Dose-dependent effect of 2-deoxy-D-glucose on glycoprotein mannosylation in cancer cells

IUBMB Life

Volumn 67, Issue 3, 2015, Pages 218-226

  Ahadova, Aysel ^a,b,c   Gebert, Johannes ^a,b,c   Von Knebel Doeberitz, Magnus ^a,b,c   Kopitz, Juergen ^a,b,c   Kloor, Matthias ^a,b,c  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

cellular glucose metabolism; glycobiology; membrane proteins

Indexed keywords

CELL SURFACE PROTEIN; CONCANAVALIN A; DEOXYGLUCOSE; LECTIN; MANNOSE; MANNOSIDASE; MEMBRANE PROTEIN; GLYCOPROTEIN;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CELL DENSITY; CELL MEMBRANE; CELL SURFACE; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; ENZYME INHIBITION; FLUORESCENCE ACTIVATED CELL SORTING; GLYCOPROTEIN SYNTHESIS; HCT116 CELL LINE; LECTIN BINDING; LOW DRUG DOSE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN MANNOSYLATION; PROTEIN SYNTHESIS; ANIMAL; COLORECTAL TUMOR; DOSE RESPONSE; DRUG EFFECTS; GLYCOSYLATION; HUMAN; METABOLISM; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DEOXYGLUCOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOPROTEINS; GLYCOSYLATION; HCT116 CELLS; HUMANS; LECTINS; MANNOSE; MEMBRANE PROTEINS; MICE;

EID: 84928495468     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1364     Document Type: Article

References (34)

