Enhancement of doxorubicin content by the antitumor drug lonidamine in resistant ehrlich ascites tumor cells through modulation of energy metabolism

Biochemical Pharmacology

Volumn 56, Issue 7, 1998, Pages 841-849

  Floridi, Aristide ^a,b   Bruno, Tiziana ^b   Miccadei, Stefania ^b   Fanciulli, Maurizio ^b   Federico, Antonio ^b   Paggi, Marco G ^b  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b Ctr Exp Res Regina Elena C   (Italy)

Author keywords

Doxorubicin; Ehrlich tumor cells; Energy metabolism; Ionidamine; Multidrug resistance

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; LONIDAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER; EHRLICH ASCITES TUMOR CELL; ENERGY METABOLISM; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

ADENINE NUCLEOTIDES; ANIMALS; BIOLOGICAL TRANSPORT; CARCINOMA, EHRLICH TUMOR; CELL RESPIRATION; DOXORUBICIN; ENERGY METABOLISM; FEMALE; GLYCOLYSIS; HEXOKINASE; INDAZOLES; MALE; MICE; MICE, INBRED DBA; MITOCHONDRIA;

EID: 0032190467     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00054-9     Document Type: Article

References (39)

1. Simon S.M., Schindler M. Cell biologic mechanisms of multidrug resistance in tumors. Proc Natl Acad Sci. 91:1994;3497-3504.
2. Gottesman M.M., Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporters. Ann Rev Biochem. 62:1993;385-427.
3. Fanciulli M., Valentini A., Bruno T., Citro G., Zupi G., Floridi A. Effect of the antitumor drug lonidamine on glucose metabolism of adriamycin-sensitive and -resistant human breast cancer cells. Oncol Res. 8:1996;111-120.
4. Fanciulli M., Bruno T., Castiglione S., Del Carlo C., Paggi M.G., Floridi A. Glucose metabolism in doxorubicin-sensitive and -resistant LoVo human colon carcinoma cells. Oncol Res. 5:1993;357-362.
5. Floridi A., Lehninger A.L. Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria. Arch Biochem Biophys. 226:1983;73-83.
6. Floridi A., Paggi M.G., Marcante M.L., Silvestrini B., Caputo A., De Martino C. Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells. J Natl Cancer Inst. 66:1981;497-499.
7. Floridi A., Paggi M.G., D'Atri S., De Martino C., Marcante M.L., Silvestrini B., Caputo A. Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells. Cancer Res. 41:1981;4661-4666.
8. Pedersen P.L. Tumor mitochondria and bioenergetics of cancer cell. Prog Exp Tumor Res. 22:1978;190-274.
9. Raaphorst G.P., Feeley M.M., Heller D.P., Danjoux C.E., Martin L., Maroun J.A., De Santis A.J. Lonidamine can enhance the cytotoxic effect of cis-platin in human and rodent cells. Anticancer Res. 10:1990;923-928.
10. Zupi G., Greco C., Laudonio N., Benassi M., Silvestrini B., Caputo A. In vitro and in vivo potentiation of the antitumor effect of adriamycin. Anticancer Res. 6:1986;1245-1250.
11. Rosbe K.W., Brann T.W., Holden S.A., Teicher B.A., Frei E. III. Effect of lonidamine on the cytotoxicity of four alkylating agents in vitro. Cancer Chemother and Pharmacol. 25:1989;32-36.
12. Kim J.H., Alfieri A.A., Kim S.H., Young C.W. Potentiation of radiation effects of two murine tumors by lonidamine. Cancer Res. 46:1986;1120-1123.
13. Raaphorst G.P., Feeley M.M., Danjoux C.E., Martin L., Mariun J., De Santis J. The effect of lonidamine (LND) on radiation and thermal responses of human and rodent cell lines. Int J Radiat Oncol Biol Phys. 20:1991;509-515.
14. Raaphorst G.P., Feeley M.M., Martin L., Danjoux C.E., Mariun J., De Santis J., Ko D. Enhancement of sensitivity to hyperthermia by lonidamine in human cancer cells. Int J Hyperthermia. 7:1991;763-772.
15. Cividalli A, Gentile Fp, Alonzi A, Beanssi M, Mauro F and Floridi A, In vivo control of tumor growth by lonidamine and radiations: influence of the timing and sequence of drug administration and irradiation treatment. Int J Oncology 1: 561-565, 1992.
16. Floridi A., Gentile F.P., Bruno T., Delpino A., Iacobini C., Paggi M.G., Castiglione S., Benassi M. Thermal behavior of a human cell line and its response to combinations of hyperthermia and lonidamine. Oncol Res. 5:1993;1-10.
17. Floridi A., Gambacurta A., Bagnato A., Bianchi C., Paggi M.G., Silvestrini B., Caputo A. Modulation of adriamycin uptake by lonidamine in Ehrlich ascites tumor cells. Exp Mol Pathol. 49:1988;421-431.
