2-Deoxy-D-glucose preferentially kills multidrug-resistant human KB carcinoma cell lines by apoptosis

British Journal of Cancer

Volumn 78, Issue 11, 1998, Pages 1464-1470

  Bell, S E ^a   Quinn, D M ^a   Kellett, G L ^a   Warr, J R ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

2 Deoxy D glucose; Collateral sensitivity; Multidrug resistance

Indexed keywords

DEOXYGLUCOSE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL KILLING; CONTROLLED STUDY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; TUMOR CELL LINE;

EID: 0031796023     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.708     Document Type: Article

References (31)

1. Akiyama SI. Fojo A, Hanover JA, Pastan I and Gottesman MM (1985) Isolation and genetic characterisation of human KB cell lines resistant to multiple drugs. Somatic Cell Mol Genet 11: 117-126
2. Bellamy WT and Dalton WS (1994) Multidrug resistance in the laboratory and clinic. Adv Clin Chem 31: 1-61
3. Bentley J, Bell SE, Quinn DM, Kellett GL, and Warr JR (1996) 2-Deoxy-D-glucose toxicity and transport in human multidrug resistant KB carcinoma cell lines. Oncol Res 8: 77-84
4. Cohen JS and Lyon RC (1987) Multinuclear NMR study of the metabolism of drug-sensitive and drug-resistant human breast cancer cells. Ann NY Acad Sci 508: 216-228
5. Drew L, Groome G, Hallam TJ, Warr JR and Rumsby MG (1994) Changes in protein kinase C subspecies expression and activity in a series of multidrug resistant human KB carcinoma cell lines. Oncol Res 6: 429-438
6. Eguchi Y, Shimizu S and Tsujimoto Y (1997) Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 57: 1835-1840
7. Fanciulli M, Bruno T, Castiglione S, Del Carlo C, Paggi MG and Floridi A (1993) Glucose metabolism in adriamycin-sensitive and -resistant LoVo human colon carcinoma cells. Oncol Res 5: 357-162
8. Filipits M, Suchomel RW, Zöchbauer S, Malayeri R and Pirker R (1996) Clinical relevance of drug resistance genes in malignant diseases. Leukemia 10: S10-S17
9. Germann UA (1996) P-glycoprotein - a mediator of multidrug resistance in tumour cells. Eur J Cancer 32A: 927-944
10. Gottesman MM and Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427
11. Hale AJ, Smith CA, Sutherland LC, Stoneman VEA, Longthorne VL, Culhane AC and Williams GT (1996) Apoptosis: molecular regulation of cell death. Eur J Biochem 236: 1-26
12. Hannun YA (1996) Functions of ceramide in coordinating cellular responses to stress. Science 274: 1855-1859
13. Harrison SA, Buxton JM, Clancy BM and Czech MP (1990) Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem 265: 20106-20116
14. Jain VK, Kalia VK, Sharma R, Maharajan V and Menon M (1985) Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells. Int J Radiat Oncol Biol Phys 11: 943-950
15. Kaplan O, Navon G, Lyon RC, Faustino PJ, Straka EJ and Cohen JS (1990) Effects of 2-deoxyglucose on drug-sensitive and drug-resistant human breast cancer cells: toxicity and magnetic resonance spectroscopy studies of metabolism. Cancer Res 50: 544-551
16. 11P nuclear magnetic resonance characterisation and 2-deoxyglucose toxicity. Cancer Res 51: 1638-1644
17. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE and Poirier GG (1993) Specific cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 53: 3976-3985
18. Koopman G, Reutelingsperger CPM, Kuijten GAM, Keehnen RMJ, Pals ST and van Oers MHJ (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84: 1415-1420
19. Lavie Y, Cao H, Bursten SL, Giuliano AE and Cabot MC (1996) Accumulation of glucosylceramides in multidrug-resistant cancer cells. J Biol Chem 271: 19530-19536
20. Leszczynski D (1996) The role of protein kinase C in regulation of apoptosis: a brief overview of the controversy. Cancer J 9: 308-313
21. Lyon RC, Cohen JS, Faustino PJ. Megnin F and Myers CE (1988) Glucose metabolism in drug-sensitive and drug-resistant human breast cancer cells monitored by magnetic resonance spectroscopy. Cancer Res 48: 870-877
22. Malayeri R, Filipits M, Suchomel RW, Zöchbauer S, Lechner K and Pirker R (1996) Multidrug resistance in leukemias and its reversal. Leukemia Lymphoma 23: 451-458
23. Martin SJ and Cotter TG (1991) Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis. Int J Radiat Biol 59: 1001-1016
24. Martin SJ, Reutelingsperger CPM, McGahon AJ, Rader JA, van Schie RCAA, LaFace DM and Green DR (1995) Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 182: 1545-1556
25. 11C NMR spectroscopic study of wild type and multidrug resistant Ehrlich ascites tumour cells. Oncol Res 5: 119-126
26. Shen DW, Cardarelli C, Hwang J, Cornwell M, Richert N, Ishiii S, Pastan I and Gottesman MM (1986) Multiple drug resistant human KB carcinoma cells independently selected for high level resistance to colchicine, adriamycin or vinblastine show changes in expression of specific proteins. J Biol Chem 261: 7762-7770
27. Shustik C, Dalton W and Gros P (1995) P-glycoprotein-mediated multidrug resistance in tumour cells: biochemistry, clinical relevance and modulation. Mol Aspects Med 16: 1-78
28. Trock BJ, Leonessa F and Clarke R (1997) Multidrug resistance in breast cancer: a meta-analysis of MDRI/gp170 expression and its possible functional significance. J Natl Cancer Inst 89: 917-931
29. Umansky SR (1996) Apoptosis: molecular and cellular mechanisms (a review). Mol Biol 30: 285-295
30. van Engeland M, Ramaekers FCS, Schutte B and Reutelingsperger CPM (1996) A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in cullure. Cytomtery 24: 131-139
31. Wick AN, Drury DR, Nakada HI and Wolfe JB (1957) Localisation of the primary metabolic block produced by 2-deoxyglucose. J Biol Chem 224: 963-969