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Volumn 2015, Issue , 2015, Pages

Reviving Lonidamine and 6-diazo-5-oxo-l-norleucine to be used in combination for metabolic cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

6 DIAZO 5 OXONORLEUCINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; LONIDAMINE; ANTINEOPLASTIC AGENT; INDAZOLE DERIVATIVE;

EID: 84942292107     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/690492     Document Type: Review
Times cited : (96)

References (119)
  • 1
    • 78649891511 scopus 로고    scopus 로고
    • Balancing biosynthesis and bioenergetics: Metabolic programs in oncogenesis
    • J. F. Barger and D. R. Plas, "Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis, " Endocrine-Related Cancer, vol. 17, no. 4, pp. R287-R304, 2010.
    • (2010) Endocrine-Related Cancer , vol.17 , Issue.4 , pp. R287-R304
    • Barger, J.F.1    Plas, D.R.2
  • 2
    • 84920268667 scopus 로고    scopus 로고
    • A nexus for cellular homeostasis: The interplay between metabolic and signal transduction pathways
    • A. P. Gomes and J. Blenis, "A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways, " Current Opinion in Biotechnology, vol. 34, pp. 110-117, 2015.
    • (2015) Current Opinion in Biotechnology , vol.34 , pp. 110-117
    • Gomes, A.P.1    Blenis, J.2
  • 3
    • 84859345091 scopus 로고    scopus 로고
    • Metabolic sensors and their interplay with cell signalling and transcription
    • A. Krejci, "Metabolic sensors and their interplay with cell signalling and transcription, " Biochemical Society Transactions, vol. 40, no. 2, pp. 311-323, 2012.
    • (2012) Biochemical Society Transactions , vol.40 , Issue.2 , pp. 311-323
    • Krejci, A.1
  • 5
    • 79953705886 scopus 로고    scopus 로고
    • Choosing between glycolysis and oxidative phosphorylation: A tumors dilemma?
    • C. Jose, N. Bellance, and R. Rossignol, "Choosing between glycolysis and oxidative phosphorylation: a tumors dilemma?" Biochimica et BiophysicaActa-Bioenergetics, vol. 1807, no. 6, pp. 552-561, 2011.
    • (2011) Biochimica et BiophysicaActa-Bioenergetics , vol.1807 , Issue.6 , pp. 552-561
    • Jose, C.1    Bellance, N.2    Rossignol, R.3
  • 6
    • 0016220406 scopus 로고
    • Intracellular free amino acid concentration in humanmuscle tissue
    • J. Bergstrm, P. Furst, L. O. Nore, and E. Vinnars, "Intracellular free amino acid concentration in humanmuscle tissue, " Journal of Applied Physiology, vol. 36, no. 6, pp. 693-697, 1974.
    • (1974) Journal of Applied Physiology , vol.36 , Issue.6 , pp. 693-697
    • Bergstrm, J.1    Furst, P.2    Nore, L.O.3    Vinnars, E.4
  • 7
    • 0032881950 scopus 로고    scopus 로고
    • Determination of glutamine inmuscle protein facilitates accurate assessment of proteolysis and de novo synthesis-derived endogenous glutamine production
    • K. S. Kuhn, K. Schuhmann, P. Stehle, D. Darmaun, and P. Frst, "Determination of glutamine inmuscle protein facilitates accurate assessment of proteolysis and de novo synthesis-derived endogenous glutamine production, " The American Journal of Clinical Nutrition, vol. 70, no. 4, pp. 484-489, 1999.
    • (1999) The American Journal of Clinical Nutrition , vol.70 , Issue.4 , pp. 484-489
    • Kuhn, K.S.1    Schuhmann, K.2    Stehle, P.3    Darmaun, D.4    Frst, P.5
  • 8
    • 0017754333 scopus 로고
    • Metabolism and transport of glutamine and glucose in vascularly perfused small intestine rat
    • P. J. Hanson and D. S. Parsons, "Metabolism and transport of glutamine and glucose in vascularly perfused small intestine rat, " Biochemical Journal, vol. 166, no. 3, pp. 509-519, 1977.
    • (1977) Biochemical Journal , vol.166 , Issue.3 , pp. 509-519
    • Hanson, P.J.1    Parsons, D.S.2
  • 9
    • 0023664719 scopus 로고
    • End products of glucose and glutamine metabolism by L929 cells
    • K. W. Lanks, "End products of glucose and glutamine metabolism by L929 cells, " The Journal of Biological Chemistry, vol. 262, no. 21, pp. 10093-10097, 1987.
    • (1987) The Journal of Biological Chemistry , vol.262 , Issue.21 , pp. 10093-10097
    • Lanks, K.W.1
  • 10
    • 0022196860 scopus 로고
    • Glutamine metabolism in lymphocytes: Its biochemical, physiological and clinical importance
    • E. A. Newsholme, B. Crabtree, and M. S. M. Ardawi, "Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance, " Quarterly Journal of Experimental Physiology, vol. 70, no. 4, pp. 473-489, 1985.
    • (1985) Quarterly Journal of Experimental Physiology , vol.70 , Issue.4 , pp. 473-489
    • Newsholme, E.A.1    Crabtree, B.2    Ardawi, M.S.M.3
  • 11
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • R. J. DeBerardinis, A. Mancuso, E. Daikhin et al. , "Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis, " Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 49, pp. 19345-19350, 2007.
    • (2007) Proceedings of the National Academy of Sciences of the United States of America , vol.104 , Issue.49 , pp. 19345-19350
    • DeBerardinis, R.J.1    Mancuso, A.2    Daikhin, E.3
  • 12
    • 84856014884 scopus 로고    scopus 로고
    • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    • C. M. Metallo, P. A. Gameiro, E. L. Bell et al. , "Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia, " Nature, vol. 481, no. 7381, pp. 380-384, 2012.
    • (2012) Nature , vol.481 , Issue.7381 , pp. 380-384
    • Metallo, C.M.1    Gameiro, P.A.2    Bell, E.L.3
  • 13
    • 3042615495 scopus 로고    scopus 로고
    • Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes
    • H. Yoo, G. Stephanopoulos, and J. K. Kelleher, "Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes, " The Journal of Biological Chemistry, vol. 45, no. 7, pp. 1324-1332, 2004.
    • (2004) The Journal of Biological Chemistry , vol.45 , Issue.7 , pp. 1324-1332
    • Yoo, H.1    Stephanopoulos, G.2    Kelleher, J.K.3
  • 14
    • 77958478353 scopus 로고    scopus 로고
    • Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells
    • M. Meng, S. Chen, T. Lao, D. Liang, and N. Sang, "Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells, " Cell Cycle, vol. 9, no. 19, pp. 3921-3932, 2010.
    • (2010) Cell Cycle , vol.9 , Issue.19 , pp. 3921-3932
    • Meng, M.1    Chen, S.2    Lao, T.3    Liang, D.4    Sang, N.5
  • 15
    • 0019898583 scopus 로고
    • Glycolysis, glutaminolysis and cell proliferation
    • W. L. McKeehan, "Glycolysis, glutaminolysis and cell proliferation, " Cell Biology International Reports, vol. 6, no. 7, pp. 635-650, 1982.
    • (1982) Cell Biology International Reports , vol.6 , Issue.7 , pp. 635-650
    • McKeehan, W.L.1
  • 16
    • 34347402459 scopus 로고    scopus 로고
    • Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
    • M. Yuneva, N. Zamboni, P. Oefner, R. Sachidanandam, and Y. Lazebnik, "Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells, " The Journal of Cell Biology, vol. 178, no. 1, pp. 93-105, 2007.
    • (2007) The Journal of Cell Biology , vol.178 , Issue.1 , pp. 93-105
    • Yuneva, M.1    Zamboni, N.2    Oefner, P.3    Sachidanandam, R.4    Lazebnik, Y.5
  • 18
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • A. J. Levine and A. M. Puzio-Kuter, "The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes, " Science, vol. 330, no. 6009, pp. 1340-1344, 2010.