18. Miccadei S., Fanciulli M., Bruno T., Paggi M.G., Floridi A. Energy metabolism of adriamycin-sensitive and -resistant Ehrlich ascites tumor cells. Oncol Res. 8:1996;27-35.
19. 2 solubility in aqueous media determined by kinetic method. Anal Biochem. 45:1985;430-450.
20. Hohorst H.J. Determination with lactic-dehydrogenase and DPN. In Methods of Enzymatic Analysis (Ed . Bergmeyer HU), pp. 1965;266-270 Academic Press, New York.
21. Parry D.M., Pedersen P.L. Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. J Biol Chem. 258:1983;10904-10912.
22. Floridi A., Barbieri R., Pulselli R., Fanciulli M., Arcuri E. Effect of the local anesthetic bupivacaine on the energy metabolism of Ehrlich ascites tumor cells. Oncol Res. 6:1994;593-601.
23. Kaushal V., Barnes L.D. Effect of zwitterionic buffers on measurement of small masses of protein with bicinchoninic acid. Anal Biochem. 157:1986;291-294.
24. Stocchi V., Cucchiarini L., Magnani M., Chiarantin L., Palma P., Crescentini G. Simultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotides in human red blood cells. Anal Biochem. 146:1985;118-124.
25. Levinson C. Regulatory volume increase in Ehrlich ascites tumor cells. Biochem Biophys Acta. 1021:1990;1-8.
26. Nielsen D., Maare C., Skovsgaard T. Influx of daunorubicin in multidrug resistant Ehrlich ascites tumour cells: Correlation to expression of P-glycoprotein and efflux. Influence of verapamil. Biochem Pharmacol. 50:1995;443-450.
27. Malorni W., Arancia G., De Martino C., Nista A., Accinni L., Masella R., Cantafora A. On the mechanism of action of lonidamine: A study on human erythrocyte membrane. Exp Mol Pathol. 49:1988;361-372.
28. Santini MT, Cametti C, Indovina PL, Malorni W, Benassi M, Gentile Fp, Castiglione S and Floridi A, Effects of lonidamine on the membrane electrical properties of Ehrlich ascites tumor cells. FEBS Lett 291: 196-172, 1991.
29. Chance B., Hess B. Metabolic control mechanism. IV. The effect of glucose upon the steady-state of respiratory enzymes in the ascites cells. J Biol Chem. 234:1959;2421-2427.
30. 13C nuclear magnetic resonance studies. Cancer Res. 55:1995;2814-2821.
31. Oudard S., Poirson F., Miccoli L., Bourgeois Y., Vassault A., Poisson M., Magdelenat H., Dutrillaux B., Poupon M.F. Mitochondria-bound hexokinase as target for therapy of malignant gliomas. Int J Cancer. 62:1995;216-222.
32. Malorni W., Arancia G., De Martino C., Nista A., Accinni L., Masella R., Cantafora A. On the mechanism of action of lonidamine: A study on the human erythrocyte membrane. Exp Mol Pathol. 49:1988;361-372.
33. Arancia G., Malorni W. Crateri Trovalusci P, Isacchi G, Giannella G and De Martino C, Differential effect of lonidamine on the plasma membrane ultrastructure of normal and leukemic human lymphocytes. Exp Mol Pathol. 48:1988;37-47.
34. Lyon R.C., Cohen J.S., Faustino P.J., Megnin F., Myers C.E. Glucose metabolism in drug-sensitive and drug-resistant human breast cancer cells monitored by magnetic resonance spectroscopy. Cancer Res. 48:1988;870-877.
35. Vivi A, Tassini M, Navon G and Kaplan O, Comparison of action of anti-neoplastic drug lonidamine between drug sensitive and multidrug resistant MCF-7 human breast cancer cells. Proceeding of the Third International Congress of the Magnetic Resonance Society, pp. 1699-1699. Nice, France, August 1995.
36. Paggi M.G., Caputo A. Clinical significance of a rearranged hexokinase isozyme expression in neoplastic phenotype: The astrocytoma model. Klavins J.V., Plimentel E., Salvatore F. Human Tumor Markers. 1987;869-881 Walter De Gruyter & Co, Berlin.
37. Floridi A., D'Atri S., Paggi M.G., Marcante M.L., De Martino C., Silvestrini B., Caputo A., Lehninger A.L. Binding of lonidamine to Ehrlich ascites tumor and liver mitochondria. Galeotti T., Cittadini A., Neri G., Papa S. Membranes and Tumor Growth. 1982;559-565 Elsevier Biomedical Press, Amsterdam.
38. Bates D.A., Mackillop W.J. Hyperthermia, adriamycin transport and cytotoxicity in drug-sensitive and -resistant Chinese hamster ovary cells. Cancer Res. 46:1986;5477-5481.
39. Citro G., Cucco C., Verdina A., Zupi G. Reversal of adriamycin resistance by lonidamine in a human breast cancer cell line. Br J Cancer. 64:1991;534-536.