.; Romero, Y.; Duenas-Gonzalez, A. Reviving lonidamine and 6-Diazo-5-oxo-L-norleucine to be used in combination for metabolic cancer Therapy. Biomed Res. Int., 2015, 2015, 690492.
    • (2015) Biomed Res. Int. , vol.2015 , pp. 690492
    • Cervantes-Madrid, D.1    Romero, Y.2    Duenas-Gonzalez, A.3
  • 45
    • 84964503274 scopus 로고    scopus 로고
    • In vivo synergistic antitumor effect and safety of siRNA and lonidamine dualloaded hierarchical targeted nanoparticles
    • Zhang, B.F.; Xing, L.; Qiao, J.B.; Cui, P.F.; Wang, F.Z.; Zhang, J.L.; Xu, C.X.; Jiang, H.L. In vivo synergistic antitumor effect and safety of siRNA and lonidamine dualloaded hierarchical targeted nanoparticles. Int. J. Pharm., 2016, 506(1-2), 207-213.
    • (2016) Int. J. Pharm. , vol.506 , Issue.1-2 , pp. 207-213
    • Zhang, B.F.1    Xing, L.2    Qiao, J.B.3    Cui, P.F.4    Wang, F.Z.5    Zhang, J.L.6    Xu, C.X.7    Jiang, H.L.8
  • 46
    • 0025638922 scopus 로고
    • Cytotoxicity of lonidamine alone and in combination with other drugs against murine RIF-1 and human HT1080 cells in vitro
    • Ning, S.C.; Hahn, G.M. Cytotoxicity of lonidamine alone and in combination with other drugs against murine RIF-1 and human HT1080 cells in vitro. Cancer Res., 1990, 50 (24), 7867-7870.
    • (1990) Cancer Res. , vol.50 , Issue.24 , pp. 7867-7870
    • Ning, S.C.1    Hahn, G.M.2
  • 47
    • 0025776309 scopus 로고
    • Reversal of adriamycin resistance by lonidamine in a human breast cancer cell line
    • Citro, G.; Cucco, C.; Verdina, A.; Zupi, G. Reversal of adriamycin resistance by lonidamine in a human breast cancer cell line. Br. J. Cancer, 1991, 64(3), 534-536.
    • (1991) Br. J. Cancer , vol.64 , Issue.3 , pp. 534-536
    • Citro, G.1    Cucco, C.2    Verdina, A.3    Zupi, G.4
  • 49
    • 0032190467 scopus 로고    scopus 로고
    • Enhancement of doxorubicin content by the antitumor drug lonidamine in resistant Ehrlich ascites tumor cells through modulation of energy metabolism
    • Floridi, A.; Bruno, T.; Miccadei, S.; Fanciulli, M.; Federico, A.; Paggi, M.G. Enhancement of doxorubicin content by the antitumor drug lonidamine in resistant Ehrlich ascites tumor cells through modulation of energy metabolism. Biochemical. Pharmacol., 1998, 56(7), 841-849.
    • (1998) Biochemical. Pharmacol. , vol.56 , Issue.7 , pp. 841-849
    • Floridi, A.1    Bruno, T.2    Miccadei, S.3    Fanciulli, M.4    Federico, A.5    Paggi, M.G.6
  • 50
    • 0028984960 scopus 로고
    • Relative cytotoxicities of adriamycin and epirubicin in combination with lonidamine against human bladder cancer cell lines
    • Popert, R.J.; Masters, J.R.; Coptcoat, M.; Zupi, G. Relative cytotoxicities of adriamycin and epirubicin in combination with lonidamine against human bladder cancer cell lines. Urol. Res., 1995, 22(6), 367-372.
    • (1995) Urol. Res. , vol.22 , Issue.6 , pp. 367-372
    • Popert, R.J.1    Masters, J.R.2    Coptcoat, M.3    Zupi, G.4
  • 51
    • 0029952517 scopus 로고    scopus 로고
    • Effect of the antitumor drug lonidamine on glucose metabolism of adriamycin-sensitive and -resistant human breast cancer cells
    • Fanciulli, M.; Valentini, A.; Bruno, T.; Citro, G.; Zupi, G.; Floridi, A. Effect of the antitumor drug lonidamine on glucose metabolism of adriamycin-sensitive and -resistant human breast cancer cells. Oncol. Res., 1996, 8(3), 111-120.