    • (2010) Science , vol.330 , Issue.6009 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 19
    • 0033079597 scopus 로고    scopus 로고
    • Oncogenic alterations of metabolism
    • C. V. Dang and G. L. Semenza, "Oncogenic alterations of metabolism, " Trends in Biochemical Sciences, vol. 24, no. 2, pp. 68-72, 1999.
    • (1999) Trends in Biochemical Sciences , vol.24 , Issue.2 , pp. 68-72
    • Dang, C.V.1    Semenza, G.L.2
  • 20
    • 58149136865 scopus 로고    scopus 로고
    • Roles of p53, MYC and HIF-1 in regulating glycolysis-the seventh hallmark of cancer
    • S. J. Yeung, J. Pan, and M.-H. Lee, "Roles of p53, MYC and HIF-1 in regulating glycolysis-the seventh hallmark of cancer, " Cellular and Molecular Life Sciences, vol. 65, no. 24, pp. 3981-3999, 2008.
    • (2008) Cellular and Molecular Life Sciences , vol.65 , Issue.24 , pp. 3981-3999
    • Yeung, S.J.1    Pan, J.2    Lee, M.-H.3
  • 21
    • 80051866908 scopus 로고    scopus 로고
    • OncogenicK-Ras decouples glucose and glutaminemetabolismto support cancer cell growth
    • article 523
    • D. Gaglio, C. M. Metallo, P. A. Gameiroet al. , "OncogenicK-Ras decouples glucose and glutaminemetabolismto support cancer cell growth, " Molecular Systems Biology, vol. 7, article 523, 2011.
    • (2011) Molecular Systems Biology , vol.7
    • Gaglio, D.1    Metallo, C.M.2    Gameiro, P.A.3
  • 22
    • 84883501150 scopus 로고    scopus 로고
    • HIF-1 mediates metabolic responses to intratumoral hypoxia andoncogenicmutations
    • G. L. Semenza, "HIF-1 mediates metabolic responses to intratumoral hypoxia andoncogenicmutations, "The Journal of Clinical Investigation, vol. 123, no. 9, pp. 3664-3671, 2013.
    • (2013) The Journal of Clinical Investigation , vol.123 , Issue.9 , pp. 3664-3671
    • Semenza, G.L.1
  • 23
    • 84055178474 scopus 로고    scopus 로고
    • Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
    • B. Magnuson, B. Ekim, and D. C. Fingar, "Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks, " Biochemical Journal, vol. 441, no. 1, pp. 1-21, 2012.
    • (2012) Biochemical Journal , vol.441 , Issue.1 , pp. 1-21
    • Magnuson, B.1    Ekim, B.2    Fingar, D.C.3
  • 24
    • 84878532557 scopus 로고    scopus 로고
    • Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
    • C. C. Dibble and B. D. Manning, "Signal integration by mTORC1 coordinates nutrient input with biosynthetic output, " Nature Cell Biology, vol. 15, no. 6, pp. 555-564, 2013.
    • (2013) Nature Cell Biology , vol.15 , Issue.6 , pp. 555-564
    • Dibble, C.C.1    Manning, B.D.2
  • 26
    • 33646706052 scopus 로고    scopus 로고
    • Oncogenic PI3K and its role in cancer
    • Y. Samuels and K. Ericson, "Oncogenic PI3K and its role in cancer, " Current Opinion in Oncology, vol. 18, no. 1, pp. 77-82, 2006.
    • (2006) Current Opinion in Oncology , vol.18 , Issue.1 , pp. 77-82
    • Samuels, Y.1    Ericson, K.2
  • 27
    • 4143056826 scopus 로고    scopus 로고
    • Mutational activation of the RAS-RAF-MAPK and the wnt pathway in small intestinal adenocarcinomas
    • H. Blker, B. Helmchen, A. Bnisch et al. , "Mutational activation of the RAS-RAF-MAPK and the wnt pathway in small intestinal adenocarcinomas, " Scandinavian Journal of Gastroenterology, vol. 39, no. 8, pp. 748-753, 2004.
    • (2004) Scandinavian Journal of Gastroenterology , vol.39 , Issue.8 , pp. 748-753
    • Blker, H.1    Helmchen, B.2    Bnisch, A.3
  • 29
    • 0021253118 scopus 로고
    • Phase i and clinical pharmacologic evaluation of lonidamine in patients with advanced cancer
    • C. W. Young, V. E. Currie, J. H. Kim, M. A. OHehir, F. M. Farag, and J. E. Kinahan, "Phase I and clinical pharmacologic evaluation of lonidamine in patients with advanced cancer, " Oncology, vol. 41, no. 1, pp. 60-65, 1984.
    • (1984) Oncology , vol.41 , Issue.1 , pp. 60-65
    • Young, C.W.1    Currie, V.E.2    Kim, J.H.3    OHehir, M.A.4    Farag, F.M.5    Kinahan, J.E.6
  • 30
    • 0023701036 scopus 로고
    • Phase i trial of lonidaminewithwhole body hyperthermia in advanced cancer
    • H. I. Robins, W. L. Longo, R. K. Lagoni et al. , "Phase I trial of lonidaminewithwhole body hyperthermia in advanced cancer, " Cancer Research, vol. 48, no. 22, pp. 6587-6592, 1988.
    • (1988) Cancer Research , vol.48 , Issue.22 , pp. 6587-6592
    • Robins, H.I.1    Longo, W.L.2    Lagoni, R.K.3
  • 31
    • 0019461053 scopus 로고
    • Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase
    • H. Rosenfeld and J. Roberts, "Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase, " Cancer Research, vol. 41, no. 4, pp. 1324-1328, 1981.
    • (1981) Cancer Research , vol.41 , Issue.4 , pp. 1324-1328
    • Rosenfeld, H.1    Roberts, J.2
  • 33
    • 0022357556 scopus 로고
    • Phase i study and clinical pharmacology of 6-diazo-5-oxo-Lnorleucine (DON)
    • A. Rahman, F. P. Smith, P.-V. T. Luc, and P. V. Wooley, "Phase I study and clinical pharmacology of 6-diazo-5-oxo-Lnorleucine (DON), " Investigational New Drugs, vol. 3, no. 4, pp. 369-374, 1985.
    • (1985) Investigational New Drugs , vol.3 , Issue.4 , pp. 369-374
    • Rahman, A.1    Smith, F.P.2    Luc, P.-V.T.3    Wooley, P.V.4
  • 34
    • 0019988924 scopus 로고
    • Phase i trial of 6-diazo-5-oxo-L-norleucine (DON) administered by 5-day courses
    • R. H. Earhart, J. M. Koeller, and H. L. Davis, "Phase I trial of 6-diazo-5-oxo-L-norleucine (DON) administered by 5-day courses, " Cancer Treatment Reports, vol. 66, no. 5, pp. 1215-1217, 1982.
    • (1982) Cancer Treatment Reports , vol.66 , Issue.5 , pp. 1215-1217
    • Earhart, R.H.1    Koeller, J.M.2    Davis, H.L.3
  • 35
    • 0023856453 scopus 로고
    • Pharmacokinetic and phase i study of intravenous DON (6-diazo-5-oxo-L-norleucine) in children
    • M. P. Sullivan, J. A. Nelson, S. Feldman, and B. Van Nguyen, "Pharmacokinetic and phase I study of intravenous DON (6-diazo-5-oxo-L-norleucine) in children, " Cancer Chemotherapy and Pharmacology, vol. 21, no. 1, pp. 78-84, 1988.
    • (1988) Cancer Chemotherapy and Pharmacology , vol.21 , Issue.1 , pp. 78-84
    • Sullivan, M.P.1    Nelson, J.A.2    Feldman, S.3    Van Nguyen, B.4
  • 36
    • 0032751627 scopus 로고    scopus 로고
    • Weekly epirubicin plus lonidamine in advanced breast carcinoma
    • C. Nistico, C. Garufi, M. Milella et al. , "Weekly epirubicin plus lonidamine in advanced breast carcinoma, " Breast Cancer Research and Treatment, vol. 56, no. 3, pp. 233-237, 1999.
