Differential sensitivity of normal and malignant breast epithelial cells to genistein is partly mediated by p21WAF11

Clinical Cancer Research

Volumn 7, Issue 6, 2001, Pages 1782-1789

  Upadhyay, S ^a   Neburi, M ^a   Chinni, S R ^a   Alhasan, S ^a   Miller, F ^a   Sarkar, F H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENISTEIN; PROTEIN P21;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIVITY; FLOW CYTOMETRY; GENE INDUCTION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DIPLOIDY; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EPITHELIAL CELLS; FLOW CYTOMETRY; GENISTEIN; HUMANS; LUCIFERASES; NEOPLASM METASTASIS; PROMOTER REGIONS (GENETICS); RNA; TRANSFECTION; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0034896440     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. A review of the clinical effects of phytoestrogens
2. Phytoestrogens: Epidemiology and a possible role in cancer protection
3. Dietary effects on breast-cancer risk in Singapore
4. Effects of soya consumption for one month on steroid hormones in premenopausal women: Implications for breast cancer risk reduction
5. Soybeans inhibit mammary tumors in models of breast cancer
6. Dietary soybean isolate and methionine supplementation affect mammary tumor progression in rats
7. Genistein inhibition of the growth of human breast cancer cells: Independence from estrogen receptors and the multidrug resistance gene
8. Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells
9. 1 to S phase transition in mouse fibroblast and melanoma cells
10. 2 arrest in the human breast cancer cells MDA-MB-231 and renders them competent for DNA rereplication
11. Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade
12. 1 cyclin-dependent kinases
13. WAF1, a potential mediator of p53 tumor suppression
14. Inhibition of cyclin-dependent kinases by p21
15. 1 arrest in human cancer cells
16. WAF1/C1P1 -/- human cancer cells
17. Nuclear accumulation of p21Cip1 at the onset of mitosis: A role at the G2/M-phase transition
18. 2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication
19. 1 checkpoint control
20. Bypass of senescence after disruption of p21C1P1/WAF1 gene in normal diploid human fibroblasts
21. p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells
22. Genetic determinants of p53-induced apoptosis and growth arrest
23. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10
24. Ultrastructural and immuno-cytochemical characterization of an immortalized human breast epithelial cell line, MCF-10
25. Chromosomal markers of immortalization in human breast epithelium
26. Xenograft model of progressive human proliferative breast disease
27. p53 independent apoptosis induced by genistein in lung cancer cells
28. Genistein induced molecular changes in a squamous cell carcinoma of the head and neck cell line
29. Genistein exerts multiple suppressive effects on human breast carcinoma cells
30. Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells
31. Caspases: Enemies within
32. The Bcl-2 protein family: Arbiters of cell survival
33. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
34. Deregulation of p53/p21Cip1/Waf1 pathway contributes to polyploidy and apoptosis of E1A + cHa-ras transformed cells after γ-irradiation