    • (1996) Oncol. Res. , vol.8 , Issue.3 , pp. 111-120
    • Fanciulli, M.1    Valentini, A.2    Bruno, T.3    Citro, G.4    Zupi, G.5    Floridi, A.6
  • 52
    • 0026446255 scopus 로고
    • Enhancement of cisplatin activity by lonidamine in human ovarian cancer cells
    • Silvestrini, R.; Zaffaroni, N.; Villa, R.; Orlandi, L.; Costa, A. Enhancement of cisplatin activity by lonidamine in human ovarian cancer cells. Int. J. Cancer, 1992, 52(5), 813-817.
    • (1992) Int. J. Cancer , vol.52 , Issue.5 , pp. 813-817
    • Silvestrini, R.1    Zaffaroni, N.2    Villa, R.3    Orlandi, L.4    Costa, A.5
  • 53
    • 0027103922 scopus 로고
    • An adriamycinresistant subline is more sensitive than the parent human small cell lung cancer cell line to lonidamine
    • Kiura, K.; Ohnoshi, T.; Ueoka, H.; Takigawa, N.; Tabata, M.; Segawa, Y.; Shibayama, T.; Kimura, I. An adriamycinresistant subline is more sensitive than the parent human small cell lung cancer cell line to lonidamine. Anticancer Drug Des., 1992, 7(6), 463-470.
    • (1992) Anticancer Drug Des. , vol.7 , Issue.6 , pp. 463-470
    • Kiura, K.1    Ohnoshi, T.2    Ueoka, H.3    Takigawa, N.4    Tabata, M.5    Segawa, Y.6    Shibayama, T.7    Kimura, I.8
  • 54
    • 0034534119 scopus 로고    scopus 로고
    • Lonidamine cytotoxicity: Involvement of the lysosomal compartment
    • Dell'Antone, P.; Bragadin, M.; Piergallini, L. Lonidamine cytotoxicity: Involvement of the lysosomal compartment. J Int Med Res, 2000, 28(6), 269-276.
    • (2000) J Int Med Res , vol.28 , Issue.6 , pp. 269-276
    • Dell'Antone, P.1    Bragadin, M.2    Piergallini, L.3
  • 55
    • 0029969632 scopus 로고    scopus 로고
    • Efficacy of lonidamine combined with different DNA-damaging agents in the treatment of the MX-1 tumor xenograft
    • Pratesi, G.; De Cesare, M.; Zunino, F. Efficacy of lonidamine combined with different DNA-damaging agents in the treatment of the MX-1 tumor xenograft. Cancer Chemother. Pharmacol., 1996, 38(2), 123-128.
    • (1996) Cancer Chemother. Pharmacol. , vol.38 , Issue.2 , pp. 123-128
    • Pratesi, G.1    De Cesare, M.2    Zunino, F.3
  • 57
    • 0027272273 scopus 로고
    • Recovery of response to adriamycin and cyclophosphamide by lonidamine in previously treated metastatic breast-cancer patients. Int
    • Tomirotti, M.; Bernardo, G.; Epifani, C.; Biasioli, R.; Franchi, R.; Mensi, F.; Carnaghi, P.; Schieppati, G.; Scanni, A. Recovery of response to adriamycin and cyclophosphamide by lonidamine in previously treated metastatic breast-cancer patients. Int. J. oncol., 1993, 3(2), 213-217.
    • (1993) J. Oncol. , vol.3 , Issue.2 , pp. 213-217
    • Tomirotti, M.1    Bernardo, G.2    Epifani, C.3    Biasioli, R.4    Franchi, R.5    Mensi, F.6    Carnaghi, P.7    Schieppati, G.8    Scanni, A.9
  • 60
    • 8944237973 scopus 로고    scopus 로고
    • Epirubicin, and vindesine with or without lonidamine in the treatment of inoperable nonsmall cell lung carcinoma: A multicenter randomized clinical trial
    • Ianniello, G.P.; De Cataldis, G.; Comella, P.; Scarpati, M.D.; Maiorino, A.; Brancaccio, L.; Cioffi, R.; Lombardi, A.; Carnicelli, P.; Tinessa, V. Cisplatin, epirubicin, and vindesine with or without lonidamine in the treatment of inoperable nonsmall cell lung carcinoma: A multicenter randomized clinical trial. Cancer, 1996, 78(1), 63-69.
