Phytoestrogens alter adrenocortical function: Genistein and daidzein suppress glucocorticoid and stimulate androgen production by cultured adrenal cortical cells

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 7, 1999, Pages 2443-2448

  Mesiano, Sam ^a,b   Katz, Steven L ^a,c   Lee, Janet Y ^a   Jaffe, Robert B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOHN HUNTER HOSPITAL   (Australia)

^c California North Bay Fertility Associates   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DAIDZEIN; GENISTEIN; PHYTOESTROGEN; PRASTERONE; RNA; STEROID 21 MONOOXYGENASE;

ADRENAL CORTEX FUNCTION; ANDROGEN SYNTHESIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; STEROIDOGENESIS;

EID: 0033306059     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.7.2443     Document Type: Article

References (36)

1. Naturally occurring non-steroidal estrogens of dietary origin
2. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β
3. Are the differences between estradiol and other estrogens merely semantical?
4. Naturally occurring oestrogens in foods-a review
5. High-performance liquid chromatographic assay of isoflavonoids and coumestrol from human urine
6. Rapid HPLC analysis of dietary phytoestrogens from legumes and from human urine
7. Naturally occurring food toxicants: Estrogens
8. Isoflavone content of commercial soybean foods
9. Infertility in ewes grazing subterranean clover pastures. Observations on breeding following transfer to sound country
10. The effects of plant oestrogens on animal reproduction
11. Reproductive and general metabolic effects of phytoestrogens in mammals
12. Phytochemical mimicry of reproductive hormones and modulation of herbivore fertility by phytoestrogens
13. Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women
14. A review of the clinical effects of phytoestrogens
15. Soy intake and cancer risk: A review of the in vitro and in vivo data
16. Inhibition of in vitro microsomal lipid peroxidation by isoflavonoids
17. Meta-analysis of the effects of soy protein intake on serum lipids
18. Genistein as an inducer of tumor cell differentiation: Possible mechanisms of action
19. Genistein, a dietary-derived inhibitor of in vitro angiogenesis
20. The effects of progesterone, pregnenolone, estriol, ACTH and hCG on steroid secretion of cultured human fetal adrenals
21. The control of steroidogenesis by human fetal adrenal cells in tissue culture. IV. The effects of exposure to placental steroids
22. Interaction of insulin-like growth factor-II and estradiol directs steroidogenesis in the human fetal adrenal toward dehydroepiandrosterone sulfate production
23. Determination of lignans and isoflavonoids in human female plasma following dietary supplementation
24. Plasma concentrations of phyto-oestrogens in Japanese men
25. Exposure of infants to phyto-oestrogens from soy-based infant formula
26. Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta
27. Cytochrome P450c17 (steroid 17α-hydroxylase/17,20 lyase): Cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues
28. Abundant adrenal-specific transcription of the human P450c21A pseudogene
29. 4-isomerase in human adrenals and gonads
30. Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11)
31. Basic fibroblast growth factor expression is regulated by ACTH in the human fetal adrenal: A model for adrenal growth regulation
32. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
33. Genistein, a specific inhibitor of tyrosine-specific protein kinases
34. Steroid inhibitory effects upon human adrenal 3β-hydroxysteroid dehydrogenase activity
35. Effect of estradiol on DHEAS production in the human adrenocortical cell line, H295R
36. Hormonal changes in girls with precocious adrenarche: A possible role for estradiol or prolactin