-
1
-
-
84897537717
-
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
-
Birsoy K., Possemato R., Lorbeer F.K., Bayraktar E.C., Thiru P., Yucel B., Wang T., Chen W.W., Clish C.B., Sabatini D.M. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature 2014, 508:108-112.
-
(2014)
Nature
, vol.508
, pp. 108-112
-
-
Birsoy, K.1
Possemato, R.2
Lorbeer, F.K.3
Bayraktar, E.C.4
Thiru, P.5
Yucel, B.6
Wang, T.7
Chen, W.W.8
Clish, C.B.9
Sabatini, D.M.10
-
2
-
-
84863552418
-
A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans
-
Bricker D.K., Taylor E.B., Schell J.C., Orsak T., Boutron A., Chen Y.-C., Cox J.E., Cardon C.M., Van Vranken J.G., Dephoure N., et al. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 2012, 337:96-100.
-
(2012)
Science
, vol.337
, pp. 96-100
-
-
Bricker, D.K.1
Taylor, E.B.2
Schell, J.C.3
Orsak, T.4
Boutron, A.5
Chen, Y.-C.6
Cox, J.E.7
Cardon, C.M.8
Van Vranken, J.G.9
Dephoure, N.10
-
3
-
-
84930664270
-
Imaging metabolism with hyperpolarized (13)C-labeled cell substrates
-
Brindle K.M. Imaging metabolism with hyperpolarized (13)C-labeled cell substrates. J. Am. Chem. Soc. 2015, 137:6418-6427.
-
(2015)
J. Am. Chem. Soc.
, vol.137
, pp. 6418-6427
-
-
Brindle, K.M.1
-
4
-
-
84925503908
-
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
-
Carey B.W., Finley L.W.S., Cross J.R., Allis C.D., Thompson C.B. Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 2015, 518:413-416.
-
(2015)
Nature
, vol.518
, pp. 413-416
-
-
Carey, B.W.1
Finley, L.W.S.2
Cross, J.R.3
Allis, C.D.4
Thompson, C.B.5
-
5
-
-
84867595989
-
Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma
-
Caro P., Kishan A.U., Norberg E., Stanley I.A., Chapuy B., Ficarro S.B., Polak K., Tondera D., Gounarides J., Yin H., et al. Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell 2012, 22:547-560.
-
(2012)
Cancer Cell
, vol.22
, pp. 547-560
-
-
Caro, P.1
Kishan, A.U.2
Norberg, E.3
Stanley, I.A.4
Chapuy, B.5
Ficarro, S.B.6
Polak, K.7
Tondera, D.8
Gounarides, J.9
Yin, H.10
-
6
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
Christofk H.R., Vander Heiden M.G., Wu N., Asara J.M., Cantley L.C. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008, 452:181-186.
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
7
-
-
84878396462
-
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
-
Commisso C., Davidson S.M., Soydaner-Azeloglu R.G., Parker S.J., Kamphorst J.J., Hackett S., Grabocka E., Nofal M., Drebin J.A., Thompson C.B., et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 2013, 497:633-637.
-
(2013)
Nature
, vol.497
, pp. 633-637
-
-
Commisso, C.1
Davidson, S.M.2
Soydaner-Azeloglu, R.G.3
Parker, S.J.4
Kamphorst, J.J.5
Hackett, S.6
Grabocka, E.7
Nofal, M.8
Drebin, J.A.9
Thompson, C.B.10
-
8
-
-
33745713171
-
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
-
Degenhardt K., Mathew R., Beaudoin B., Bray K., Anderson D., Chen G., Mukherjee C., Shi Y., Gélinas C., Fan Y., et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006, 10:51-64.
-
(2006)
Cancer Cell
, vol.10
, pp. 51-64
-
-
Degenhardt, K.1
Mathew, R.2
Beaudoin, B.3
Bray, K.4
Anderson, D.5
Chen, G.6
Mukherjee, C.7
Shi, Y.8
Gélinas, C.9
Fan, Y.10
-
9
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 2003, 3:11-22.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
10
-
-
64749116346
-
C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
Gao P., Tchernyshyov I., Chang T.-C., Lee Y.-S., Kita K., Ochi T., Zeller K.I., De Marzo A.M., Van Eyk J.E., Mendell J.T., Dang C.V. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009, 458:762-765.