    • (1996) Cancer , vol.78 , Issue.1 , pp. 63-69
    • Ianniello, G.P.1    De Cataldis, G.2    Comella, P.3    Scarpati, M.D.4    Maiorino, A.5    Brancaccio, L.6    Cioffi, R.7    Lombardi, A.8    Carnicelli, P.9    Cisplatin, T.V.10
  • 61
    • 0028872418 scopus 로고
    • Clinical modulation of epirubicin resistance by lonidamine in patients with advanced soft-tissue sarcomas. Int
    • Lopez, M.; Carpano, S.; Dilauro, L.; Chiatti, L.; Vici, P.; Cavaliere, F.; Gentile, P.; Citro, G. Clinical modulation of epirubicin resistance by lonidamine in patients with advanced soft-tissue sarcomas. Int. J. oncol., 1995, 6(2), 363-367.
    • (1995) J. Oncol. , vol.6 , Issue.2 , pp. 363-367
    • Lopez, M.1    Carpano, S.2    Dilauro, L.3    Chiatti, L.4    Vici, P.5    Cavaliere, F.6    Gentile, P.7    Citro, G.8
  • 67
    • 0035877967 scopus 로고    scopus 로고
    • Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis
    • Sordet, O.; Rebe, C.; Leroy, I.; Bruey, J.M.; Garrido, C.; Miguet, C.; Lizard, G.; Plenchette, S.; Corcos, L.; Solary, E. Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis. Blood, 2001, 97(12), 3931-3940.
    • (2001) Blood , vol.97 , Issue.12 , pp. 3931-3940
    • Sordet, O.1    Rebe, C.2    Leroy, I.3    Bruey, J.M.4    Garrido, C.5    Miguet, C.6    Lizard, G.7    Plenchette, S.8    Corcos, L.9    Solary, E.10
  • 68
    • 0032608639 scopus 로고    scopus 로고
    • Modulation of cytotoxic drug activity by mitotane and lonidamine in human adrenocortical carcinoma cells
    • Villa, R.; Orlandi, L.; Berruti, A.; Dogliotti, L.; Zaffaroni, N., Modulation of cytotoxic drug activity by mitotane and lonidamine in human adrenocortical carcinoma cells. Int. J. oncol., 1999, 14(1), 133-138.
    • (1999) Int. J. Oncol. , vol.14 , Issue.1 , pp. 133-138
    • Villa, R.1    Orlandi, L.2    Berruti, A.3    Dogliotti, L.4    Zaffaroni, N.5
  • 69
    • 84940063528 scopus 로고    scopus 로고
    • Chronic dietary administration of the glycolytic inhibitor 2- Deoxy-D-Glucose (2- DG) inhibits the growth of implanted ehrlich's ascites tumor in mice
    • Saurabh, S.; Sanjay, P.; Anant, N.B.; Richa, C.; Vikas, B.; Namita, K.; Ravi, S.; Bal, G.R.; Daman, S.; Bilikere, S.D. Chronic dietary administration of the glycolytic inhibitor 2- Deoxy-D-Glucose (2- DG) inhibits the growth of implanted ehrlich's ascites tumor in mice. PLoS One, 2015, e0132089.
    • (2015) PLoS One , pp. e0132089
    • Saurabh, S.1    Sanjay, P.2    Anant, N.B.3    Richa, C.4    Vikas, B.5    Namita, K.6    Ravi, S.7    Bal, G.R.8    Daman, S.9    Bilikere, S.D.10
  • 73
    • 0023639297 scopus 로고
    • Inhibition of established rat fibrosarcoma growth by the glucose antagonist 2-deoxy-Dglucose
    • Kern, K.A.; Norton, J.A. Inhibition of established rat fibrosarcoma growth by the glucose antagonist 2-deoxy-Dglucose. Surgery, 1987, 102(2), 380-385.
    • (1987) Surgery , vol.102 , Issue.2 , pp. 380-385
    • Kern, K.A.1    Norton, J.A.2
  • 74
    • 84916631342 scopus 로고    scopus 로고
    • Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen- induced rat hepatocarcinogenesis by restricting cancer cell metabolism
    • Wang, Z.; Zhang, L.; Zhang, D.; Sun, R.; Wang, Q.; Liu, X. Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen- induced rat hepatocarcinogenesis by restricting cancer cell metabolism. Mol. Med. Rep., 2015, 11(3), 1917- 1924.
