메뉴 건너뛰기




Volumn 87, Issue 7, 2002, Pages 805-812

Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell death

Author keywords

Apoptosis; Breast cancer; Glucose metabolism; Tumour metabolism

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIINFECTIVE AGENT; CASPASE; CASPASE 3; DEOXYGLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER 1;

EID: 0037163688     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600547     Document Type: Article
Times cited : (234)

References (72)
  • 1
    • 0033568454 scopus 로고    scopus 로고
    • Glut-1 and hexokinase expression: Relationship with 2-fluoro-2-deoxy-D-glucose uptake in A431 and T47D cells in culture
    • Aloj L, Caraco C, Jagoda E, Eckelman W, Neumann R (1999) Glut-1 and hexokinase expression: relationship with 2-fluoro-2-deoxy-D-glucose uptake in A431 and T47D cells in culture. Cancer Res 59: 4709-4714
    • (1999) Cancer Res , vol.59 , pp. 4709-4714
    • Aloj, L.1    Caraco, C.2    Jagoda, E.3    Eckelman, W.4    Neumann, R.5
  • 2
    • 0034327411 scopus 로고    scopus 로고
    • An informatics approach identifying markers of chemosensitivity in human cancer cell lines
    • Amundson S, Myers T, Scudiero D, Kitada S, Reed J, Fornace A (2000) An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res 60: 6101-6110
    • (2000) Cancer Res , vol.60 , pp. 6101-6110
    • Amundson, S.1    Myers, T.2    Scudiero, D.3    Kitada, S.4    Reed, J.5    Fornace, A.6
  • 3
    • 0033523118 scopus 로고    scopus 로고
    • Functional interaction between the N- and C-terminal halves of human hexokinase II
    • Ardehali H, Printz R, Whitesell R, May J, Granner D (1999) Functional interaction between the N- and C-terminal halves of human hexokinase II. J Biol Chem 274: 15986-15989
    • (1999) J Biol Chem , vol.274 , pp. 15986-15989
    • Ardehali, H.1    Printz, R.2    Whitesell, R.3    May, J.4    Granner, D.5
  • 5
    • 0026598426 scopus 로고
    • Hexokinase receptors: Preferential enzyme binding in normal cells to non-mitochondrial sites and in transformed cells to mitochondrial sites
    • Arora K, Parry D, Pedersen P (1992) Hexokinase receptors: preferential enzyme binding in normal cells to non-mitochondrial sites and in transformed cells to mitochondrial sites. J Bioenergetics Biomembranes 24: 47-53
    • (1992) J Bioenergetics Biomembranes , vol.24 , pp. 47-53
    • Arora, K.1    Parry, D.2    Pedersen, P.3
  • 6
    • 0024237766 scopus 로고
    • Functional significance of mitochondrial bound hexokinase in tumor cell metabolism
    • Arora K, Pedersen P (1988) Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. J Biol Chem 263: 17422-17428
    • (1988) J Biol Chem , vol.263 , pp. 17422-17428
    • Arora, K.1    Pedersen, P.2
  • 7
    • 0010946317 scopus 로고
    • Influence of glucose anti-metabolites on the Walker tumor
    • Ball H, Wick A, Sanders C (1957) Influence of glucose anti-metabolites on the Walker tumor. Cancer Res 17: 235-239
    • (1957) Cancer Res , vol.17 , pp. 235-239
    • Ball, H.1    Wick, A.2    Sanders, C.3
  • 9
    • 0023132221 scopus 로고
    • Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription
    • Birnbaum M, Haspel H, Rosen O (1987) Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science 235: 1495-1498
    • (1987) Science , vol.235 , pp. 1495-1498
    • Birnbaum, M.1    Haspel, H.2    Rosen, O.3
  • 11
    • 0027489912 scopus 로고
    • Over-expression of Glut1 glucose transporter in human breast cancer: An immunohistochemistry study
    • Brown R, Wahl R (1993) Over-expression of Glut1 glucose transporter in human breast cancer: an immunohistochemistry study. Cancer 15: 2979-2985
    • (1993) Cancer , vol.15 , pp. 2979-2985
    • Brown, R.1    Wahl, R.2
  • 13
