메뉴 건너뛰기




Volumn 119, Issue , 2017, Pages 13-22

Genistein: Its role in metabolic diseases and cancer

Author keywords

Adipogenesis; Cancer; Genistein; Insulin; Metabolic diseases

Indexed keywords

CORTICOTROPIN; ERLOTINIB; GEMCITABINE; GENISTEIN; HYDROCORTISONE; INSULIN;

EID: 85032703044     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2017.09.004     Document Type: Review
Times cited : (215)

References (156)
  • 2
    • 68849108869 scopus 로고    scopus 로고
    • Inflammation and cancer: how friendly is the relationship for cancer patients?
    • Aggarwal, B.B., Gehlot, P., Inflammation and cancer: how friendly is the relationship for cancer patients?. Curr. Opin. Pharmacol. 9 (2009), 351–369.
    • (2009) Curr. Opin. Pharmacol. , vol.9 , pp. 351-369
    • Aggarwal, B.B.1    Gehlot, P.2
  • 3
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal, B.B., Shishodia, S., Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 71 (2006), 1397–1421.
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 4
    • 15044361086 scopus 로고    scopus 로고
    • Suppression of the nuclear factor B activation pathway by spice derived phytochemicals: reasoning for seasoning
    • (20041030)
    • Aggarwal, B.B., Shishodia, S., Suppression of the nuclear factor B activation pathway by spice derived phytochemicals: reasoning for seasoning. Ann. N. Y. Acad. Sci., 2016, 434–441 (20041030).
    • (2016) Ann. N. Y. Acad. Sci. , pp. 434-441
    • Aggarwal, B.B.1    Shishodia, S.2
  • 6
    • 33947646506 scopus 로고    scopus 로고
    • Flavonoids: Chemistry, Biochemistry and Applications
    • CRC Press
    • Andersen, Ø.M., Markham, K.R., Flavonoids: Chemistry, Biochemistry and Applications. 2006, CRC Press.
    • (2006)
    • Andersen, Ø.M.1    Markham, K.R.2
  • 7
    • 77950648248 scopus 로고    scopus 로고
    • Absolute bioavailability of isoflavones from soy protein isolate-containing food in female BALB/c mice
    • Andrade, J.E., Twaddle, N.C., Helferich, W.G., et al. Absolute bioavailability of isoflavones from soy protein isolate-containing food in female BALB/c mice. J. Agric. Food Chem. 58 (2010), 4529–4536.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 4529-4536
    • Andrade, J.E.1    Twaddle, N.C.2    Helferich, W.G.3
  • 8
    • 1542286874 scopus 로고    scopus 로고
    • Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats
    • Ascencio, C., Torres, N., Isoard-Acosta, F., et al. Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. J. Nutr., 134, 2004, 522.
    • (2004) J. Nutr. , vol.134 , pp. 522
    • Ascencio, C.1    Torres, N.2    Isoard-Acosta, F.3
  • 9
    • 0025264482 scopus 로고
    • Body fate dwistribution and Breast cancer in the framingham study
    • Ballard-Barbash, R., Schatzkin, A., Carter, C.L., et al. Body fate dwistribution and Breast cancer in the framingham study. J. Natl. Cancer Inst., 82, 1990, 286.
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 286
    • Ballard-Barbash, R.1    Schatzkin, A.2    Carter, C.L.3
  • 10
    • 48749117943 scopus 로고    scopus 로고
    • Multi-targeted therapy of cancer by genistein
    • Banerjee, S., Li, Y., Wang, Z., et al. Multi-targeted therapy of cancer by genistein. Cancer Lett. 269 (2008), 226–242.
    • (2008) Cancer Lett. , vol.269 , pp. 226-242
    • Banerjee, S.1    Li, Y.2    Wang, Z.3
  • 11
    • 55749097776 scopus 로고    scopus 로고
    • Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function
    • Basak, S., Pookot, D., Noonan, E.J., et al. Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function. Mol. Cancer Ther., 7, 2008, 3195.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3195
    • Basak, S.1    Pookot, D.2    Noonan, E.J.3
  • 12
    • 58149202128 scopus 로고    scopus 로고
    • Is NF- B a good target for cancer therapy: hopes and pitfalls
    • Baud, V., Karin, M., Is NF- B a good target for cancer therapy: hopes and pitfalls. Nat. Rev. Drug Discov. 8 (2009), 33–40.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 13
    • 9944226670 scopus 로고    scopus 로고
    • Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes
    • Bazuine, M., van den Broek, P.J.A., Maassen, J., Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 326 (2005), 511–514.
    • (2005) Biochem. Biophys. Res. Commun. , vol.326 , pp. 511-514
    • Bazuine, M.1    van den Broek, P.J.A.2    Maassen, J.3
  • 14
    • 26944486576 scopus 로고    scopus 로고
    • Molecular effects of the isoflavonoid genistein in prostate cancer
    • Bektic, J., Guggenberger, R., Eder, I.E., et al. Molecular effects of the isoflavonoid genistein in prostate cancer. Clin. Genitourin. Cancer 4 (2005), 124–129.
    • (2005) Clin. Genitourin. Cancer , vol.4 , pp. 124-129
    • Bektic, J.1    Guggenberger, R.2    Eder, I.E.3
  • 15
    • 0029961485 scopus 로고    scopus 로고
    • Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-l-integrin
    • Bergan, R., Kyle, E., Nguyen, P., et al. Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-l-integrin. Clin. Exp. Metastasis 14 (1996), 389–398.
    • (1996) Clin. Exp. Metastasis , vol.14 , pp. 389-398
    • Bergan, R.1    Kyle, E.2    Nguyen, P.3
  • 16
    • 33646422404 scopus 로고    scopus 로고
    • Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system
    • Budak, E., Fernández Sánchez, M., Bellver, J., et al. Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertil. Steril. 85 (2006), 1563–1581.
    • (2006) Fertil. Steril. , vol.85 , pp. 1563-1581
    • Budak, E.1    Fernández Sánchez, M.2    Bellver, J.3
  • 17
    • 0036135553 scopus 로고    scopus 로고
    • Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men
    • Busby, M.G., Jeffcoat, A.R., Bloedon, L.T., et al. Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men. Am. J. Clin. Nutr. 75 (2002), 126–136.
    • (2002) Am. J. Clin. Nutr. , vol.75 , pp. 126-136
    • Busby, M.G.1    Jeffcoat, A.R.2    Bloedon, L.T.3
  • 18
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P., Jain, R.K., Angiogenesis in cancer and other diseases. Nature-London, 2000, 249–257.
    • (2000) Nature-London , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 19
    • 33750692714 scopus 로고    scopus 로고
    • Factors affecting the bioavailability of soy isoflavones in humans
    • Cassidy, A., Factors affecting the bioavailability of soy isoflavones in humans. J. AOAC Int. 89 (2006), 1182–1188.
    • (2006) J. AOAC Int. , vol.89 , pp. 1182-1188
    • Cassidy, A.1
  • 20
    • 0029563167 scopus 로고
    • Metabolism of daidzein and genistein by intestinal bacteria
    • Chang, Y.-C., Nair, M.G., Metabolism of daidzein and genistein by intestinal bacteria. J. Nat. Prod. 58 (1995), 1892–1896.
    • (1995) J. Nat. Prod. , vol.58 , pp. 1892-1896
    • Chang, Y.-C.1    Nair, M.G.2
  • 21
    • 0033916580 scopus 로고    scopus 로고
    • Mass spectrometric determination of genistein tissue distribution in diet-exposed Sprague-Dawley rats
    • Chang, H.C., Churchwell, M.I., Delclos, K.B., et al. Mass spectrometric determination of genistein tissue distribution in diet-exposed Sprague-Dawley rats. J. Nutr. 130 (2000), 1963–1970.
    • (2000) J. Nutr. , vol.130 , pp. 1963-1970
    • Chang, H.C.1    Churchwell, M.I.2    Delclos, K.B.3
  • 22
    • 67349182609 scopus 로고    scopus 로고
    • Effect of genistein on insulin resistance, renal lipid metabolism, and antioxidative activities in ovariectomized rats
    • Choi, J.S., Song, J., Effect of genistein on insulin resistance, renal lipid metabolism, and antioxidative activities in ovariectomized rats. Nutrition 25 (2009), 676–685.