    • (1999) Breast Cancer Research and Treatment , vol.56 , Issue.3 , pp. 233-237
    • Nistico, C.1    Garufi, C.2    Milella, M.3
  • 37
    • 0028866197 scopus 로고
    • Intrapatient comparison of single-agent epirubicin with or without lonidamine in metastatic breast cancer
    • M. Lopez, P. Vici, L. Di Lauro et al. , "Intrapatient comparison of single-agent epirubicin with or without lonidamine in metastatic breast cancer, " European Journal of Cancer, vol. 31, no. 10, pp. 1611-1614, 1995.
    • (1995) European Journal of Cancer , vol.31 , Issue.10 , pp. 1611-1614
    • Lopez, M.1    Vici, P.2    Di Lauro, L.3
  • 38
    • 0031472882 scopus 로고    scopus 로고
    • Cisplatin and epirubicin plus oral lonidamine as first-line treatment for metastatic breast cancer: A phase II study of the Southern Italy Oncology Group (GOIM)
    • V. Gebbia, N. Borsellino, A. Testa et al. , "Cisplatin and epirubicin plus oral lonidamine as first-line treatment for metastatic breast cancer: a phase II study of the Southern Italy Oncology Group (GOIM), " Anti-Cancer Drugs, vol. 8, no. 10, pp. 943-948, 1997.
    • (1997) Anti-Cancer Drugs , vol.8 , Issue.10 , pp. 943-948
    • Gebbia, V.1    Borsellino, N.2    Testa, A.3
  • 39
    • 0031975799 scopus 로고    scopus 로고
    • Cisplatin, epirubicin, and lonidamine combination regimen as first-line chemotherapy for metastatic: Breast cancer: A pilot study
    • L. Dogliotti, S. Danese, A. Berruti et al. , "Cisplatin, epirubicin, and lonidamine combination regimen as first-line chemotherapy for metastatic: breast cancer: a pilot study, " Cancer Chemotherapy and Pharmacology, vol. 41, no. 4, pp. 333-338, 1998.
    • (1998) Cancer Chemotherapy and Pharmacology , vol.41 , Issue.4 , pp. 333-338
    • Dogliotti, L.1    Danese, S.2    Berruti, A.3
  • 40
    • 0025726913 scopus 로고
    • Lonidamine in non-small-cell lung cancer: A phase II study
    • A. Contu, N. A. Olmeo, P. Pani, A. Deriu, S. Ortu, and C. Paga, "Lonidamine in non-small-cell lung cancer: a phase II study, " Tumori, vol. 77, no. 1, pp. 52-55, 1991.
    • (1991) Tumori , vol.77 , Issue.1 , pp. 52-55
    • Contu, A.1    Olmeo, N.A.2    Pani, P.3    Deriu, A.4    Ortu, S.5    Paga, C.6
  • 41
    • 0032949450 scopus 로고    scopus 로고
    • Cisplatin, gemcitabine, and vinorelbine combination therapy in advanced non-smallcell lung cancer: A phase II randomized Study of the Southern Italy Cooperative Oncology Group
    • P. Comella, G. Frasci, N. Panza et al. , "Cisplatin, gemcitabine, and vinorelbine combination therapy in advanced non-smallcell lung cancer: a phase II randomized Study of the Southern Italy Cooperative Oncology Group, " Journal of Clinical Oncology, vol. 17, no. 5, pp. 1526-1534, 1999.
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.5 , pp. 1526-1534
    • Comella, P.1    Frasci, G.2    Panza, N.3
  • 42
    • 0032862447 scopus 로고    scopus 로고
    • Treatment of inoperable non-small cell lung carcinomastage IIIB and IVwith cisplatin, epidoxorubicin, vindesine and lonidamine: A phase II study
    • L. Portalone, A. Lombardi, A. Antilli et al. , "Treatment of inoperable non-small cell lung carcinomastage IIIB and IVwith cisplatin, epidoxorubicin, vindesine and lonidamine: a phase II study, " Tumori, vol. 85, no. 4, pp. 239-242, 1999.
    • (1999) Tumori , vol.85 , Issue.4 , pp. 239-242
    • Portalone, L.1    Lombardi, A.2    Antilli, A.3
  • 43
    • 0035123284 scopus 로고    scopus 로고
    • Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study
    • M. De Lena, V. Lorusso, A. Latorre et al. , "Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study, " European Journal of Cancer, vol. 37, no. 3, pp. 364-368, 2001.
    • (2001) European Journal of Cancer , vol.37 , Issue.3 , pp. 364-368
    • De Lena, M.1    Lorusso, V.2    Latorre, A.3
  • 44
    • 0013522965 scopus 로고    scopus 로고
    • Revertant and potentiating activity of lonidamine in patients with ovarian cancer previously treated with platinum
    • M. De Lena, V. Lorusso, C. Bottalico et al. , "Revertant and potentiating activity of lonidamine in patients with ovarian cancer previously treated with platinum, " Journal of Clinical Oncology, vol. 15, no. 10, pp. 3208-3213, 1997.
    • (1997) Journal of Clinical Oncology , vol.15 , Issue.10 , pp. 3208-3213
    • De Lena, M.1    Lorusso, V.2    Bottalico, C.3
  • 45
    • 0030499482 scopus 로고    scopus 로고
    • Correlation between HPLC-determined lonidamine serum levels and clinical response in patients with advanced ovarian cancer
    • C. Bottalico, V. Lorusso, M. Brandi et al. , "Correlation between HPLC-determined lonidamine serum levels and clinical response in patients with advanced ovarian cancer, " Anticancer Research, vol. 16, no. 6, pp. 3865-3869, 1996.
    • (1996) Anticancer Research , vol.16 , Issue.6 , pp. 3865-3869
    • Bottalico, C.1    Lorusso, V.2    Brandi, M.3
  • 46
    • 0028051653 scopus 로고
    • Epidoxorubicin and lonidamine in refractory or recurrent epithelial ovarian cancer
    • A. Gadducci, I. Brunetti, M. P. Muttini et al. , "Epidoxorubicin and lonidamine in refractory or recurrent epithelial ovarian cancer, " European Journal of Cancer, vol. 30, no. 10, pp. 1432-1435, 1994.
    • (1994) European Journal of Cancer , vol.30 , Issue.10 , pp. 1432-1435
    • Gadducci, A.1    Brunetti, I.2    Muttini, M.P.3
  • 47
    • 0021241466 scopus 로고
    • Lonidamine and radiotherapy in head and neck cancers. APilot Study
    • L. Magno, F. Terraneo, and G. B. Ciottoli, "Lonidamine and radiotherapy in head and neck cancers. APilot Study, "Oncology, vol. 41, no. 1, pp. 113-115, 1984.
    • (1984) Oncology , vol.41 , Issue.1 , pp. 113-115
    • Magno, L.1    Terraneo, F.2    Ciottoli, G.B.3
  • 48
    • 0027990705 scopus 로고
    • Randomised phase II study of methotrexate (MTX) versus methotrexate plus lonidamine (MTX + LND) in recurrent and/or metastatic carcinoma of the head and neck
    • E. Colella, M. Merlano, F. Blengio et al. , "Randomised phase II study of methotrexate (MTX) versus methotrexate plus lonidamine (MTX + LND) in recurrent and/or metastatic carcinoma of the head and neck, " European Journal of Cancer, vol. 30, no. 7, pp. 928-930, 1994.
    • (1994) European Journal of Cancer , vol.30 , Issue.7 , pp. 928-930
    • Colella, E.1    Merlano, M.2    Blengio, F.3
  • 50
    • 20244386234 scopus 로고
    • Fluorouracil, doxorubicin, and cyclophosphamide versus fluorouracil, doxorubicin, and cyclophosphamide plus lonidamine for the treatment of advanced breast cancer: A multicentric randomized clinical study
    • F. Calabresi, L. Di Lauro, P. Marolla et al. , "Fluorouracil, doxorubicin, and cyclophosphamide versus fluorouracil, doxorubicin, and cyclophosphamide plus lonidamine for the treatment of advanced breast cancer: a multicentric randomized clinical study, " Seminars in Oncology, vol. 18, no. 2, supplement 4, pp. 66-72, 1991.