-
(2009)
Nature
, vol.458
, pp. 762-765
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.-C.3
Lee, Y.-S.4
Kita, K.5
Ochi, T.6
Zeller, K.I.7
De Marzo, A.M.8
Van Eyk, J.E.9
Mendell, J.T.10
Dang, C.V.11
-
11
-
-
0019420651
-
Association of the src-gene product of Rous sarcoma virus with a pyruvate-kinase inactivation factor
-
Glossmann H., Presek P., Eigenbrodt E. Association of the src-gene product of Rous sarcoma virus with a pyruvate-kinase inactivation factor. Mol. Cell. Endocrinol. 1981, 23:49-63.
-
(1981)
Mol. Cell. Endocrinol.
, vol.23
, pp. 49-63
-
-
Glossmann, H.1
Presek, P.2
Eigenbrodt, E.3
-
12
-
-
84858043444
-
The clinical use of PET with (11)C-acetate
-
Grassi I., Nanni C., Allegri V., Morigi J.J., Montini G.C., Castellucci P., Fanti S. The clinical use of PET with (11)C-acetate. Am. J. Nucl. Med. Mol. Imaging 2012, 2:33-47.
-
(2012)
Am. J. Nucl. Med. Mol. Imaging
, vol.2
, pp. 33-47
-
-
Grassi, I.1
Nanni, C.2
Allegri, V.3
Morigi, J.J.4
Montini, G.C.5
Castellucci, P.6
Fanti, S.7
-
13
-
-
84920971232
-
Breast cancer risk in metabolically healthy but overweight postmenopausal women
-
Gunter M.J., Xie X., Xue X., Kabat G.C., Rohan T.E., Wassertheil-Smoller S., Ho G.Y.F., Wylie-Rosett J., Greco T., Yu H., et al. Breast cancer risk in metabolically healthy but overweight postmenopausal women. Cancer Res. 2015, 75:270-274.
-
(2015)
Cancer Res.
, vol.75
, pp. 270-274
-
-
Gunter, M.J.1
Xie, X.2
Xue, X.3
Kabat, G.C.4
Rohan, T.E.5
Wassertheil-Smoller, S.6
Ho, G.Y.F.7
Wylie-Rosett, J.8
Greco, T.9
Yu, H.10
-
14
-
-
63549121490
-
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
-
Hayes J.D., McMahon M. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem. Sci. 2009, 34:176-188.
-
(2009)
Trends Biochem. Sci.
, vol.34
, pp. 176-188
-
-
Hayes, J.D.1
McMahon, M.2
-
15
-
-
84883497454
-
Glutamine and cancer: cell biology, physiology, and clinical opportunities
-
Hensley C.T., Wasti A.T., DeBerardinis R.J. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J. Clin. Invest. 2013, 123:3678-3684.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 3678-3684
-
-
Hensley, C.T.1
Wasti, A.T.2
DeBerardinis, R.J.3
-
16
-
-
84863553135
-
Identification and functional expression of the mitochondrial pyruvate carrier
-
Herzig S., Raemy E., Montessuit S., Veuthey J.-L., Zamboni N., Westermann B., Kunji E.R.S., Martinou J.-C. Identification and functional expression of the mitochondrial pyruvate carrier. Science 2012, 337:93-96.
-
(2012)
Science
, vol.337
, pp. 93-96
-
-
Herzig, S.1
Raemy, E.2
Montessuit, S.3
Veuthey, J.-L.4
Zamboni, N.5
Westermann, B.6
Kunji, E.R.S.7
Martinou, J.-C.8
-
18
-
-
84878464291
-
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
-
Kamphorst J.J., Cross J.R., Fan J., de Stanchina E., Mathew R., White E.P., Thompson C.B., Rabinowitz J.D. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc. Natl. Acad. Sci. USA 2013, 110:8882-8887.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 8882-8887
-
-
Kamphorst, J.J.1
Cross, J.R.2
Fan, J.3
de Stanchina, E.4
Mathew, R.5
White, E.P.6
Thompson, C.B.7
Rabinowitz, J.D.8
-
19
-
-
84923148982
-
Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate
-
Kamphorst J.J., Chung M.K., Fan J., Rabinowitz J.D. Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer Metab. 2014, 2:23.
-
(2014)
Cancer Metab.