    • (2009) Nutrition , vol.25 , pp. 676-685
    • Choi, J.S.1    Song, J.2
  • 23
    • 0342980276 scopus 로고    scopus 로고
    • P53 independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells
    • Choi, Y.H., Lee, W.H., Park, K.Y., et al. P53 independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells. Cancer Sci. 91 (2000), 164–173.
    • (2000) Cancer Sci. , vol.91 , pp. 164-173
    • Choi, Y.H.1    Lee, W.H.2    Park, K.Y.3
  • 24
    • 0032984699 scopus 로고    scopus 로고
    • Apoptosis: mechanisms of life and death in the immune system
    • Cohen, J.J., Apoptosis: mechanisms of life and death in the immune system. J. Allergy Clin. Immunol. 103 (1999), 548–554.
    • (1999) J. Allergy Clin. Immunol. , vol.103 , pp. 548-554
    • Cohen, J.J.1
  • 25
    • 0034654655 scopus 로고    scopus 로고
    • Pharmacokinetics of [14C] genistein in the rat: gender-related differences, potential mechanisms of biological action, and implications for human health
    • Coldham, N.G., Sauer, M.J., Pharmacokinetics of [14C] genistein in the rat: gender-related differences, potential mechanisms of biological action, and implications for human health. Toxicol. Appl. Pharmacol. 164 (2000), 206–215.
    • (2000) Toxicol. Appl. Pharmacol. , vol.164 , pp. 206-215
    • Coldham, N.G.1    Sauer, M.J.2
  • 26
    • 0036825350 scopus 로고    scopus 로고
    • Absolute bioavailability of [14C] genistein in the rat; plasma pharmacokinetics of parent compound, genistein glucuronide and total radioactivity
    • Coldham, N.G., Zhang, A.-Q., Key, P., et al. Absolute bioavailability of [14C] genistein in the rat; plasma pharmacokinetics of parent compound, genistein glucuronide and total radioactivity. Eur. J. Drug Metab. Pharmacokinet. 27 (2002), 249–258.
    • (2002) Eur. J. Drug Metab. Pharmacokinet. , vol.27 , pp. 249-258
    • Coldham, N.G.1    Zhang, A.-Q.2    Key, P.3
  • 27
    • 2142662105 scopus 로고    scopus 로고
    • Dietary phytoestrogens and health
    • Cornwell, T., Cohick, W., Raskin, I., Dietary phytoestrogens and health. Phytochemistry 65 (2004), 995–1016.
    • (2004) Phytochemistry , vol.65 , pp. 995-1016
    • Cornwell, T.1    Cohick, W.2    Raskin, I.3
  • 29
    • 64049109107 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung
    • Harris, R., Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung. Inflammopharmacology 17 (2009), 55–67.
    • (2009) Inflammopharmacology , vol.17 , pp. 55-67
    • Harris, R.1
  • 30
    • 0346368096 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 in human neoplasia: rationale and promise
    • Dannenberg, A.J., Subbaramaiah, K., Targeting cyclooxygenase-2 in human neoplasia: rationale and promise. Cancer Cell, 4, 2003, 431.
    • (2003) Cancer Cell , vol.4 , pp. 431
    • Dannenberg, A.J.1    Subbaramaiah, K.2
  • 31
    • 0033509354 scopus 로고    scopus 로고
    • Genistein inhibits NF-kB activation in prostate cancer cells
    • Davis, J.N., Kucuk, O., Sarkar, F.H., Genistein inhibits NF-kB activation in prostate cancer cells. Nutr. Cancer 35 (1999), 167–174.
    • (1999) Nutr. Cancer , vol.35 , pp. 167-174
    • Davis, J.N.1    Kucuk, O.2    Sarkar, F.H.3
  • 32
    • 0242691046 scopus 로고    scopus 로고
    • AP-1: a double-edged sword in tumorigenesis
    • Eferl, R., Wagner, E.F., AP-1: a double-edged sword in tumorigenesis. Nat. Rev. Cancer 3 (2003), 859–868.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 859-868
    • Eferl, R.1    Wagner, E.F.2
  • 33
    • 65949113410 scopus 로고    scopus 로고
    • Identification of a biphasic role for genistein in the regulation of prostate cancer growth and metastasis
    • El Touny, L.H., Banerjee, P.P., Identification of a biphasic role for genistein in the regulation of prostate cancer growth and metastasis. Cancer Res., 69, 2009, 3695.
    • (2009) Cancer Res. , vol.69 , pp. 3695
    • El Touny, L.H.1    Banerjee, P.P.2
  • 34
    • 33751264196 scopus 로고    scopus 로고
    • Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor- B
    • El-Rayes, B.F., Ali, S., Ali, I.F., et al. Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor- B. Cancer Res., 66, 2006, 10553.
    • (2006) Cancer Res. , vol.66 , pp. 10553
    • El-Rayes, B.F.1    Ali, S.2    Ali, I.F.3
  • 35
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: opportunities, challenges and limitations
    • Engelman, J.A., Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat. Rev. Cancer 9 (2009), 550–562.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 36
    • 33845572153 scopus 로고    scopus 로고
    • Quantitative distribution of a panel of circulating mRNA in preeclampsia versus controls
    • Farina, A., Sekizawa, A., Purwosunu, Y., et al. Quantitative distribution of a panel of circulating mRNA in preeclampsia versus controls. Prenat. Diagn. 26 (2006), 1115–1120.
    • (2006) Prenat. Diagn. , vol.26 , pp. 1115-1120
    • Farina, A.1    Sekizawa, A.2    Purwosunu, Y.3
  • 37
    • 73249129188 scopus 로고    scopus 로고
    • Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells
    • Ferenc, P., Solár, P., Kleban, J., et al. Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells. J. Photochem. Photobiol., B 98 (2010), 25–34.
    • (2010) J. Photochem. Photobiol., B , vol.98 , pp. 25-34
    • Ferenc, P.1    Solár, P.2    Kleban, J.3
  • 38
    • 33750625445 scopus 로고    scopus 로고
    • Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma
    • Fisher, R.I., Bernstein, S.H., Kahl, B.S., et al. Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma. J. Clin. Oncol., 24, 2006, 4867.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 4867
    • Fisher, R.I.1    Bernstein, S.H.2    Kahl, B.S.3
  • 39
    • 30544433479 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the US
    • Ford, E.S., Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the US. Diabetes Care, 28, 2005, 2745.
    • (2005) Diabetes Care , vol.28 , pp. 2745
    • Ford, E.S.1
  • 40
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: diversity and escape mechanisms
    • Friedl, P., Wolf, K., Tumour-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer 3 (2003), 362–374.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 41
    • 0001357019 scopus 로고
    • (An isoflavone glucoside) and its aglucone, genistein, from soybeans
    • Genistin, Walter E., (An isoflavone glucoside) and its aglucone, genistein, from soybeans. J. Am. Chem. Soc. 63 (1941), 3273–3276.
    • (1941) J. Am. Chem. Soc. , vol.63 , pp. 3273-3276
    • Genistin, W.E.1
  • 43
    • 0031930629 scopus 로고    scopus 로고
    • Suppression of tumour development by substances derived from the diet—mechanisms and clinical implications
    • Gescher, A., Pastorino, U., Plummer, S.M., et al. Suppression of tumour development by substances derived from the diet—mechanisms and clinical implications. Br. J. Clin. Pharmacol. 45 (1998), 1–12.
    • (1998) Br. J. Clin. Pharmacol. , vol.45 , pp. 1-12
    • Gescher, A.1    Pastorino, U.2    Plummer, S.M.3
  • 44
    • 0041589149 scopus 로고    scopus 로고
    • Inactivation of NF- B by genistein is mediated via Akt signaling pathway in breast cancer cells
    • Gong, L., Li, Y., Nedeljkovic-Kurepa, A., et al. Inactivation of NF- B by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene 22 (2003), 4702–4709.
    • (2003) Oncogene , vol.22 , pp. 4702-4709
    • Gong, L.1    Li, Y.2    Nedeljkovic-Kurepa, A.3
  • 45
    • 33646429464 scopus 로고    scopus 로고
    • Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women
    • Gu, L., House, S.E., Prior, R.L., et al. Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women. J. Nutr. 136 (2006), 1215–1221.
