Extending the time window of mammalian heart regeneration by thymosin beta 4

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 12, 2014, Pages 2417-2424

  Rui, Liu ^a   Yu, Nie ^a   Hong, Lian ^a   Feng, He ^a   Chunyong, Han ^a   Jian, Meng ^a   Zhe, Zheng ^a   Shengshou, Hu ^a  

^a FUWAI HOSPITAL   (China)

Author keywords

Cardiac regeneration; EPDCs; Neonatal mouse; T 4

Indexed keywords

MAMMALIA;

ACTININ; THYMOSIN; THYMOSIN BETA(4); TROPONIN T; WT1 PROTEIN;

ANIMAL; CELL MOTION; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECTS; ECHOCARDIOGRAPHY; HEART MUSCLE CELL; HEART STROKE VOLUME; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; MOUSE; NEWBORN; PERICARDIUM; PHYSIOLOGY; REGENERATION; SARCOMERE; TIME;

ACTININ; ANIMALS; ANIMALS, NEWBORN; CELL MOVEMENT; ECHOCARDIOGRAPHY; INJECTIONS, INTRAPERITONEAL; MICE; MICROSCOPY, CONFOCAL; MYOCYTES, CARDIAC; PERICARDIUM; REGENERATION; SARCOMERES; STROKE VOLUME; THYMOSIN; TIME FACTORS; TROPONIN T; WT1 PROTEINS;

EID: 84911438539     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12421     Document Type: Article

References (20)

1. Bergmann O, Bhardwaj RD, Bernard S, et al. Evidence for cardiomyocyte renewal in humans. Science. 2009; 324: 98-102.
2. Kajstura J, Urbanek K, Perl S, et al. Cardiomyogenesis in the adult human heart. Circ Res. 2010; 107: 305-15.
3. Porrello ER, Mahmoud AI, Simpson E, et al. Transient regenerative potential of the neonatal mouse heart. Science. 2011; 331: 1078-80.
4. Cismasiu VB, Radu E, Popescu LM. miR-193 expression differentiates telocytes from other stromal cells. J Cell Mol Med. 2011; 15: 1071-4.
5. Popescu LM, Manole CG, Gherghiceanu M, et al. Telocytes in human epicardium. J Cell Mol Med. 2010; 14: 2085-93.
6. Gherghiceanu M, Popescu LM. Cardiac telocytes - their junctions and functional implications. Cell Tissue Res. 2012; 348: 265-79.
7. Gherghiceanu M, Popescu LM. Heterocellular communication in the heart: electron tomography of telocyte-myocyte junctions. J Cell Mol Med. 2011; 15: 1005-11.
8. Zhao B, Chen S, Liu J, et al. Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat. J Cell Mol Med. 2013; 17: 123-33.
9. Manole CG, Cismasiu V, Gherghiceanu M, et al. Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis. J Cell Mol Med. 2011; 15: 2284-96.
10. Martinez-Estrada OM, Lettice LA, Essafi A, et al. Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin. Nat Genet. 2010; 42: 89-93.
11. Zhou B, Ma Q, Rajagopal S, et al. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008; 454: 109-13.
12. Zhou B, Honor LB, He H, et al. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Investig. 2011; 121: 1894-904.
13. Smart N, Risebro CA, Melville AA, et al. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007; 445: 177-82.
14. Smart N, Bollini S, Dube KN, et al. De novo cardiomyocytes from within the activated adult heart after injury. Nature. 2011; 474: 640-4.
15. Philp D, Goldstein AL, Kleinman HK. Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development. Mech Ageing Dev. 2004; 125: 113-5.
16. Laugwitz KL, Moretti A, Lam J, et al. Postnatal isl1 + cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005; 433: 647-53.
17. Moretti A, Caron L, Nakano A, et al. Multipotent embryonic isl1 + progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006; 127: 1151-65.
18. Prall OW, Menon MK, Solloway MJ, et al. An Nk2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007; 128: 947-59.
19. Wu SM, Fujiwara Y, Cibulsky SM, et al. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 2006; 127: 1137-50.
20. Qian L, Huang Y, Spencer CI, et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 2012; 485: 593-8.