    • 0023130372 scopus 로고
    • Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
    • Carmichael J, DeGraff W, Gadzar A, Minna J, Mitchell J (1987) Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 47: 936-942
    • (1987) Cancer Res , vol.47 , pp. 936-942
    • Carmichael, J.1    DeGraff, W.2    Gadzar, A.3    Minna, J.4    Mitchell, J.5
  • 15
    • 15844398095 scopus 로고    scopus 로고
    • Translocation of Glut1 does not account for elevated glucose transport in glucose-deprived 3T3-L1 adipocytes
    • Fisher M, Frost S (1996) Translocation of Glut1 does not account for elevated glucose transport in glucose-deprived 3T3-L1 adipocytes. J Biol Chem 271: 11806-11809
    • (1996) J Biol Chem , vol.271 , pp. 11806-11809
    • Fisher, M.1    Frost, S.2
  • 16
    • 0023158728 scopus 로고
    • Elevated levels of glucose transport and transporter mRNA are induced by ras or src oncogenes
    • Flier J, Mueckler M, Usher P, Lodish H (1987) Elevated levels of glucose transport and transporter mRNA are induced by ras or src oncogenes. Science 235: 1492-1495
    • (1987) Science , vol.235 , pp. 1492-1495
    • Flier, J.1    Mueckler, M.2    Usher, P.3    Lodish, H.4
  • 18
    • 0029879211 scopus 로고    scopus 로고
    • Hypoglycemia-induced AP-1 transcription factor and basic fibroblast growth factor gene expression in multidrug resistant breast carcinoma MCF-7/ADR
    • Galoforo S, Berns C, Erdos G, Corry P, Lee Y (1996) Hypoglycemia-induced AP-1 transcription factor and basic fibroblast growth factor gene expression in multidrug resistant breast carcinoma MCF-7/ADR. Mol Cell Biochem 155: 163-171
    • (1996) Mol Cell Biochem , vol.155 , pp. 163-171
    • Galoforo, S.1    Berns, C.2    Erdos, G.3    Corry, P.4    Lee, Y.5
  • 19
    • 0034983918 scopus 로고    scopus 로고
    • Inhibition of early apoptotic events at Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
    • Gottlob K, Majewski N, Kennedy S, Kandel E, Robey R, Hay N (2001) Inhibition of early apoptotic events at Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 15: 1406-1418
    • (2001) Genes Dev , vol.15 , pp. 1406-1418
    • Gottlob, K.1    Majewski, N.2    Kennedy, S.3    Kandel, E.4    Robey, R.5    Hay, N.6
  • 20
    • 0027960973 scopus 로고
    • Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production
    • Greiner E, Guppy M, Brand K (1994) Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production. J Biol Chem 269: 31482-31490
    • (1994) J Biol Chem , vol.269 , pp. 31482-31490
    • Greiner, E.1    Guppy, M.2    Brand, K.3
  • 21
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross A, McDonnell J, Korsmeyer S (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911
    • (1999) Genes Dev , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.2    Korsmeyer, S.3
  • 22
    • 0030966135 scopus 로고    scopus 로고
    • Differential effect of glucose deprivation on MAPK activation in drug sensitive human breast carcinoma MCF-7 and multidrug resistant MCF-7/ADR cells
    • Gupta A, Lee Y, Galoforo S, Berns C, Martinez A, Corry P, Wu X, Guan K (1997) Differential effect of glucose deprivation on MAPK activation in drug sensitive human breast carcinoma MCF-7 and multidrug resistant MCF-7/ADR cells. Mol Cell Biochem 170: 23-30
    • (1997) Mol Cell Biochem , vol.170 , pp. 23-30
    • Gupta, A.1    Lee, Y.2    Galoforo, S.3    Berns, C.4    Martinez, A.5    Corry, P.6    Wu, X.7    Guan, K.8
  • 23
    • 0033567219 scopus 로고    scopus 로고
    • Activation of Glut1 glucose transporter in response to inhibition of oxidative phosphorylation
    • Hamrahian A, Zhang J, Elkhairi F, Prasad R, Ismail-Beigi F (1999) Activation of Glut1 glucose transporter in response to inhibition of oxidative phosphorylation. Arch Biochem Biophys 368: 375-379
