The influence of coumestrol, zearalenone, and genistein administration on insulin receptors and insulin secretion in ovariectomized rats

Journal of Receptors and Signal Transduction

Volumn 22, Issue 1-4, 2002, Pages 449-457

  Nogowski, L ^a   Nowak, K W ^a   Kaczmarek, P ^a   Mackowiak P ^a  

^a POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Coumestrol; Genistein; Insulin; Insulin receptor; Rat; Zearalenone

Indexed keywords

COUMESTROL; ESTRONE; FATTY ACID; GENISTEIN; GLUCOSE; GLYCOGEN; INSULIN; INSULIN RECEPTOR; PHYTOESTROGEN; ZEARALENONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BINDING AFFINITY; CARBOHYDRATE METABOLISM; CONFERENCE PAPER; ESTROGEN ACTIVITY; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; LIPID METABOLISM; NONHUMAN; OVARIECTOMY; RAT; RECEPTOR BINDING; UTERUS WEIGHT;

ANIMALS; BLOOD GLUCOSE; COUMESTROL; ESTROGENS; ESTROGENS, NON-STEROIDAL; FATTY ACIDS, NONESTERIFIED; FEMALE; GENISTEIN; INSULIN; LIVER; LIVER GLYCOGEN; ORGAN SIZE; OVARIECTOMY; RATS; RATS, WISTAR; RECEPTOR, INSULIN; UTERUS; ZEARALENONE;

ANIMALIA;

EID: 0036978248     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.1081/RRS-120014613     Document Type: Conference Paper

References (22)

1. Reinli, K.; Block, G. Phytoestrogen Content of Foods - A Compendium of Literature Values. Nutr. Cancer 1996, 26, 123-148.
2. Price, K.R.; Fenwick, G.R. Naturally Occurring Oestrogens in Foods - A Review. Food Addit. Contam. 1985, 2, 73-106.
3. Kurzer, M.S.; Xu, X. Dietary Phytoestrogens. Annu. Rev. Nutr. 1997, 17, 353-381.
4. Adlercreutz, H. Epidemiology of Phytoestrogens. Baillieres Clin. Endocrinol. Metab. 1998, 12, 605-623.
5. Setchell, K.D.R. Phytoestrogens: The Biochemistry, Physiology, and Implications for Human Health of Soy Isoflavones. Am. J. Clin. Nutr. 1998, 68 (suppl.), 1333S-1346S.
6. Nogowski, L. Effect of the MycoOestrogen Zearalenone on Carbohydrate and Lipid Metabolism Indices in Ovariectomized Female Rats. J. Anim. Physiol. Anim. Nutr. 1996, 75, 156-163.
7. Nogowski, L. Effects of Phytoestrogen-Coumestrol on Lipid and Carbohydrate Metabolism in Young Ovariectomized Rats May be Independent of its Estrogenicity. J. Nutr. Biochem. 1999, 10, 664-669.
8. Nogowski, L.; Mackowiak, P.; Nowak, K.W. Isoflavone-Genistein Changes Tissues Glycogen and Blood Glucose Concentration in Ovariectomized Rats: Possible Ways of Action. J. Anim. Physiol. Anim. Nutr. 1998, 80, 1-9.
9. Nogowski, L.; Mackowiak, P.; Kandulska, K.; Szkudelski, T.; Nowak, K.W. Genistein Induced Changes in Lipid Metabolism of Ovariectomized Rats. Ann. Nutr. Metab. 1998, 42, 360-366.
10. Duncombe, D. The Colorimetric Micro-Determination of Non-Estrified Fatty Acids in Plasma. Clin. Chim. Acta 1964, 9, 122-125.
11. Havrankova, J.; Roth, J.; Brownstein, M.J. Insulin Receptors are Widely Distributed in the Central Nervous System of the Rat. Nature 1978, 272, 827-829.
12. Munson, P.J.; Rodbard, D. LIGAND: A Versatile Computerized Approach for Characterization of Ligand-Binding Systems. Anal. Biochem. 1980, 107, 220-239.
13. Nogowski, L. Effect of Coumestrol and Oestrone on Lipid and Carbohydrate Metabolism in Male Rats. Possible Role of Insulin and its Liver Reception. J. Anim. Physiol. Anim. Nutr. 1993, 70, 53-58.
14. Nogowski, L.; Mackowiak, P.; Nowak, K.W. Comparison of Phytooestrogen-Coumestrol and Oestrone Effects on the Liver Membranes Insulin Receptors in Ovariectomized Female Rats. Bull. Environ. Contain. Toxicol. 1993, 51, 219-225.
15. Nogowski, L.; Mackowiak, P.; Nowak, K.W. Effect of a Mycooestrogen, Zearalenone, and a Phytooestrogen, Coumestrol on the Liver Membrane Insulin Receptor of Ovariectomized Female Rats. Acta Biochim. Pol. 1993, 40, 147-150.
16. Nogowski, L.; Mackowiak, P.; Nowak, K.W. Mycooestrogen-Zearalenone Affects Insulin/Glucagon Ratio and Glycogen Content in Ovariectomized Female Rats. Horm. metab. Res. 1994, 26, 253-254.
17. Nogowski, L.; Nowak, K.W.; Mackowiak, P. Effect of Phytooestrogen-Coumestrol on Some Aspects of Carbohydrate Metabolism in Ovariectomized Female Rats. Arch. Vet. Pol. 1992, 3-4, 79-84.
18. Kandulska, K.; Nogowski, L.; Szkudelski, T. Effect of Some Phytoestrogens on Metabolism of Rat Adipocytes. Reprod. Nutr. Dev. 1999, 39, 497-501.
19. Mackowiak, P.; Nogowski, L.; Nowak, K.W. Effect of Isoflavone Genistein on Insulin Receptors in Perfused Liver of Ovariectomized Rats. J. Recept. Signal Transd. Res. 1999, 19, 283-292.
20. Chakravorty, A.; Joslyn, M.I.; Davis, J.S. Characterization of Insulin and Insulin-Like Growth Factor-I Actions in the Bovine Luteal Cell: Regulation of Receptor Tyrosine Kinase Activity, Phosphatidylinositol-3-Kinase, and Deoxyribonucleic Acid Synthesis. Endocrinology 1993, 133, 1331-1340.
21. Abler, A.; Smith, J.A.; Randazzo, P.A.; Rothenberg, P.L.; Jarett, L. Genistein Differentially Inhibits Postreceptor Effects of Insulin in Rat Adipocytes without Inhibiting the Insulin Receptor Kinase. J. Biol. Chem. 1992, 267, 3946-3951.
22. Smith, R.M.; Tiesinga, J.J.; Shah, N.; Smith, J.A.; Jarett, L. Genistein Inhibits Insulin-Stimulated Glucose Transport and Decreases Immunocytochemical Labeling of Glut4 Carboxyl-Terminus without Affecting Translocation of GLUT4 in Isolated Rat Adipocytes: Additional Evidence of GLUT4 Activation by Insulin. Arch. Biochem. Biophys. 1993, 300, 238-246.