    • (2006) J. Nutr. , vol.136 , pp. 1215-1221
    • Gu, L.1    House, S.E.2    Prior, R.L.3
  • 46
    • 73949149188 scopus 로고    scopus 로고
    • Inhibitory effects of genistein on metastasis of human hepatocellular carcinoma
    • Gu, Y., Zhu, C.F., Dai, Y.L., et al. Inhibitory effects of genistein on metastasis of human hepatocellular carcinoma. World J. Gastroenterol., 15, 2009, 4952.
    • (2009) World J. Gastroenterol. , vol.15 , pp. 4952
    • Gu, Y.1    Zhu, C.F.2    Dai, Y.L.3
  • 47
    • 34548562078 scopus 로고    scopus 로고
    • Anti-Inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STATand NF-B activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-B activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages
    • Hämäläinen, M., Nieminen, R., Vuorela, P., et al. Anti-Inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STATand NF-B activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-B activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm., 2007, 2007, 1.
    • (2007) Mediators Inflamm. , vol.2007 , pp. 1
    • Hämäläinen, M.1    Nieminen, R.2    Vuorela, P.3
  • 48
    • 7444240283 scopus 로고    scopus 로고
    • Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model
    • Hillman, G.G., Wang, Y., Kucuk, O., et al. Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model. Mol. Cancer Ther., 3, 2004, 1271.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1271
    • Hillman, G.G.1    Wang, Y.2    Kucuk, O.3
  • 49
    • 17144426480 scopus 로고    scopus 로고
    • Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells
    • Huang, X., Chen, S., Xu, L., et al. Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells. Cancer Res., 65, 2005, 3470.
    • (2005) Cancer Res. , vol.65 , pp. 3470
    • Huang, X.1    Chen, S.2    Xu, L.3
  • 50
    • 0032547326 scopus 로고    scopus 로고
    • Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women
    • Hulley, S., Grady, D., Bush, T., et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA, 280, 1998, 605.
    • (1998) JAMA , vol.280 , pp. 605
    • Hulley, S.1    Grady, D.2    Bush, T.3
  • 51
    • 0036278213 scopus 로고    scopus 로고
    • Isolation of an anaerobic intestinal bacterium capable of cleaving the C-ring of the isoflavonoid daidzein
    • Hur, H.-G., Beger, R.D., Heinze, T.M., et al. Isolation of an anaerobic intestinal bacterium capable of cleaving the C-ring of the isoflavonoid daidzein. Arch. Microbiol. 178 (2002), 8–12.
    • (2002) Arch. Microbiol. , vol.178 , pp. 8-12
    • Hur, H.-G.1    Beger, R.D.2    Heinze, T.M.3
  • 52
    • 35348823188 scopus 로고    scopus 로고
    • Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation
    • Ismail, I.A., Kang, K.S., Lee, H.A., et al. Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation. Eur. J. Pharmacol. 575 (2007), 12–20.
    • (2007) Eur. J. Pharmacol. , vol.575 , pp. 12-20
    • Ismail, I.A.1    Kang, K.S.2    Lee, H.A.3
  • 53
    • 67650821911 scopus 로고    scopus 로고
    • Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers
    • Izukawa, T., Nakajima, M., Fujiwara, R., et al. Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers. Drug Metab. Dispos. 37 (2009), 1759–1768.
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 1759-1768
    • Izukawa, T.1    Nakajima, M.2    Fujiwara, R.3
  • 54
    • 77953608981 scopus 로고    scopus 로고
    • Long-term genistein treatment of MCF-7 cells decreases acetylated histone 3 expression and alters growth responses to mitogens and histone deacetylase inhibitors
    • Jawaid, K., Crane, S.R., Nowers, J.L., et al. Long-term genistein treatment of MCF-7 cells decreases acetylated histone 3 expression and alters growth responses to mitogens and histone deacetylase inhibitors. J. Steroid Biochem. Mol. Biol. 120 (2010), 164–171.
    • (2010) J. Steroid Biochem. Mol. Biol. , vol.120 , pp. 164-171
    • Jawaid, K.1    Crane, S.R.2    Nowers, J.L.3
  • 55
    • 33845655517 scopus 로고    scopus 로고
    • Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression
    • Jernås, M., Palming, J., Sjöholm, K., et al. Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression. FASEB J., 20, 2006, 1540.
    • (2006) FASEB J. , vol.20 , pp. 1540
    • Jernås, M.1    Palming, J.2    Sjöholm, K.3
  • 56
    • 0037378823 scopus 로고    scopus 로고
    • Functional characterization of cytochrome P450 2B6 allelic variants
    • Jinno, H., Tanaka-Kagawa, T., Ohno, A., et al. Functional characterization of cytochrome P450 2B6 allelic variants. Drug Metab. Dispos., 31, 2003, 398.
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 398
    • Jinno, H.1    Tanaka-Kagawa, T.2    Ohno, A.3
  • 57
    • 0028909910 scopus 로고
    • Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets
    • Jonas, J.C., Plant, T., Gilon, P., et al. Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets. Br. J. Pharmacol., 114, 1995, 872.
    • (1995) Br. J. Pharmacol. , vol.114 , pp. 872
    • Jonas, J.C.1    Plant, T.2    Gilon, P.3
  • 58
    • 43749107872 scopus 로고    scopus 로고
    • The role of herbs and spices in cancer prevention
    • Kaefer, C.M., Milner, J.A., The role of herbs and spices in cancer prevention. J. Nutr. Biochem. 19 (2008), 347–361.
    • (2008) J. Nutr. Biochem. , vol.19 , pp. 347-361
    • Kaefer, C.M.1    Milner, J.A.2
  • 59
    • 33748304352 scopus 로고    scopus 로고
    • Bioavailability of isoflavones after ingestion of soy beverages in healthy adults
    • Kano, M., Takayanagi, T., Harada, K., et al. Bioavailability of isoflavones after ingestion of soy beverages in healthy adults. J. Nutr. 136 (2006), 2291–2296.
    • (2006) J. Nutr. , vol.136 , pp. 2291-2296
    • Kano, M.1    Takayanagi, T.2    Harada, K.3
  • 60
    • 34247167103 scopus 로고    scopus 로고
    • Variations in cyclin D1 levels through the cell cycle determine the proliferative fate of a cell
    • Ke, Y., Masahiro, H., Dennis, S., Variations in cyclin D1 levels through the cell cycle determine the proliferative fate of a cell. Cell Div, 2006.
    • (2006) Cell Div
    • Ke, Y.1    Masahiro, H.2    Dennis, S.3
  • 61
    • 46049103996 scopus 로고    scopus 로고
    • Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells
    • Kikuno, N., Shiina, H., Urakami, S., et al. Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. Int. J. Cancer 123 (2008), 552–560.
    • (2008) Int. J. Cancer , vol.123 , pp. 552-560
    • Kikuno, N.1    Shiina, H.2    Urakami, S.3
  • 62
    • 67649352637 scopus 로고    scopus 로고
    • Nuclear cyclin D1: an oncogenic driver in human cancer
    • Kim, J.K., Diehl, J.A., Nuclear cyclin D1: an oncogenic driver in human cancer. J. Cell. Physiol. 220 (2009), 292–296.
    • (2009) J. Cell. Physiol. , vol.220 , pp. 292-296
    • Kim, J.K.1    Diehl, J.A.2
  • 63
    • 84902652551 scopus 로고    scopus 로고
    • Absolute configuration of (−)-2-(4-hydroxyphenyl) propionic acid: stereochemistry of soy isoflavone metabolism
    • Kim, M., Han, J., Absolute configuration of (−)-2-(4-hydroxyphenyl) propionic acid: stereochemistry of soy isoflavone metabolism. Bull. Korean Chem. Soc. 35 (2014), 1883–1886.
    • (2014) Bull. Korean Chem. Soc. , vol.35 , pp. 1883-1886
    • Kim, M.1    Han, J.2
  • 64
    • 84906937353 scopus 로고    scopus 로고
    • Chiroptical study and absolute configuration of (–)–O-DMA produced from daidzein metabolism
    • Kim, M., Han, J., Chiroptical study and absolute configuration of (–)–O-DMA produced from daidzein metabolism. Chirality 26 (2014), 434–437.
