Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study)

American Journal of Cardiology

Volumn 105, Issue 10, 2010, Pages

  Abbate, Antonio ^a   Kontos, Michael C ^a   Grizzard, John D ^a   Biondi Zoccai, Giuseppe G L ^b   Van Tassell, Benjamin W ^a   Robati, Roshanak ^a   Roach, Lenore M ^a   Arena, Ross A ^a   Roberts, Charlotte S ^a   Varma, Amit ^a   Gelwix, Christopher C ^a   Salloum, Fadi N ^a   Hastillo, Andrea ^a   Dinarello, Charles A ^c   Vetrovec, George W ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; PLACEBO; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; BLOOD CLOT LYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY STENT; DOUBLE BLIND PROCEDURE; DRUG SAFETY; ECHOCARDIOGRAPHY; FALSE ANEURYSM; FEMALE; HEART FAILURE; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART VENTRICLE REMODELING; HUMAN; INJECTION SITE PAIN; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; THORAX PAIN; UNSTABLE ANGINA PECTORIS;

EID: 77951665667     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2009.12.059     Document Type: Article

References (27)

1. Frangogiannis N. The immune system and cardiac repair. Pharmacol Rev 58 (2008) 88-111
2. Velagaleti R., Pencina M., Murabito J., Wang T., Parikh N., D'Agostino R., Levy D., Kannel W., and Vasan R. Long-term trends in the incidence of heart failure after myocardial infarction. Circulation 118 (2008) 2057-2062
3. Goldberg R., Spencer F., Yarzebski J., Lessard D., Gore J., Alpert J., and Dalen J.A. 25-Year perspective into the changing landscape of patients hospitalized with acute myocardial infarction (the Worcester Heart Attack Study). Am J Cardiol 94 (2004) 1373-1378
4. Dinarello C. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27 (2009) 519-550
5. Pomerantz B.J., Reznikov L.L., Harken A.H., and Dinarello C.A. Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta. Proc Natl Acad Sci U S A 98 (2001) 2871-2876
6. Bujak M., and Frangogiannis N. The role of IL-1 in the pathogenesis of heart disease. Arch Immunol Ther Exp 57 (2009) 165-176
7. Abbate A., Salloum F., Vecile E., Das A., Hoke N., Straino S., Biondi-Zoccai G.G.L., Houser J., Qureshi I., Ownby E., Gustini E., Biasucci L., Severino A., Capogrossi M., Vetrovec G., Crea F., Baldi A., Kukreja R., and Dobrina A. Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction. Circulation 117 (2008) 2670-2683
8. Bujak M., Dobaczewski M., Chatila K., Mendoza L.H., Li N., Reddy A., and Frangogiannis N.G. Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol 173 (2008) 57-67
9. Saraste A., Nekolla S., and Schwaiger M. Contrast-enhanced magnetic resonance imaging in the assessment of myocardial infarction and viability. J Nucl Cardiol 15 (2008) 105-117
10. Gardin J., Adams D., Douglas P., Feigenbaum H., Forst D., Fraser A., Grayburn P., Katz A., Keller A., Kerber R., Khandheria B., Klein A., Lang R., Pierard L., Quinones M., and Schnittger I. Recommendations for a standardized report for adult transthoracic echocardiography: a report from the American Society of Echocardiography's Nomenclature and Standards Committee and Task Force for a Standardized Echocardiography Report. J Am Soc Echocardiogr 15 (2002) 275-290
11. Braunwald E. Shattuck lecture-cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med 337 (1997) 1360-1369
12. Rosamond W., Flegal K., Furie K., Go A., Greenlund K., Haase N., Hailpern S., Ho M., Howard V., Kissela B., Kittner S., Lloyd-Jones D., McDermott M., Meigs J., Moy C., Nichol G., O'Donnell C., Roger V., Sorlie P., Steinberger J., Thom T., Wilson M., and Hong Y. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 117 (2008) e25-e146
13. Marino P., Zanolla L., and Zardini P. Effect of streptokinase on left ventricular modeling and function after myocardial infarction: the GISSI (Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico) trial. J Am Coll Cardiol 14 (1989) 1149-1158
14. St John Sutton M., Pfeffer M.A., Plappert T., Rouleau J.L., Moyé L.A., Dagenais G.R., Lamas G.E., Klein M., Sussex B., Goldman S., and SAVE investigators. Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction: the protective effects of captopril. Circulation 89 (1994) 68-75
15. Doughty R.N., Whalley G.A., Walsh H.A., Gamble G.D., Lopez-Sendon J., Sharpe N., and CAPRICORN ECHO Substudy Investigators. Effects of carvedilol on left ventricular remodeling after acute myocardial infarction. Circulation 109 (2004) 201-206
16. GISSI Group. Long-term effects of intravenous thrombolysis in acute myocardial infarction: final report of the GISSI study. Gruppo Italiano per lo studio della Streptochinasi nell'Infarto Miocardico (GISSI). Lancet 2 (1987) 871-874
17. Pfeffer M.A., Lamas G.E., Vaughan D.E., Parisi A.F., and Braunwald E. Effect of captopril on progressive ventricular dilatation after anterior myocardial infarction. N Engl J Med 319 (1988) 80-86
18. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI) Group. GISSI 3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Lancet 343 (1994) 1115-1122
19. CAPRICORN Investigators. Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. Lancet 357 (2001) 1385-1390
20. Kaplanski G., Porat R., Aiura K.E.J., Gelfand J.A., and Dinarello C.A. Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event. Blood 81 (1993) 2492-2495
21. Suzuki k., Murtuza B., Smolenski R.T., Sammut I.A., Suzuki N., Kaneda Y., and Yacoub M.H. Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction of apoptosis. Circulation 104 Suppl I (2001) I308-I313
22. Anand I., Florea V., and Fisher L. Surrogate end points in heart failure. J Am Coll Cardiol 39 (2002) 1414-1421
23. White H.D., Norris R.M., Brown M.A., Brandt P.W., Whitlock R.N., and Wild C.J. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation 76 (1987) 44-51
24. Crossman D., Morton A., Gunn J., Greenwood J., Hall A., Fox K., Lucking A., Flather M., Lees B., and Foley C. Investigation of the effect of interleukin-1 receptor antagonist (IL-1RA) on markers of inflammation in non-ST elevation acute coronary syndromes (the MRC-ILA-HEART Study). Trials 9 (2008) 8-14
25. Furst D. Anakinra: review of recombinant human interleukin-I receptor antagonist in the treatment of rheumatoid arthritis. Clin Ther 26 (2004) 1960-1975
26. Ikonomidis I., Lekakis J.P., Nikolau M., Paraskevaidis I., Andreaudou I., Kaplanoglou T., Katsimbri P., Skarantavous G., Soucacos P.N., and Kremastinos D.T. Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritis. Circulation 117 (2008) 2662-2669
27. Orn S., Manhenke C., Ueland T., Dams J., Mollnes T., Edvardsen T., Aukrust P., and Dickstein K. C-reactive protein, infarct size, microvascular obstruction, and left-ventricular remodelling following acute myocardial infarction. Eur Heart J 30 (2009) 1180-1186