Heart regeneration and repair after myocardial infarction: Translational opportunities for novel therapeutics

Nature Reviews Drug Discovery

Volumn 16, Issue 10, 2017, Pages 699-717

  Cahill, Thomas J ^a,b   Choudhury, Robin P ^a,b   Riley, Paul R ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 10; BRG1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1C; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 4; FIBROBLAST GROWTH FACTOR 16; HEART AND NEURAL CREST DERIVATIVES EXPRESSED PROTEIN 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 6; MEIS1 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NEU DIFFERENTIATION FACTOR; PROTEIN SERINE THREONINE KINASE; PROTEIN SWI; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; STROMAL CELL DERIVED FACTOR 1; THYMOSIN BETA4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 21; TRANSCRIPTION FACTOR SNF; TRANSCRIPTION FACTOR YAP1; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR 2; WNT3A PROTEIN; WNT7B PROTEIN;

AGING; ANGIOGENESIS; CARDIAC MUSCLE CELL; CELL POPULATION; CELL PROLIFERATION; CONGENITAL HEART DISEASE; DNA REPLICATION; DRUG INDUSTRY; EMBRYONIC STEM CELL; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; HEART INFARCTION; HEART MUSCLE REVASCULARIZATION; HEART REGENERATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NEOVASCULARIZATION (PATHOLOGY); NEW YORK HEART ASSOCIATION CLASS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR REPROGRAMMING; PERCUTANEOUS CORONARY INTERVENTION; PRIMARY PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; TISSUE REGENERATION; UPREGULATION; WNT SIGNALING; ANIMAL; CLINICAL TRIAL (TOPIC); GENETICS; METABOLISM; MYOCARDIAL INFARCTION; PHYSIOLOGY; PROCEDURES; REGENERATION; STEM CELL TRANSPLANTATION; TRANSLATIONAL RESEARCH; TRANSPLANTATION; TRENDS;

ANIMALS; CLINICAL TRIALS AS TOPIC; HUMANS; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; REGENERATION; STEM CELL TRANSPLANTATION; TRANSLATIONAL MEDICAL RESEARCH;

EID: 85030769476     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd.2017.106     Document Type: Review

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