-
1
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186, 1971.
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
3
-
-
12144287046
-
Hypoxia-mediated down-regulation of bid and bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
-
Erler JT, Cawthorne CJ, Williams KJ, et al: Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol 24: 2875-2889, 2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 2875-2889
-
-
Erler, J.T.1
Cawthorne, C.J.2
Williams, K.J.3
-
4
-
-
77956529790
-
Stereotactic ablative radiotherapy should be combined with a hypoxic cell radiosensitizer
-
Brown JM, Diehn M and Loo BW Jr.: Stereotactic ablative radiotherapy should be combined with a hypoxic cell radiosensitizer. Int J Radiat Oncol Biol Phys 78: 323-327, 2010.
-
(2010)
Int J Radiat Oncol Biol Phys
, vol.78
, pp. 323-327
-
-
Brown, J.M.1
Diehn, M.2
Loo Jr., B.W.3
-
5
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O: On the origin of cancer cells. Science 123: 309-314, 1956.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
6
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, et al: Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59: 5830-5835, 1999.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
-
7
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL and Wang GL: A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12: 5447-5454, 1992.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
8
-
-
0030961006
-
Hypoxia-inducible factor 1alpha (hif-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda S and Caro J: Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272: 22642-22647, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
9
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on map kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda R, Hirota K, Fan F, et al: Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277: 38205-38211, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
-
10
-
-
33947498749
-
Hypoxia inducible factor-1 mediates effects of insulin on pancreatic cancer cells and disturbs host energy homeostasis
-
Wang F, Li SS, Segersvärd R, et al: Hypoxia inducible factor-1 mediates effects of insulin on pancreatic cancer cells and disturbs host energy homeostasis. Am J Pathol 170: 469-477, 2007.
-
(2007)
Am J Pathol
, vol.170
, pp. 469-477
-
-
Wang, F.1
Li, S.S.2
Segersvärd, R.3
-
11
-
-
34548044509
-
Synergistic up-regulation of hexokinase-2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose deprivation and hypoxia
-
Natsuizaka M, Ozasa M, Darmanin S, et al: Synergistic up-regulation of Hexokinase-2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose deprivation and hypoxia. Exp Cell Res 313: 3337-3348, 2007.
-
(2007)
Exp Cell Res
, vol.313
, pp. 3337-3348
-
-
Natsuizaka, M.1
Ozasa, M.2
Darmanin, S.3
-
12
-
-
60249083822
-
Hexokinase-2 bound to mitochondria: Cancer's stygian link to the 'warburg effect' and a pivotal target for effective therapy
-
Mathupala SP, Ko YH and Pedersen PL: Hexokinase-2 bound to mitochondria: cancer's stygian link to the 'Warburg Effect' and a pivotal target for effective therapy. Semin Cancer Biol 19: 17-24, 2009.
-
(2009)
Semin Cancer Biol
, vol.19
, pp. 17-24
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
-
13
-
-
69749117834
-
Hif-1 prevents the overproduction of mitochondrial ros after cytokine stimulation through induction of pdk-1
-
Kirito K, Hu Y and Komatsu N: HIF-1 prevents the overproduction of mitochondrial ROS after cytokine stimulation through induction of PDK-1. Cell Cycle 8: 2844-2849, 2009.
-
(2009)
Cell Cycle
, vol.8
, pp. 2844-2849
-
-
Kirito, K.1
Hu, Y.2
Komatsu, N.3
-
14
-
-
34547902505
-
Different toxic mechanisms of 2-deoxy-d-glucose versus 2-fluorodeoxy-d-glucose in hypoxic and normoxic tumor cells
-
Kurtoglu M, Maher JC and Lampidis TJ: Different toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells. Antioxid Redox Signal 9: 1383-1390, 2007.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 1383-1390
-
-
Kurtoglu, M.1
Maher, J.C.2
Lampidis, T.J.3
-
15
-
-
29144467160
-
Differential sensitivity to 2-deoxy-d-glucose between two pancreatic cell lines correlates with glut-1 expression
-
Maher JC, Savaraj N, Priebe W, et al: Differential sensitivity to 2-deoxy-D-glucose between two pancreatic cell lines correlates with GLUT-1 expression. Pancreas 30: e34-e39, 2005.
-
(2005)
Pancreas
, vol.30
-
-
Maher, J.C.1
Savaraj, N.2
Priebe, W.3
-
16
-
-
49849099471
-
Intrinsically lower akt, mtor and hif activity correlates with increased sensitivity to 2-deoxy-d-glucose under hypoxia in lung cancer cell lines
-
Wangpaichitr M, Savaraj N, Maher J, et al: Intrinsically lower AKT, mTOR and HIF activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines. Mol Cancer Ther 7: 1506-1513, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1506-1513
-
-
Wangpaichitr, M.1
Savaraj, N.2
Maher, J.3
-
17
-
-
33847353815
-
Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-d-glucose
-
Maher JC, Wangpaichitr M, Savaraj N, et al: Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose. Mol Cancer Ther 6: 732-741, 2007.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 732-741
-
-
Maher, J.C.1
Wangpaichitr, M.2
Savaraj, N.3
-
18
-
-
44949149074
-
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir
-
Hernlund E, Ihrlund LS, Khan O, et al: Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. Int J Cancer 123: 476-483, 2008.