    • (1999) Arch Biochem Biophys , vol.368 , pp. 375-379
    • Hamrahian, A.1    Zhang, J.2    Elkhairi, F.3    Prasad, R.4    Ismail-Beigi, F.5
  • 24
    • 0025729026 scopus 로고
    • Glucose deprivation induces the selective accumulation of hexose transporter Glut1 in the plasma membrane of normal rat kidneys
    • Haspel H, Mynarcik D, Oritz P, Honkanen R, Rosenfeld M (1991) Glucose deprivation induces the selective accumulation of hexose transporter Glut1 in the plasma membrane of normal rat kidneys. Mol Endocrinol 5: 61-72
    • (1991) Mol Endocrinol , vol.5 , pp. 61-72
    • Haspel, H.1    Mynarcik, D.2    Oritz, P.3    Honkanen, R.4    Rosenfeld, M.5
  • 25
    • 0027485461 scopus 로고
    • Bcl-2 functions in an antioxidant pathway to prevent apoptosis
    • Hockenbery D, Oltvai Z, Yin X, Milliman C, Korsmeyer S (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251
    • (1993) Cell , vol.75 , pp. 241-251
    • Hockenbery, D.1    Oltvai, Z.2    Yin, X.3    Milliman, C.4    Korsmeyer, S.5
  • 26
    • 0015855708 scopus 로고
    • Enzymatic and cerebral metabolic effects of 2-deoxy-D-glucose
    • Horton R, Meldrum B, Bachelard H (1982) Enzymatic and cerebral metabolic effects of 2-deoxy-D-glucose. J Neurochem 21: 507-520
    • (1982) J Neurochem , vol.21 , pp. 507-520
    • Horton, R.1    Meldrum, B.2    Bachelard, H.3
  • 27
    • 0021993763 scopus 로고
    • Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells
    • Jain V, Kalia V, Sharma R, Maharajan V, Menon M (1985) Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells. Int J Radiat Oncol Biol Phys 11: 943-950
    • (1985) Int J Radiat Oncol Biol Phys , vol.11 , pp. 943-950
    • Jain, V.1    Kalia, V.2    Sharma, R.3    Maharajan, V.4    Menon, M.5
  • 28
    • 0028049621 scopus 로고
    • Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line
    • Kan O, Baldwin S, Whetton A (1994) Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line. J Exp Med 180: 917-923
    • (1994) J Exp Med , vol.180 , pp. 917-923
    • Kan, O.1    Baldwin, S.2    Whetton, A.3
  • 30
    • 0025067416 scopus 로고
    • Effects of 2-deoxyglucose on drug-sensitive and drug-resistant human breast cancer cells: Toxicity and magnetic resonance spectroscopy of metabolism
    • Kaplan O, Lyon R, Faustino P, Straka E, Cohen J (1990a) Effects of 2-deoxyglucose on drug-sensitive and drug-resistant human breast cancer cells: toxicity and magnetic resonance spectroscopy of metabolism. Cancer Res 50: 544-551
    • (1990) Cancer Res , vol.50 , pp. 544-551
    • Kaplan, O.1    Lyon, R.2    Faustino, P.3    Straka, E.4    Cohen, J.5
  • 31
    • 0025196187 scopus 로고
    • Information from combined 1H and 31P NMR studies of cell extracts: Differences in metabolism between drug sensitive and drug resistant MCF-7 human breast cancer cells
    • Kaplan O, van Zijl P, Cohen J (1990b) Information from combined 1H and 31P NMR studies of cell extracts: differences in metabolism between drug sensitive and drug resistant MCF-7 human breast cancer cells. Biochem Biophys Res Commun 169: 383-390
    • (1990) Biochem Biophys Res Commun , vol.169 , pp. 383-390
    • Kaplan, O.1    Van Zijl, P.2    Cohen, J.3
  • 32
    • 0023639297 scopus 로고
    • Inhibition of established rat fibrosarcoma growth by the glucose antagonist 2-deoxy-D-glucose
    • Kern K, Norton J (1987) Inhibition of established rat fibrosarcoma growth by the glucose antagonist 2-deoxy-D-glucose. Surgery 102: 380-385
    • (1987) Surgery , vol.102 , pp. 380-385
    • Kern, K.1    Norton, J.2
  • 33
    • 0027497449 scopus 로고
    • Effect of glucose deprivation on Glut1 expression in 3T3-L1 adipocytes