    • (2015) Mol. Med. Rep. , vol.11 , Issue.3 , pp. 1917-1924
    • Wang, Z.1    Zhang, L.2    Zhang, D.3    Sun, R.4    Wang, Q.5    Liu, X.6
  • 75
    • 84908220531 scopus 로고    scopus 로고
    • 2- Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy
    • Zhang, D.; Li, J.; Wang, F.; Hu, J.; Wang, S.; Sun, Y. 2- Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Lett., 2014, 355(2), 176-183.
    • (2014) Cancer Lett. , vol.355 , Issue.2 , pp. 176-183
    • Zhang, D.1    Li, J.2    Wang, F.3    Hu, J.4    Wang, S.5    Sun, Y.6
  • 76
    • 84928495468 scopus 로고    scopus 로고
    • Dose-dependent effect of 2-deoxy-D-glucose on glycoprotein mannosylation in cancer cells
    • Ahadova, A.; Gebert, J.; von Knebel Doeberitz, M.; Kopitz, J.; Kloor, M. Dose-dependent effect of 2-deoxy-D-glucose on glycoprotein mannosylation in cancer cells. IUBMB Life, 2015, 67(3), 218-226.
    • (2015) IUBMB Life , vol.67 , Issue.3 , pp. 218-226
    • Ahadova, A.1    Gebert, J.2    Von Knebel Doeberitz, M.3    Kopitz, J.4    Kloor, M.5
  • 78
    • 0021993763 scopus 로고
    • Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells
    • Jain, V.K.; Kalia, V.K.; Sharma, R.; Maharajan, V.; Menon, M. Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells. Int. J. Radiat. Oncol. Biol. Phys., 1985, 11(5), 943-950.
    • (1985) Int. J. Radiat. Oncol. Biol. Phys. , vol.11 , Issue.5 , pp. 943-950
    • Jain, V.K.1    Kalia, V.K.2    Sharma, R.3    Maharajan, V.4    Menon, M.5
  • 79
    • 84864025896 scopus 로고    scopus 로고
    • Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia
    • DeSalvo, J.; Kuznetsov, J.N.; Du, J.; Leclerc, G.M.; Leclerc, G.J.; Lampidis, T.J.; Barredo, J.C. Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia. Mol. Cancer Res., 2012, 10(7), 969-978.
    • (2012) Mol. Cancer Res. , vol.10 , Issue.7 , pp. 969-978
    • Desalvo, J.1    Kuznetsov, J.N.2    Du, J.3    Leclerc, G.M.4    Leclerc, G.J.5    Lampidis, T.J.6    Barredo, J.C.7
  • 81
    • 0029864659 scopus 로고    scopus 로고
    • 2-deoxy-D-glucose toxicity and transport in human multidrug-resistant KB carcinoma cell lines
    • Bentley, J.; Bell, S.E.; Quinn, D.M.; Kellett, G.L.; Warr, J.R. 2-deoxy-D-glucose toxicity and transport in human multidrug-resistant KB carcinoma cell lines. Oncol. Res., 1996, 8(2), 77-84.
    • (1996) Oncol. Res. , vol.8 , Issue.2 , pp. 77-84
    • Bentley, J.1    Bell, S.E.2    Quinn, D.M.3    Kellett, G.L.4    Warr, J.R.5
  • 82
    • 0031796023 scopus 로고    scopus 로고
    • 2-Deoxy- D-glucose preferentially kills multidrug-resistant human KB carcinoma cell lines by apoptosis
    • Bell, S.E.; Quinn, D.M.; Kellett, G.L.; Warr, J.R. 2-Deoxy- D-glucose preferentially kills multidrug-resistant human KB carcinoma cell lines by apoptosis. Brit. J. cancer, 1998, 78(11), 1464-1470.
    • (1998) Brit. J. Cancer , vol.78 , Issue.11 , pp. 1464-1470
    • Bell, S.E.1    Quinn, D.M.2    Kellett, G.L.3    Warr, J.R.4
  • 83
    • 0037163688 scopus 로고    scopus 로고
    • Evaluation of 2-deoxy-Dglucose as a chemotherapeutic agent: Mechanism of cell death
    • Aft, R.L.; Zhang, F.W.; Gius, D. Evaluation of 2-deoxy-Dglucose as a chemotherapeutic agent: Mechanism of cell death. Brit. J. Cancer, 2002, 87(7), 805-812.