, vol.2
, pp. 23
-
-
Kamphorst, J.J.1
Chung, M.K.2
Fan, J.3
Rabinowitz, J.D.4
-
20
-
-
84961288972
-
Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein
-
Kamphorst J.J., Nofal M., Commisso C., Hackett S.R., Lu W., Grabocka E., Vander Heiden M.G., Miller G., Drebin J.A., Bar-Sagi D., et al. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res. 2015, 75:544-553.
-
(2015)
Cancer Res.
, vol.75
, pp. 544-553
-
-
Kamphorst, J.J.1
Nofal, M.2
Commisso, C.3
Hackett, S.R.4
Lu, W.5
Grabocka, E.6
Vander Heiden, M.G.7
Miller, G.8
Drebin, J.A.9
Bar-Sagi, D.10
-
21
-
-
84885735554
-
Mutational landscape and significance across 12 major cancer types
-
Kandoth C., McLellan M.D., Vandin F., Ye K., Niu B., Lu C., Xie M., Zhang Q., McMichael J.F., Wyczalkowski M.A., et al. Mutational landscape and significance across 12 major cancer types. Nature 2013, 502:333-339.
-
(2013)
Nature
, vol.502
, pp. 333-339
-
-
Kandoth, C.1
McLellan, M.D.2
Vandin, F.3
Ye, K.4
Niu, B.5
Lu, C.6
Xie, M.7
Zhang, Q.8
McMichael, J.F.9
Wyczalkowski, M.A.10
-
22
-
-
84938588282
-
Metabolic rewiring by oncogenic BRAF V600E links ketogenesis pathway to BRAF-MEK1 signaling
-
Kang H.-B., Fan J., Lin R., Elf S., Ji Q., Zhao L., Jin L., Seo J.H., Shan C., Arbiser J.L., et al. Metabolic rewiring by oncogenic BRAF V600E links ketogenesis pathway to BRAF-MEK1 signaling. Mol. Cell 2015, 59:345-358.
-
(2015)
Mol. Cell
, vol.59
, pp. 345-358
-
-
Kang, H.-B.1
Fan, J.2
Lin, R.3
Elf, S.4
Ji, Q.5
Zhao, L.6
Jin, L.7
Seo, J.H.8
Shan, C.9
Arbiser, J.L.10
-
23
-
-
84928395993
-
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
-
Kim D., Fiske B.P., Birsoy K., Freinkman E., Kami K., Possemato R.L., Chudnovsky Y., Pacold M.E., Chen W.W., Cantor J.R., et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature 2015, 520:363-367.
-
(2015)
Nature
, vol.520
, pp. 363-367
-
-
Kim, D.1
Fiske, B.P.2
Birsoy, K.3
Freinkman, E.4
Kami, K.5
Possemato, R.L.6
Chudnovsky, Y.7
Pacold, M.E.8
Chen, W.W.9
Cantor, J.R.10
-
24
-
-
84934281252
-
P53 in survival, death and metabolic health: a lifeguard with a licence to kill
-
Kruiswijk F., Labuschagne C.F., Vousden K.H. p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nat. Rev. Mol. Cell Biol. 2015, 16:393-405.
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 393-405
-
-
Kruiswijk, F.1
Labuschagne, C.F.2
Vousden, K.H.3
-
25
-
-
84926633413
-
Imaging tumor metabolism using positron emission tomography
-
Lewis D.Y., Soloviev D., Brindle K.M. Imaging tumor metabolism using positron emission tomography. Cancer J. 2015, 21:129-136.
-
(2015)
Cancer J.
, vol.21
, pp. 129-136
-
-
Lewis, D.Y.1
Soloviev, D.2
Brindle, K.M.3
-
26
-
-
84881177291
-
Serine, glycine and one-carbon units: cancer metabolism in full circle
-
Locasale J.W. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat. Rev. Cancer 2013, 13:572-583.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 572-583
-
-
Locasale, J.W.1
-
27
-
-
80052258995
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
-
Locasale J.W., Grassian A.R., Melman T., Lyssiotis C.A., Mattaini K.R., Bass A.J., Heffron G., Metallo C.M., Muranen T., Sharfi H., et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 2011, 43:869-874.
-
(2011)
Nat. Genet.
, vol.43
, pp. 869-874
-
-
Locasale, J.W.1
Grassian, A.R.2
Melman, T.3
Lyssiotis, C.A.4
Mattaini, K.R.5
Bass, A.J.6
Heffron, G.7
Metallo, C.M.8
Muranen, T.9
Sharfi, H.10
-
28
-
-
84872905650
-
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
-
Maddocks O.D.K., Berkers C.R., Mason S.M., Zheng L., Blyth K., Gottlieb E., Vousden K.H. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 2013, 493:542-546.
