Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Zhang, Rihua ^a   Pan, Xiaolin ^a   Huang, Zuhu ^a   Weber, Georg F ^b   Zhang, Guoxin ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF CINCINNATI ACADEMIC HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD44V6 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; GELATINASE A; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOPONTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECOMBINANT OSTEOPONTIN; STRESS ACTIVATED PROTEIN KINASE; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; CXCL12 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN; HERMES ANTIGEN; MMP2 PROTEIN, HUMAN; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; CARCINOMA CELL; CELL INVASION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR BINDING; UPREGULATION; WESTERN BLOTTING; BIOLOGICAL MODEL; CANCER INVASION; DRUG EFFECT; ENZYMOLOGY; LIVER TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTIGENS, CD44; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHEMOKINE CXCL12; HUMANS; INTEGRIN ALPHAVBETA3; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 2; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; OSTEOPONTIN; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CXCR4; UP-REGULATION;

EID: 80052316134     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023831     Document Type: Article

References (37)

1. Ogawa K, (2009) Molecular pathology of early stage chemically induced hepatocarcinogenesis. Pathol Int 59: 605-622.
2. Ramaiah SK, Rittling S, (2008) Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer. Toxicol Sci 103: 4-13.
3. Gazitt Y, (2004) Homing and mobilization of hematopoietic stem cells and hematopoietic cancer cells are mirror image processes, utilizing similar signaling pathways and occurring concurrently: circulating cancer cells constitute an ideal target for concurrent treatment with chemotherapy and ntilineage-specific antibodies. Leukemia 18: 1-10.
4. Lunxiu Q, Zhaoyou T, (2002) The prognostic molecular markers in hepatocellular carcinoma. World J Gastroenterol 8: 385-392.
5. Scatena M, Liaw L, Giachelli CM, (2007) Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol 27: 2302-2309.
6. Mi Z, Guo H, Russell MB, Liu Y, Sullenger BA, et al. (2009) RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells. Mol Ther 17: 153-161.
7. E1-Tanani M, (2008) Role of osteopontin in cellular signaling and metastatic phenotype. Front Biosci 13: 4276-4284.
8. Junko M, Shigeyuki K, Yutaka M, Toshimitsu U, (2010) Osteopontin; as a target molecule for the treatment of inflammatory diseases. Curr Drug Targets 22: 494-505.
9. Jaszczynska-Nowinka K, Markowska A, (2009) New cytokine: stromal derived factor-1. Eur J Gynaecol Oncol 30: 124-127.
10. Miroslaw J, (2009) Functional diversity of SDF-1 splicing variants. Cell Adh Migr 3: 243-249.
11. Tiveron M-C, Cremer H, (2008) CXCL12/CXCR4 signalling in neuronal cell migration. Curr Opin Neurobiol 18: 237-244.
12. Kang Y, Chen BJ, Deoliveira D, Mito J, Chao NJ, (2010) Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model. PLoS One 5: 113-116.
13. Veldkamp CT, Seibert C, Peterson FC, De la Cruz NB, Haugner JC, et al. (2008) Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12. Sci Signal 1: ra4.
14. Brakora KA, Lee H, Yusuf R, Sullivan L, Harris A, et al. (2004) Utility of osteopontin as a biomarker in recurrent epithelial ovarian cancer. Gynecol Oncol 93: 361-365.
15. Clark IM, Hawkes SP, Li H, Taniguchi GT, (1990) Methods in Molecular Biology Humana Press.
16. Xiang Z-L, Zeng Z-C, Tang Z-Y, Fan J, Zhuang P-Y, et al. (2009) Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival. BMC Cancer 9: 176.
17. Wang B, Hsu SH, Majumder S, Kutay H, Huang W, et al. (2010) TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. oncogene 29: 1787-1797.
18. Takafuji V, Forgues M, Unsworth E, Goldsmith P, Wang XW, (2007) An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma. oncogene 26: 6361-6371.
19. Levicar N, Nuttall RK, Lah TT, (2003) Proteases in brain tumour progression. Acta Neurochir (Wien) 145: 825-838.
20. Philip S, Bulbule A, Kundu GC, (2004) Matrix metalloproteinase-2: mechanism and regulation of NF-kappaB-mediated activation and its role in cell motility and ECM-invasion. Glycoconj J 21: 429-441.
21. Lai CF, Seshadri V, Huang K, Shao JS, Cai J, et al. (2006) An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells. Circ Res 98: 1479-1489.
22. Ye S, (2006) Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome. Cardiovasc Res 69: 636-645.
23. Hu T, Luan R, Zhang H, Lau WB, Wang Q, et al. (2009) Hydrogen peroxide enhances osteopontin expression and matrix metalloproteinase activity in aortic vascular smooth muscle cells. Clin Exp Pharmacol Physiol 36: 626-630.
24. Song G, Ouyang G, Mao Y, Ming Y, Bao S, et al. (2009) Osteopontin promotes gastric cancer metastasis by augmenting cell survival and invasion through Akt-mediated HIF-1alpha up-regulation and MMP9 activation. J Cell Mol Med 13: 1706-1718.
25. Yan W, Qian C, Zhao P, Zhang J, Shi L, et al. (2010) Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells. Neuro Oncol 12: 765-775.
26. Ling Wang YL, Chen Yan, (2010) Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. Cancer Letters 297: 42-48.
27. Hong I-K, Kim Y.-M, Lee H, (2005) Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells. Experimental and Molecular Medicine 37: 230-239.
28. McKenna GJ, Chen Y, Smith RM, Meneghetti A, Ong C, et al. (2002) A role for matrix metalloproteinases and tumor host interaction in hepatocellular carcinomas. Am J Surg 183: 588-594.
29. Liu H, Pan Z, Li A, Fu S, Lei Y, et al. (2008) Roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in metastasis of hepatocellular carcinoma cells. Cell Mol Immunol 5: 373-378.
30. Budhu AS, Zipser B, Forgues M, Ye QH, Sun Z, et al. (2005) The molecular signature of metastases of human hepatocellular carcinoma. Oncology 69: 23-27.
31. Jakobsen LP, Borup R, Vestergaard J, Larsen LA, Lage K, et al. (2009) Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal development. Exp Mol Med 41: 77-85.
32. Otsuru S, Tamai K, Yamazaki T, Yoshikawa H, Kaneda Y, (2008) Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/stromal cell-derived factor-1 pathway. Stem Cells 26: 223-234.
33. Kollet O, Dar A, Shivtiel S, Kalinkovich A, Lapid K, et al. (2006) Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med 12: 657-664.
34. Javelaud D, Mohammad K, McKenna CR, Fournier P, Luciani F, et al. (2007) Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis. Cancer Res 67: 2317-2324.
35. Lin HM, Chatterjee A, Lin YH, Anjomshoaa A, Fukuzawa R, et al. (2007) Genome wide expression profiling identifies genes associated with colorectal liver metastasis. Oncol Rep 17: 1541-1549.
36. Gaviraghi M, Tunici P, Valensin S, Rossi M, Giordano C, et al. (2010) Pancreatic cancer spheres are more than just aggregates of stem marker positive cells. Biosci Rep Epub ahead of print.
37. Rogers CD, Fukushima N, Sato N, Shi C, Prasad N, et al. (2006) Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. Cancer Biol Ther 5: 1383-1389.