    • (2014) Chirality , vol.26 , pp. 434-437
    • Kim, M.1    Han, J.2
  • 65
    • 0034956425 scopus 로고    scopus 로고
    • Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta
    • Kim, H., Xu, J., Su, Y., et al. Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta. Biochem. Soc. Trans. 29 (2001), 216–221.
    • (2001) Biochem. Soc. Trans. , vol.29 , pp. 216-221
    • Kim, H.1    Xu, J.2    Su, Y.3
  • 66
    • 2942529395 scopus 로고    scopus 로고
    • Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPAR [alpha]
    • Kim, S., Shin, H.J., Kim, S.Y., et al. Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPAR [alpha]. Mol. Cell. Endocrinol. 220 (2004), 51–58.
    • (2004) Mol. Cell. Endocrinol. , vol.220 , pp. 51-58
    • Kim, S.1    Shin, H.J.2    Kim, S.Y.3
  • 67
    • 69149098095 scopus 로고    scopus 로고
    • Genistein inhibits cell growth by modulating various mitogen activated protein kinases and AKT in cervical cancer cells
    • Kim, S.H., Kim, Y.B., Jeon, Y.T., et al. Genistein inhibits cell growth by modulating various mitogen activated protein kinases and AKT in cervical cancer cells. Ann. N. Y. Acad. Sci. 1171 (2009), 495–500.
    • (2009) Ann. N. Y. Acad. Sci. , vol.1171 , pp. 495-500
    • Kim, S.H.1    Kim, Y.B.2    Jeon, Y.T.3
  • 68
    • 0031969620 scopus 로고    scopus 로고
    • Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans
    • King, R.A., Bursill, D.B., Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am. J. Clin. Nutr. 67 (1998), 867–872.
    • (1998) Am. J. Clin. Nutr. , vol.67 , pp. 867-872
    • King, R.A.1    Bursill, D.B.2
  • 69
    • 39749140314 scopus 로고    scopus 로고
    • Modulation of gene methylation by genistein or lycopene in breast cancer cells
    • King-Batoon, A., Leszczynska, J.M., Klein, C.B., Modulation of gene methylation by genistein or lycopene in breast cancer cells. Environ. Mol. Mutagen. 49 (2008), 36–45.
    • (2008) Environ. Mol. Mutagen. , vol.49 , pp. 36-45
    • King-Batoon, A.1    Leszczynska, J.M.2    Klein, C.B.3
  • 70
    • 33646047101 scopus 로고    scopus 로고
    • Effects of the natural isoflavonoid genistein on growth, signaling pathways and gene expression of matrix macromolecules by breast cancer cells
    • Kousidou, O.C., Tzanakakis, G., Karamanos, N., Effects of the natural isoflavonoid genistein on growth, signaling pathways and gene expression of matrix macromolecules by breast cancer cells. Mini Rev. Med. Chem. 6 (2006), 331–337.
    • (2006) Mini Rev. Med. Chem. , vol.6 , pp. 331-337
    • Kousidou, O.C.1    Tzanakakis, G.2    Karamanos, N.3
  • 71
    • 0033491193 scopus 로고    scopus 로고
    • CD95 (APO-1/Fas)-mediated apoptosis: live and let die
    • Krammer, P.H., CD95 (APO-1/Fas)-mediated apoptosis: live and let die. Adv. Immunol. 71 (1998), 163–210.
    • (1998) Adv. Immunol. , vol.71 , pp. 163-210
    • Krammer, P.H.1
  • 72
    • 36148944490 scopus 로고    scopus 로고
    • Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
    • Kuhn, D.J., Chen, Q., Voorhees, P.M., et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood 110 (2007), 3281–3290.
    • (2007) Blood , vol.110 , pp. 3281-3290
    • Kuhn, D.J.1    Chen, Q.2    Voorhees, P.M.3
  • 73
    • 33846188115 scopus 로고    scopus 로고
    • Influence of genistein isoflavone on matrix metalloproteinase-2 expression in prostate cancer cells
    • Kumi-Diaka, J., Hassanhi, M., Merchant, K., et al. Influence of genistein isoflavone on matrix metalloproteinase-2 expression in prostate cancer cells. J. Med. Food 9 (2006), 491–497.
    • (2006) J. Med. Food , vol.9 , pp. 491-497
    • Kumi-Diaka, J.1    Hassanhi, M.2    Merchant, K.3
  • 74
    • 0037423299 scopus 로고    scopus 로고
    • Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs) UGT1A9 is more resistant to detergent inhibition than the other UGTS and was purified as an active dimeric enzyme
    • Kurkela, M., Garcı́a-Horsman, J.A., Luukkanen, L., et al. Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs) UGT1A9 is more resistant to detergent inhibition than the other UGTS and was purified as an active dimeric enzyme. J. Biol. Chem. 278 (2003), 3536–3544.
    • (2003) J. Biol. Chem. , vol.278 , pp. 3536-3544
    • Kurkela, M.1    Garcı́a-Horsman, J.A.2    Luukkanen, L.3
  • 75
    • 0031017360 scopus 로고    scopus 로고
    • Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity
    • Kyle, E., Neckers, L., Takimoto, C., et al. Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol. Pharmacol., 51, 1997, 193.
    • (1997) Mol. Pharmacol. , vol.51 , pp. 193
    • Kyle, E.1    Neckers, L.2    Takimoto, C.3
  • 76
    • 45849115105 scopus 로고    scopus 로고
    • The key importance of soy isoflavone bioavailability to understanding health benefits
    • Larkin, T., Price, W.E., Astheimer, L., The key importance of soy isoflavone bioavailability to understanding health benefits. Crit. Rev. Food Sci. Nutr. 48 (2008), 538–552.
    • (2008) Crit. Rev. Food Sci. Nutr. , vol.48 , pp. 538-552
    • Larkin, T.1    Price, W.E.2    Astheimer, L.3
  • 77
    • 80055008824 scopus 로고    scopus 로고
    • Soybean isoflavone genistein regulates apoptosis through NF-[kappa] B dependent and independent pathways
    • Lee, Y.K., Park, O.J., Soybean isoflavone genistein regulates apoptosis through NF-[kappa] B dependent and independent pathways. Exp. Toxicol. Pathol., 2011.
    • (2011) Exp. Toxicol. Pathol.
    • Lee, Y.K.1    Park, O.J.2
  • 78
    • 55749101363 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy
    • Lee, M.J., Kim, Y.S., Kummar, S., et al. Histone deacetylase inhibitors in cancer therapy. Curr. Opin. Oncol., 20, 2008, 639.
    • (2008) Curr. Opin. Oncol. , vol.20 , pp. 639
    • Lee, M.J.1    Kim, Y.S.2    Kummar, S.3
  • 79
    • 0035992417 scopus 로고    scopus 로고
    • Inhibition of nuclear factor B activation in PC3 cells by genistein is mediated via Akt signaling pathway
    • Li, Y., Sarkar, F.H., Inhibition of nuclear factor B activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin. Cancer Res., 8, 2002, 2369.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2369
    • Li, Y.1    Sarkar, F.H.2
  • 80
    • 0033761908 scopus 로고    scopus 로고
    • Endothelial cell survival and apoptosis in the tumor vasculature
    • Liu, W., Ahmad, S., Reinmuth, N., et al. Endothelial cell survival and apoptosis in the tumor vasculature. Apoptosis 5 (2000), 323–328.
    • (2000) Apoptosis , vol.5 , pp. 323-328
    • Liu, W.1    Ahmad, S.2    Reinmuth, N.3
  • 81
    • 33750066662 scopus 로고    scopus 로고
    • Neurotrophic property of geniposide for inducing the neuronal differentiation of PC12 cells
    • Liu, J., Zheng, X., Yin, F., et al. Neurotrophic property of geniposide for inducing the neuronal differentiation of PC12 cells. Int. J. Dev. Neurosci. 24 (2006), 419–424.