-
(2008)
Int J Cancer
, vol.123
, pp. 476-483
-
-
Hernlund, E.1
Ihrlund, L.S.2
Khan, O.3
-
19
-
-
1642494855
-
2-Deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo
-
Maschek G, Savaraj N, Priebe W, et al: 2-Deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo. Cancer Res 64: 31-34, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 31-34
-
-
Maschek, G.1
Savaraj, N.2
Priebe, W.3
-
20
-
-
0035829074
-
Glucose catabolism in the rabbit vx2 tumor model for liver cancer: Characterization and targeting hexokinase
-
Ko YH, Pedersen PL and Geschwind JF: Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett 173: 83-91, 2001.
-
(2001)
Cancer Lett
, vol.173
, pp. 83-91
-
-
Ko, Y.H.1
Pedersen, P.L.2
Geschwind, J.F.3
-
21
-
-
65449119234
-
Role of mitochondria-associated hexokinase ii in cancer cell death induced by 3-bromopyruvate
-
Chen Z, Zhang H, Lu W and Huang P: Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate. Biochim Biophys Acta 1787: 553-560, 2009.
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 553-560
-
-
Chen, Z.1
Zhang, H.2
Lu, W.3
Huang, P.4
-
22
-
-
60849101819
-
Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells: Ros-mediated cell death by 3-brpa
-
Kim JS, Ahn KJ, Kim JA, et al: Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells: ROS-mediated cell death by 3-BrPA. J Bioenerg Biomembr 40: 607-618, 2008.
-
(2008)
J Bioenerg Biomembr
, vol.40
, pp. 607-618
-
-
Kim, J.S.1
Ahn, K.J.2
Kim, J.A.3
-
23
-
-
61849134364
-
Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells
-
Hulleman E, Kazemier KM, Holleman A, et al: Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells. Blood 113: 2014-2021, 2009.
-
(2009)
Blood
, vol.113
, pp. 2014-2021
-
-
Hulleman, E.1
Kazemier, K.M.2
Holleman, A.3
-
24
-
-
4744341871
-
Advanced cancers: Eradication in all cases using 3-bromopyruvate therapy to deplete atp
-
Ko YH, Smith BL, Wang Y, et al: Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. Biochem Biophys Res Commun 324: 269-275, 2004.
-
(2004)
Biochem Biophys Res Commun
, vol.324
, pp. 269-275
-
-
Ko, Y.H.1
Smith, B.L.2
Wang, Y.3
-
25
-
-
59849092584
-
Inhibition of energy-producing pathways of hepg2 cells by 3-bromopyruvate
-
Pereira da Silva AP, El-Bacha T, Kyaw N, et al: Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. Biochem J 417: 717-726, 2009.
-
(2009)
Biochem J
, vol.417
, pp. 717-726
-
-
Pereira Da Silva, A.P.1
El-Bacha, T.2
Kyaw, N.3
-
26
-
-
21344438419
-
Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (hif-1)
-
Greijer AE, van der Groep P, Kemming D, et al: Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J Pathol 206: 291-304, 2005.
-
(2005)
J Pathol
, vol.206
, Issue.291-304
-
-
Greijer, A.E.1
Van Der Groep, P.2
Kemming, D.3
-
27
-
-
79955591914
-
Recent advances in apoptosis, mitochondria and drug resistance in cancer cells
-
Indran IR, Tufo G, Pervaiz S and Brenner C: Recent advances in apoptosis, mitochondria and drug resistance in cancer cells. Biochim Biophys Acta 1807: 735-745, 2011.
-
(2011)
Biochim Biophys Acta
, vol.1807
, pp. 735-745
-
-
Indran, I.R.1
Tufo, G.2
Pervaiz, S.3
Brenner, C.4
-
28
-
-
78649601369
-
How to kill tumor cells with inhibitors of poly(adp-ribosyl) ation
-
Mangerich A and Bürkle A: How to kill tumor cells with inhibitors of poly(ADP-ribosyl)ation. Int J Cancer 128: 251-265, 2011.
-
(2011)
Int J Cancer
, vol.128
, pp. 251-265
-
-
Mangerich, A.1
Bürkle, A.2
-
29
-
-
33947520506
-
Inhibition of hypoxia-inducible factor (hif) hydroxylases by citric acid cycle intermediates: Possible links between cell metabolism and stabilization of hif
-
Koivunen P, Hirsilä M, Remes AM, et al: Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J Biol Chem 282: 4524-4532, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 4524-4532
-
-
Koivunen, P.1
Hirsilä, M.2
Remes, A.M.3
-
30
-
-
77957751549
-
Sod1 and mitotempo partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after atp depletion recovery
-
Liang HL, Sedlic F, Bosnjak Z and Nilakantan V: SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. Free Radic Biol Med 49: 1550-1560, 2010.
-
(2010)
Free Radic Biol Med
, vol.49
, pp. 1550-1560
-
-
Liang, H.L.1
Sedlic, F.2
Bosnjak, Z.3
Nilakantan, V.4
-
31
-
-
0033598713
-
Poly(adp-ribose) polymerase is a mediator of necrotic cell death by atp depletion
-
Ha HC and Snyder SH: Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci USA 96: 13978-13982, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13978-13982
-
-
Ha, H.C.1
Snyder, S.H.2
-
32
-
-
77952745676
-
3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines
-
Qin JZ, Xin H and Nickoloff BJ: 3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines. Biochem Biophys Res Commun 396: 495-500, 2010.
-
(2010)
Biochem Biophys Res Commun
, vol.396
, pp. 495-500
-
-
Qin, J.Z.1
Xin, H.2
Nickoloff, B.J.3
|