    • Kitzman H, McMahon R, Williams M, Frost S (1993) Effect of glucose deprivation on Glut1 expression in 3T3-L1 adipocytes. J Biol Chem 268: 1320-1325
    • (1993) J Biol Chem , vol.268 , pp. 1320-1325
    • Kitzman, H.1    McMahon, R.2    Williams, M.3    Frost, S.4
  • 34
    • 0035829074 scopus 로고    scopus 로고
    • Glucose catabolism in the rabbit VX2 tumor model for liver cancer: Characterization and targeting hexokinase
    • Ko Y, Pedersen P, Geschwind J (2001) Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett 173: 83-91
    • (2001) Cancer Lett , vol.173 , pp. 83-91
    • Ko, Y.1    Pedersen, P.2    Geschwind, J.3
  • 35
    • 0001422847 scopus 로고
    • Certain metabolic and pharmacologic effects in cancer patients given an infusion of 2-deoxy-D-glucose
    • Landau B, Laszlo J, Stengle J, Burk D (1958) Certain metabolic and pharmacologic effects in cancer patients given an infusion of 2-deoxy-D-glucose. J Natl Cancer Inst 21: 485-494
    • (1958) J Natl Cancer Inst , vol.21 , pp. 485-494
    • Landau, B.1    Laszlo, J.2    Stengle, J.3    Burk, D.4
  • 36
    • 0001739944 scopus 로고
    • Effects of glucose analogues (2-deoxy-D-glucose, 2-deoxy-D-galactose) on experimental tumors
    • Laszlo J, Humphreys S, Goldin A (1960) Effects of glucose analogues (2-deoxy-D-glucose, 2-deoxy-D-galactose) on experimental tumors. J Natl Cancer Inst 24: 267-280
    • (1960) J Natl Cancer Inst , vol.24 , pp. 267-280
    • Laszlo, J.1    Humphreys, S.2    Goldin, A.3
  • 37
    • 0010889756 scopus 로고
    • The effect of glucose analogues on the metabolism of human leukemia cells
    • Laszlo J, Landau B, Wight K, Burk D (1958) The effect of glucose analogues on the metabolism of human leukemia cells. J Natl Cancer Inst 21: 475-483
    • (1958) J Natl Cancer Inst , vol.21 , pp. 475-483
    • Laszlo, J.1    Landau, B.2    Wight, K.3    Burk, D.4
  • 38
    • 0032491442 scopus 로고    scopus 로고
    • Metabolic oxidative stress-induced HSP70 gene expression is mediated through SAPK pathway
    • Lee Y, Corry P (1998) Metabolic oxidative stress-induced HSP70 gene expression is mediated through SAPK pathway. J Biol Chem 273: 29857-29863
    • (1998) J Biol Chem , vol.273 , pp. 29857-29863
    • Lee, Y.1    Corry, P.2
  • 39
    • 0032570704 scopus 로고    scopus 로고
    • Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug resistant human breast carcinoma cells
    • Lee Y, Galoforo S, Berns C, Chen J, Davis B, Sim J, Corry P, Spitz D (1998) Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug resistant human breast carcinoma cells. J Biol Chem 273: 5294-5299
    • (1998) J Biol Chem , vol.273 , pp. 5294-5299
    • Lee, Y.1    Galoforo, S.2    Berns, C.3    Chen, J.4    Davis, B.5    Sim, J.6    Corry, P.7    Spitz, D.8
  • 40
    • 0030973825 scopus 로고    scopus 로고
    • Glucose deprivation-induced cytotoxicity in drug resistant human breast carcinoma MCF-7/ADR cells: Role of c-myc and bcl-2 in apoptotic cell death
    • Lee Y, Galoforo S, Berns C, Tong W, Kim H, Corry P (1997) Glucose deprivation-induced cytotoxicity in drug resistant human breast carcinoma MCF-7/ADR cells: role of c-myc and bcl-2 in apoptotic cell death. J Cell Sci 110: 681-686
    • (1997) J Cell Sci , vol.110 , pp. 681-686
    • Lee, Y.1    Galoforo, S.2    Berns, C.3    Tong, W.4    Kim, H.5    Corry, P.6
  • 41
    • 0030921506 scopus 로고    scopus 로고
    • Hypoglycemia-induced c-Jun phosphorylation is mediated by c-Jun N-terminal kinase 1 and Lyn kinase in drug-resistant human breast carcinoma MCF-7/ADR cells
    • Liu X, Gupta A, Corry P, Lee Y (1997) Hypo-glycemia-induced c-Jun phosphorylation is mediated by c-Jun N-terminal kinase 1 and Lyn kinase in drug-resistant human breast carcinoma MCF-7/ADR cells. J Biol Chem 272: 11690-11693