-
(2013)
Nature
, vol.493
, pp. 542-546
-
-
Maddocks, O.D.K.1
Berkers, C.R.2
Mason, S.M.3
Zheng, L.4
Blyth, K.5
Gottlieb, E.6
Vousden, K.H.7
-
29
-
-
84919903877
-
Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
-
Mashimo T., Pichumani K., Vemireddy V., Hatanpaa K.J., Singh D.K., Sirasanagandla S., Nannepaga S., Piccirillo S.G., Kovacs Z., Foong C., et al. Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell 2014, 159:1603-1614.
-
(2014)
Cell
, vol.159
, pp. 1603-1614
-
-
Mashimo, T.1
Pichumani, K.2
Vemireddy, V.3
Hatanpaa, K.J.4
Singh, D.K.5
Sirasanagandla, S.6
Nannepaga, S.7
Piccirillo, S.G.8
Kovacs, Z.9
Foong, C.10
-
30
-
-
84921950738
-
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
-
Mayers J.R., Wu C., Clish C.B., Kraft P., Torrence M.E., Fiske B.P., Yuan C., Bao Y., Townsend M.K., Tworoger S.S., et al. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat. Med. 2014, 20:1193-1198.
-
(2014)
Nat. Med.
, vol.20
, pp. 1193-1198
-
-
Mayers, J.R.1
Wu, C.2
Clish, C.B.3
Kraft, P.4
Torrence, M.E.5
Fiske, B.P.6
Yuan, C.7
Bao, Y.8
Townsend, M.K.9
Tworoger, S.S.10
-
31
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
Metallo C.M., Gameiro P.A., Bell E.L., Mattaini K.R., Yang J., Hiller K., Jewell C.M., Johnson Z.R., Irvine D.J., Guarente L., et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2012, 481:380-384.
-
(2012)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
Mattaini, K.R.4
Yang, J.5
Hiller, K.6
Jewell, C.M.7
Johnson, Z.R.8
Irvine, D.J.9
Guarente, L.10
-
32
-
-
84863764614
-
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
-
Mitsuishi Y., Taguchi K., Kawatani Y., Shibata T., Nukiwa T., Aburatani H., Yamamoto M., Motohashi H. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 2012, 22:66-79.
-
(2012)
Cancer Cell
, vol.22
, pp. 66-79
-
-
Mitsuishi, Y.1
Taguchi, K.2
Kawatani, Y.3
Shibata, T.4
Nukiwa, T.5
Aburatani, H.6
Yamamoto, M.7
Motohashi, H.8
-
33
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
Mullen A.R., Wheaton W.W., Jin E.S., Chen P.H., Sullivan L.B., Cheng T., Yang Y., Linehan W.M., Chandel N.S., DeBerardinis R.J. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 2012, 481:385-388.
-
(2012)
Nature
, vol.481
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
Chen, P.H.4
Sullivan, L.B.5
Cheng, T.6
Yang, Y.7
Linehan, W.M.8
Chandel, N.S.9
DeBerardinis, R.J.10
-
34
-
-
84902343371
-
Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects
-
Mullen A.R., Hu Z., Shi X., Jiang L., Boroughs L.K., Kovacs Z., Boriack R., Rakheja D., Sullivan L.B., Linehan W.M., et al. Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Cell Rep. 2014, 7:1679-1690.
-
(2014)
Cell Rep.
, vol.7
, pp. 1679-1690
-
-
Mullen, A.R.1
Hu, Z.2
Shi, X.3
Jiang, L.4
Boroughs, L.K.5
Kovacs, Z.6
Boriack, R.7
Rakheja, D.8
Sullivan, L.B.9
Linehan, W.M.10
-
35
-
-
77951227871
-
TOR-dependent control of autophagy: biting the hand that feeds
-
Neufeld T.P. TOR-dependent control of autophagy: biting the hand that feeds. Curr. Opin. Cell Biol. 2010, 22:157-168.
-
(2010)
Curr. Opin. Cell Biol.