    • (2002) Brit. J. Cancer , vol.87 , Issue.7 , pp. 805-812
    • Aft, R.L.1    Zhang, F.W.2    Gius, D.3
  • 84
    • 0030152958 scopus 로고    scopus 로고
    • The interaction among glucose transport, hexokinase, and glucose-6- phosphatase with respect to 3H-2-deoxyglucose retention in murine tumor models
    • Nelson, C.A.; Wang, J.Q.; Leav, I.; Crane, P.D. The interaction among glucose transport, hexokinase, and glucose-6- phosphatase with respect to 3H-2-deoxyglucose retention in murine tumor models. Nucl. Med. Biol., 1996, 23(4), 533-541.
    • (1996) Nucl. Med. Biol. , vol.23 , Issue.4 , pp. 533-541
    • Nelson, C.A.1    Wang, J.Q.2    Leav, I.3    Crane, P.D.4
  • 85
    • 33847353815 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose
    • Maher, J.C.; Wangpaichitr, M.; Savaraj, N.; Kurtoglu, M.; Lampidis, T.J. Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose. Mol. Cancer Ther., 2007, 6(2), 732-741.
    • (2007) Mol. Cancer Ther. , vol.6 , Issue.2 , pp. 732-741
    • Maher, J.C.1    Wangpaichitr, M.2    Savaraj, N.3    Kurtoglu, M.4    Lampidis, T.J.5
  • 86
    • 84859363762 scopus 로고    scopus 로고
    • FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice
    • Goldberg, L.; Israeli, R.; Kloog, Y. FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice. Cell Death Dis., 2012, 3, e284.
    • (2012) Cell Death Dis. , vol.3 , pp. e284
    • Goldberg, L.1    Israeli, R.2    Kloog, Y.3
  • 87
    • 0031923084 scopus 로고    scopus 로고
    • The effects of 2- deoxyglucose and amino-oxyacetic acid on the radiation response of mammalian cells in vitro
    • Hunter, A.J.; Blekkenhorst, G.H. The effects of 2- deoxyglucose and amino-oxyacetic acid on the radiation response of mammalian cells in vitro. Int. J. Radiat. Biol., 1998, 73(3), 311-324.
    • (1998) Int. J. Radiat. Biol. , vol.73 , Issue.3 , pp. 311-324
    • Hunter, A.J.1    Blekkenhorst, G.H.2
  • 88
    • 0442313668 scopus 로고    scopus 로고
    • Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions
    • Maher, J.C.; Krishan, A.; Lampidis, T.J. Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer chemother. Pharmacol., 2004, 53(2), 116-122.
    • (2004) Cancer Chemother. Pharmacol. , vol.53 , Issue.2 , pp. 116-122
    • Maher, J.C.1    Krishan, A.2    Lampidis, T.J.3
  • 90
    • 0019948401 scopus 로고
    • Experimental evaluation of the glucose antimetabolite 2-deoxy-D-glucose (2-DG) as a possible adjuvant to radiotherapy of tumors: I. Kinetics of growth and survival of Ehrlich ascites tumor cells (EATC) in vitro and of growth of solid tumors after 2-DG and Xirradiation
    • Purohit, S.C.; Pohlit, W. Experimental evaluation of the glucose antimetabolite, 2-deoxy-D-glucose (2-DG) as a possible adjuvant to radiotherapy of tumors: I. Kinetics of growth and survival of Ehrlich ascites tumor cells (EATC) in vitro and of growth of solid tumors after 2-DG and Xirradiation. Int. J. Radiat. Oncol. Biol. Phys., 1982, 8(3-4), 495-499.
    • (1982) Int. J. Radiat. Oncol. Biol. Phys. , vol.8 , Issue.3-4 , pp. 495-499
    • Purohit, S.C.1    Pohlit, W.2
  • 91
    • 84865140782 scopus 로고    scopus 로고
    • Enhanced radiosensitivity and chemosensitivity of breast cancer cells by 2-deoxy-d-glucose in combination therapy
    • Aghaee, F.; Pirayesh Islamian, J.; Baradaran, B. Enhanced radiosensitivity and chemosensitivity of breast cancer cells by 2-deoxy-d-glucose in combination therapy. J. breast cancer, 2012, 15(2), 141-147.
    • (2012) J. Breast Cancer , vol.15 , Issue.2 , pp. 141-147
    • Aghaee, F.1    Pirayesh Islamian, J.2    Baradaran, B.3
  • 92
    • 77951217521 scopus 로고    scopus 로고
    • Short-term exposure of multicellular tumor spheroids of a human glioma cell line to the glycolytic inhibitor 2-deoxy-Dglucose is more toxic than continuous exposure
    • Khaitan, D.; Chandna, S.; Dwarakanath, S.B. Short-term exposure of multicellular tumor spheroids of a human glioma cell line to the glycolytic inhibitor 2-deoxy-Dglucose is more toxic than continuous exposure. J. Cancer Res. Ther., 2009, 5 Suppl 1, S67-S73.