    • (1991) Seminars in Oncology , vol.18 , Issue.2 , pp. 66-72
    • Calabresi, F.1    Di Lauro, L.2    Marolla, P.3
  • 51
    • 7344255198 scopus 로고    scopus 로고
    • Modulating effect of lonidamine on response to doxorubicin in metastatic breast cancer patients: Results from a multicenter prospective randomized trial
    • D. Amadori, G. L. Frassineti, A. De Matteis et al. , "Modulating effect of lonidamine on response to doxorubicin in metastatic breast cancer patients: results from a multicenter prospective randomized trial, " Breast Cancer Research and Treatment, vol. 49, no. 3, pp. 209-217, 1998.
    • (1998) Breast Cancer Research and Treatment , vol.49 , Issue.3 , pp. 209-217
    • Amadori, D.1    Frassineti, G.L.2    De Matteis, A.3
  • 52
    • 17444448833 scopus 로고    scopus 로고
    • FEC (5-fluorouracil, epidoxorubicin and cyclophosphamide) versus em (epidoxorubicin and mitomycin-C) with or without lonidamine as first-line treatment for advanced breast cancer. A multicentric randomised study. Final results
    • P. Pacini, M. Rinaldini, R. Algeri et al. , "FEC (5-fluorouracil, epidoxorubicin and cyclophosphamide) versus EM (epidoxorubicin and mitomycin-C) with or without lonidamine as first-line treatment for advanced breast cancer. A multicentric randomised study. Final results, " European Journal of Cancer, vol. 36, no. 8, pp. 966-975, 2000.
    • (2000) European Journal of Cancer , vol.36 , Issue.8 , pp. 966-975
    • Pacini, P.1    Rinaldini, M.2    Algeri, R.3
  • 53
    • 9244240959 scopus 로고    scopus 로고
    • Lonidamine significantly increases the activity of epirubicin in patients with advanced breast cancer: Results from a multicenter prospective randomized trial
    • L. Dogliotti, A. Berruti, T. Buniva et al. , "Lonidamine significantly increases the activity of epirubicin in patients with advanced breast cancer: results from a multicenter prospective randomized trial, " Journal of Clinical Oncology, vol. 14, no. 4, pp. 1165-1172, 1996.
    • (1996) Journal of Clinical Oncology , vol.14 , Issue.4 , pp. 1165-1172
    • Dogliotti, L.1    Berruti, A.2    Buniva, T.3
  • 54
    • 0037108676 scopus 로고    scopus 로고
    • Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: Final results of a phase III study with a factorial design
    • A. Berruti, R. Bitossi, G. Gorzegno et al. , "Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: final results of a phase III study with a factorial design, " Journal of Clinical Oncology, vol. 20, no. 20, pp. 4150-4159, 2002.
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.20 , pp. 4150-4159
    • Berruti, A.1    Bitossi, R.2    Gorzegno, G.3
  • 55
    • 0025802885 scopus 로고
    • Phase III trial with and without lonidamine in non-small cell lung cancer
    • U. Gatzemeier, F. Cavalli, K. Hussinger et al. , "Phase III trial with and without lonidamine in non-small cell lung cancer, " Seminars in Oncology, vol. 18, no. 2, supplement 4, pp. 42-48, 1991.
    • (1991) Seminars in Oncology , vol.18 , Issue.2 , pp. 42-48
    • Gatzemeier, U.1    Cavalli, F.2    Hussinger, K.3
  • 56
    • 8944237973 scopus 로고    scopus 로고
    • Cisplatin, epirubicin, and vindesine with or without lonidamine in the treatment of inoperable nonsmall cell lung carcinoma: A multicenter randomized clinical trial
    • G. P. Ianniello, G. De Cataldis, P. Comella et al. , "Cisplatin, epirubicin, and vindesine with or without lonidamine in the treatment of inoperable nonsmall cell lung carcinoma: a multicenter randomized clinical trial, " Cancer, vol. 78, no. 1, pp. 63-69, 1996.
    • (1996) Cancer , vol.78 , Issue.1 , pp. 63-69
    • Ianniello, G.P.1    De Cataldis, G.2    Comella, P.3
  • 57
    • 0028132052 scopus 로고
    • A randomised trial of MACC chemotherapy with or without lonidamine in advanced nonsmall cell lung cancer
    • G. Buccheri and D. Ferrigno, "A randomised trial of MACC chemotherapy with or without lonidamine in advanced nonsmall cell lung cancer, " European Journal of Cancer, vol. 30, no. 10, pp. 1424-1431, 1994.
    • (1994) European Journal of Cancer , vol.30 , Issue.10 , pp. 1424-1431
    • Buccheri, G.1    Ferrigno, D.2
  • 58
    • 0032813958 scopus 로고    scopus 로고
    • The role of vindesine and lonidamine in the treatment of elderly patients with advanced non-small cell lung cancer: A phase III randomized FONICAP trial. Italian Lung Cancer Task Force
    • F. De Marinis, M. Rinaldi, A. Ardizzoni et al. , "The role of vindesine and lonidamine in the treatment of elderly patients with advanced non-small cell lung cancer: a phase III randomized FONICAP trial. Italian Lung Cancer Task Force, " Tumori, vol. 85, no. 3, pp. 177-182, 1999.
    • (1999) Tumori , vol.85 , Issue.3 , pp. 177-182
    • De Marinis, F.1    Rinaldi, M.2    Ardizzoni, A.3
  • 59
    • 0027938368 scopus 로고
    • A prospective randomized comparison of radiation therapy plus lonidamine versus radiation therapy plus placebo as initial treatment of clinically localized but nonresectable nonsmall cell lung cancer
    • C. W. Scarantino, A. J. McCunniff, G. Evans, C. W. Young, and D. A. Paggiarino, "A prospective randomized comparison of radiation therapy plus lonidamine versus radiation therapy plus placebo as initial treatment of clinically localized but nonresectable nonsmall cell lung cancer, " International Journal of Radiation Oncology, Biology, Physics, vol. 29, no. 5, pp. 999-1004, 1994.
    • (1994) International Journal of Radiation Oncology, Biology, Physics , vol.29 , Issue.5 , pp. 999-1004
    • Scarantino, C.W.1    McCunniff, A.J.2    Evans, G.3    Young, C.W.4    Paggiarino, D.A.5
  • 60
    • 0019959129 scopus 로고
    • Phase II study of DON in patients with previously treated advanced lung cancer
    • R. T. Eagan, S. Frytak, W. C. Nichols, E. T. Creagan, and J. N. Ingle, "Phase II study of DON in patients with previously treated advanced lung cancer, " Cancer Treatment Reports, vol. 66, no. 8, pp. 1665-1666, 1982.
    • (1982) Cancer Treatment Reports , vol.66 , Issue.8 , pp. 1665-1666
    • Eagan, R.T.1    Frytak, S.2    Nichols, W.C.3    Creagan, E.T.4    Ingle, J.N.5
  • 61
    • 0020562902 scopus 로고
    • A phase II study of 6-diazo-5-oxo-L-norleucine (DON, NSC-7365) in advanced large bowel carcinoma
    • J. Rubin, S. Sorensen, A. J. Schutt et al. , "A phase II study of 6-diazo-5-oxo-L-norleucine (DON, NSC-7365) in advanced large bowel carcinoma, " American Journal of Clinical Oncology, vol. 6, no. 3, pp. 325-326, 1983.
