INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells

Biochemical and Biophysical Research Communications

Volumn 440, Issue 1, 2013, Pages 137-142

  Min, Joong Won ^a   Kim, Kwang Il ^a   Kim, Hyun Ah ^b   Kim, Eun Kyu ^b   Noh, Woo Chul ^b   Jeon, Hong Bae ^c   Cho, Dong Hyung ^d   Oh, Jeong Su ^e   Park, In Chul ^a   Hwang, Sang Gu ^a   Kim, Jae Sung ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Korea Cancer Center Hospital   (South Korea)

^c MEDIPOST Co Ltd   (South Korea)

^d Kyung Hee University   (South Korea)

^e Sungkyunkwan University   (South Korea)

Author keywords

Glycolysis; INPP4B; Laryngeal cancer; Tumor resistance

Indexed keywords

ANTINEOPLASTIC AGENT; HEXOKINASE; HEXOKINASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; INOSITOL POLYPHOSPHATE; INOSITOL POLYPHOSPHATE 4 PHOSPHATASE TYPE 2; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA SEQUENCE; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; IRRADIATION; LARYNX CANCER; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RADIOSENSITIVITY; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; TUMOR RESISTANCE;

ERK-1/2; EXTRACELLULAR SIGNAL-REGULATED PROTEIN KINASE-1/2; FDG; FLUORODEOXYGLUCOSE; GLYCOLYSIS; HEXOKINASE 2; HIF-1Α; HK2; HYPOXIA-INDUCIBLE FACTOR-1Α; INOSITOL POLYPHOSPHATE 4-PHOSPHATASE TYPE II; INPP4B; LARYNGEAL CANCER; PHOSPHATASE AND TENSIN HOMOLOG; PHOSPHOINOSITIDE 3-KINASES; PI3K; PTEN; RADIORESISTANT HEP-2; RR-HEP-2; SIRNA; SMALL INTERFERING RNA; TUMOR RESISTANCE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; GLUCOSE; GLYCOLYSIS; HEXOKINASE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LARYNGEAL NEOPLASMS; LARYNX; PHOSPHORIC MONOESTER HYDROLASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; TOR SERINE-THREONINE KINASES;

EID: 84885375054     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.09.041     Document Type: Article

References (24)

1. Parkin D.M., Bray F., Ferlay J., Pisani P. Estimating the world cancer burden: Globocan 2000. Int. J. Cancer 2001, 94:153-156. (Journal international du cancer).
2. Lefebvre J.L. Laryngeal preservation in head and neck cancer: multidisciplinary approach. Lancet Oncol. 2006, 7:747-755.
3. Begg A.C., Stewart F.A., Vens C. Strategies to improve radiotherapy with targeted drugs. Nat. Rev. Cancer 2011, 11:239-253.
4. Brown J.M., Wilson W.R. Exploiting tumor hypoxia in cancer treatment. Nat. Rev. Cancer 2004, 4:437-447.
5. Gatenby R.A., Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat. Rev. Cancer 2004, 4:891-899.
6. Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003, 3:721-732.
7. Kunkel M., Reichert T.E., Benz P., Lehr H.A., Jeong J.H., Wieand S., Bartenstein P., Wagner W., Whiteside T.L. Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma. Cancer 2003, 97:1015-1024.
8. Younes M., Brown R.W., Stephenson M., Gondo M., Cagle P.T. Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer 1997, 80:1046-1051.
9. Smith T.A. Mammalian hexokinases and their abnormal expression in cancer. Br. J. Biomed. Sci. 2000, 57:170-178.
10. Palmieri D., Fitzgerald D., Shreeve S.M., Hua E., Bronder J.L., Weil R.J., Davis S., Stark A.M., Merino M.J., Kurek R., Mehdorn H.M., Davis G., Steinberg S.M., Meltzer P.S., Aldape K., Steeg P.S. Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis. Mol. Cancer Res. 2009, 7:1438-1445.
11. Norris F.A., Auethavekiat V., Majerus P.W. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. J. Biol. Chem. 1995, 270:16128-16133.
12. Norris F.A., Atkins R.C., Majerus P.W. The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J. Biol. Chem. 1997, 272:23859-23864.
13. Gewinner C., Wang Z.C., Richardson A., Teruya-Feldstein J., Etemadmoghadam D., Bowtell D., Barretina J., Lin W.M., Rameh L., Salmena L., Pandolfi P.P., Cantley L.C. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 2009, 16:115-125.
14. Di Paolo G., De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature 2006, 443:651-657.
15. Kok K., Geering B., Vanhaesebroeck B. Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem. Sci. 2009, 34:115-127.
16. Kim J.S., Yun H.S., Um H.D., Park J.K., Lee K.H., Kang C.M., Lee S.J., Hwang S.G. Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells. Cancer Biol. Ther. 2012, 13:1307-1318.
17. Kim J.S., Chang J.W., Yun H.S., Yang K.M., Hong E.H., Kim D.H., Um H.D., Lee K.H., Lee S.J., Hwang S.G. Chloride intracellular channel 1 identified using proteomic analysis plays an important role in the radiosensitivity of HEp-2 cells via reactive oxygen species production. Proteomics 2010, 10:2589-2604.
18. Kim J.S., Chang J.W., Park J.K., Hwang S.G. Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal cancer cells via modulating p53. Cancer Biol. Ther. 2012, 13:638-646.
19. Ke Q., Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol. Pharmacol. 2006, 70:1469-1480.
20. Moeller B.J., Cao Y., Li C.Y., Dewhirst M.W. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 2004, 5:429-441.
21. Kroemer G., Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 2008, 13:472-482.
22. Mathupala S.P., Ko Y.H., Pedersen P.L. Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 2006, 25:4777-4786.
23. Fedele C.G., Ooms L.M., Ho M., Vieusseux J., O'Toole S.A., Millar E.K., Lopez-Knowles E., Sriratana A., Gurung R., Baglietto L., Giles G.G., Bailey C.G., Rasko J.E., Shields B.J., Price J.T., Majerus P.W., Sutherland R.L., Tiganis T., McLean C.A., Mitchell C.A. Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc. Natl. Acad. Sci. USA 2010, 107:22231-22236.
24. Hodgson M.C., Shao L.J., Frolov A., Li R., Peterson L.E., Ayala G., Ittmann M.M., Weigel N.L., Agoulnik I.U. Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer. Cancer Res. 2011, 71:572-582.