    • (2009) J. Cancer Res. Ther. , vol.5 , pp. S67-S73
    • Khaitan, D.1    Chandna, S.2    Dwarakanath, S.B.3
  • 95
    • 0036711587 scopus 로고    scopus 로고
    • 3-Bromopyruvate kills cancer cells in animals
    • Nelson, K. 3-Bromopyruvate kills cancer cells in animals. Lancet Oncol., 2002, 3(9), 524.
    • (2002) Lancet Oncol. , vol.3 , Issue.9 , pp. 524
    • Nelson, K.1
  • 96
    • 0037099685 scopus 로고    scopus 로고
    • Novel therapy for liver cancer: Direct intraarterial injection of a potent inhibitor of ATP production
    • Geschwind, J.F.; Ko, Y.H.; Torbenson, M.S.; Magee, C.; Pedersen, P.L. Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. Cancer Res., 2002, 62(14), 3909-3913.
    • (2002) Cancer Res. , vol.62 , Issue.14 , pp. 3909-3913
    • Geschwind, J.F.1    Ko, Y.H.2    Torbenson, M.S.3    Magee, C.4    Pedersen, P.L.5
  • 97
    • 33947726287 scopus 로고    scopus 로고
    • Intraarterial therapy with a new potent inhibitor of tumor metabolism (3-bromopyruvate): Identification of therapeutic dose and method of injection in an animal model of liver cancer
    • Vali, M.; Liapi, E.; Kowalski, J.; Hong, K.; Khwaja, A.; Torbenson, M.S.; Georgiades, C.; Geschwind, J.F. Intraarterial therapy with a new potent inhibitor of tumor metabolism (3-bromopyruvate): Identification of therapeutic dose and method of injection in an animal model of liver cancer. J. Vasc. Interv. Radiol., 2007, 18(1 Pt 1), 95-101.
    • (2007) J. Vasc. Interv. Radiol. , vol.18 , Issue.1 , pp. 95-101
    • Vali, M.1    Liapi, E.2    Kowalski, J.3    Hong, K.4    Khwaja, A.5    Torbenson, M.S.6    Georgiades, C.7    Geschwind, J.F.8
  • 98
    • 53949087157 scopus 로고    scopus 로고
    • Development of a new orthotopic animal model of metastatic liver cancer in the rabbit VX2 model: Effect on metastases after partial hepatectomy, intra-arterial treatment with 3-bromopyruvate and chemoembolization
    • Vossen, J.A.; Buijs, M.; Syed, L.; Kutiyanwala, F.; Kutiyanwala, M.; Geschwind, J.F.; Vali, M., Development of a new orthotopic animal model of metastatic liver cancer in the rabbit VX2 model: Effect on metastases after partial hepatectomy, intra-arterial treatment with 3-bromopyruvate and chemoembolization. Clin Exp Metastasis, 2008, 25(7), 811-817.
    • (2008) Clin Exp Metastasis , vol.25 , Issue.7 , pp. 811-817
    • Vossen, J.A.1    Buijs, M.2    Syed, L.3    Kutiyanwala, F.4    Kutiyanwala, M.5    Geschwind, J.F.6    Vali, M.7
  • 101
    • 64949118623 scopus 로고    scopus 로고
    • Novel therapy for malignant pleural mesothelioma based on anti-energetic effect: An experimental study using 3-Bromopyruvate on nude mice
    • Zhang, X.; Varin, E.; Briand, M.; Allouche, S.; Heutte, N.; Schwartz, L.; Poulain, L.; Icard, P. Novel therapy for malignant pleural mesothelioma based on anti-energetic effect: an experimental study using 3-Bromopyruvate on nude mice. Anticancer Res., 2009, 29(4), 1443-1448.