    • (1983) American Journal of Clinical Oncology , vol.6 , Issue.3 , pp. 325-326
    • Rubin, J.1    Sorensen, S.2    Schutt, A.J.3
  • 62
    • 0020368021 scopus 로고
    • Phase II evaluation of DON (6-Diazo-5-Oxo-L-Norleucine) in patients with advanced colorectal carcinoma
    • G. Lynch, N. Kemeny, and E. Casper, "Phase II evaluation of DON (6-Diazo-5-Oxo-L-Norleucine) in patients with advanced colorectal carcinoma, " American Journal of Clinical Oncology, vol. 5, no. 5, pp. 541-543, 1982.
    • (1982) American Journal of Clinical Oncology , vol.5 , Issue.5 , pp. 541-543
    • Lynch, G.1    Kemeny, N.2    Casper, E.3
  • 63
    • 0025262229 scopus 로고
    • Phase II trial of 6-diazo-5-oxo-L-norleucine versus aclacinomycin-A in advanced sarcomas and mesotheliomas
    • R. H. Earhart, D. J. Amato, A. Yuang-Chi Chang et al. , "Phase II trial of 6-diazo-5-oxo-L-norleucine versus aclacinomycin-A in advanced sarcomas and mesotheliomas, " Investigational New Drugs, vol. 8, no. 1, pp. 113-119, 1990.
    • (1990) Investigational New Drugs , vol.8 , Issue.1 , pp. 113-119
    • Earhart, R.H.1    Amato, D.J.2    Yuang-Chi Chang, A.3
  • 64
    • 84882538118 scopus 로고    scopus 로고
    • A phase II study of PEGylated glutaminase (PEG-PGA) plus 6-diazo-5-oxo-Lnorleucine (DON) in patients with advanced refractory solid tumors
    • abstract 2533 ASCO Annual Meeting
    • C. Mueller, S. Al-Batran, E. Jaeger et al. , "A phase II study of PEGylated glutaminase (PEG-PGA) plus 6-diazo-5-oxo-Lnorleucine (DON) in patients with advanced refractory solid tumors, " Journal of Clinical Oncology, vol. 26, no. 15S, abstract 2533, 2008, ASCO Annual Meeting.
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.15
    • Mueller, C.1    Al-Batran, S.2    Jaeger, E.3
  • 65
    • 84888798201 scopus 로고    scopus 로고
    • Tumor glycolysis as a target for cancer therapy: Progress and prospects
    • article 152
    • S. Ganapathy-Kanniappan and J.-F. H. Geschwind, "Tumor glycolysis as a target for cancer therapy: progress and prospects, " Molecular Cancer, vol. 12, article 152, 2013.
    • (2013) Molecular Cancer , vol.12
    • Ganapathy-Kanniappan, S.1    Geschwind, J.-F.H.2
  • 66
    • 84864402951 scopus 로고    scopus 로고
    • Anticancer agents that counteract tumor glycolysis
    • C. Granchi and F. Minutolo, "Anticancer agents that counteract tumor glycolysis, " ChemMedChem, vol. 7, no. 8, pp. 1318-1350, 2012.
    • (2012) ChemMedChem , vol.7 , Issue.8 , pp. 1318-1350
    • Granchi, C.1    Minutolo, F.2
  • 67
    • 0018698892 scopus 로고
    • Azaserine, DON, and azotomycin: Three diazo analogs of Lglutamine with clinical antitumor activity
    • R. Catane, D. D. von Hoff, D. L. Glaubiger, and F. M. Muggia, "Azaserine, DON, and azotomycin: three diazo analogs of Lglutamine with clinical antitumor activity, " Cancer Treatment Reports, vol. 63, no. 6, pp. 1033-1038, 1979.
    • (1979) Cancer Treatment Reports , vol.63 , Issue.6 , pp. 1033-1038
    • Catane, R.1    Von Hoff, D.D.2    Glaubiger, D.L.3    Muggia, F.M.4
  • 68
    • 0022197820 scopus 로고
    • Enzyme targets of antiglutamine agents in cancer chemotherapy
    • N. Prajda, "Enzyme targets of antiglutamine agents in cancer chemotherapy, " Advances in Enzyme Regulation, vol. 24, pp. 207-223, 1985.
    • (1985) Advances in Enzyme Regulation , vol.24 , pp. 207-223
    • Prajda, N.1
  • 69
    • 84882662490 scopus 로고    scopus 로고
    • Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors
    • A. G. Thomas, C. Rojas, C. Tanega et al. , "Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors, " Biochemical and Biophysical Research Communications, vol. 438, no. 2, pp. 243-248, 2013.
    • (2013) Biochemical and Biophysical Research Communications , vol.438 , Issue.2 , pp. 243-248
    • Thomas, A.G.1    Rojas, C.2    Tanega, C.3
  • 70
    • 84904645105 scopus 로고    scopus 로고
    • Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer
    • M. I. Gross, S. D. Demo, J. B. Dennisonet al. , "Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer, " Molecular Cancer Therapeutics, vol. 13, no. 4, pp. 890-901, 2014.
    • (2014) Molecular Cancer Therapeutics , vol.13 , Issue.4 , pp. 890-901
    • Gross, M.I.1    Demo, S.D.2    Dennison, J.B.3
  • 71
    • 84908852603 scopus 로고
    • Antispermatogenic activity of diclondazolic acid in rats
    • A. Fabbrini and E. Steinberger, Eds. Academic Press, New York, NY, USA
    • B. Silvestrini, C. DeMartino, V. Cioli et al. , "Antispermatogenic activity of diclondazolic acid in rats, " in Recent Progress in Andrology, A. Fabbrini and E. Steinberger, Eds. , pp. 453-457, Academic Press, New York, NY, USA, 1978.
    • (1978) Recent Progress in Andrology , pp. 453-457
    • Silvestrini, B.1    DeMartino, C.2    Cioli, V.3
  • 73
    • 0019868629 scopus 로고
    • Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells
    • A. Floridi, M. G. Paggi, S. DAtri et al. , "Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells, " Cancer Research, vol. 41, no. 11, pp. 4661-4666, 1981.
    • (1981) Cancer Research , vol.41 , Issue.11 , pp. 4661-4666
    • Floridi, A.1    Paggi, M.G.2    DAtri, S.3
  • 74
    • 84936760075 scopus 로고    scopus 로고
    • Targeting prostate cancer cell metabolism: Impact of hexokinase andCPT-1 enzymes
    • R. N. Sadeghi, F. Karami-Tehrani, and S. Salami, "Targeting prostate cancer cell metabolism: impact of hexokinase andCPT-1 enzymes, " Tumor Biology, vol. 36, no. 4, pp. 2893-2905, 2015.
    • (2015) Tumor Biology , vol.36 , Issue.4 , pp. 2893-2905
    • Sadeghi, R.N.1    Karami-Tehrani, F.2    Salami, S.3
  • 75
    • 0024261874 scopus 로고
    • Effect of lonidamine on human malignant gliomas: Biochemical studies
    • M. G. Paggi, C. M. Carapella, M. Fanciulli et al. , "Effect of lonidamine on human malignant gliomas: biochemical studies, " Journal of Neuro-Oncology, vol. 6, no. 3, pp. 203-209, 1988.
    • (1988) Journal of Neuro-Oncology , vol.6 , Issue.3 , pp. 203-209
    • Paggi, M.G.1    Carapella, C.M.2    Fanciulli, M.3
  • 76
    • 0029073748 scopus 로고
    • Mechanism of action of the antineoplastic drug lonidamine: 31P and 13C nuclear magnetic resonance studies
    • H. Ben-Horin, M. Tassini, A. Vivi, G. Navon, and O. Kaplan, "Mechanism of action of the antineoplastic drug lonidamine: 31P and 13C nuclear magnetic resonance studies, " Cancer Research, vol. 55, no. 13, pp. 2814-2821, 1995.
