Inhibitory effects of 3-bromopyruvate on human gastric cancer implant tumors in nude mice

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 7, 2014, Pages 3175-3178

  Xian, Shu Lin ^a   Cao, Wei ^a   Zhang, Xiao Dong ^a   Lu, Yun Fei ^a  

^a FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

3 bromopyruvate; Gastric cancer; Inhibitory effect; Nude mice

Indexed keywords

ANTINEOPLASTIC AGENT; BROMOPYRUVATE; ENZYME INHIBITOR; FLUOROURACIL; PYRUVIC ACID DERIVATIVE;

ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; FEMALE; HUMAN; MOUSE; NUDE MOUSE; PATHOLOGY; STOMACH NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INHIBITORS; FEMALE; FLUOROURACIL; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; PYRUVATES; STOMACH NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84900868710     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.7.3175     Document Type: Article

References (22)

1. Cao X, Jia G, Zhang T, et al (2008). Non-invasive MRI tumor imaging and synergistic anticancer effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model. Cancer Chemoth Pharm, 62, 985-94.
2. Chesney J, Mitchell R, Benigni F, et al (1999). An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect. Proc Natl Acad Sci, 96, 3047-52.
3. Danial NN, Gramm CF, Scorrano L, et al (2003). BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature, 424, 952-6.
4. Ferraro E, Pulicati A, Cencioni MT, et al (2008). Apoptosomedeficient cells lose cytochrome c through proteasomal degradation but survive by autophagy-dependent glycolysis. Mol Biol Cell, 8, 3576-88.
5. Ganapathy KS, Geschwind JF, Kunjithapatham R, et al (2010). 3-Bromopyruvate induces endoplasmic reticulum stress, overcomes autophagy and causes apoptosis in human HCC cell lines. Anticancer Res, 30, 923-35.
6. Ganapathy KS, Vali M, Kunjithapatham R, et al (2010). 3-bromopyruvate: a new targeted antiglycolytic agent and a promise for cancer therapy. Curr Pharm Biotechnol, 11, 510-7.
7. Garber K (2004). Energy boost: the Warburg effect returns in a new theory of cancer. J Natl Cancer Inst, 96, 1805-6.
8. Geschwind JF, Ko YH, Torbenson MS, et al (2002). Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. Cancer Res, 62, 3909-13.
9. Jiang W, Huang Y, Wang JP, et al (2013). The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo. Asian Pac J Cancer Prev, 14, 4615-9.
10. Kim KW, Chow O, Parikh K, et al (2014). Peritoneal carcinomatosis in patients with gastric cancer, and the role for surgical resection, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy. Am J Surg, 207, 78-83.
11. Liu XH, Zheng XF, Wang YL, et al (2009). Inhibitive effect of 3-bromopyruvic acid on human breast cancer MCF-7 cells involves cell cycle arrest and apoptotic induction. Chin Med J, 122, 1681-5.
12. Nelson K (2002). 3-Bromopyruvate kills cancer cells in animals. Lancet Oncol, 3, 524.
13. Ota S, Geschwind JF, Buijs M, et al (2013). Ultrasound-guided direct delivery of 3-bromopyruvate blocks tumor progression in an orthotopic mouse model of human pancreatic cancer. Target Oncol, 8, 145-51.
14. Parks SK, Mazure NM, Counillon L, et al (2013). Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels. J Cell Physiol, 228, 1854-62.
15. Pereira AP, Bacha T, Kyaw N, et al (2009). Inhibition of energyproducing pathways of HepG2 cells by 3-bromopyruvate. Biochem J, 417, 717-26.
16. Sener A, Giroix MH, Dufrane SP, et al (1985). Anomeric specificity of hexokinase and glucokinase activities in liver and insulin-producing cells. Biochem J, 230, 345-51.
17. Warburg O (1956). On the origin of cancer cells. Science, 123, 309-14.
18. Xian SL, Cao W, Lu YF (2013). Research on the inhibitive effect on human gastric cancer cell line SGC-7901. GuangDong Med in chinese, 23, 92-4.
19. Xu J, Wang J, Xu B, et al (2013). Colorectal cancer cells refractory to anti-VEGF treatment are vulnerable to glycolytic blockade due to persistent impairment of mitochondria. Mol Cancer Ther, 12, 717-24.
20. Zare A, Mahmoodi M, Mohammad K, et al (2013). Survival analysis of patients with gastric cancer undergoing surgery at the iran cancer institute: a method based on multi-state models. Asian Pac J Cancer Prev, 14, 6369-73.
21. Zhang X, Varin E, Briand M, et al (2009). Novel therapy for malignant pleural mesothelioma based on anti-energetic effec: an experimental study using 3-bromopyruvate on nude mice. Anticancer Res, 29, 1249-54.
22. Zuo X, Djordjevic JT, Bijosono OJ, et al (2011). Miltefosine induces apoptosis-like cell death in yeast via Cox9p in cytochrome c oxidase. Mol Pharm, 80, 476-85.