, vol.22
, pp. 157-168
-
-
Neufeld, T.P.1
-
36
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive K.P., Jacobetz M.A., Davidson C.J., Gopinathan A., McIntyre D., Honess D., Madhu B., Goldgraben M.A., Caldwell M.E., Allard D., et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009, 324:1457-1461.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
Madhu, B.7
Goldgraben, M.A.8
Caldwell, M.E.9
Allard, D.10
-
37
-
-
84937253537
-
The utilization of extracellular proteins as nutrients is suppressed by mTORC1
-
Palm W., Park Y., Wright K., Pavlova N.N., Tuveson D.A., Thompson C.B. The utilization of extracellular proteins as nutrients is suppressed by mTORC1. Cell 2015, 162:259-270.
-
(2015)
Cell
, vol.162
, pp. 259-270
-
-
Palm, W.1
Park, Y.2
Wright, K.3
Pavlova, N.N.4
Tuveson, D.A.5
Thompson, C.B.6
-
38
-
-
84939787271
-
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism
-
Perera R.M., Stoykova S., Nicolay B.N., Ross K.N., Fitamant J., Boukhali M., Lengrand J., Deshpande V., Selig M.K., Ferrone C.R., et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature 2015, 524:361-365.
-
(2015)
Nature
, vol.524
, pp. 361-365
-
-
Perera, R.M.1
Stoykova, S.2
Nicolay, B.N.3
Ross, K.N.4
Fitamant, J.5
Boukhali, M.6
Lengrand, J.7
Deshpande, V.8
Selig, M.K.9
Ferrone, C.R.10
-
39
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato R., Marks K.M., Shaul Y.D., Pacold M.E., Kim D., Birsoy K., Sethumadhavan S., Woo H.-K., Jang H.G., Jha A.K., et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 2011, 476:346-350.
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
Marks, K.M.2
Shaul, Y.D.3
Pacold, M.E.4
Kim, D.5
Birsoy, K.6
Sethumadhavan, S.7
Woo, H.-K.8
Jang, H.G.9
Jha, A.K.10
-
40
-
-
84902435628
-
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
-
Rhim A.D., Oberstein P.E., Thomas D.H., Mirek E.T., Palermo C.F., Sastra S.A., Dekleva E.N., Saunders T., Becerra C.P., Tattersall I.W., et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 2014, 25:735-747.
-
(2014)
Cancer Cell
, vol.25
, pp. 735-747
-
-
Rhim, A.D.1
Oberstein, P.E.2
Thomas, D.H.3
Mirek, E.T.4
Palermo, C.F.5
Sastra, S.A.6
Dekleva, E.N.7
Saunders, T.8
Becerra, C.P.9
Tattersall, I.W.10
-
41
-
-
84923164098
-
Molecular pathways: trafficking of metabolic resources in the tumor microenvironment
-
Romero I.L., Mukherjee A., Kenny H.A., Litchfield L.M., Lengyel E. Molecular pathways: trafficking of metabolic resources in the tumor microenvironment. Clin. Cancer Res. 2015, 21:680-686.
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 680-686
-
-
Romero, I.L.1
Mukherjee, A.2
Kenny, H.A.3
Litchfield, L.M.4
Lengyel, E.5
-
42
-
-
84922445353
-
A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth
-
Schell J.C., Olson K.A., Jiang L., Hawkins A.J., Van Vranken J.G., Xie J., Egnatchik R.A., Earl E.G., DeBerardinis R.J., Rutter J. A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. Mol. Cell 2014, 56:400-413.
-
(2014)
Mol. Cell
, vol.56
, pp. 400-413
-
-
Schell, J.C.1
Olson, K.A.2
Jiang, L.3
Hawkins, A.J.4
Van Vranken, J.G.5
Xie, J.6
Egnatchik, R.A.7
Earl, E.G.8
DeBerardinis, R.J.9
Rutter, J.10
-
43
-
-
84927563455
-
Fatty acid carbon is essential for dNTP synthesis in endothelial cells
-
Schoors S., Bruning U., Missiaen R., Queiroz K.C.S., Borgers G., Elia I., Zecchin A., Cantelmo A.R., Christen S., Goveia J., et al. Fatty acid carbon is essential for dNTP synthesis in endothelial cells. Nature 2015, 520:192-197.
-
(2015)
Nature
, vol.520
, pp. 192-197
-
-
Schoors, S.1
Bruning, U.2
Missiaen, R.3
Queiroz, K.C.S.4
Borgers, G.5
Elia, I.6
Zecchin, A.7
Cantelmo, A.R.8
Christen, S.9
Goveia, J.10
-
44
-
-
84947648620
-
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress
-
Schug Z.T., Peck B., Jones D.T., Zhang Q., Grosskurth S., Alam I.S., Goodwin L.M., Smethurst E., Mason S., Blyth K., et al. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell 2015, 27:57-71.