    • (1995) Cancer Research , vol.55 , Issue.13 , pp. 2814-2821
    • Ben-Horin, H.1    Tassini, M.2    Vivi, A.3    Navon, G.4    Kaplan, O.5
  • 77
    • 0031883221 scopus 로고    scopus 로고
    • Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification
    • O. Ben-Yoseph, J. C. Lyons, C. W. Song, and B. D. Ross, "Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification, " Journal of Neuro-Oncology, vol. 36, no. 2, pp. 149-157, 1998.
    • (1998) Journal of Neuro-Oncology , vol.36 , Issue.2 , pp. 149-157
    • Ben-Yoseph, O.1    Lyons, J.C.2    Song, C.W.3    Ross, B.D.4
  • 78
    • 0035877967 scopus 로고    scopus 로고
    • Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis
    • O. Sordet, C. Rb, I. Leroy et al. , "Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis, " Blood, vol. 97, no. 12, pp. 3931-3940, 2001.
    • (2001) Blood , vol.97 , Issue.12 , pp. 3931-3940
    • Sordet, O.1    Rb, C.2    Leroy, I.3
  • 79
    • 0033516635 scopus 로고    scopus 로고
    • Bcl-2 inhibits mitochondrial metabolism and lonidamine-induced apoptosis in adriamycin-resistant MCF7 cells
    • A. Biroccio, D. Del Bufalo, M. Fanciulli, T. Bruno, G. Zupi, and A. Floridi, "bcl-2 inhibits mitochondrial metabolism and lonidamine-induced apoptosis in adriamycin-resistant MCF7 cells, " International Journal of Cancer, vol. 82, no. 1, pp. 125-130, 1999.
    • (1999) International Journal of Cancer , vol.82 , Issue.1 , pp. 125-130
    • Biroccio, A.1    Del Bufalo, D.2    Fanciulli, M.3    Bruno, T.4    Zupi, G.5    Floridi, A.6
  • 80
    • 0032578682 scopus 로고    scopus 로고
    • Lonidamine as a modulator of taxol activity in human ovarian cancer cells: Effects on cell cycle and induction of apoptosis
    • L. Orlandi, N. Zaffaroni, A. Bearzatto, R. Villa, C. DeMarco, and R. Silvestrini, "Lonidamine as a modulator of taxol activity in human ovarian cancer cells: effects on cell cycle and induction of apoptosis, " International Journal of Cancer, vol. 78, no. 3, pp. 377-384, 1998.
    • (1998) International Journal of Cancer , vol.78 , Issue.3 , pp. 377-384
    • Orlandi, L.1    Zaffaroni, N.2    Bearzatto, A.3    Villa, R.4    DeMarco, C.5    Silvestrini, R.6
  • 81
    • 0033594404 scopus 로고    scopus 로고
    • Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
    • L. Ravagnan, I. Marzo, P. Costantini et al. , "Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore, " Oncogene, vol. 18, no. 16, pp. 2537-2546, 1999.
    • (1999) Oncogene , vol.18 , Issue.16 , pp. 2537-2546
    • Ravagnan, L.1    Marzo, I.2    Costantini, P.3
  • 82
    • 0035891212 scopus 로고    scopus 로고
    • Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437
    • A.-S. Belzacq, C. E. Hamel, H. L. A. Vieira et al. , "Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437, " Oncogene, vol. 20, no. 52, pp. 7579-7587, 2001.
    • (2001) Oncogene , vol.20 , Issue.52 , pp. 7579-7587
    • Belzacq, A.-S.1    Hamel, C.E.2    Vieira, H.L.A.3
  • 83
    • 49149087268 scopus 로고    scopus 로고
    • Disruption of the hexokinase-VDAC complex for tumor therapy
    • L. Galluzzi, O. Kepp, N. Tajeddine, andG. Kroemer, "Disruption of the hexokinase-VDAC complex for tumor therapy, " Oncogene, vol. 27, no. 34, pp. 4633-4635, 2008.
    • (2008) Oncogene , vol.27 , Issue.34 , pp. 4633-4635
    • Galluzzi, L.1    Kepp, O.2    Tajeddine, N.3    Kroemer, G.4
  • 84
    • 47749093652 scopus 로고    scopus 로고
    • Methyl jasmonate binds to and detaches mitochondria-bound hexokinase
    • N. Goldin, L. Arzoine, A. Heyfets et al. , "Methyl jasmonate binds to and detaches mitochondria-bound hexokinase, " Oncogene, vol. 27, no. 34, pp. 4636-4643, 2008.
    • (2008) Oncogene , vol.27 , Issue.34 , pp. 4636-4643
    • Goldin, N.1    Arzoine, L.2    Heyfets, A.3
  • 85
    • 0021280469 scopus 로고
    • Pharmacokinetics of lonidamine after oral administration in cancer patients
    • J. G. Besner, R. Leclaire, P. R. Band, M. Deschamps, A. J. De Sanctis, and B. Catanese, "Pharmacokinetics of lonidamine after oral administration in cancer patients, " Oncology, vol. 41, supplement 1, pp. 48-52, 1984.
    • (1984) Oncology , vol.41 , pp. 48-52
    • Besner, J.G.1    Leclaire, R.2    Band, P.R.3    Deschamps, M.4    De Sanctis, A.J.5    Catanese, B.6
  • 86
    • 0025804907 scopus 로고
    • The pharmacokinetics of oral lonidamine in breast cancer and lung cancer patients
    • D. R. Newell, J. Mansi, and J. Hardy, "The pharmacokinetics of oral lonidamine in breast cancer and lung cancer patients, " Seminars in Oncology, vol. 18, no. 2, pp. 11-17, 1991.
    • (1991) Seminars in Oncology , vol.18 , Issue.2 , pp. 11-17
    • Newell, D.R.1    Mansi, J.2    Hardy, J.3
  • 87
    • 0025773309 scopus 로고
    • A phase II clinical and pharmacokinetic study of lonidamine in patients with advanced breast cancer
    • J. L. Mansi, A. de Graeff, D. R. Newell et al. , "A phase II clinical and pharmacokinetic study of lonidamine in patients with advanced breast cancer, " British Journal of Cancer, vol. 64, no. 3, pp. 593-597, 1991.
    • (1991) British Journal of Cancer , vol.64 , Issue.3 , pp. 593-597
    • Mansi, J.L.1    De Graeff, A.2    Newell, D.R.3
  • 88
    • 0025877905 scopus 로고
    • Toxicity and clinical tolerance of lonidamine
    • G. R. della Cuna and P. Pedrazzoli, "Toxicity and clinical tolerance of lonidamine, " Seminars in Oncology, vol. 18, no. 2, supplement 4, pp. 18-22, 1991.
    • (1991) Seminars in Oncology , vol.18 , Issue.2 , pp. 18-22
    • Della Cuna, G.R.1    Pedrazzoli, P.2
  • 89
    • 0042467933 scopus 로고
    • 6-Diazo-5-oxo-L-norleucine, a newtumor-inhibitory substance. II. Isolation and characterization
    • H. W. Dion, S. A. Fusari, Z. L. Jakubowski, J. G. Zora, and Q. R. Bartz, "6-Diazo-5-oxo-L-norleucine, a newtumor-inhibitory substance. II. Isolation and characterization, " Journal of the American Chemical Society, vol. 78, no. 13, pp. 3075-3077, 1956.
    • (1956) Journal of the American Chemical Society , vol.78 , Issue.13 , pp. 3075-3077
    • Dion, H.W.1    Fusari, S.A.2    Jakubowski, Z.L.3    Zora, J.G.4    Bartz, Q.R.5
  • 90
    • 0017324665 scopus 로고
    • Glutamine binding sites
    • L. M. Pinkus, "Glutamine binding sites, " Methods in Enzymology, vol. 46, no. C, pp. 414-427, 1977.
    • (1977) Methods in Enzymology , vol.46 , Issue.C , pp. 414-427
    • Pinkus, L.M.1
  • 91
    • 84965810298 scopus 로고
    • Pyrimidine studies I. Effect ofDON(6-diazo-5oxo-L-norleucine) on incorporation of precursors into nucleic acid pyrimidines
    • M. L. Eidinoff, J. E. Knoll, B. Marano et al. , "Pyrimidine studies I. Effect ofDON(6-diazo-5oxo-L-norleucine) on incorporation of precursors into nucleic acid pyrimidines, " Cancer Research, vol. 18, pp. 105-109, 1958.