    • (1997) J Biol Chem , vol.272 , pp. 11690-11693
    • Liu, X.1    Gupta, A.2    Corry, P.3    Lee, Y.4
  • 42
    • 0029075014 scopus 로고
    • Nutrient control of Glut1 processing and turnover in 3T3-L1 adipocytes
    • MacMahon R, Frost S (1995) Nutrient control of Glut1 processing and turnover in 3T3-L1 adipocytes. J Biol Chem 270: 12094-12099
    • (1995) J Biol Chem , vol.270 , pp. 12094-12099
    • MacMahon, R.1    Frost, S.2
  • 43
    • 0034647711 scopus 로고    scopus 로고
    • Glucose deprivation does not affect Glut1 targeting in 3T3-L1 adipocytes
    • MacMahon R, Hwang J, Frost S (2000) Glucose deprivation does not affect Glut1 targeting in 3T3-L1 adipocytes. Biochem Biophys Res Commun 273: 859-864
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 859-864
    • MacMahon, R.1    Hwang, J.2    Frost, S.3
  • 44
    • 0027272345 scopus 로고
    • Germline manipulation of glucose homeostasis via alteration in glucose transporter levels in skeletal muscle
    • Marshall B, Ren J, Johnson D, Gibbs E, Lillquist J, Soeller W, Holloszy J, Mueckler M (1993) Germline manipulation of glucose homeostasis via alteration in glucose transporter levels in skeletal muscle. J Biol Chem 268: 18442-18445
    • (1993) J Biol Chem , vol.268 , pp. 18442-18445
    • Marshall, B.1    Ren, J.2    Johnson, D.3    Gibbs, E.4    Lillquist, J.5    Soeller, W.6    Holloszy, J.7    Mueckler, M.8
  • 47
    • 0032855506 scopus 로고    scopus 로고
    • Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway
    • Nomura K, Imai H, Koumura T, Arai M, Nakagawa Y (1999) Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway. J Biol Chem 274: 29294-29302
    • (1999) J Biol Chem , vol.274 , pp. 29294-29302
    • Nomura, K.1    Imai, H.2    Koumura, T.3    Arai, M.4    Nakagawa, Y.5
  • 49
    • 0020562212 scopus 로고
    • Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor
    • Parry D, Pedersen P (1983) Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. J Biol Chem 258: 10904-10912
    • (1983) J Biol Chem , vol.258 , pp. 10904-10912
    • Parry, D.1    Pedersen, P.2
  • 50
    • 0033635249 scopus 로고    scopus 로고
    • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
    • Rathmell J, Vander Heiden M, Harris M, Frauwirth K, Thompson C (2000) In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell 6: 683-692
    • (2000) Mol Cell , vol.6 , pp. 683-692
    • Rathmell, J.1    Vander Heiden, M.2    Harris, M.3    Frauwirth, K.4    Thompson, C.5
  • 51
    • 0025291006 scopus 로고
    • 3T3-L1 adipocyte glucose transporter sequence and regulation of protein and mRNA expression by insulin, differentiation and glucose starvation
    • Reed B, Shade D, Alperovich F, Vang M (1990) 3T3-L1 adipocyte glucose transporter sequence and regulation of protein and mRNA expression by insulin, differentiation and glucose starvation. Arch Biochem Biophys 279: 261-274
    • (1990) Arch Biochem Biophys , vol.279 , pp. 261-274
    • Reed, B.1    Shade, D.2    Alperovich, F.3    Vang, M.4
  • 52
    • 0029891049 scopus 로고    scopus 로고
    • Glucose catabolism in cancer cells: Amplification of the gene encoding type II hexokinase
    • Rempel A, Mathupala S, Griffin C, Hawkins A, Pedersen P (1996) Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase. Cancer Res 56: 2468-2471
    • (1996) Cancer Res , vol.56 , pp. 2468-2471
    • Rempel, A.1    Mathupala, S.2    Griffin, C.3    Hawkins, A.4    Pedersen, P.5
  • 53
    • 0033826602 scopus 로고    scopus 로고
    • Glucose transporters and transport kinetics in retinoic acid differentiated T47D human breast cancer cells