-
(2015)
Cancer Cell
, vol.27
, pp. 57-71
-
-
Schug, Z.T.1
Peck, B.2
Jones, D.T.3
Zhang, Q.4
Grosskurth, S.5
Alam, I.S.6
Goodwin, L.M.7
Smethurst, E.8
Mason, S.9
Blyth, K.10
-
45
-
-
84961287801
-
Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation
-
Sellers K., Fox M.P., Bousamra M., Slone S.P., Higashi R.M., Miller D.M., Wang Y., Yan J., Yuneva M.O., Deshpande R., et al. Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J. Clin. Invest. 2015, 125:687-698.
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 687-698
-
-
Sellers, K.1
Fox, M.P.2
Bousamra, M.3
Slone, S.P.4
Higashi, R.M.5
Miller, D.M.6
Wang, Y.7
Yan, J.8
Yuneva, M.O.9
Deshpande, R.10
-
46
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza G.L. Hypoxia-inducible factors in physiology and medicine. Cell 2012, 148:399-408.
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
47
-
-
84907302546
-
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition
-
Shaul Y.D., Freinkman E., Comb W.C., Cantor J.R., Tam W.L., Thiru P., Kim D., Kanarek N., Pacold M.E., Chen W.W., et al. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell 2014, 158:1094-1109.
-
(2014)
Cell
, vol.158
, pp. 1094-1109
-
-
Shaul, Y.D.1
Freinkman, E.2
Comb, W.C.3
Cantor, J.R.4
Tam, W.L.5
Thiru, P.6
Kim, D.7
Kanarek, N.8
Pacold, M.E.9
Chen, W.W.10
-
48
-
-
84887984423
-
Lin28 enhances tissue repair by reprogramming cellular metabolism
-
Shyh-Chang N., Zhu H., Yvanka de Soysa T., Shinoda G., Seligson M.T., Tsanov K.M., Nguyen L., Asara J.M., Cantley L.C., Daley G.Q. Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell 2013, 155:778-792.
-
(2013)
Cell
, vol.155
, pp. 778-792
-
-
Shyh-Chang, N.1
Zhu, H.2
Yvanka de Soysa, T.3
Shinoda, G.4
Seligson, M.T.5
Tsanov, K.M.6
Nguyen, L.7
Asara, J.M.8
Cantley, L.C.9
Daley, G.Q.10
-
49
-
-
0018688102
-
Plasma acetate turnover and oxidation
-
Skutches C.L., Holroyde C.P., Myers R.N., Paul P., Reichard G.A. Plasma acetate turnover and oxidation. J. Clin. Invest. 1979, 64:708-713.
-
(1979)
J. Clin. Invest.
, vol.64
, pp. 708-713
-
-
Skutches, C.L.1
Holroyde, C.P.2
Myers, R.N.3
Paul, P.4
Reichard, G.A.5
-
50
-
-
84875894714
-
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
-
Son J., Lyssiotis C.A., Ying H., Wang X., Hua S., Ligorio M., Perera R.M., Ferrone C.R., Mullarky E., Shyh-Chang N., et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 2013, 496:101-105.
-
(2013)
Nature
, vol.496
, pp. 101-105
-
-
Son, J.1
Lyssiotis, C.A.2
Ying, H.3
Wang, X.4
Hua, S.5
Ligorio, M.6
Perera, R.M.7
Ferrone, C.R.8
Mullarky, E.9
Shyh-Chang, N.10
-
51
-
-
0018734583
-
Measurement of acetate in human blood by gas chromatography: effects of sample preparation, feeding, and various diseases
-
Tollinger C.D., Vreman H.J., Weiner M.W. Measurement of acetate in human blood by gas chromatography: effects of sample preparation, feeding, and various diseases. Clin. Chem. 1979, 25:1787-1790.
-
(1979)
Clin. Chem.
, vol.25
, pp. 1787-1790
-
-
Tollinger, C.D.1
Vreman, H.J.2
Weiner, M.W.3
-
52
-
-
84922430730
-
Regulation of substrate utilization by the mitochondrial pyruvate carrier
-
Vacanti N.M., Divakaruni A.S., Green C.R., Parker S.J., Henry R.R., Ciaraldi T.P., Murphy A.N., Metallo C.M. Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol. Cell 2014, 56:425-435.