    • (1958) Cancer Research , vol.18 , pp. 105-109
    • Eidinoff, M.L.1    Knoll, J.E.2    Marano, B.3
  • 92
    • 0007782538 scopus 로고
    • Biosynthesis of the purines XV. the effect of Aza-L-Serine and 6-Diazo-5-Oxo-L-Norleucine on inosinic acid biosynthesis de novo
    • B. Levenberg, I. Melnick, and J. M. Buchanan, "Biosynthesis of the purines, XV. The effect of Aza-L-Serine and 6-Diazo-5-Oxo-L-Norleucine on inosinic acid biosynthesis de novo, " The Journal of Biological Chemistry, vol. 225, no. 1, pp. 163-176, 1957.
    • (1957) The Journal of Biological Chemistry , vol.225 , Issue.1 , pp. 163-176
    • Levenberg, B.1    Melnick, I.2    Buchanan, J.M.3
  • 93
    • 0025232412 scopus 로고
    • Metabolism and action of amino acid analog anti-cancer agents
    • G. S. Ahluwalia, J. L. Grem, Z. Hao, and D. A. Cooney, "Metabolism and action of amino acid analog anti-cancer agents, " Pharmacology andTherapeutics, vol. 46, no. 2, pp. 243-271, 1990.
    • (1990) Pharmacology AndTherapeutics , vol.46 , Issue.2 , pp. 243-271
    • Ahluwalia, G.S.1    Grem, J.L.2    Hao, Z.3    Cooney, D.A.4
  • 94
    • 0013882493 scopus 로고
    • Effects of 6-diazo-5-oxolnorleucine and other tumor inhibitors on the biosynthesis of nicotinamide adenine dinucleotide in mice
    • R. K. Barclay and M. A. Phillipps, "Effects of 6-diazo-5-oxolnorleucine and other tumor inhibitors on the biosynthesis of nicotinamide adenine dinucleotide in mice, " Cancer Research, vol. 26, no. 2, pp. 282-286, 1966.
    • (1966) Cancer Research , vol.26 , Issue.2 , pp. 282-286
    • Barclay, R.K.1    Phillipps, M.A.2
  • 96
    • 84924635622 scopus 로고
    • 6-Diazo-5-oxo-L-norleucine, a new tumor-inhibitory substance. I. Biologic studies
    • G. L. Coffey, J. Ehrlich, M. W. Fisher et al. , "6-Diazo-5-oxo-L-norleucine, a new tumor-inhibitory substance. I. Biologic studies, " Antibiotics and Chemotherapy, vol. 6, no. 8, pp. 487-497, 1956.
    • (1956) Antibiotics and Chemotherapy , vol.6 , Issue.8 , pp. 487-497
    • Coffey, G.L.1    Ehrlich, J.2    Fisher, M.W.3
  • 97
    • 0033661413 scopus 로고    scopus 로고
    • Identification of two human glutaminase loci and tissue-specific expression of the two related genes
    • J. C. Aledo, P. M. Gmez-Fabre, L. Olalla, and J. Mrquez, "Identification of two human glutaminase loci and tissue-specific expression of the two related genes, " Mammalian Genome, vol. 11, no. 12, pp. 1107-1110, 2000.
    • (2000) Mammalian Genome , vol.11 , Issue.12 , pp. 1107-1110
    • Aledo, J.C.1    Gmez-Fabre, P.M.2    Olalla, L.3    Mrquez, J.4
  • 98
    • 84909630871 scopus 로고    scopus 로고
    • Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA)
    • article 3827
    • K. Thangavelu, Q. Y. Chong, B. C. Low, and J. Sivaraman, "Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA), " Scientific Reports, vol. 4, article 3827, 2014.
    • (2014) Scientific Reports , vol.4
    • Thangavelu, K.1    Chong, Q.Y.2    Low, B.C.3    Sivaraman, J.4
  • 99
    • 77950556779 scopus 로고
    • Effects of combinations of azaserine and of 6-diazo-5-oxo-L-norleucine with purine analogs and other antimetabolites on the growth of two mouse mammary carcinomas
    • G. S. Tarnowski and C. C. Stock, "Effects of combinations of azaserine and of 6-diazo-5-oxo-L-norleucine with purine analogs and other antimetabolites on the growth of two mouse mammary carcinomas, " Cancer Research, vol. 17, no. 10, pp. 1033-1039, 1957.
    • (1957) Cancer Research , vol.17 , Issue.10 , pp. 1033-1039
    • Tarnowski, G.S.1    Stock, C.C.2
  • 100
    • 0018743607 scopus 로고
    • Efficacy of 6-diazo-5-oxo-l-norleucine and N-[Nγ-glutamyl-6-diazo-5-oxo-norleucinyl]-6-diazo-5-oxonorleucine against experimental tumors in conventional and nude mice
    • A. A. Ovejera, D. P. Houchens, R. Catane, M. A. Sheridan, and F. M. Muggia, "Efficacy of 6-diazo-5-oxo-l-norleucine and N-[N-γ-glutamyl-6-diazo-5-oxo-norleucinyl]-6-diazo-5-oxonorleucine against experimental tumors in conventional and nude mice, " Cancer Research, vol. 39, no. 8, pp. 3220-3224, 1979.
    • (1979) Cancer Research , vol.39 , Issue.8 , pp. 3220-3224
    • Ovejera, A.A.1    Houchens, D.P.2    Catane, R.3    Sheridan, M.A.4    Muggia, F.M.5
  • 101
    • 0022376073 scopus 로고
    • Combination chemotherapy in vitro exploiting glutamine metabolism of human glioma and medulloblastoma
    • G. Dranoff, G. B. Elion, H. S. Friedman, and D. D. Bigner, "Combination chemotherapy in vitro exploiting glutamine metabolism of human glioma and medulloblastoma, " Cancer Research, vol. 45, no. 9, pp. 4082-4086, 1985.
    • (1985) Cancer Research , vol.45 , Issue.9 , pp. 4082-4086
    • Dranoff, G.1    Elion, G.B.2    Friedman, H.S.3    Bigner, D.D.4
  • 102
    • 0023182525 scopus 로고
    • Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines
    • K. R. Huber, E. P. Mayer, D. F. Mitchell, and J. Roberts, "Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines, " British Journal of Cancer, vol. 55, no. 6, pp. 653-656, 1987.
    • (1987) British Journal of Cancer , vol.55 , Issue.6 , pp. 653-656
    • Huber, K.R.1    Mayer, E.P.2    Mitchell, D.F.3    Roberts, J.4
  • 103
    • 0033166518 scopus 로고    scopus 로고
    • A mechanism behind the antitumour effect of 6-diazo-5-oxo-L-norleucine (DON): Disruption of mitochondria
    • F. Wu, A. Lukinius, M. Bergstrm, B. Eriksson, Y. Watanabe, and B. Langstrm, "A mechanism behind the antitumour effect of 6-diazo-5-oxo-L-norleucine (DON): disruption of mitochondria, " European Journal of Cancer, vol. 35, no. 7, pp. 1155-1161, 1999.
    • (1999) European Journal of Cancer , vol.35 , Issue.7 , pp. 1155-1161
    • Wu, F.1    Lukinius, A.2    Bergstrm, M.3    Eriksson, B.4    Watanabe, Y.5    Langstrm, B.6
  • 104
    • 0030857220 scopus 로고    scopus 로고
    • Effect of 6-diazo-5-oxo-L-norleucine (DON) on human carcinoid tumor cell aggregates
    • F. Wu, M. Bergstrm, M. Stridsberg et al. , "Effect of 6-diazo-5-oxo-L-norleucine (DON) on human carcinoid tumor cell aggregates, " Anticancer Research, vol. 17, no. 4 A, pp. 2363-2367, 1997.