1. Hanahan, D., and, Weinberg, R. A., (2011) Hallmarks of cancer: the next generation. Cell 144, 646-674.
2. Warburg, O., Wind, F., and, Negelein, E., (1927) The metabolism of tumors in the body. J. Gen. Physiol. 8, 519-530.
3. Hawkins, R. A., and, Phelps, M. E., (1988) PET in clinical oncology. Cancer Metastasis Rev. 7, 119-142.
4. Jiang, L., Tu, Y., Shi, H., and, Cheng, Z., (2014) PET probes beyond F-FDG. J. Biomed. Res. 28, 435-446.
5. Robinson, G. L., Dinsdale, D., Macfarlane, M., and, Cain, K., (2012) Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL. Oncogene 31, 4996-5006.
6. Zhang, D., Li, J., Wang, F., Hu, J., Wang, S., et al.,. (2014) 2-Deoxy- d -glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Lett. 355, 176-183.
7. Aft, R. L., Zhang, F. W., and, Gius, D., (2002) Evaluation of 2-deoxy- d -glucose as a chemotherapeutic agent: mechanism of cell death. Br. J. Cancer 87, 805-812.
8. Zhang, X. D., Deslandes, E., Villedieu, M., Poulain, L., Duval, M., et al.,. (2006) Effect of 2-deoxy- d -glucose on various malignant cell lines in vitro. Anticancer Res. 26, 3561-3566.
9. Kurtoglu, M., Gao, N., Shang, J., Maher, J. C., Lehrman, M. A., et al.,. (2007) Under normoxia, 2-deoxy- d -glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation. Mol. Cancer Ther. 6, 3049-3058.
10. Stein, M., Lin, H., Jeyamohan, C., Dvorzhinski, D., Gounder, M., et al.,. (2010) Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies. Prostate 70, 1388-1394.
11. Raez, L. E., Papadopoulos, K., Ricart, A. D., Chiorean, E. G., Dipaola, R. S., et al.,. (2013) A phase I dose-escalation trial of 2-deoxy- d -glucose alone or combined with docetaxel in patients with advanced solid tumors. Cancer Chemother. Pharmacol. 71, 523-530.
12. Schwarz, R. T., Schmidt, M. F., and, Datema, R., (1979) Inhibition of glycosylation of viral glycoproteins. Biochem. Soc. Trans. 7, 322-326.
13. Tuccillo, F. M., de Laurentiis, A., Palmieri, C., Fiume, G., Bonelli, P., et al.,. (2014) Aberrant glycosylation as biomarker for cancer: focus on CD43. Biomed. Res. Int. 2014, 742831.
14. Xi, H., Kurtoglu, M., and, Lampidis, T. J., (2014) The wonders of 2-deoxy- d -glucose. IUBMB Life 66, 110-121.
15. Gebert, J., Kloor, M., Lee, J., Lohr, M., Andre, S., et al.,. (2012) Colonic carcinogenesis along different genetic routes: glycophenotyping of tumor cases separated by microsatellite instability/stability. Histochem. Cell Biol. 138, 339-350.
16. Lee, J., Ballikaya, S., Schonig, K., Ball, C. R., Glimm, H., et al.,. (2013) Transforming growth factor beta receptor 2 (TGFBR2) changes sialylation in the microsatellite unstable (MSI) colorectal cancer cell line HCT116. PLoS One 8, e57074.
17. Kaprio, T., Satomaa, T., Heiskanen, A., Hokke, C. H., Deelder, A. M., et al.,. (2014) N-Glycomic profiling as a tool to separate rectal adenomas from carcinomas. Mol. Cell. Proteomics 14, 277-288.
18. Nicastri, A., Gaspari, M., Sacco, R., Elia, L., Gabriele, C., et al.,. (2014) N-Glycoprotein analysis discovers new up-regulated glycoproteins in colorectal cancer tissue. J. Proteome Res. 13, 4932-4941.
19. Michel, S., Linnebacher, M., Alcaniz, J., Voss, M., Wagner, R., et al.,. (2010) Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes. Int. J. Cancer 127, 889-898.
20. Christiansen, M. N., Chik, J., Lee, L., Anugraham, M., Abrahams, J. L., et al.,. (2014) Cell surface protein glycosylation in cancer. Proteomics 14, 525-546.
21. Hauselmann, I., and, Borsig, L., (2014) Altered tumor-cell glycosylation promotes metastasis. Front. Oncol. 4, 28.
22. Zhang, Y., Jiao, J., Yang, P., and, Lu, H., (2014) Mass spectrometry-based N-glycoproteomics for cancer biomarker discovery. Clin. Proteomics 11, 18.
23. Santagata, S., Mendillo, M. L., Tang, Y. C., Subramanian, A., Perley, C. C., et al.,. (2013) Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science 341, 1238303.
24. Reading, C. L., and, Hutchins, J. T., (1985) Carbohydrate structure in tumor immunity. Cancer Metastasis Rev. 4, 221-260.
25. Rabinovich, G. A., van Kooyk, Y., and, Cobb, B. A., (2012) Glycobiology of immune responses. Ann. NY Acad. Sci. 1253, 1-15.
26. Padler-Karavani, V., (2014) Aiming at the sweet side of cancer: aberrant glycosylation as possible target for personalized-medicine. Cancer Lett. 352, 102-112.
27. Andresen, L., Skovbakke, S. L., Persson, G., Hagemann-Jensen, M., Hansen, K. A., et al.,. (2012) 2-Deoxy d -glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation. J. Immunol. 188, 1847-1855.
28. Kaluza, G., Schmidt, M. F., and, Scholtissek, C., (1973) Effect of 2-deoxy- d -glucose on the multiplication of Semliki Forest virus and the reversal of the block by mannose. Virology 54, 179-189.
29. Schwarz, R. T., and, Klenk, H. D., (1974) Proceedings: Inhibition of glycosylation of the influenza virus hemagglutinin. Hoppe Seylers Z. Physiol. Chem. 355, 1254.
30. Datema, R., and, Schwarz, R. T., (1978) Formation of 2-deoxyglucose-containing lipid-linked oligosaccharides. Interference with glycosylation of glycoproteins. Eur. J. Biochem. 90, 505-516.
31. Hunt, L. A., (1981) Sindbis virus glycoproteins acquire unusual neutral oligosaccharides in both normal and lectin-resistant Chinese Hamster ovary cell lines. Virology 113, 534-543.
32. Minor, R. K., Smith, D. L., Jr,., Sossong, A. M., Kaushik, S., Poosala, S., et al.,. (2010) Chronic ingestion of 2-deoxy- d -glucose induces cardiac vacuolization and increases mortality in rats. Toxicol. Appl. Pharmacol. 243, 332-339.
33. De Mejia, E. G., and, Prisecaru, V. I., (2005) Lectins as bioactive plant proteins: a potential in cancer treatment. Crit. Rev. Food Sci. Nutr. 45, 425-445.
34. Harmsma, M., Ummelen, M., Dignef, W., Tusenius, K. J., and, Ramaekers, F. C., (2006) Effects of mistletoe (Viscum album L.) extracts Iscador on cell cycle and survival of tumor cells. Arzneimittelforschung 56, 474-482.