-
(2014)
Mol. Cell
, vol.56
, pp. 425-435
-
-
Vacanti, N.M.1
Divakaruni, A.S.2
Green, C.R.3
Parker, S.J.4
Henry, R.R.5
Ciaraldi, T.P.6
Murphy, A.N.7
Metallo, C.M.8
-
53
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
54
-
-
10644234769
-
The role of hypoxia-induced factors in tumor progression
-
Vaupel P. The role of hypoxia-induced factors in tumor progression. Oncologist 2004, 9(Suppl 5):10-17.
-
(2004)
Oncologist
, vol.9
, pp. 10-17
-
-
Vaupel, P.1
-
55
-
-
10644270846
-
Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response
-
Vaupel P., Harrison L. Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Oncologist 2004, 9(Suppl 5):4-9.
-
(2004)
Oncologist
, vol.9
, pp. 4-9
-
-
Vaupel, P.1
Harrison, L.2
-
56
-
-
84911861458
-
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
-
Viale A., Pettazzoni P., Lyssiotis C.A., Ying H., Sánchez N., Marchesini M., Carugo A., Green T., Seth S., Giuliani V., et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 2014, 514:628-632.
-
(2014)
Nature
, vol.514
, pp. 628-632
-
-
Viale, A.1
Pettazzoni, P.2
Lyssiotis, C.A.3
Ying, H.4
Sánchez, N.5
Marchesini, M.6
Carugo, A.7
Green, T.8
Seth, S.9
Giuliani, V.10
-
57
-
-
84905673351
-
The Intercellular Metabolic Interplay between Tumor and Immune Cells
-
Wang T., Liu G., Wang R. The Intercellular Metabolic Interplay between Tumor and Immune Cells. Front. Immunol. 2014, 5:358.
-
(2014)
Front. Immunol.
, vol.5
, pp. 358
-
-
Wang, T.1
Liu, G.2
Wang, R.3
-
59
-
-
83755178091
-
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
-
Wise D.R., Ward P.S., Shay J.E.S., Cross J.R., Gruber J.J., Sachdeva U.M., Platt J.M., DeMatteo R.G., Simon M.C., Thompson C.B. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc. Natl. Acad. Sci. USA 2011, 108:19611-19616.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 19611-19616
-
-
Wise, D.R.1
Ward, P.S.2
Shay, J.E.S.3
Cross, J.R.4
Gruber, J.J.5
Sachdeva, U.M.6
Platt, J.M.7
DeMatteo, R.G.8
Simon, M.C.9
Thompson, C.B.10
-
60
-
-
79952229430
-
Pancreatic cancers require autophagy for tumor growth
-
Yang S., Wang X., Contino G., Liesa M., Sahin E., Ying H., Bause A., Li Y., Stommel J.M., Dell'antonio G., et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011, 25:717-729.
-
(2011)
Genes Dev.
, vol.25
, pp. 717-729
-
-
Yang, S.1
Wang, X.2
Contino, G.3
Liesa, M.4
Sahin, E.5
Ying, H.6
Bause, A.7
Li, Y.8
Stommel, J.M.9
Dell'antonio, G.10
-
61
-
-
84922468705
-
Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport
-
Yang C., Ko B., Hensley C.T., Jiang L., Wasti A.T., Kim J., Sudderth J., Calvaruso M.A., Lumata L., Mitsche M., et al. Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. Mol. Cell 2014, 56:414-424.
-
(2014)
Mol. Cell
, vol.56
, pp. 414-424
-
-
Yang, C.1
Ko, B.2
Hensley, C.T.3
Jiang, L.4
Wasti, A.T.5
Kim, J.6
Sudderth, J.7
Calvaruso, M.A.8
Lumata, L.9
Mitsche, M.10
-
62
-
-
84915746768
-
Serine catabolism regulates mitochondrial redox control during hypoxia
-
Ye J., Fan J., Venneti S., Wan Y.-W., Pawel B.R., Zhang J., Finley L.W.S., Lu C., Lindsten T., Cross J.R., et al. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov. 2014, 4:1406-1417.
-
(2014)
Cancer Discov.