    • (2006) Int. J. Dev. Neurosci. , vol.24 , pp. 419-424
    • Liu, J.1    Zheng, X.2    Yin, F.3
  • 82
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu, P., Cheng, H., Roberts, T.M., et al. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat. Rev. Drug Discov. 8 (2009), 627–644.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3
  • 83
    • 14844314485 scopus 로고    scopus 로고
    • A randomised double-blind controlled trial of oral soy supplements versus placebo for treatment of menopausal symptoms in patients with early breast cancer
    • MacGregor, C., Canney, P., Patterson, G., et al. A randomised double-blind controlled trial of oral soy supplements versus placebo for treatment of menopausal symptoms in patients with early breast cancer. Eur. J. Cancer 41 (2005), 708–714.
    • (2005) Eur. J. Cancer , vol.41 , pp. 708-714
    • MacGregor, C.1    Canney, P.2    Patterson, G.3
  • 84
    • 0033062560 scopus 로고    scopus 로고
    • Effect of isoflavone genistein on insulin receptors in perfused liver of ovariectomized rats
    • Mackowiak, P., Nogowski, L., Nowak, K., Effect of isoflavone genistein on insulin receptors in perfused liver of ovariectomized rats. J. Recept. Signal Transduct. 19 (1999), 283–292.
    • (1999) J. Recept. Signal Transduct. , vol.19 , pp. 283-292
    • Mackowiak, P.1    Nogowski, L.2    Nowak, K.3
  • 85
    • 36148941364 scopus 로고    scopus 로고
    • Fat cell size, insulin sensitivity, and inflammation in obese children
    • Maffeis, C., Silvagni, D., Bonadonna, R., et al. Fat cell size, insulin sensitivity, and inflammation in obese children. J. Pediatr. 151 (2007), 647–652.
    • (2007) J. Pediatr. , vol.151 , pp. 647-652
    • Maffeis, C.1    Silvagni, D.2    Bonadonna, R.3
  • 86
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach, C., Williamson, G., Morand, C., et al. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 81 (2005), 230S–242S.
    • (2005) Am. J. Clin. Nutr. , vol.81 , pp. 230S-242S
    • Manach, C.1    Williamson, G.2    Morand, C.3
  • 87
    • 70449727026 scopus 로고    scopus 로고
    • Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects
    • Masharani, U., Goldfine, I.D., Youngren, J.F., Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects. Metabolism 58 (2009), 1602–1608.
    • (2009) Metabolism , vol.58 , pp. 1602-1608
    • Masharani, U.1    Goldfine, I.D.2    Youngren, J.F.3
  • 88
    • 0036533493 scopus 로고    scopus 로고
    • Balancing susceptibility to infection and autoimmunity: a role for leptin?
    • Matarese, G., La Cava, A., Sanna, V., et al. Balancing susceptibility to infection and autoimmunity: a role for leptin?. Trends Immunol. 23 (2002), 182–187.
    • (2002) Trends Immunol. , vol.23 , pp. 182-187
    • Matarese, G.1    La Cava, A.2    Sanna, V.3
  • 90
    • 58349091690 scopus 로고    scopus 로고
    • Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity
    • Meng, R.D., Shelton, C.C., Li, Y.M., et al. Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res., 69, 2009, 573.
    • (2009) Cancer Res. , vol.69 , pp. 573
    • Meng, R.D.1    Shelton, C.C.2    Li, Y.M.3
  • 91
    • 0033306059 scopus 로고    scopus 로고
    • Phytoestrogens alter adrenocortical function: genistein and daidzein suppress glucocorticoid and stimulate androgen production by cultured adrenal cortical cells
    • Mesiano, S., Katz, S.L., Lee, J.Y., et al. Phytoestrogens alter adrenocortical function: genistein and daidzein suppress glucocorticoid and stimulate androgen production by cultured adrenal cortical cells. J. Clin. Endocrinol. Metab., 84, 1999, 2443.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 2443
    • Mesiano, S.1    Katz, S.L.2    Lee, J.Y.3
  • 92
    • 38049132497 scopus 로고    scopus 로고
    • Genistein inhibits the contact-stimulated migration of prostate cancer cells
    • Mi kus, K., Madeja, Z., Genistein inhibits the contact-stimulated migration of prostate cancer cells. Cell. Mol. Biol. Lett. 12 (2007), 348–361.
    • (2007) Cell. Mol. Biol. Lett. , vol.12 , pp. 348-361
    • Mi kus, K.1    Madeja, Z.2
  • 93
    • 12144290914 scopus 로고    scopus 로고
    • Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
    • Mitsiades, C.S., Mitsiades, N.S., McMullan, C.J., et al. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 5 (2004), 221–230.
    • (2004) Cancer Cell , vol.5 , pp. 221-230
    • Mitsiades, C.S.1    Mitsiades, N.S.2    McMullan, C.J.3
  • 94
    • 0033509296 scopus 로고    scopus 로고
    • Cortisol in teleosts: dynamics, mechanisms of action, and metabolic regulation
    • Mommsen, T.P., Vijayan, M.M., Moon, T.W., Cortisol in teleosts: dynamics, mechanisms of action, and metabolic regulation. Rev. Fish Biol. Fish. 9 (1999), 211–268.
    • (1999) Rev. Fish Biol. Fish. , vol.9 , pp. 211-268
    • Mommsen, T.P.1    Vijayan, M.M.2    Moon, T.W.3
  • 95
    • 0033004033 scopus 로고    scopus 로고
    • In vitro and in vivo effects of genistein on murine alveolar macrophage TNF production
    • Morris, P.E., Olmstead, L.E., Howard-Carroll, A.E., et al. In vitro and in vivo effects of genistein on murine alveolar macrophage TNF production. Inflammation 23 (1999), 231–239.
    • (1999) Inflammation , vol.23 , pp. 231-239
    • Morris, P.E.1    Olmstead, L.E.2    Howard-Carroll, A.E.3
  • 96
    • 3242798960 scopus 로고    scopus 로고
    • Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor (ER) and ER in human cells
    • Mueller, S.O., Simon, S., Chae, K., et al. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor (ER) and ER in human cells. Toxicol. Sci., 80, 2004, 14.
    • (2004) Toxicol. Sci. , vol.80 , pp. 14
    • Mueller, S.O.1    Simon, S.2    Chae, K.3
  • 97
    • 78651264366 scopus 로고    scopus 로고
    • Reproductive regulators in decapod crustaceans: an overview
    • Nagaraju, G.P., Reproductive regulators in decapod crustaceans: an overview. J. Exp. Biol. 214 (2011), 3–16.
    • (2011) J. Exp. Biol. , vol.214 , pp. 3-16
    • Nagaraju, G.P.1
  • 98
    • 71049121968 scopus 로고    scopus 로고
    • A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy
    • Nakamura, Y., Yogosawa, S., Izutani, Y., et al. A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol. Cancer, 8, 2009, 100.
    • (2009) Mol. Cancer , vol.8 , pp. 100
    • Nakamura, Y.1    Yogosawa, S.2    Izutani, Y.3
  • 99
    • 0036554394 scopus 로고    scopus 로고
    • Signaling to localized degranulation in neutrophils adherent to immune complexes
    • Nauclér, C., Grinstein, S., Sundler, R., et al. Signaling to localized degranulation in neutrophils adherent to immune complexes. J. Leukoc. Biol., 71, 2002, 701.
    • (2002) J. Leukoc. Biol. , vol.71 , pp. 701
    • Nauclér, C.1    Grinstein, S.2    Sundler, R.3
  • 100
    • 34249897244 scopus 로고    scopus 로고
    • Review of the factors affecting bioavailability of soy isoflavones in humans
    • Nielsen, I.L.F., Williamson, G., Review of the factors affecting bioavailability of soy isoflavones in humans. Nutr. Cancer 57 (2007), 1–10.
    • (2007) Nutr. Cancer , vol.57 , pp. 1-10
    • Nielsen, I.L.F.1    Williamson, G.2
  • 101
    • 0032403545 scopus 로고    scopus 로고
    • [beta] A novel estrogen receptor offers the potential for new drug development
    • Nilsson, S., Kuiper, G., Gustafsson, J.A.E.R., [beta] A novel estrogen receptor offers the potential for new drug development. Trends Endocrinol. Metab. 9 (1998), 387–395.