    • Rivenzon-Segal D, Rushkin E, Polak-Charcon S, Degani H (2000) Glucose transporters and transport kinetics in retinoic acid differentiated T47D human breast cancer cells. Am J Physiol Endocrinol Metabol 279: E508-E519
    • (2000) Am J Physiol Endocrinol Metabol , vol.279 , pp. E508-E519
    • Rivenzon-Segal, D.1    Rushkin, E.2    Polak-Charcon, S.3    Degani, H.4
  • 54
    • 0029617274 scopus 로고
    • Detection of poly(ADP-ribose) polymerase and its apoptotic-specific fragment by a nonisotopic activity-western blot technique
    • Shah G, Kaufmann S, Piorier G (1995) Detection of poly(ADP-ribose) polymerase and its apoptotic-specific fragment by a nonisotopic activity-western blot technique. Anal Biochem 232: 251-254
    • (1995) Anal Biochem , vol.232 , pp. 251-254
    • Shah, G.1    Kaufmann, S.2    Piorier, G.3
  • 55
    • 0032539534 scopus 로고    scopus 로고
    • A unique glucose-dependent apoptotic pathway induced by c-Myc
    • Shim H, Chun Y, Lewis B, Dang C (1998) A unique glucose-dependent apoptotic pathway induced by c-Myc. Proc Natl Acad Sci USA 95: 1511-1516
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1511-1516
    • Shim, H.1    Chun, Y.2    Lewis, B.3    Dang, C.4
  • 56
    • 0034687754 scopus 로고    scopus 로고
    • An alternative, nonapoptotic form of programmed cell death
    • Sperandio S, Belle I, Bredesen D (2000) An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci USA 97: 14376-14381
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 14376-14381
    • Sperandio, S.1    Belle, I.2    Bredesen, D.3
  • 57
    • 0034038708 scopus 로고    scopus 로고
    • Glucose deprivation-induced oxidative stress in human tumor cells: A fundamental defect in metabolism?
    • Spitz D, Sim J, Ridnour L, Galoforo S, Lee Y (2000) Glucose deprivation-induced oxidative stress in human tumor cells: a fundamental defect in metabolism? Ann NY Acad Sci 899: 349-362
    • (2000) Ann NY Acad Sci , vol.899 , pp. 349-362
    • Spitz, D.1    Sim, J.2    Ridnour, L.3    Galoforo, S.4    Lee, Y.5
  • 58
    • 0035866785 scopus 로고    scopus 로고
    • Induction of the mitochondrial permeability transition mediates the killing of HeLa cells by staurosporine
    • Tafani M, Minchenko D, Serroni A, Farber J (2001) Induction of the mitochondrial permeability transition mediates the killing of HeLa cells by staurosporine. Cancer Res 61: 2446-2459
    • (2001) Cancer Res , vol.61 , pp. 2446-2459
    • Tafani, M.1    Minchenko, D.2    Serroni, A.3    Farber, J.4
  • 59
    • 0035135693 scopus 로고    scopus 로고
    • Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anticancer drugs
    • Tannock I, Lee C (2001) Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anticancer drugs. Br J Cancer 84: 100-105
    • (2001) Br J Cancer , vol.84 , pp. 100-105
    • Tannock, I.1    Lee, C.2
  • 60
    • 0034904776 scopus 로고    scopus 로고
    • Growth factors can influence cell growth and survival through effects on glucose metabolism
    • Vander Heiden M, Plas D, Rathmell J, Fox C, Harris M, Thompson C (2001) Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol 21: 5899-5912
    • (2001) Mol Cell Biol , vol.21 , pp. 5899-5912
    • Vander Heiden, M.1    Plas, D.2    Rathmell, J.3    Fox, C.4    Harris, M.5    Thompson, C.6
  • 61
    • 0034532663 scopus 로고    scopus 로고
    • Glucose deprivation induces Akt-dependent synthesis and incorporation of Glut1, but not Glut4, into the plasma membrane of 3T3-L1 adipocytes
    • von der Crone S, Deppe C, Barthel A, Sasson S, Joost H, Schurmann A (2000) Glucose deprivation induces Akt-dependent synthesis and incorporation of Glut1, but not Glut4, into the plasma membrane of 3T3-L1 adipocytes. Eur J Biochem 79: 943-949
    • (2000) Eur J Biochem , vol.79 , pp. 943-949