, vol.4
, pp. 1406-1417
-
-
Ye, J.1
Fan, J.2
Venneti, S.3
Wan, Y.-W.4
Pawel, B.R.5
Zhang, J.6
Finley, L.W.S.7
Lu, C.8
Lindsten, T.9
Cross, J.R.10
-
63
-
-
84923837881
-
An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation
-
Ye P., Liu Y., Chen C., Tang F., Wu Q., Wang X., Liu C.-G., Liu X., Liu R., Liu Y., Zheng P. An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation. Mol. Cell 2015, 57:708-720.
-
(2015)
Mol. Cell
, vol.57
, pp. 708-720
-
-
Ye, P.1
Liu, Y.2
Chen, C.3
Tang, F.4
Wu, Q.5
Wang, X.6
Liu, C.-G.7
Liu, X.8
Liu, R.9
Liu, Y.10
Zheng, P.11
-
64
-
-
84860321700
-
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
-
Ying H., Kimmelman A.C., Lyssiotis C.A., Hua S., Chu G.C., Fletcher-Sananikone E., Locasale J.W., Son J., Zhang H., Coloff J.L., et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 2012, 149:656-670.
-
(2012)
Cell
, vol.149
, pp. 656-670
-
-
Ying, H.1
Kimmelman, A.C.2
Lyssiotis, C.A.3
Hua, S.4
Chu, G.C.5
Fletcher-Sananikone, E.6
Locasale, J.W.7
Son, J.8
Zhang, H.9
Coloff, J.L.10
-
65
-
-
70349331678
-
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
-
Yun J., Rago C., Cheong I., Pagliarini R., Angenendt P., Rajagopalan H., Schmidt K., Willson J.K.V., Markowitz S., Zhou S., et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 2009, 325:1555-1559.
-
(2009)
Science
, vol.325
, pp. 1555-1559
-
-
Yun, J.1
Rago, C.2
Cheong, I.3
Pagliarini, R.4
Angenendt, P.5
Rajagopalan, H.6
Schmidt, K.7
Willson, J.K.V.8
Markowitz, S.9
Zhou, S.10
-
66
-
-
84922270824
-
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion
-
Zhang J., Fan J., Venneti S., Cross J.R., Takagi T., Bhinder B., Djaballah H., Kanai M., Cheng E.H., Judkins A.R., et al. Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Mol. Cell 2014, 56:205-218.
-
(2014)
Mol. Cell
, vol.56
, pp. 205-218
-
-
Zhang, J.1
Fan, J.2
Venneti, S.3
Cross, J.R.4
Takagi, T.5
Bhinder, B.6
Djaballah, H.7
Kanai, M.8
Cheng, E.H.9
Judkins, A.R.10
-
67
-
-
84924576198
-
Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation
-
Zhang D., Wang Y., Shi Z., Liu J., Sun P., Hou X., Zhang J., Zhao S., Zhou B.P., Mi J. Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation. Cell Rep. 2015, 10:1335-1348.
-
(2015)
Cell Rep.
, vol.10
, pp. 1335-1348
-
-
Zhang, D.1
Wang, Y.2
Shi, Z.3
Liu, J.4
Sun, P.5
Hou, X.6
Zhang, J.7
Zhao, S.8
Zhou, B.P.9
Mi, J.10
-
68
-
-
80053481600
-
The Lin28/let-7 axis regulates glucose metabolism
-
Zhu H., Shyh-Chang N., Segrè A.V., Shinoda G., Shah S.P., Einhorn W.S., Takeuchi A., Engreitz J.M., Hagan J.P., Kharas M.G., et al. The Lin28/let-7 axis regulates glucose metabolism. Cell 2011, 147:81-94. DIAGRAM Consortium, MAGIC InvestigatorsMAGIC Investigators.
-
(2011)
Cell
, vol.147
, pp. 81-94
-
-
Zhu, H.1
Shyh-Chang, N.2
Segrè, A.V.3
Shinoda, G.4
Shah, S.P.5
Einhorn, W.S.6
Takeuchi, A.7
Engreitz, J.M.8
Hagan, J.P.9
Kharas, M.G.10
-
69
-
-
29944438881
-
Necrotic death as a cell fate
-
Zong W.-X., Thompson C.B. Necrotic death as a cell fate. Genes Dev. 2006, 20:1-15.
-
(2006)
Genes Dev.
, vol.20
, pp. 1-15
-
-
Zong, W.-X.1
Thompson, C.B.2
|