Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine

Oncotarget

Volumn 5, Issue 13, 2014, Pages 5177-5189

  Isayev, Orkhan ^a,b   Rausch, Vanessa ^a,b   Bauer, Nathalie ^a,b   Liu, Li ^a,b   Fan, Pei ^a,b   Zhang, Yiyao ^a,b   Gladkich, Jury ^a,b   Nwaeburu, Clifford C ^a,b   Mattern, Jürgen ^b   Mollenhauer, Martin ^b   Rückert, Felix ^c   Zach, Sebastian ^c   Haberkorn, Uwe ^a   Gross, Wolfgang ^a,b   Schönsiegel, Frank ^a,b   Bazhin, Alexandr V ^b   Herr, Ingrid ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

3 Bromopyruvate; Cancer stem cells; Novel therapeutics; Pancreatic cancer; Warburg effect

Indexed keywords

ALDEHYDE DEHYDROGENASE; ANNEXIN; ANTINEOPLASTIC AGENT; BROMOPYRUVIC ACID; GEMCITABINE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE ISOENZYME 1; LACTATE DEHYDROGENASE ISOENZYME 5; PROTEIN ALDH1; PYRUVIC ACID DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; BROMOPYRUVATE; DEOXYCYTIDINE; ISOENZYME; TUMOR MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER RESISTANCE; CANCER STEM CELL; CARCINOMA CELL; CELL METABOLISM; CELL PROLIFERATION; CELL RENEWAL; CELL VIABILITY; CHEMOSENSITIVITY; CHICKEN; COLONY FORMATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG TARGETING; EGG; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GEL MOBILITY SHIFT ASSAY; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; METABOLIC INHIBITION; METABOLIC RATE; METASTASIS; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PREDICTION; PRIMARY TUMOR; PROTEIN BINDING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPHEROID CELL; TARGET CELL DESTRUCTION; TUMOR ENGRAFTMENT; WESTERN BLOTTING; XENOTRANSPLANTATION; ANALOGS AND DERIVATIVES; ANIMAL; CARCINOMA, PANCREATIC DUCTAL; CELL SURVIVAL; CHICK EMBRYO; DRUG EFFECTS; DRUG SCREENING; GENETICS; INBRED MOUSE STRAIN; METABOLISM; NUDE MOUSE; PANCREATIC NEOPLASMS; RNA INTERFERENCE; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BLOTTING, WESTERN; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CELL SURVIVAL; CHICK EMBRYO; DEOXYCYTIDINE; FEMALE; GLUCOSE; GLYCOLYSIS; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; L-LACTATE DEHYDROGENASE; MICE, INBRED STRAINS; MICE, NUDE; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; PYRUVATES; RNA INTERFERENCE; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84905041477     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2120     Document Type: Article

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