    • (1998) Trends Endocrinol. Metab. , vol.9 , pp. 387-395
    • Nilsson, S.1    Kuiper, G.2    Gustafsson, J.A.E.R.3
  • 102
    • 84869884590 scopus 로고    scopus 로고
    • Effect of the genistein metabolite on leptin secretion in murine adipocytes in vitro
    • Niwa, T., Yokoyama, T., Osawa, S.-i., Effect of the genistein metabolite on leptin secretion in murine adipocytes in vitro. Food Chem. 138 (2013), 122–125.
    • (2013) Food Chem. , vol.138 , pp. 122-125
    • Niwa, T.1    Yokoyama, T.2    Osawa, S.-I.3
  • 103
    • 0036978248 scopus 로고    scopus 로고
    • The influence of coumestrol, zearalenone, and genistein administration on insulin receptors and insulin secretion in ovariectomized rats
    • Nogowski, L., Nowak, K., Kaczmarek, P., et al. The influence of coumestrol, zearalenone, and genistein administration on insulin receptors and insulin secretion in ovariectomized rats. J. Recept. Signal Transduct. 22 (2002), 449–457.
    • (2002) J. Recept. Signal Transduct. , vol.22 , pp. 449-457
    • Nogowski, L.1    Nowak, K.2    Kaczmarek, P.3
  • 104
    • 77649185714 scopus 로고    scopus 로고
    • Lipid raft cholesterol and genistein inhibit the cell viability of prostate cancer cells via the partial contribution of EGFR-Akt/p70S6k pathway and down-regulation of androgen receptor
    • Oh, H.Y., Leem, J., Yoon, S.J., et al. Lipid raft cholesterol and genistein inhibit the cell viability of prostate cancer cells via the partial contribution of EGFR-Akt/p70S6k pathway and down-regulation of androgen receptor. Biochem. Biophys. Res. Commun. 393 (2010), 319–324.
    • (2010) Biochem. Biophys. Res. Commun. , vol.393 , pp. 319-324
    • Oh, H.Y.1    Leem, J.2    Yoon, S.J.3
  • 105
    • 0042266265 scopus 로고    scopus 로고
    • Electron transfer process of poly (ethylene oxide)-modified cytochrome c in imidazolium type ionic liquid
    • Ohno, H., Suzuki, C., Fukumoto, K., et al. Electron transfer process of poly (ethylene oxide)-modified cytochrome c in imidazolium type ionic liquid. Chem. Lett. 32 (2003), 450–451.
    • (2003) Chem. Lett. , vol.32 , pp. 450-451
    • Ohno, H.1    Suzuki, C.2    Fukumoto, K.3
  • 106
    • 0032520921 scopus 로고    scopus 로고
    • Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
    • Okuno, A., Tamemoto, H., Tobe, K., et al. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J. Clin. Invest., 101, 1998, 1354.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1354
    • Okuno, A.1    Tamemoto, H.2    Tobe, K.3
  • 107
    • 71549153495 scopus 로고    scopus 로고
    • Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways
    • Ouyang, G., Yao, L., Ruan, K., et al. Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. Cell Biol. Int. 33 (2009), 1237–1244.
    • (2009) Cell Biol. Int. , vol.33 , pp. 1237-1244
    • Ouyang, G.1    Yao, L.2    Ruan, K.3
  • 108
    • 33645738383 scopus 로고    scopus 로고
    • Towards third generation matrix metalloproteinase inhibitors for cancer therapy
    • Overall, C., Kleifeld, O., Towards third generation matrix metalloproteinase inhibitors for cancer therapy. Br. J. Cancer 94 (2006), 941–946.
    • (2006) Br. J. Cancer , vol.94 , pp. 941-946
    • Overall, C.1    Kleifeld, O.2
  • 109
    • 33847195428 scopus 로고    scopus 로고
    • Matrix metalloproteinases and the regulation of tissue remodelling
    • Page-McCaw, A., Ewald, A.J., Werb, Z., Matrix metalloproteinases and the regulation of tissue remodelling. Nat. Rev. Mol. Cell Biol. 8 (2007), 221–233.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 221-233
    • Page-McCaw, A.1    Ewald, A.J.2    Werb, Z.3
  • 110
    • 77951239433 scopus 로고    scopus 로고
    • Combined cetuximab and genistein treatment shows additive anti-cancer effect on oral squamous cell carcinoma
    • Park, S.J., Kim, M.J., Kim, Y.K., et al. Combined cetuximab and genistein treatment shows additive anti-cancer effect on oral squamous cell carcinoma. Cancer Lett. 292 (2010), 54–63.
    • (2010) Cancer Lett. , vol.292 , pp. 54-63
    • Park, S.J.1    Kim, M.J.2    Kim, Y.K.3
  • 111
    • 80052629054 scopus 로고    scopus 로고
    • Stereospecific microbial production of isoflavanones from isoflavones and isoflavone glucosides
    • Park, H.-Y., Kim, M., Han, J., Stereospecific microbial production of isoflavanones from isoflavones and isoflavone glucosides. Appl. Microbiol. Biotechnol. 91 (2011), 1173–1181.
    • (2011) Appl. Microbiol. Biotechnol. , vol.91 , pp. 1173-1181
    • Park, H.-Y.1    Kim, M.2    Han, J.3
  • 112
    • 76449119846 scopus 로고    scopus 로고
    • Prepubertal genistein exposure affects erbB2/Akt signal and reduces rat mammary tumorigenesis
    • Peng, J.H., Zhu, J.D., Mi, M.T., et al. Prepubertal genistein exposure affects erbB2/Akt signal and reduces rat mammary tumorigenesis. Eur. J. Cancer Prev., 19, 2010, 110.
    • (2010) Eur. J. Cancer Prev. , vol.19 , pp. 110
    • Peng, J.H.1    Zhu, J.D.2    Mi, M.T.3
  • 113
    • 33751549494 scopus 로고    scopus 로고
    • Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner
    • Penza, M., Montani, C., Romani, A., et al. Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner. Endocrinology 147 (2006), 5740–5751.
    • (2006) Endocrinology , vol.147 , pp. 5740-5751
    • Penza, M.1    Montani, C.2    Romani, A.3
  • 114
    • 0027193012 scopus 로고
    • Vasopressin stimulates cortisol secretion from human adrenocortical tissue through activation of V1 receptors
    • Perraudin, V., Delarue, C., Lefebvre, H., et al. Vasopressin stimulates cortisol secretion from human adrenocortical tissue through activation of V1 receptors. J. Clin. Endocrinol. Metab., 76, 1993, 1522.
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 1522
    • Perraudin, V.1    Delarue, C.2    Lefebvre, H.3
  • 115
    • 0032997908 scopus 로고    scopus 로고
    • Estrogen modulates neuronal bcl xl expression and amyloid induced apoptosis
    • Pike, C.J., Estrogen modulates neuronal bcl xl expression and amyloid induced apoptosis. J. Neurochem. 72 (1999), 1552–1563.
    • (1999) J. Neurochem. , vol.72 , pp. 1552-1563
    • Pike, C.J.1
  • 116
    • 33748934979 scopus 로고    scopus 로고
    • mTORC2 caught in a SINful Akt
    • Polak, P., Hall, M.N., mTORC2 caught in a SINful Akt. Developmental cell 11 (2006), 433–434.
    • (2006) Developmental cell , vol.11 , pp. 433-434
    • Polak, P.1    Hall, M.N.2
  • 117
    • 33748453503 scopus 로고    scopus 로고
    • Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones
    • Puli, S., Lai, J.C.K., Bhushan, A., Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones. J. Neurooncol. 79 (2006), 135–142.
    • (2006) J. Neurooncol. , vol.79 , pp. 135-142
    • Puli, S.1    Lai, J.C.K.2    Bhushan, A.3
  • 118
    • 33646727546 scopus 로고    scopus 로고
    • Genistein inhibits radiation-induced activation of NF-κB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest
    • Raffoul, J., Wang, Y., Kucuk, O., et al. Genistein inhibits radiation-induced activation of NF-κB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC Cancer, 6, 2006, 107.
    • (2006) BMC Cancer , vol.6 , pp. 107
    • Raffoul, J.1    Wang, Y.2    Kucuk, O.3
  • 119
    • 34248172404 scopus 로고    scopus 로고
    • Entamoeba histolytica: apoptosis induced in vitro by nitric oxide species
    • Ramos, E., Olivos-Garcia, A., Nequiz, M., et al. Entamoeba histolytica: apoptosis induced in vitro by nitric oxide species. Exp. Parasitol. 116 (2007), 257–265.