    • (1997) Anticancer Research , vol.17 , Issue.4 A , pp. 2363-2367
    • Wu, F.1    Bergstrm, M.2    Stridsberg, M.3
  • 105
    • 84921799428 scopus 로고    scopus 로고
    • Antagonizing BCL-2 family members sensitizes neuroblastoma and Ewings sarcoma to an inhibitor of glutamine metabolism
    • Article IDe0116998
    • R. R. Olsen, M. N. Mary-Sinclair, Z. Yin, and K. W. Freeman, "Antagonizing BCL-2 family members sensitizes neuroblastoma and Ewings sarcoma to an inhibitor of glutamine metabolism, " PLoS ONE, vol. 10, no. 1, Article IDe0116998, 2015.
    • (2015) PLoS ONE , vol.10 , Issue.1
    • Olsen, R.R.1    Mary-Sinclair, M.N.2    Yin, Z.3    Freeman, K.W.4
  • 106
    • 78049515429 scopus 로고    scopus 로고
    • Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model
    • L. M. Shelton, L. C. Huysentruyt, andT. N. Seyfried, "Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model, " International Journal of Cancer, vol. 127, no. 10, pp. 2478-2485, 2010.
    • (2010) International Journal of Cancer , vol.127 , Issue.10 , pp. 2478-2485
    • Shelton, L.M.1    Huysentruyt, L.C.2    Seyfried, T.N.3
  • 109
    • 84923323462 scopus 로고    scopus 로고
    • Bioanalysis of 6-diazo-5-oxo-L-norleucine in plasma and brain by ultraperformance liquid chromatography mass spectrometry
    • J. Alt, M. C. Potter, C. Rojas, and B. S. Slusher, "Bioanalysis of 6-diazo-5-oxo-L-norleucine in plasma and brain by ultraperformance liquid chromatography mass spectrometry, " Analytical Biochemistry, vol. 474, pp. 28-34, 2015.
    • (2015) Analytical Biochemistry , vol.474 , pp. 28-34
    • Alt, J.1    Potter, M.C.2    Rojas, C.3    Slusher, B.S.4
  • 110
    • 33748538371 scopus 로고    scopus 로고
    • Glutamine or glucose starvation in hybridoma cultures induces death receptor and mitochondrial apoptotic pathways
    • J. H. M. Yeo, J. C. Y. Lo, P. M. Nissom, and V. V. T. Wong, "Glutamine or glucose starvation in hybridoma cultures induces death receptor and mitochondrial apoptotic pathways, " Biotechnology Letters, vol. 28, no. 18, pp. 1445-1452, 2006.
    • (2006) Biotechnology Letters , vol.28 , Issue.18 , pp. 1445-1452
    • Yeo, J.H.M.1    Lo, J.C.Y.2    Nissom, P.M.3    Wong, V.V.T.4
  • 111
    • 0027692808 scopus 로고
    • Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture
    • L. Fitzpatrick, H. A. Jenkins, and M. Butler, "Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture, " Applied Biochemistry and Biotechnology, vol. 43, no. 2, pp. 93-116, 1993.
    • (1993) Applied Biochemistry and Biotechnology , vol.43 , Issue.2 , pp. 93-116
    • Fitzpatrick, L.1    Jenkins, H.A.2    Butler, M.3
  • 112
    • 84887123920 scopus 로고    scopus 로고
    • Molecular pathways: Targeting MYCinduced metabolic reprogramming and oncogenic stress in cancer
    • B. Li and M. C. Simon, "Molecular pathways: targeting MYCinduced metabolic reprogramming and oncogenic stress in cancer, " Clinical Cancer Research, vol. 19, no. 21, pp. 5835-5841, 2013.
    • (2013) Clinical Cancer Research , vol.19 , Issue.21 , pp. 5835-5841
    • Li, B.1    Simon, M.C.2
  • 113
    • 70350217425 scopus 로고    scopus 로고
    • Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
    • Y. Chendong, J. Sudderth, D. Tuyen, R. G. Bachoo, J. G. McDonald, and R. J. DeBerardinis, "Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling, " Cancer Research, vol. 69, no. 20, pp. 7986-7993, 2009.
    • (2009) Cancer Research , vol.69 , Issue.20 , pp. 7986-7993
    • Chendong, Y.1    Sudderth, J.2    Tuyen, D.3    Bachoo, R.G.4    McDonald, J.G.5    DeBerardinis, R.J.6
  • 114
    • 84920055991 scopus 로고    scopus 로고
    • PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells
    • H. Wu, Z. Li, P. Yang, L. Zhang, Y. Fan, and Z. Li, "PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells, " Cellular Signalling, vol. 26, no. 11, pp. 2397-2405, 2014.
    • (2014) Cellular Signalling , vol.26 , Issue.11 , pp. 2397-2405
    • Wu, H.1    Li, Z.2    Yang, P.3    Zhang, L.4    Fan, Y.5    Li, Z.6
  • 115
    • 84919598908 scopus 로고    scopus 로고
    • Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer
    • T. Pan, L. Gao, G. Wu et al. , "Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer, " Biochemical and Biophysical Research Communications, vol. 456, no. 1, pp. 452-458, 2015.
    • (2015) Biochemical and Biophysical Research Communications , vol.456 , Issue.1 , pp. 452-458
    • Pan, T.1    Gao, L.2    Wu, G.3
  • 116
    • 34548139370 scopus 로고    scopus 로고
    • Chemotherapy-induced normalization of FDG uptake by colorectal liver metastases does not usually indicate complete pathologic response
    • M. C. B. Tan, D. C. Linehan, W. G. Hawkins, B. A. Siegel, and S. M. Strasberg, "Chemotherapy-induced normalization of FDG uptake by colorectal liver metastases does not usually indicate complete pathologic response, " Journal of Gastrointestinal Surgery, vol. 11, no. 9, pp. 1112-1119, 2007.
    • (2007) Journal of Gastrointestinal Surgery , vol.11 , Issue.9 , pp. 1112-1119
    • Tan, M.C.B.1    Linehan, D.C.2    Hawkins, W.G.3    Siegel, B.A.4    Strasberg, S.M.5
  • 117
    • 0027787467 scopus 로고
    • The role of glutamine and glucose analogues in metabolic inhibition of human myeloid leukaemia in vitro
    • M. Griffiths, D. Keast, G. Patrick, M. Crawford, and T. N. Palmer, "The role of glutamine and glucose analogues in metabolic inhibition of human myeloid leukaemia in vitro, " International Journal of Biochemistry, vol. 25, no. 12, pp. 1749-1755, 1988.
    • (1988) International Journal of Biochemistry , vol.25 , Issue.12 , pp. 1749-1755
    • Griffiths, M.1    Keast, D.2    Patrick, G.3    Crawford, M.4    Palmer, T.N.5
  • 118
    • 84937207425 scopus 로고    scopus 로고
    • Antitumor effects of a drug combination targeting glycolysis glutaminolysis and de novo synthesis of fatty acids
    • D. Cervantes-Madrid and A. Duenas-Gonzlez, "Antitumor effects of a drug combination targeting glycolysis, glutaminolysis and de novo synthesis of fatty acids, " Oncology Reports, vol. 34, no. 3, pp. 1533-1542, 2015.
    • (2015) Oncology Reports , vol.34 , Issue.3 , pp. 1533-1542
    • Cervantes-Madrid, D.1    Duenas-Gonzlez, A.2
  • 119
    • 73349122015 scopus 로고    scopus 로고
    • Incremental advance or seismic shift? the need to raise the bar of efficacy for drug approval
    • A. Sobrero and P. Bruzzi, "Incremental advance or seismic shift? The need to raise the bar of efficacy for drug approval, " Journal of Clinical Oncology, vol. 27, no. 35, pp. 5868-5873, 2009.
    • (2009) Journal of Clinical Oncology , vol.27 , Issue.35 , pp. 5868-5873
    • Sobrero, A.1    Bruzzi, P.2


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