    • (2009) Anticancer Res. , vol.29 , Issue.4 , pp. 1443-1448
    • Zhang, X.1    Varin, E.2    Briand, M.3    Allouche, S.4    Heutte, N.5    Schwartz, L.6    Poulain, L.7    Icard, P.8
  • 102
    • 66949147345 scopus 로고    scopus 로고
    • Specificity of the anti-glycolytic activity of 3- bromopyruvate confirmed by FDG uptake in a rat model of breast cancer
    • Buijs, M.; Vossen, J.A.; Geschwind, J.F.; Ishimori, T.; Engles, J.M.; Acha-Ngwodo, O.; Wahl, R.L.; Vali, M. Specificity of the anti-glycolytic activity of 3- bromopyruvate confirmed by FDG uptake in a rat model of breast cancer. Invest. New Drugs, 2009, 27(2), 120-123.
    • (2009) Invest. New Drugs , vol.27 , Issue.2 , pp. 120-123
    • Buijs, M.1    Vossen, J.A.2    Geschwind, J.F.3    Ishimori, T.4    Engles, J.M.5    Acha-Ngwodo, O.6    Wahl, R.L.7    Vali, M.8
  • 103
    • 79960263592 scopus 로고    scopus 로고
    • Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SHSY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: Evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment
    • Filomeni, G.; Cardaci, S.; Da Costa Ferreira, A.M.; Rotilio, G.; Ciriolo, M.R. Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SHSY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: Evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment. Biochem. J., 2011, 437(3), 443-453.
    • (2011) Biochem. J. , vol.437 , Issue.3 , pp. 443-453
    • Filomeni, G.1    Cardaci, S.2    Da Costa Ferreira, A.M.3    Rotilio, G.4    Ciriolo, M.R.5
  • 104
    • 60849101819 scopus 로고    scopus 로고
    • Role of reactive oxygen speciesmediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA
    • Kim, J.S.; Ahn, K.J.; Kim, J.A.; Kim, H.M.; Lee, J.D.; Lee, J.M.; Kim, S.J.; Park, J.H. Role of reactive oxygen speciesmediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA. J. Bioenerg. Biomembr., 2008, 40(6), 607-618.
    • (2008) J. Bioenerg. Biomembr. , vol.40 , Issue.6 , pp. 607-618
    • Kim, J.S.1    Ahn, K.J.2    Kim, J.A.3    Kim, H.M.4    Lee, J.D.5    Lee, J.M.6    Kim, S.J.7    Park, J.H.8
  • 105
    • 79551685039 scopus 로고    scopus 로고
    • The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil
    • Sanchez-Arago, M.; Cuezva, J.M. The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil. J. Transl. Med., 2011, 9, 19.
    • (2011) J. Transl. Med. , vol.9 , pp. 19
    • Sanchez-Arago, M.1    Cuezva, J.M.2
  • 107
    • 84872868296 scopus 로고    scopus 로고
    • Separate and concurrent use of 2-deoxy-D-glucose and 3-bromopyruvate in pancreatic cancer cells
    • Xiao, H.; Li, S.; Zhang, D.; Liu, T.; Yu, M.; Wang, F. Separate and concurrent use of 2-deoxy-D-glucose and 3-bromopyruvate in pancreatic cancer cells. Oncol. Rep., 2013, 29(1), 329-334.
    • (2013) Oncol. Rep. , vol.29 , Issue.1 , pp. 329-334
    • Xiao, H.1    Li, S.2    Zhang, D.3    Liu, T.4    Yu, M.5    Wang, F.6
  • 108
    • 84900868710 scopus 로고    scopus 로고
    • Inhibitory effects of 3-bromopyruvate on human gastric cancer implant tumors in nude mice
    • Xian, S.L.; Cao, W.; Zhang, X.D.; Lu, Y.F. Inhibitory effects of 3-bromopyruvate on human gastric cancer implant tumors in nude mice. Asian Pac. J. Cancer Prev., 2014, 15(7), 3175-3178.
    • (2014) Asian Pac. J. Cancer Prev. , vol.15 , Issue.7 , pp. 3175-3178
    • Xian, S.L.1    Cao, W.2    Zhang, X.D.3    Lu, Y.F.4
  • 110
    • 84937484608 scopus 로고    scopus 로고
    • Inhibition of hexokinase-2 with targeted liposomal 3- bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis
    • Gandham, S.K.; Talekar, M.; Singh, A.; Amiji, M.M. Inhibition of hexokinase-2 with targeted liposomal 3- bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis. Int. J. Nanomedicine, 2015, 10, 4405-4423.