    • (2007) Exp. Parasitol. , vol.116 , pp. 257-265
    • Ramos, E.1    Olivos-Garcia, A.2    Nequiz, M.3
  • 120
    • 34249882770 scopus 로고    scopus 로고
    • Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
    • Ramos, S., Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J. Nutr. Biochem. 18 (2007), 427–442.
    • (2007) J. Nutr. Biochem. , vol.18 , pp. 427-442
    • Ramos, S.1
  • 121
    • 67649880302 scopus 로고    scopus 로고
    • Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts
    • Relic, B., Zeddou, M., Desoroux, A., et al. Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts. Lab. Invest. 89 (2009), 811–822.
    • (2009) Lab. Invest. , vol.89 , pp. 811-822
    • Relic, B.1    Zeddou, M.2    Desoroux, A.3
  • 122
    • 70350319524 scopus 로고    scopus 로고
    • Quantitative evaluation of the expression and activity of five major sulfotransferases (SULTs) in human tissues: the SULT pie
    • Riches, Z., Stanley, E.L., Bloomer, J.C., et al. Quantitative evaluation of the expression and activity of five major sulfotransferases (SULTs) in human tissues: the SULT pie. Drug Metab. Dispos. 37 (2009), 2255–2261.
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 2255-2261
    • Riches, Z.1    Stanley, E.L.2    Bloomer, J.C.3
  • 123
    • 34047237367 scopus 로고    scopus 로고
    • Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause
    • Rossouw, J.E., Prentice, R.L., Manson, J.A.E., et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA, 297, 2007, 1465.
    • (2007) JAMA , vol.297 , pp. 1465
    • Rossouw, J.E.1    Prentice, R.L.2    Manson, J.A.E.3
  • 124
    • 33645743524 scopus 로고    scopus 로고
    • Using chemopreventive agents to enhance the efficacy of cancer therapy
    • Sarkar, F.H., Li, Y., Using chemopreventive agents to enhance the efficacy of cancer therapy. Cancer Res., 66, 2006, 3347.
    • (2006) Cancer Res. , vol.66 , pp. 3347
    • Sarkar, F.H.1    Li, Y.2
  • 125
    • 27644543932 scopus 로고    scopus 로고
    • Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation
    • Sawai, H., Okada, Y., Funahashi, H., et al. Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation. Mol. Cancer, 4, 2005, 37.
    • (2005) Mol. Cancer , vol.4 , pp. 37
    • Sawai, H.1    Okada, Y.2    Funahashi, H.3
  • 126
    • 0035072990 scopus 로고    scopus 로고
    • Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements
    • Setchell, K.D., Brown, N.M., Desai, P., et al. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J. Nutr. 131 (2001), 1362S–1375S.
    • (2001) J. Nutr. , vol.131 , pp. 1362S-1375S
    • Setchell, K.D.1    Brown, N.M.2    Desai, P.3
  • 127
    • 68649091235 scopus 로고    scopus 로고
    • Potential pharmacological control of the NF-[kappa] B pathway
    • Sethi, G., Tergaonkar, V., Potential pharmacological control of the NF-[kappa] B pathway. Trends Pharmacol. Sci. 30 (2009), 313–321.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 313-321
    • Sethi, G.1    Tergaonkar, V.2
  • 128
    • 37549004392 scopus 로고    scopus 로고
    • Nuclear factor-{kappa} B activation: from bench to bedside
    • Sethi, G., Sung, B., Aggarwal, B.B., Nuclear factor-{kappa} B activation: from bench to bedside. Exp. Biol. Med., 233, 2008, 21.
    • (2008) Exp. Biol. Med. , vol.233 , pp. 21
    • Sethi, G.1    Sung, B.2    Aggarwal, B.B.3
  • 129
    • 0034018624 scopus 로고    scopus 로고
    • Urinary pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein
    • Shelnutt, S.R., Cimino, C.O., Wiggins, P.A., et al. Urinary pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein. Cancer Epidemiol. Prev. Biomark. 9 (2000), 413–419.
    • (2000) Cancer Epidemiol. Prev. Biomark. , vol.9 , pp. 413-419
    • Shelnutt, S.R.1    Cimino, C.O.2    Wiggins, P.A.3
  • 130
    • 0036721557 scopus 로고    scopus 로고
    • Pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein in men and women after consumption of a soy beverage
    • Shelnutt, S.R., Cimino, C.O., Wiggins, P.A., et al. Pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein in men and women after consumption of a soy beverage. Am. J. Clin. Nutr. 76 (2002), 588–594.
    • (2002) Am. J. Clin. Nutr. , vol.76 , pp. 588-594
    • Shelnutt, S.R.1    Cimino, C.O.2    Wiggins, P.A.3
  • 131
    • 0033772308 scopus 로고    scopus 로고
    • FAK integrates growth-factor and integrin signals to promote cell migration
    • Sieg, D.J., Hauck, C.R., Ilic, D., et al. FAK integrates growth-factor and integrin signals to promote cell migration. Nat. Cell Biol. 2 (2000), 249–256.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 249-256
    • Sieg, D.J.1    Hauck, C.R.2    Ilic, D.3
  • 132
    • 33644822532 scopus 로고    scopus 로고
    • The invasive behaviour of prostatic cancer cells is suppressed by inhibitors of tyrosine kinase
    • Skogseth, H., Larsson, E., Halgunset, J., The invasive behaviour of prostatic cancer cells is suppressed by inhibitors of tyrosine kinase. APMIS 114 (2006), 61–66.
    • (2006) APMIS , vol.114 , pp. 61-66
    • Skogseth, H.1    Larsson, E.2    Halgunset, J.3
  • 133
    • 0027279805 scopus 로고
    • Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes: additional evidence of GLUT4 activation by insulin
    • Smith, R., Tiesinga, J., Shah, N., et al. Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes: additional evidence of GLUT4 activation by insulin. Arch. Biochem. Biophys. 300 (1993), 238–246.
    • (1993) Arch. Biochem. Biophys. , vol.300 , pp. 238-246
    • Smith, R.1    Tiesinga, J.2    Shah, N.3
  • 134
    • 0038308590 scopus 로고    scopus 로고
    • Breast cancer and obesity: an update
    • Stephenson, G.D., Rose, D.P., Breast cancer and obesity: an update. Nutr. Cancer 45 (2003), 1–16.
    • (2003) Nutr. Cancer , vol.45 , pp. 1-16
    • Stephenson, G.D.1    Rose, D.P.2
  • 135
    • 60149095682 scopus 로고    scopus 로고
    • Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates–catenin signaling in mammary epithelial cells
    • Su, Y., Simmen, R., Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates–catenin signaling in mammary epithelial cells. Carcinogenesis, 30, 2009, 331.
    • (2009) Carcinogenesis , vol.30 , pp. 331
    • Su, Y.1    Simmen, R.2
  • 136
    • 34547650840 scopus 로고    scopus 로고
    • Genistein–a dietary compound inducing hormonal and metabolic changes
    • Szkudelska, K., Nogowski, L., Genistein–a dietary compound inducing hormonal and metabolic changes. J. Steroid Biochem. Mol. Biol. 105 (2007), 37–45.
    • (2007) J. Steroid Biochem. Mol. Biol. , vol.105 , pp. 37-45
    • Szkudelska, K.1    Nogowski, L.2
  • 137
    • 70349573116 scopus 로고    scopus 로고
    • The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies
    • Taylor, C.K., Levy, R.M., Elliott, J.C., et al. The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies. Nutr. Rev. 67 (2009), 398–415.
    • (2009) Nutr. Rev. , vol.67 , pp. 398-415
    • Taylor, C.K.1    Levy, R.M.2    Elliott, J.C.3
  • 138
    • 0034896440 scopus 로고    scopus 로고
    • Differential sensitivity of normal and malignant breast epithelial cells to genistein is partly mediated by p21WAF1
    • Upadhyay, S., Neburi, M., Chinni, S.R., et al. Differential sensitivity of normal and malignant breast epithelial cells to genistein is partly mediated by p21WAF1. Clin. Cancer Res., 7, 2001, 1782.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1782
    • Upadhyay, S.1    Neburi, M.2    Chinni, S.R.3
  • 139
    • 77950822827 scopus 로고    scopus 로고
    • Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer
    • Valle, J., Wasan, H., Palmer, D.H., et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. New Engl. J. Med. 362 (2010), 1273–1281.
