Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling

Nature

Volumn 522, Issue 7555, 2015, Pages 226-230

  Wang, Jinhu ^a   Cao, Jingli ^a   Dickson, Amy L ^a   Poss, Kenneth D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SONIC HEDGEHOG PROTEIN; ZEBRAFISH PROTEIN;

BIOTRANSFORMATION; CARDIOLOGY; CARDIOVASCULAR SYSTEM; CELLS AND CELL COMPONENTS; CYPRINID; EMBRYONIC DEVELOPMENT; GENE EXPRESSION; METABOLISM; RECOMBINATION; REGROWTH;

ADULT; ADULT ANIMAL; ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EPICARDIAL REGENERATION; EPICARDIUM; EX VIVO STUDY; FEMALE; FLUORESCENCE; HEART LEFT VENTRICLE OUTFLOW TRACT; HEART MUSCLE CELL; HEART RIGHT VENTRICLE OUTFLOW TRACT; MALE; MUSCLE INJURY; MUSCLE REGENERATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGENERATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; TISSUE INTERACTION; ZEBRA FISH; ANIMAL; CYTOLOGY; GENETICS; HEART INJURY; METABOLISM; PERICARDIUM; PHYSIOLOGY; TRANSGENIC ANIMAL;

DANIO RERIO; ERINACEIDAE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL PROLIFERATION; FEMALE; HEART INJURIES; HEDGEHOG PROTEINS; MALE; MYOCYTES, CARDIAC; PERICARDIUM; REGENERATION; SIGNAL TRANSDUCTION; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84930945313     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14325     Document Type: Article

References (29)

1. Huang, G.N. et al. C/EBP transcription factors mediate epicardial activation during heart development and injury. Science 338, 1599-1603 (2012).
2. Kikuchi, K.et al.tcf211epicardialcells adoptnon-myocardialfatesduringzebrafish heart development and regeneration. Development 138, 2895-2902 (2011).
3. Smart, N. et al. De novo cardiomyocytes from within the activated adult heart after injury. Nature 474, 640-644 (2011).
4. Zhou, B. et al. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J. Clin. Invest. 121, 1894-1904 (2011).
5. Wang, J., Karra, R., Dickson, A. L. & Poss, K. D. Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. Dev. Biol. 382, 427-435 (2013).
6. Smart, N. et al. Thymosin b4 induces adult epicardial progenitor mobilization and neovascularization. Nature 445, 177-182 (2007).
7. Lepilina, A. et al. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell 127, 607-619 (2006).
8. Song, K. et al. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 485, 599-604 (2012).
9. Qian, L. et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature 485, 593-598 (2012).
10. Pisharath, H., Rhee, J. M., Swanson, M. A., Leach, S. D. & Parsons, M. J. Targeted ablationofbcells inthe embryonic zebrafish pancreas using E.coli nitroreductase. Mech. Dev. 124, 218-229 (2007).
11. Curado, S. et al. Conditional targeted cell ablation in zebrafish: a new tool for regeneration studies. Dev. Dyn. 236, 1025-1035 (2007).
12. Singh, S. P., Holdway, J. E. & Poss, K. D. Regeneration of amputated zebrafish fin rays from de novo osteoblasts. Dev. Cell 22, 879-886 (2012).
13. Poss, K. D., Wilson, L. G. & Keating, M. T. Heart regeneration in zebrafish. Science 298, 2188-2190 (2002).
14. Kikuchi, K. et al. Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. Dev. Cell 20, 397-404 (2011).
15. Kim, J., Rubin, N., Huang, Y., Tuan, T. L. & Lien, C.L. Invitro culture ofepicardial cells from adult zebrafish heart on a fibrin matrix. Nature Protocols 7, 247-255 (2012).
16. Riddle, R. D., Johnson, R. L., Laufer, E. & Tabin, C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416 (1993).
17. Roelink, H. et al. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 81, 445-455 (1995).
18. Fan, C. M. & Tessier-Lavigne, M. Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell 79, 1175-1186 (1994).
19. Roelink, H. et al. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell 76, 761-775 (1994).
20. Echelard, Y. et al. Sonic hedgehog, amemberof a family ofputative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430 (1993).
21. Johnson, R. L., Laufer, E., Riddle, R. D. & Tabin, C. Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning ofsomites. Cell 79, 1165-1173 (1994).
22. Guerrero, I. & Kornberg, T.B. Hedgehog and its circuitous journey from producing to target cells. Semin. Cell Dev. Biol. 33, 52-62 (2014).
23. Sanders, T. A., Llagostera, E. & Barna, M. Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning. Nature 497, 628-632 (2013).
24. Wang, J. et al. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development 138, 3421-3430 (2011).
25. Kikuchi, K. et al. Primary contribution to zebrafish heart regeneration by gata41 cardiomyocytes. Nature 464, 601-605 (2010).
26. Lawson, N. D. & Weinstein, B. M. In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev. Biol. 248, 307-318 (2002).
27. Shkumatava, A., Fischer, S., Muller, F., Strahle, U. & Neumann, C. J. Sonic hedgehog, secreted by amacrine cells, acts as a short-range signal to direct differentiation and lamination in the zebrafish retina. Development 131, 3849-3858 (2004).
28. Zhou, B. & Pu, W. T. Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells. Methods Mol. Biol. 843, 155-168 (2012).
29. Salic, A. & Mitchison, T. J. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc. Natl Acad. Sci. USA 105, 2415-2420 (2008).