    • (2015) Int. J. Nanomedicine , vol.10 , pp. 4405-4423
    • Gandham, S.K.1    Talekar, M.2    Singh, A.3    Amiji, M.M.4
  • 111
    • 84927627191 scopus 로고    scopus 로고
    • Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate
    • Nilsson, H.; Lindgren, D.; Mandahl Forsberg, A.; Mulder, H.; Axelson, H.; Johansson, M.E. Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate. Cell Death Dis., 2015, 6, e1585.
    • (2015) Cell Death Dis. , vol.6 , pp. e1585
    • Nilsson, H.1    Lindgren, D.2    Mandahl Forsberg, A.3    Mulder, H.4    Axelson, H.5    Johansson, M.E.6
  • 113
    • 84858698219 scopus 로고    scopus 로고
    • Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug
    • Cardaci, S.; Desideri, E.; Ciriolo, M.R. Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug. J. Bioenerg. Biomembr., 2012, 44(1), 17-29.
    • (2012) J. Bioenerg. Biomembr. , vol.44 , Issue.1 , pp. 17-29
    • Cardaci, S.1    Desideri, E.2    Ciriolo, M.R.3
  • 114
    • 84873027161 scopus 로고    scopus 로고
    • Anticancer efficacy of the metabolic blocker 3- bromopyruvate: Specific molecular targeting
    • Ganapathy-Kanniappan, S.; Kunjithapatham, R.; Geschwind, J.F. Anticancer efficacy of the metabolic blocker 3- bromopyruvate: specific molecular targeting. Anticancer Res., 2013, 33(1), 13-20.
    • (2013) Anticancer Res. , vol.33 , Issue.1 , pp. 13-20
    • Ganapathy-Kanniappan, S.1    Kunjithapatham, R.2    Geschwind, J.F.3
  • 115
    • 84925304194 scopus 로고    scopus 로고
    • Mitochondria: 3-bromopyruvate vs mitochondria? A small molecule that attacks tumors by targeting their bioenergetic diversity
    • Galina, A. Mitochondria: 3-bromopyruvate vs. mitochondria? A small molecule that attacks tumors by targeting their bioenergetic diversity. Int. J. Biochem. Cell Biol., 2014, 54, 266-271.
    • (2014) Int. J. Biochem. Cell Biol. , vol.54 , pp. 266-271
    • Galina, A.1
  • 117
    • 84918820349 scopus 로고    scopus 로고
    • The energy blockers 3-bromopyruvate and lonidamine: Effects on bioenergetics of brain mitochondria
    • Macchioni, L.; Davidescu, M.; Roberti, R.; Corazzi, L. The energy blockers 3-bromopyruvate and lonidamine: effects on bioenergetics of brain mitochondria. J. Bioenerg. Biomembr., 2014, 46(5), 389-394.
    • (2014) J. Bioenerg. Biomembr. , vol.46 , Issue.5 , pp. 389-394
    • MacChioni, L.1    Davidescu, M.2    Roberti, R.3    Corazzi, L.4
  • 120
    • 84865746708 scopus 로고    scopus 로고
    • Glutamine deprivation enhances antitumor activity of 3- bromopyruvate through the stabilization of monocarboxylate transporter-1
    • Cardaci, S.; Rizza, S.; Filomeni, G.; Bernardini, R.; Bertocchi, F.; Mattei, M.; Paci, M.; Rotilio, G.; Ciriolo, M.R. Glutamine deprivation enhances antitumor activity of 3- bromopyruvate through the stabilization of monocarboxylate transporter-1. Cancer Res, 2012, 72(17), 4526-4536.
    • (2012) Cancer Res , vol.72 , Issue.17 , pp. 4526-4536
    • Cardaci, S.1    Rizza, S.2    Filomeni, G.3    Bernardini, R.4    Bertocchi, F.5    Mattei, M.6    Paci, M.7    Rotilio, G.8    Ciriolo, M.R.9
  • 121
    • 84895557855 scopus 로고    scopus 로고
    • P53 inactivation decreases dependence on estrogen/ERK signalling for proliferation but promotes EMT and susceptility to 3- bromopyruvate in ERalpha+ breast cancer MCF-7 cells
    • Rieber, M.; Strasberg-Rieber, M., p53 inactivation decreases dependence on estrogen/ERK signalling for proliferation but promotes EMT and susceptility to 3- bromopyruvate in ERalpha+ breast cancer MCF-7 cells. Biochem. Pharmacol., 2014, 88(2), 169-177.
    • (2014) Biochem. Pharmacol. , vol.88 , Issue.2 , pp. 169-177
    • Rieber, M.1    Strasberg-Rieber, M.2


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