    • (2010) New Engl. J. Med. , vol.362 , pp. 1273-1281
    • Valle, J.1    Wasan, H.2    Palmer, D.H.3
  • 140
    • 73649131216 scopus 로고    scopus 로고
    • Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR [gamma] expression in cultured astrocytes
    • Valles, S.L., Dolz-Gaiton, P., Gambini, J., et al. Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR [gamma] expression in cultured astrocytes. Brain Res. 1312 (2010), 138–144.
    • (2010) Brain Res. , vol.1312 , pp. 138-144
    • Valles, S.L.1    Dolz-Gaiton, P.2    Gambini, J.3
  • 141
    • 0041661977 scopus 로고    scopus 로고
    • Genistein as an anti-inflammatory agent
    • Verdrengh, M., Jonsson, I., Holmdahl, R., et al. Genistein as an anti-inflammatory agent. Inflamm. Res. 52 (2003), 341–346.
    • (2003) Inflamm. Res. , vol.52 , pp. 341-346
    • Verdrengh, M.1    Jonsson, I.2    Holmdahl, R.3
  • 142
    • 57049166456 scopus 로고    scopus 로고
    • Osteopontin: role in immune regulation and stress responses
    • Wang, K.X., Denhardt, D.T., Osteopontin: role in immune regulation and stress responses. Cytokine Growth Fact. Rev. 19 (2008), 333–345.
    • (2008) Cytokine Growth Fact. Rev. , vol.19 , pp. 333-345
    • Wang, K.X.1    Denhardt, D.T.2
  • 143
    • 77956637674 scopus 로고    scopus 로고
    • Flavopiridol, the first cyclin-dependent kinase inhibitor: recent advances in combination chemotherapy
    • Wang, L.M., Ren, D.M., Flavopiridol, the first cyclin-dependent kinase inhibitor: recent advances in combination chemotherapy. Mini Rev. Med. Chem. 10 (2010), 1058–1070.
    • (2010) Mini Rev. Med. Chem. , vol.10 , pp. 1058-1070
    • Wang, L.M.1    Ren, D.M.2
  • 144
    • 77749321234 scopus 로고    scopus 로고
    • Down regulation of Notch 1 and Jagged 1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF B signaling pathways
    • Wang, Z., Li, Y., Banerjee, S., et al. Down regulation of Notch 1 and Jagged 1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF B signaling pathways. J. Cell. Biochem. 109 (2010), 726–736.
    • (2010) J. Cell. Biochem. , vol.109 , pp. 726-736
    • Wang, Z.1    Li, Y.2    Banerjee, S.3
  • 145
    • 28944434431 scopus 로고    scopus 로고
    • Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus
    • Wannamethee, S.G., Shaper, A.G., Lennon, L., et al. Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus. Arch. Intern. Med., 165, 2005, 2644.
    • (2005) Arch. Intern. Med. , vol.165 , pp. 2644
    • Wannamethee, S.G.1    Shaper, A.G.2    Lennon, L.3
  • 146
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., Loewith, R., Hall, M.N., TOR signaling in growth and metabolism. Cell 124 (2006), 471–484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 147
    • 33747618245 scopus 로고    scopus 로고
    • Genistein inhibits matrix metalloproteinase type 2 activation and prostate cancer cell invasion by blocking the transforming growth factor β-mediated activation of mitogen-activated protein kinase-activated protein kinase 2–27-kDa heat shock protein pathway
    • Xu, L., Bergan, R.C., Genistein inhibits matrix metalloproteinase type 2 activation and prostate cancer cell invasion by blocking the transforming growth factor β-mediated activation of mitogen-activated protein kinase-activated protein kinase 2–27-kDa heat shock protein pathway. Mol. Pharmacol., 70, 2006, 869.
    • (2006) Mol. Pharmacol. , vol.70 , pp. 869
    • Xu, L.1    Bergan, R.C.2
  • 148
    • 0037341891 scopus 로고    scopus 로고
    • Competitive interactions of chlorinated phenol compounds with 3, 3’ 5-triiodothyronine binding to transthyretin: detection of possible thyroid-disrupting chemicals in environmental waste water
    • Yamauchi, K., Ishihara, A., Fukazawa, H., et al. Competitive interactions of chlorinated phenol compounds with 3, 3’ 5-triiodothyronine binding to transthyretin: detection of possible thyroid-disrupting chemicals in environmental waste water. Toxicol. Appl. Pharmacol. 187 (2003), 110–117.
    • (2003) Toxicol. Appl. Pharmacol. , vol.187 , pp. 110-117
    • Yamauchi, K.1    Ishihara, A.2    Fukazawa, H.3
  • 149
    • 77649151829 scopus 로고    scopus 로고
    • Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways
    • Yan, G.R., Xiao, C.L., He, G.W., et al. Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways. Proteomics 10 (2010), 976–986.
    • (2010) Proteomics , vol.10 , pp. 976-986
    • Yan, G.R.1    Xiao, C.L.2    He, G.W.3
  • 150
    • 77952323519 scopus 로고    scopus 로고
    • Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC–MS/MS method: application to an oral bioavailability study of genistein in mice
    • Yang, Z., Zhu, W., Gao, S., et al. Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC–MS/MS method: application to an oral bioavailability study of genistein in mice. J. Pharm. Biomed. Anal. 53 (2010), 81–89.
    • (2010) J. Pharm. Biomed. Anal. , vol.53 , pp. 81-89
    • Yang, Z.1    Zhu, W.2    Gao, S.3
  • 151
    • 0037291015 scopus 로고    scopus 로고
    • The phytoestrogen genistein suppresses cell-mediated immunity in mice
    • Yellayi, S., Zakroczymski, M., Selvaraj, V., et al. The phytoestrogen genistein suppresses cell-mediated immunity in mice. J. Endocrinol., 176, 2003, 267.
    • (2003) J. Endocrinol. , vol.176 , pp. 267
    • Yellayi, S.1    Zakroczymski, M.2    Selvaraj, V.3
  • 152
    • 28644435880 scopus 로고    scopus 로고
    • Metalloproteinases: mediators of pathology and regeneration in the CNS
    • Yong, V.W., Metalloproteinases: mediators of pathology and regeneration in the CNS. Nat. Rev. Neurosci. 6 (2005), 931–944.
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 931-944
    • Yong, V.W.1
  • 153
    • 84864031902 scopus 로고    scopus 로고
    • Anti-angiogenic genistein inhibits VEGF-induced endothelial cell activation by decreasing PTK activity and MAPK activation
    • Yu, X., Zhu, J., Mi, M., et al. Anti-angiogenic genistein inhibits VEGF-induced endothelial cell activation by decreasing PTK activity and MAPK activation. Med. Oncol., 2010, 1–9.
    • (2010) Med. Oncol. , pp. 1-9
    • Yu, X.1    Zhu, J.2    Mi, M.3
  • 154
    • 76649128721 scopus 로고    scopus 로고
    • Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-[kappa] B
    • Zhang, B., Shi, Z.L., Liu, B., et al. Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-[kappa] B. Anticancer Drugs, 21, 2010, 288.
    • (2010) Anticancer Drugs , vol.21 , pp. 288
    • Zhang, B.1    Shi, Z.L.2    Liu, B.3
  • 155
    • 80052316134 scopus 로고    scopus 로고
    • Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines
    • Zhang, R., Pan, X., Huang, Z., et al. Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines. PLoS One, 6, 2011, e23831.
    • (2011) PLoS One , vol.6 , pp. e23831
    • Zhang, R.1    Pan, X.2    Huang, Z.3
  • 156
    • 53649108031 scopus 로고    scopus 로고
    • Dose-dependent absorption, metabolism, and excretion of genistein in rats
    • Zhou, S., Hu, Y., Zhang, B., et al. Dose-dependent absorption, metabolism, and excretion of genistein in rats. J. Agric. Food Chem. 56 (2008), 8354–8359.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 8354-8359
    • Zhou, S.1    Hu, Y.2    Zhang, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.