    • Von der Crone, S.1    Deppe, C.2    Barthel, A.3    Sasson, S.4    Joost, H.5    Schurmann, A.6
  • 62
    • 0025911120 scopus 로고
    • Primary and metastatic breast carcinomas: Initial clinical evaluation with PET with the radiolabelled glucose analogue 2-(F-18)-fluoro-2-deoxyglucose
    • Wahl R, Cody R, Hutchins G, Mudgett E (1991) Primary and metastatic breast carcinomas: initial clinical evaluation with PET with the radiolabelled glucose analogue 2-(F-18)-fluoro-2-deoxyglucose. Radiology 179: 765-770
    • (1991) Radiology , vol.179 , pp. 765-770
    • Wahl, R.1    Cody, R.2    Hutchins, G.3    Mudgett, E.4
  • 63
    • 0030818103 scopus 로고    scopus 로고
    • Reassessment of FDG uptake in tumor cells: High FDG uptake as a reflection of oxygen-independent glycolysis dominant energy production
    • Waki A, Fujibayashi Y, Sadato N, Ishii Y, Yokoyama A (1997) Reassessment of FDG uptake in tumor cells: high FDG uptake as a reflection of oxygen-independent glycolysis dominant energy production. Nuclear Med Biol 24: 665-670
    • (1997) Nuclear Med Biol , vol.24 , pp. 665-670
    • Waki, A.1    Fujibayashi, Y.2    Sadato, N.3    Ishii, Y.4    Yokoyama, A.5
  • 64
    • 0031693121 scopus 로고    scopus 로고
    • The importance of glucose transport activity as the rate-limiting step of 2-deoxyglucose uptake in tumor cells in vitro
    • Waki A, Kato H, Yano R, Sadato N, Yokoyama A, Ishii Y, Yonekura Y, Fujibayashi Y (1998) The importance of glucose transport activity as the rate-limiting step of 2-deoxyglucose uptake in tumor cells in vitro. Nuclear Med Biol 25: 593-597
    • (1998) Nuclear Med Biol , vol.25 , pp. 593-597
    • Waki, A.1    Kato, H.2    Yano, R.3    Sadato, N.4    Yokoyama, A.5    Ishii, Y.6    Yonekura, Y.7    Fujibayashi, Y.8
  • 65
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O (1956) On the origin of cancer cells. Science 123: 309-314
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 66
    • 0017580461 scopus 로고
    • Enzymology of cancer cells
    • Weber G (1977) Enzymology of cancer cells. N Engl J Med 296: 541-551
    • (1977) N Engl J Med , vol.296 , pp. 541-551
    • Weber, G.1
  • 67
    • 0000904661 scopus 로고
    • Localization of the primary block produced by 2-deoxyglucose
    • Wick A, Drury D, Nakada H, Wolfe J (1957) Localization of the primary block produced by 2-deoxyglucose. J Biol Chem 224: 963-969
    • (1957) J Biol Chem , vol.224 , pp. 963-969
    • Wick, A.1    Drury, D.2    Nakada, H.3    Wolfe, J.4
  • 68
    • 0031044417 scopus 로고    scopus 로고
    • An introduction to the isoenzymes of mammalian hexokinase types I-III
    • Wilson J (1997) An introduction to the isoenzymes of mammalian hexokinase types I-III. Biochem Soc Transact 25: 103-107
    • (1997) Biochem Soc Transact , vol.25 , pp. 103-107
    • Wilson, J.1
  • 70
    • 0029554059 scopus 로고
    • Glut1 expression in human breast carcinoma: Correlation with known prognostic markers
    • Younes M, Brown R, Mody D, Fernandez L, Laucricra R (1995) Glut1 expression in human breast carcinoma: correlation with known prognostic markers. Anticancer Res 15: 2895-2898
    • (1995) Anticancer Res , vol.15 , pp. 2895-2898
    • Younes, M.1    Brown, R.2    Mody, D.3    Fernandez, L.4    Laucricra, R.5
  • 71
    • 0030023026 scopus 로고    scopus 로고
    • Wide distribution of the human erythrocyte glucose transporter Glut1 in human cancers
    • Younes M, Lechago L, Somoano J, Mosharaf M, Lechago J (1996) Wide distribution of the human erythrocyte glucose transporter Glut1 in human cancers. Cancer Res 56: 1164-1167
    • (1996) Cancer Res , vol.56 , pp. 1164-1167
    • Younes, M.1    Lechago, L.2    Somoano, J.3    Mosharaf, M.4    Lechago, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.